< Back to Issue 7 Peaks and Perspectives: A Word from the Editors-in-Chief by the Editors-in-Chief 22 October 2024 illustrated by Ingrid Sefton In geometry, an apex may refer to the highest point of a solid figure, such as a pyramid. Move to the fields of ecology and evolution, and we find apex predators, overseeing population dynamics atop of the food chain. We too find ourselves situated at an apex position in society – observing, experimenting with, and utilising the world at our feet for scientific innovation and headway. Common amongst these apexes in science is unsurprisingly the emphasis on reaching soaring heights and breathtaking summits. We strive to reach these peaks, endpoints that are perceived to signal scientific greatness and knowledge. We create, we innovate, we explore – all with this vision in mind. Yet, this is not, or rather, should not be the “why” for scientific endeavour. Implicit in reaching the highest point of something is the notion that there is no further to climb. That upon reaching an apex, all that remains is to precariously balance upon this peak and hope not to misstep, tumbling down from great heights. Scientific curiosity and a yearning to understand the science underpinning our existence is not about reaching the envisioned apex. It is instead defined by the steps climbed by us and our predecessors in our journey towards discovery, and in turn, the steps that remain untrod and paths that remain uncharted. The routes we are yet to take will be forever changing. Piloted by the evolving foci of our society, where and how we may next seek to innovate remains undetermined. Infinite possibilities abound. With a birds-eye view, Apex visualises the new levels of human-tech connectivity, ills of antimicrobial resistance, and the fringes of outer space that loom on the horizon; with it, encouraging readers to envisage where the next steps may lie. Yet alongside these perspectives of the expansive, limitless world, Apex invites reflection and hypotheticals. Taking time to pause from the unfaltering upward march of innovation, this issue embraces the breathtaking view of where we are now. Apex guides us to consider time-old traditions and technicalities from a new perspective, celebrating those who have paved the way to the peaks of modern science. Wandering within, across and between disciplines of Science, it is these ruminations along the way that enrich the journey. After all, what is scientific advancement without knowing what we do not know? In the words of Sir Isaac Newton, it is by standing on the shoulders of giants that we hope to see further. So come along, and revel in the expansive view. Let the heights of scientific innovation inspire you, but don’t let such peaks constrain you. Previous article Next article apex back to

< Back to Issue 7 Timeless Titans: Billionaires defying death by Holly McNaughton 22 October 2024 edited by Arwen Nguyen-Ngo illustrated by Esme MacGillivray Humans are destined to face an unavoidable end, but what if we weren't? What if humans could push the boundaries of death and become "un-ageable"? What would be the consequences if the world's top apex predators became immortal? The concept of anti-ageing and the quest for eternal life is not new. Cleopatra supposedly bathed in donkeys’ milk to reduce wrinkles. The first emperor of the Qin dynasty (221-206 B.C.), tried to achieve immortality by taking pills. Unfortunately for him, the key ingredient was the highly toxic substance—mercury. In 16th century France, members of the nobility would drink gold to preserve youthful looks. Much like in the past, today’s leading figures in the anti-ageing field are those with power and wealth. Today, the same obsessive quest for youth persists, but now it is backed by cutting-edge science and more importantly, staggering wealth. This article delves into the latest anti-ageing trends—pills, specialised diets, and more—championed by modern-day billionaires. We’ll explore the innovations they fund, and more provocatively, what it means for humanity when death is no longer inevitable. Anti-ageing pills The first “key” to anti-ageing is metformin, which dates to the1920s and was first discovered in the medicinal herb Galega officinalis . It lowers blood sugar levels and is taken as a popular treatment for type 2 diabetes (Bailey, 2017). Metformin works by tricking your body into thinking there is not enough energy, lowering blood glucose levels, and helping the insulin your body makes to work better. In a 2014 clinical study, patients with type 2 diabetes initiated with metformin had longer survivals than non-diabetics who did not receive the drug (Bannister et al. 2014). Although this is a correlation, not causation, some studies state Metformin has increased lifespan in mice (Martin-Montalvo et al., 2013). While we are anticipating the results of a trial on the effects on humans, and particularly the effects on non-diabetic lifespan, some are already convinced by the results from preliminary studies, such as Byran Johnson. Johnson is a self-proclaimed Professional Rejuvenation Athlete and founder of Project Blueprint. The Blueprint protocol is an extensive regimen of exercise, health tests, supplements, and a strict diet, to reverse biological age. Bryan has been following the protocol since 2021 and has successfully slowed down his rate of ageing to 0.76, meaning that for every year, Bryan is only ageing 277 days. Luckily, it only costs him 2 million a year. As part of the protocol, Bryan takes several prescription drugs daily, including metformin twice a day and rapamycin. Rapamycin is another promising “key” anti-ageing drug that works as a mTOR inhibitor. mTOR is a key component in cell growth, proliferation and survival. By inhibiting mTOR, cell growth and protein synthesis processes are slowed, thus reducing the chance of pathology (disease and/or injury) of cells and tissues. It has been shown to extend the lifespan of mice, yeast, worms and fruit flies (Harrison et al., 2009) and in 2018, elderly humans given rapamycin showed promising results with improvement in immune function and decreased infection rates (Mannick et al., 2018), which could ultimately lead to longer lifespans. Young blood transfusion Throughout history, blood has been a popular anti-ageing remedy. In the 15th century, Pope Innocent VIII drank the blood of three young boys, to heal his ailments (Scott & DeFrancesco, 2015). It did not work. The term “Young Blood transfusion” is now used to refer to the practice of transfusing blood from a young person into an older one to tackle age-related diseases. The rationale comes from parabiosis experiments. Parabiosis is the anatomical and physiological union of two organisms, and in the 1950s it was performed on two mice, surgically stitched together. A month after the procedure, the older mice showed rejuvenation (Conboy et al., 2005). In 2017, a new startup called Ambrosia emerged offering transfusion from young people at $8,000 a session. According to the U.S Food and Drug Administration, there were no clinical benefits of this treatment, and it was shortly shut down. PayPal founder Peter Thiel believes he will live to be 120 years old; a fan of young blood transfusions, he also credits his future success to taking human growth hormones daily and following a strict paleo diet. The science of which diet is best for anti-ageing is constantly changing. The paleo diet cuts out sugar, carbohydrates and highly processed food and is praised by celebs, but is not currently supported by science for having anti-aging benefits. Other diets such as intermittent fasting, keto and veganism are all praised for their anti-aging properties, but again the claims are under-researched. However, there is a growing body of evidence that a whole-food, plant-based diet can aid in the prevention, and in some cases reversal, of chronic diseases (Solway et al., 2020). For example, in Loma Linda, California, one of the world's five original blue zones (areas of the world with the healthiest, longest-living populations), the life expectancy is 10 years longer than the average American, which has been linked to the high number of Adventist vegetarians in the community. The key link between all five blue zones is a mostly whole-food, plant-based diet. Ethical and social implications – consequences of immortal humans The cure to ageing is still a while away but there is already a growing body of evidence of how we can extend our lifespans, but is that a good idea? The first argument against extending human lifespans is the risk of furthering the gaps in inequality. There is already a 30–40-year life expectancy gap between first-world and third-world countries. As highlighted in this article, it is primarily the wealthy benefiting from advancements in anti-ageing. Although, it is the responsibility of politicians and governments to remove the disparities worldwide. Thus, the question arises – should our focus and resources be directed towards addressing the health crises in developing countries instead? The second argument is overpopulation. An interesting study that looked at a 100-year projection of population size if no one aged after 60 showed that total population size only increased by 22% or 9 million to 11 million (Gavrilov & Gavrilova, 2010). They also pointed out that many members of society may choose to reject new anti-ageing technologies due to religious reasons, fear of side effects and/or costs. I would also like to point out that the world’s declining birth rates due to increased fertility issues may also mean overpopulation won’t be a near-future issue. An increasing population size does however mean increased demand for finite resources like water. Increases in water demand could cause an increase in civil and international conflicts over existing water supplies. In Australia, water scarcity is already a persistent issue, given the relatively dry and variable climate and an increased population size will see demand rise above our limits. To conclude, science has not found a cure for mortality, but with the development in age reversal or anti-ageing science, we may see the longevity of life increasing as well as quality of life. There are several ethical and social implications of an “un-ageable” race, but most importantly, developments in the anti-ageing community may allow loved ones to be healthier for longer. References AIHW, Australian Institute of Health and Welfare. (2024). Deaths in Australia. Retrieved from https://www.aihw.gov.au/reports/life-expectancy-deaths/deaths-in-australia Bannister, C. A., Holden, S. E., Jenkins-Jones, S., Morgan, C. L., Halcox, J. P., Schernthaner, G.,Mukherjee, J., & Currie, C. J. (2014). Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes Metab , 16 (11), 1165-1173. https://doi.org/10.1111/dom.12354 Bailey, C. J. (2017). Metformin: historical overview. Diabetologia , 60 (9), 1566-1576. Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature , 433 (7027), 760-764. https://doi.org/10.1038/nature03260 Gavrilov, L. A., & Gavrilova, N. S. (2010). Demographic consequences of defeating aging. Rejuvenation Res , 13 (2-3), 329-334. https://doi.org/10.1089/rej.2009.0977 doi.org Metformin: historical overview - Diabetologia Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat’s rue), a traditional herbal medicine in Europe, found to be rich in guanidine, which, in 1918, was shown to lower blood glucose. Guanidine derivatives, including metformin, were synthesised and some (not metformin) were used to treat diabetes in the 1920s and 1930s but were discontinued due to toxicity and the increased availability of insulin. Metformin was rediscovered in the search for antimalarial agents in the 1940s and, during clinical tests, proved useful to treat influenza when it sometimes lowered blood glucose. This property was pursued by the French physician Jean Sterne, who first reported the use of metformin to treat diabetes in 1957. However, metformin received limited attention as it was less potent than other glucose-lowering biguanides (phenformin and buformin), which were generally discontinued in the late 1970s due to high risk of lactic acidosis. Metformin’s future was precarious, its reputation tarnished by association with other biguanides despite evident differences. The ability of metformin to counter insulin resistance and address adult-onset hyperglycaemia without weight gain or increased risk of hypoglycaemia gradually gathered credence in Europe, and after intensive scrutiny metformin was introduced into the USA in 1995. Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, providing a new rationale to adopt metformin as initial therapy to manage hyperglycaemia in type 2 diabetes. Sixty years after its introduction in diabetes treatment, metformin has become the most prescribed glucose-lowering medicine worldwide with the potential for further therapeutic applications. Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E., & Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature , 460 (7253), 392-395. https://doi.org/10.1038/nature08221 Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M. J., Schwab, M., Pollak, M., Zhang, Y., Yu, Y., Becker, K. G., Bohr, V. A., Ingram, D. K., Sinclair, D. A., Wolf, N. S., . . . de Cabo, R. (2013). Metformin improves healthspan and lifespan in mice. Nat Commun , 4 , 2192. https://doi.org/10.1038/ncomms3192 Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., Glass, D. J., & Klickstein, L. B. (2018). TORC1 inhibition enhances immune function and reduces infections in the elderly. Science Translational Medicine , 10 (449), eaaq1564. https://doi.org/doi:10.1126/scitranslmed.aaq1564 Scott, C., & DeFrancesco, L. (2015). Selling Long Life. Nature Biotechnology , 33 , 28-37. Solway, J., McBride, M., Haq, F., Abdul, W., & Miller, R. (2020). Diet and Dermatology: The Role of a Whole-food, doi.org Selling long life - Nature Biotechnology A new generation of commercial entities is beginning to explore opportunities for new types of interventions and services in a graying world. Plant-based Diet in Preventing and Reversing Skin Aging-A Review. J Clin Aesthet Dermatol , 13 (5), 38-43. Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T.,Haghani, A., Gong, T., Hedman, A. M., Andolf, E., Pershagen, G., Almqvist, C., Clish, C. B., Horvath, S., White, J. P., & Gladyshev, V. N. (2023). Biological age is increased by stress and restored upon recovery. Cell Metab , 35 (5), 807-820.e805. https://doi.org/10.1016/j.cmet.2023.03.015 Previous article Next article apex back to

< Back to Issue 7 Tip of the Iceberg: An Overview of Cancer Treatment Breakthroughs by Arwen Nguyen-Ngo 22 October 2024 edited by Zeinab Jishi illustrated by Louise Cen Throughout the history of science, there have been many firsts. Anaximander, a Greek scholar, was the first person to suggest the idea of evolution. Contrary to popular belief, the Montgolfier brothers were the pioneers of human flight by their invention of the hot air balloon, as opposed to another pair of brothers, the Wright brothers. In 1976, the first ever vaccine was created by an English doctor, who tested his theory in a rather peculiar manner that would not be approved by today’s ethics guidelines (Rocheleau, 2020). While there have been many extraordinary discoveries, there continue to be many firsts and many breakthroughs that have pathed the way for the next steps in research. In particular is research into ground-breaking treatments for cancer patients. 1890s: Radiotherapy (Gianfaldoni, S., Gianfaldoni, R., Wollina, U., Lotti, J., Tchernev, G., & Lotti, T. 2017) In the last decade of the 19th century, Wilhelm Conrad Rцntgen made the discovery of X-rays, drastically changing the medical scene for treating many diseases. From this discovery, Emil Herman Grubbe commenced the first X-ray treatment for breast cancer, while Antoine Henri Becquerel began to delve deeper into researching radioactivity and its natural sources. In the same year that Rцntgen discovered X-rays, Maria Sklodowska-Curie and Pierre Curie shared theirs vows together, and only three years later, discovered radium as a source for radiation. By then, during a time where skin cancers were frequently treated, this discovery had kick-started the research field into X-rays as well as the use of X-rays in the medical field. Scientists and clinicians have gained a greater understanding of radiation as treatment for diseases, but the research does not stop there and the advancement of radiotherapy only continues to thrive. 1940s: First Bone Marrow Transplant (Morena & Gatti, 2011) Following World War II, the physical consequences of war accelerated research into tissue transplantation. Skin grafts were needed for burn victims, blood transfusions needed ABO blood typing, and the high doses of radiation led to marrow failure and death. During this time, Peter Medawar started his research into rejection of skin grafts as requested by the Medical Research Council during World War II. It was a priority for the treatment of burn victims. Medawar had concluded that graft rejection was a result of an immunological phenomenon related to histocompatibility antigens. Histocompatibility antigens are cell surface glycoproteins that play critical roles in interactions with immune cells. They are unique to every individual and essentially flags one’s cell as their own, therefore making every individual physically unique. 1953: First Human Tumour Cured In 1953, Roy Hertz and Min Chiu Li used a drug, methotrexate, to treat the first human tumour — a patient with choriocarcinoma. Choriocarcinoma is an aggressive neoplastic trophoblastic disease, and can be categorised into two types — gestational and non-gestational (Bishop & Edemekong, 2023). The cancer primarily affects women, as it grows aggressively in a woman’s uterus (MedlinePlus., 2024). However, it can also occur in men as part of a mixed germ cell tumour (Bishop & Edemekong, 2023). Methotrexate is commonly used in chemotherapy as it acts as an antifolate antimetabolite that induces a cytotoxic effect on cells. Once methotrexate is taken up by cells, it forms methotrexate-polyglutamate, which in turn inhibits dihydrofolate reductase, an enzyme important for DNA and RNA synthesis (Hanood & Mittal, 2023). Therefore, by inhibiting DNA synthesis, the drug induces a cytotoxic effect on the cancerous cells. Since the first cure of choriocarcinoma using methotrexate, the drug has both been commonly used for chemotherapy and other applications, including as an immunosuppressant for autoimmune diseases (Hanoodi & Mittal, 2023). 1997: First ever targeted drug: rituximab (Pierpont, Limper, & Richards, 2018) Jumping ahead a few decades and 1997 was the year that JK Rowling published Harry Potter and the Philosopher’s Stone . It was also the year that the first targeted anti-cancer drug was approved by the U.S Food and Drug Administration (FDA), rituximab. Ronald Levy created rituximab with the purpose of targeting malignant B cells. B cells express an antigen – CD20 – which allows B cells to develop and differentiate. Rituximab is an anti-CD20 monoclonal antibody, meaning that it targets the CD20 antigens expressed on malignant B cells. It had improved the progression-free survival and overall survival rates of many patients who had been diagnosed with B cell leukemias and lymphomas (Pavlasova & Mraz, 2020). Much like the Philosopher’s Stone, you may consider rituximab to increase longevity of patients diagnosed with B cell cancers. Although Levy created this drug, his predecessors should not be ignored. Prior to his research and development of rituximab, research and development of monoclonal antibodies can be dated all the way back to the late 1970s (Pavlasova & Mraz, 2020). César Milstein and Georges J. F. Köhler developed the first monoclonal antibody in the mid-1970s, and first described the method for generating large amounts of monoclonal antibodies (Leavy, 2016). Milstein and Köhler were able to achieve this by producing a hybridoma – “ a cell that can be grown in culture and that produces immunoglobulins that all have the same sequence of amino acids and consequently the same affinity for only one epitope on an antigen that has been chosen by the investigator” (Crowley & Kyte, 2014). They had produced a cell with origins from a myeloma cell line and spleen cells from mice immunised against sheep red blood cells (Leavy, 2016). Going forward: CAR T Cells The most recent and exciting development in cancer research has been the development and usage of chimeric antigen receptor (CAR) T cells. CAR T cell therapy is a unique therapy customised to each individual patient, as the CAR T cells used are derived from the patient’s own T cells. The process involves leukapheresis, where the patient’s T cells are collected, and these collected T cells are then re-engineered to include the CAR gene. The patient’s own CAR T cells are produced, expanded and subsequently infused back into the patient. The first concept of CAR T cells to be described was in 1987 by Yoshihisa Kuwana and others in Japan. Following this, different generations of CAR T cells have now been developed and trialled, leading to the FDA’s first two approvals for CAR T cells (Wikipedia Contributors, 2024). This research avenue has only scratched the surface, with many individuals now exploring the best collection methods and how best to stimulate the “fittest” T cells - the apex predator of immune cells. A recent paper was published where CAR T cells were trialled as a second line therapy to follow ibrutinib-treated blood cancers. The phase 2 TARMAC study involved using anti-CD19 CAR T cells to treat patients with relapsed mantle cell lymphoma (MCL) who had been exposed to ibrutinib, a drug used to treat B cell cancers by targeting Bruton Kinase Tyrosine (BTK) found in B cells. The study showed that 80% of patients who had previous exposure to ibrutinib and were treated with CAR T cells as a second-line therapy achieved a complete response. Furthermore, at the 13-month follow-up, the 12-month progression free survival rate was estimated to be 75% and the overall survival rate to be 100% (Minson et al., 2024)! It is without a doubt that as humans, we are naturally curious creatures. It is with this curiosity that we have journeyed through the many scientific breakthroughs and innovations. And within each special nook and cranny of countless fields of science, from flight to evolution, from vaccines to cancer treatments, there have been multitudes of discoveries. There is no doubt that the number of innovations will only continue to grow. References Bishop, B., & Edemekong, P. (2023). Choriocarcinoma. StatPearls . Crowley, T., & Kyte, J. (2014). Section 1 - Purification and characterization of ferredoxin-NADP+ reductase from chloroplasts of S. oleracea . In Experiments in the Purification and Characterization of Enzymes (pp. 25–102). Gianfaldoni, S., Gianfaldoni, R., Wollina, U., Lotti, J., Tchernev, G., & Lotti, T. (2017). An overview on radiotherapy: From its history to its current applications in dermatology. Open Access Macedonian Journal of Medical Sciences, 5 (4), 521–525. https://doi.org/10.3889/oamjms.2017.122 Hanoodi, M., & Mittal, M. (2023). Methotrexate. StatPearls . Leavy, O. (2016). The birth of monoclonal antibodies. Nature Immunology, 17 (Suppl 1), S13. https://doi.org/10.1038/ni.3608 MedlinePlus. (2024). Choriocarcinoma. MedlinePlus . https://medlineplus.gov/ency/article/001496.htm#:~:text=Choriocarcinoma%20is%20a%20fast%2Dgrowing,pregnancy%20to%20feed%20the%20fetus Minson, A., Hamad, N., Cheah, C. Y., Tam, C., Blombery, P., Westerman, D., Ritchie, D., Morgan, H., Holzwart, N., Lade, S., Anderson, M. A., Khot, A., Seymour, J. F., Robertson, M., Caldwell, I., Ryland, G., Saghebi, J., Sabahi, Z., Xie, J., Koldej, R., & Dickinson, M. (2024). CAR T cells and time-limited ibrutinib as treatment for relapsed/refractory mantle cell lymphoma: The phase 2 TARMAC study. Blood, 143 (8), 673–684. https://doi.org/10.1182/blood.2023021306 Morena, M., & Gatti, R. (2011). A history of bone marrow transplantation. Haematology/Oncology Clinics, 21 (1), 1–15. Pavlasova, G., & Mraz, M. (2020). The regulation and function of CD20: An "enigma" of B-cell biology and targeted therapy. Haematologica, 105 (6), 1494–1506. https://doi.org/10.3324/haematol.2019.243543 Pierpont, T. M., Limper, C. B., & Richards, K. L. (2018). Past, present, and future of rituximab: The world’s first oncology monoclonal antibody therapy. Frontiers in Oncology, 8 , 163. https://doi.org/10.3389/fonc.2018.00163 Rocheleau, J. (2020). 50 famous firsts from science history. Stacker . https://stacker.com/environment/50-famous-firsts-science-history Wikipedia contributors. (2024, October 6). CAR T cell. In Wikipedia, The Free Encyclopedia . Retrieved October 17, 2024, from https://en.wikipedia.org/w/index.php?title=CAR_T_cell&oldid=1249695600 Previous article Next article apex back to

Issue 6: Elemental 28 May 2024 This issue explores the building blocks that comprise the world we live in. Our talented writers braved the elements - have a read below! Editorial by Ingrid Sefton & Rachel Ko A word from our Editors-in-Chief. Fire and Brimstone by Jesse Allen The world has long been subject to the fury of fire and volcanic eruptions. Technology to predict seismic activity may allow us to tame this elemental force. Hidden in Plain Sight: The dangerous chemicals in our everyday products by Kara Miwa-Dale Drink bottles, tinned food, receipts: a recipe for disaster? Interviewing A/Prof Mark Green, Kara exposes the hidden dangers of endocrine disrupting chemicals. A Frozen Odyssey: Shackleton’s Trans-Antarctic Expedition by Ethan Bisogni A pursuit of knowledge and a testament to survival, Ethan navigates the enthralling legacy of Sir Ernest Shackleton's Trans-Antarctic Expedition. Everything, Everywhere, All at Once: The Art of Decomposition by Arwen Nguyen-Ngo Arwen breaks down the intricacies of decomposition, leading us to consider the fundamental power not only in creation, but destruction. Out of our element by Serenie Tsai Following the industrial revolution, humankind has exploited and degraded the Earth's natural resources. Serenie shows how nature resists, maintaining the capacity to restore what humans have destroyed. Cosmic Carbon Vs Artificial Intelligence by Gaurika Loomba Carbon constitutes life and death, shaping conscious human existence. What threat could AI hold to the power of this element? Proprioception: Our Invisible Sixth Sense by Ingrid Sefton Our mysterious, yet omnipresent sixth sense - proprioception is the reason we know where our body and limbs are, even in the dark. A Brief History of the Elements: Finding a Seat at the Periodic Table by Xenophon Papas There's hydrogen and helium, then lithium, beryllium - or is there? The periodic table we know today was not always so, as Xen recounts.

< Back to Issue 9 Human-Cetacean Relations by Andrew Irvin 28 October 2025 Illustrated by Aisyah Mohammad Sulhanuddin Edited by Kara Miwa-Dale Creative, fascinating and full of interesting little tidbits, "Human-Cetacean Relations" would be best viewed as a PDF to retain its formatting, footnotes and references - check it out here! Andrew's article here A copy without footnotes and references is available on this page. – Tonga, 2049 – The Doctorate Isles When asked which nations take their PhD. scholarship most seriously, few people would venture a guess that Tonga had been closely keeping tabs on its academic attainment for decades. One of those Tongans was Tofa’s mom, who unflinchingly raised the reality of her eldest child’s enrolment gap nearly every time they had a conversation. Having met the eclectic and charming Rafael Bauer at the start of an undergraduate career, Lesieli didn’t let her relationship interrupt her first love – studying, which led to a steady, unbroken path through postdoctoral fellowships – eventually resulting in a tenured position in Medical Anthropology. Both in stature and demeanour, Tofa’s mother was a force to behold. Tofa’s dad, Rafael, was an American of much more indeterminate qualities; an electrical technician alongside his wife at University of California, Berkeley, he was a lifelong gearhead who never quite gave up the rock club sound tech roots of his youth. Rafael was a uniquely West Coast mix of pre-United States Californian, Bay area railroad-era immigrant Chinese, and late 20 th century Silicon Valley surf nerd, who despite his own parents’ cultural pedigree had always felt as though he were moving between worlds, even when he couldn’t manage to be any more deeply at home. This was a sentiment Tofa had always shared, but despite a temperamental affinity with their father, they found themselves growing into the spitting image of their mother. So as Tofa stared at the holo-tablet, they were confronted by a miniature version of themselves, twenty-five years on, in an alternate, hypothetical world where Tofa may have embraced a life of both femininity and pedantry. Tofa braced themselves, eyes pre-emptively glazing over slightly, as their mother laid in, yet again… “Why won’t you just pick a lane and stay the course, you know? See something through to the end?” On their periodic video calls, Dr. Lokotui – having kept her maiden name for the sake of her publication record – always ended up asking some form of the same question. It never failed to trigger Tofa’s ire. “Med school is literally the only thing I’ve walked away from, and that’s because I didn’t even start ,” they reminded their mother in persistent exasperation. “I have finished four albums, and for each and every one, I have toured for at least a year, always to the end.” In that process, Tofa noted, they had managed to build enough of a persona to dispense with the necessary attachment of a surname entirely, successfully avoiding the uncomfortable explanation of preferential nomenclature between their parents. Tofa knew their mother reserved a uniquely complicated form of resentment for her eldest child, and they spent concerted effort trying not to actively exacerbate this reaction, which they seemed to elicit simply by being themselves. Their younger brother, Tanginoa, had carved a much cleaner path to adoration in their mother’s books; playing rugby through college on the way to a sports medicine residency. The cumulative anxiety of navigating the conversation now had Tofa pacing with a purpose, weightily padding the deck of their beachside three-bedroom bungalow, overlooking Monterey Bay. Irate, they snidely remarked, “…and I don’t need to pick a lane when I go swimming. I’ve got the whole ocean to splash around in, Doctor Mom.” “ Si'i lile, Tofa…” Lesieli sighed in a combination of consternation and resignation, years beyond rising to active irritation at Tofa’s sarcastically applied epithet of respect. Tofa, in turn, was endlessly frustrated by the fundamentally uptight approach toward life their mother consistently decided to apply. “I’ve got to get back to grading, but here – talk to your father…” she said, unceremoniously passing the holo-tablet over to Tofa’s dad, Rafael. Growing up, Tofa often wondered how the most easy-going guy in California had ended up with—possibly—the most tenacious woman ever to make her way out of Tonga. He had drolly explained one night when Tofa was headlining one of the 90 th anniversary shows at the Fillmore Auditorium, “You know, I’ve never had to make a decision I didn’t feel was worth the trouble of thinking about.” He had admitted this while they were tucked away in the green room, leaning forward from the overstuffed, formerly vibrant yellow couch, tour-stained and wine-mottled. Fidgeting quietly against the Piñatex upholstery, he paused to sip a Pacifico loaded with lime before he’d continued, “Your mother isn’t wrong often…so I let her make the waves and just ride them all the way to shore.” He pointed the mouth of his beer bottle solemnly, slowly, in Tofa’s direction. Despite the flurry of activity and noise emanating from all directions, on-stage and off, as the festival wore on, Rafael managed to manufacture a moment of connection, encapsulated in this glimpse into his marriage to Tofa’s mother, “Don’t tell her that – if she ever realizes how easy all her empowerment has made things, she’ll start giving me extra homework.” Tofa had laughed uproariously at hearing this then, five years back. There wasn’t a problem Dr. Lokotui didn’t think could be solved with more studying. Now, seeing their dad again, Tofa suddenly felt a smile stretching across their face. “Hey, pops! What’s new?” “Oh, steady as she goes over here, Tof’. Looks like good weather down your way. It’s been a gnarly winter - how’s the surf been down the coast?” Rafael asked, peering around the miniature holo-view on the tablet, trying to get a glimpse of the sea. Tofa realigned themselves to show a view of the roaring, rolling January waves. “Heavy hitters – I haven’t gone out since Sunday when the swells at Asilomar were more my size. I tried out the new suit, though, and I think the CetaceaSkin team is on to something with these new fibre layers. I could’ve stayed in the water all day if I hadn’t been getting thrashed. Can’t spend too much time floating around – tryna get busy sorting out samples for the new single,” Tofa explained, happy to have a receptive audience with shared interests in their father. “I don’t know about those drysuits – half the fun of spending time in the ocean is getting wet! But tell me more about this song. Is there anything I can hear yet?” their father asked. “Which species are you putting up front in the mix on this one?" “I haven’t broken down all the logs yet, but based upon what I spotted, I’ve got some new clips from the Manuma'a, Lafu, Hengehenga, and I finally got a good take of the Malau to include,” Tofa rattled off the local birds they’d captured on record. The Malau was a point of pride, as they hadn’t seen one since they were twelve, and despite improved conservation efforts, it remained a vulnerable species. Since having the opportunity to go on vacation throughout the entirety of their childhood was relegated to the few visits when their mother hauled Tofa along with their little brother back to Nuku’alofa and out to ‘Eua to see their extended family, Tofa found these days of calm gave them the opportunity to both listen both closely and broadly. As they learned how their family extended across the islands, Tofa also learned every layer of life that flitted through the ocean air. Summer break in the United States was always the thick of Tongan “winter,” so apart from the few weeks of term break when their cousins were free to roam with them, they spent a lot of time along the shore, watching –hearing–seabirds. From the second visit onward, once they were old enough to handle their own recording device, that meant they had an opportunity to put everything on-file for later listening and editing. Unlike many bird spotters, they were less interested in snapping photos, instead tuning in tightly on the sounds each species would make as they walked along the sand. It was always stunning to them how differently the same ocean could strike an impression on a person, all because of what was happening on land. They became obsessed with sensorial experience of the intertidal zone, discovering how sound sped up beneath the waves. It was here they first heard the song beneath the sea. Wading out, head dipping beneath the waves, the humpbacks hailed the young musician. All Tofa wanted was to get closer, and better know the source of that sound. “How is that underwater rig you’ve been working on coming along?” Tofa’s father asked, bringing their reflections upon the deep back to the present. “So far, so good. Tweaking the input parameters to ensure it can handle the decibel thresholds, but the octave dropper on the output is working just fine. It should be ready for testing soon. We’ve got until the end of the season for sea trials before the holo-band. I think we’ll finally be able to provide some level of justice in truly hearing what they’ve been singing to us all these years,” Tofa explained, partially in an effort to convince themselves of the value in their long-running effort toward coordinated antiphony, lining out parts for their friends of the deep to commune upon. Rafael smiled proudly, with a shake of his head, “You’ve definitely got your mother’s intellect, Tofa.” “I don’t see why they can’t make a dissertation out of it!” Dr. Lokotui called the other room, still clearly keeping an ear tuned in to Tofa’s conversation. Diving Decibels Deep Six Months later The booming enormity of the waves of pressure across the ocean as the Earth birthed another island into the waters of Tonga were disorienting to every sense. Feeling reality shudder and shift around you, realizing the atmosphere, the sea – the planet itself can burble and burp, and rattle humans to their core or wipe them from the map with only a slight shift of its crust – it instills a sense of geological humility in a person. Perhaps this was the reason Tofa had been so vociferously opposed to the various seismic charges and sonar tests perpetrated by the navies of Pacific Rim nations over the course of human history. They knew how waves in every form could be monumentally catastrophic upon unsuspecting populations. More than most of the world, Tonga had cultivated an affinity for marine mammals, with non-trivial portion of the tourism economy tied to the seasonal migration of humpback whales, and increasingly close attention to dolphins residing within the expanded marine protected areas of the country. This interest in sound had honed itself from a precocious curiosity into a unilaterally focused passion over the course of their childhood, and now Tofa finally had a means of sharing those sentiments with the perennial subjects of their attention. Their years of devouring all the emerging research, when accompanied with a dedicated interest in music theory – and unfettered access to a wide range of remaining paywalled journals through good ol’ Dr. Mom’s home office accounts – left Tofa uniquely positioned to explore the coastal waters of ‘Eua, experienced through a filter of their own design. Now, as a child of Tonga who had endeavoured understand their ancestral home as a shared space, Tofa had a platform to offer the world an invitation to a symphony performed by an otherwise inscrutable chorus. Tofa had constructed a seat along the Humpback Highway, not on the front row, but in the orchestra pit, itself. With the Strat-Stat coverage providing a relay point overhead to feed the signal out, it was Tofa’s turn to benefit from performing behind a paywall. Project Ceti was happy to hear over forty thousand people had pledged support for this holo-band broadcast, and the audience continued to swell online now that word was out Tofa was finally underwater. It had taken over six months from the time Tofa had commissioned the design to get all the pieces in place for their new drysuit, but it was working better than they’d expected. While the tech for long-duration SCUBA operations had never been employed in this manner to-date, and with a comms-enabled IDM, Tofa was most excited about the two-way Soundfish system they’d been able to pull together with the help of a few submarine engineering colleagues and audio technician friends. Taken independently, any element of the Soundfish design might not seem new or innovative, but when daisy-chained in the manner Tofa intended, they now held the means of embedding themselves – or any operator – within the social life of a pod on its regular migrations. With the prototype school of Soundfish numbering eight in total, Tofa had prepared to deliver an expansive soundscape rendered remotely in immersive surround – piped through speakers the world over – to give their audience a glimpse into the role they had established amongst the whales. This culmination of years of applied research into whale behaviour and increasingly documented language structure led them back to Tonga, where Tofa now floated, suspended ten meters below the surface of the ocean off the coast of ‘Eua. The soft, deep wail through their headphones had presaged the arrival of Bomp, the Humpback whale they’d become acquainted with over successive years in the water. Moments later, the call of Bomp’s companion, Wahaloo, followed, and Tofa was overjoyed. The audio was coming through as clear as they could have hoped. The interface had yet to be fully tested, as the polyphonic drop unit technically worked, but whether it carried rhetorical value to its cetacean recipients was yet to be determined. There was every reason to wonder if the Soundfish could keep up with the pods they were designed to accompany after this ceremonial introduction. The saildrone, glider, and satellite monitoring all had the benefit of being able to keep pace with the whales, but none were able to embed themselves amongst the pod communities. Tofa hoped the Soundfish would provide the appropriate avatar for human immersion in the society of their giant friends. As the sound began to swell in their headphones, Tofa beamed in response; there were three other whales out there, and from the higher frequency joining the others, at least one calf among them. Tofa had been studying the records collected each year, and had steadily incorporated each season’s shifting songs into their repertoire. The culmination of their whole endeavour was now at-hand – Tofa turned their mic off stand-by, running hot, and setting a two second delay sequence on each Soundfish channel before sending out the same signal. With a controlled croon, Tofa began softly singing their greeting, echoed by the Soundfish. The gain was markedly lower on channel five, but otherwise, all systems were operational. Tofa made a brief adjustment to the levels, pulse racing with excitement – breath control momentarily forgotten – bad praxis in the scuba days of old. In the new suit, there was far less hazard of hyperventilation. Most critically, two seconds later, Bomp replied, and Tofa’s breath caught in their chest. They understood, Hello, again , – greetings identified through coda indicating repetition and recognition, as inferred through recent prevailing research and their field notes. Working with a unique coda they had isolated to ‘Eua, Tofa’s breath caught, pulse pounding while their heart shuddered in their chest. It the first time Tofa heard the words of their floating friends, layered atop a long familiar feeling. With two more seconds, the rest of the pod joined in chorus, and Tofa’s in-mask heads-up display exploded with celebratory reactions from the multitudes around the world bearing witness on the holo-band. Well beyond the simplicity of playback contact calls, with the applied tech delivering octave shifts to match pitch, Tofa had forged a voice to bridge the gap between their land-bound life and their biggest friends in all the world. They felt tears welling up, and suddenly found themselves trying excruciatingly hard to compose their reaction, as they had no practical way to wipe their eyes. Drawing upon a life of musical theory and a ceaseless curiosity to understand the creatures all around, Tofa’s patient cooing and clicking slowly unveiled a story that took years to decipher, and the pod was finally engaged, their curiosity piqued by these oddly-shaped fish and their friendly human. The concert lasted hours. While Tofa played none of the hits for which they were best known, it proved to be the most important performance of their entire career. Decompressing from the experience after the pod wandered on, Tofa rocked slowly in a hammock, fielding questions on the exchange terminal from fans and press, as their folks called in over holo-view. “It was beautiful, Tof’. Every moment,” their father offered. But it was Dr. Lokotui, who clasped Raffael’s shoulder – nodding solemnly and silently behind his seated form – that truly gave Tofa pause. Looking over the Soundfish tracking map, they knew they had embarked on a world tour of an entirely different sort. Now that Tofa had a way to spend the rest of their days listening to, learning from, and calling back to the pod, their change of career plans came as a surprise to the general public, including derision from some of the more recalcitrant Anthropocentrists in the biological research community, still riddled with those who would deny the ontological vastness to be more deeply explored and brought within human comprehension as our species approaches the Tree of Life with greater humility. There was, however, one academic who Tofa was pleasantly surprised to find now fully supportive of their endeavours. Doctor Mom replied, her eyes alone smiling, with a glint of belated understanding and more than a hint of pride, “Sounds like a good research question for your dissertation, Tofa.” Pupuʻa Puʻu Rorqal Nova District, Kingdom of Tonga – 2449 CE Never had this many pods convened at one time – in earlier ages, most humans would have lost all sense of decorum, seeing so many whales assembled. Now, King Tupou XIV presided proudly, ministerial delegation, visiting dignitaries from Niue and scientific advisors floating, dry-suited, nearby, their drop resonators at the ready when called upon in the formalities. It was, in every way, a commemorative moment, but it was not the kind who first broke the silence, but it was the Grand Cantor briefly surfacing to lobtail before drawing level with the humans floating ten meters below – a gesture of vigor and vitality from the matriarch of the pods, now 78 years old – who drew forward through the water, lumbering silently toward the royal entourage to bring the proceedings to a start. The mount on which we gather to once again commemorate the first choral union, as echoed in the songs of the Podmothers, all passed down along through the Soundfishes’ song. The Grand Cantor paused a moment, rotating her flippers in opposition, slowly turning to behold the assembled members of the summit. Our gratitude is deep for the effort of each Pod sharing songs of the year another chorus passes. From across the seamount, sunlight was visible rippling across the caudal peduncles of those cetaceans gathered in attendance, the gathered masses of each pod lobtailing in response; a form of applause few humans had ever been graced with an opportunity to hear. Cousins of the deep, we know of those who move about the overtow – oh, humanity! – there is a greater freedom they seek among the guiding light above. Whales of various species sang out at this testament to reconciliation. The violence they have perpetrated across the deep from time immemorial may never be undone. But peace is the current of the time – for peace with each other we float now together. When walking on solid ground, the King was not inclined to bow to anyone. But now, whatever gesture of deference he could muster seemed in adequate. So instead, he spoke; the ease with which the Grand Cantor and the assembled pods heard his words was the product of three long centuries of language models built on broader understanding. He need not have sung at all, but King Tupou XIV has spent his years of study the way others may have applied themselves toward the piano, or learning French. Perhaps if he’d been Tahitian – instead, his booming timbre and tone required a much slighter drop than Tofa’s first forays into the songs of the sea. “As our ocean grows deeper, so does our bond. We are here to listen, to learn, and to leave our failings in the past. We offer all we have on land to share beneath the waves, and our peace finds inspiration in your own.” The King paused, overwhelmed by the scene. Calls of concurrence rang out through the water from whale and human alike. Flukes slapped the surface; it seemed the summit was off to an auspicious start. THE END Previous article Next article Entwined back to

< Back to Issue 9 Ancient Asian Alchemy: Big Booms by Isaac Tian 28 October 2025 Illustrated by Aisyah Mohammad Sulhanuddin Edited by Luci Ackland One question has plagued the human condition since the beginning of time: how can we escape death? Well, we certainly know who didn’t find the answer – the alchemists of ancient China. It’s 210 BC, and you are an alchemist standing before Emperor Qin Shi Huang in his court. You hand him an elixir supposed to grant him immortality and eternal reign. Only the serum contains what we now call “mercury” and if anything, you granted him mortality, as he drops dead before you (1). Where does one begin in this journey to immortality? How do we combine chemicals to find the perfect serum? Keep in mind, we have not even come close to establishing the periodic table at this point (no, that will occur about 1000 years later) (2). Saltpetre – or potassium nitrate – had been used extensively to treat common illnesses and to maintain good health. There’s our starting point (3). The search for this magic elixir persists for the next eleven centuries. We never give up… do we? The ingenuity of the alchemists spoke to them: it told them to mix in a few other ingredients to the saltpetre. With the trio of saltpetre, sulfur and charcoal, gunpowder was henceforth born into this world (4). The alchemists must have been in for a surprise when their “potion of immortality” sparked and exploded before them. So how does gunpowder explode? Why don’t other flammable items like match tips and dry wood explode when we set them alight? It comes down to a few key things. First is our perception of explosions. Chemicals don’t simply “explode” – it’s not an inherent quality of reactions – however, they can combust. Combustion is the release of energy from a fuel. Wood and matches combust, but they do so in a way that is relatively slower than gunpowder. Gunpowder combusts rapidly – so there is a large amount of energy release within a short period of time. Secondly, it’s about the availability of oxygen. Items that combust slowly typically have to wait for the oxygen to trickle in from the surrounding air, since oxygen is a critical component of combustion. This does not apply to gunpowder. The oxygen for its combustion is right there in the nitrate compound (of potassium nitrate – or saltpetre). So unlike burning wood or matches, the combustion does not need to wait for oxygen to arrive from the surrounding environment – it’s already in there with the rest of the powder (5)! To go further on that point: the closer the atoms are, the faster the combustion reaction can progress, because chemical compounds don’t need to wait long for the heat to get to them. Since gunpowder is… well… a powder, it’s rather compact and all the molecules of potassium nitrate, sulfur, and carbon sit tightly next to one another. It is this physical arrangement that permits the fast transfer of heat between molecules, ensuring that a lot of energy can be released at once. Ultimately, when all these physical and chemical phenomena occur in perfect unison, the high temperatures rapidly increase the kinetic energy of surrounding air molecules, causing them to shoot outwards at great speeds to form a “barrier” of sorts. When this barrier, also known as a shockwave, hits your eardrums, the gunpowder delivers what it does best: BOOM! Now, let’s combust some gunpowder, build up some gaseous pressure, and launch ourselves into the modern day. It’s been about twelve centuries – what have we been doing with all the gunpowder? As it turns out, we humans are very inventive, but also violent (Wow – who knew?). We quickly realised that the physical properties of the resulting gases can be harnessed to quickly move very heavy objects (6). Said heavy objects could then be guided in the direction of, say, a human being or a structure. Weaponry derived from gunpowder has existed for a very long time, albeit rather inefficient at first. The introduction of gunpowder to warfare came in the early 10th century, when soldiers applied gunpowder to arrows that would ignite and create fire arrows. Of course, whilst it might have been effective in creating a hole in humans, it was significantly less so when it came to creating holes in walls and structures. Only after 300 years did we then invent cannons and guns. However, those guns were slow – really, really slow – to the point that bows and arrows were actually preferred during warfare of that era. It would be another 600 years before we realised that there were more effective ways of reloading a gun; brandishing a new trend of military technology that would set the stage for the First and Second World Wars (7). By that point, the most terrifying of weapons had begun to stray away from the use of gunpowder. Missiles and rockets began employing other chemicals as propellants, owing to the advantage it had over gunpowder (7). It would also be remiss of this article to omit the exploitation of atomic power – pervading the world with such destruction that gunpowder appeared like a child’s toy (8). The tragic irony of a supposed innovation in immortality leading to mortality by war and conflict will forever embed itself into our history. Even with the right intentions, the invention by the great minds of alchemy has sparked a chain reaction for widespread destruction and warfare. It only makes you wonder – what are we making now that will lead us further astray in the future? References 1. Glancey J. The army that conquered the world. BBC. Accessed August 24, 2025. https://www.bbc.com/culture/article/20170411-the-army-that-conquered-the-world 2. Guharay DM. A brief history of the periodic table. ASBMBTODAY. Accessed August 28, 2025. https://www.asbmb.org/asbmb-today/science/020721/a-brief-history-of-the-periodic-table 3. Butler A, Moffett J. Saltpetre in Early and Medieval Chinese Medicine. Asian Medicine . 2009;5(1):173-185. doi: 10.1163/157342109X568982 4. Paradowski, R.J. Invention of Gunpowder and Guns. EBSCO Research Starters. 2022. Accessed August 24, 2025. https://www.ebsco.com/research-starters/history/invention-gunpowder-and-guns 5. Stanford University. Detonation and Combustion. Stanford University. Accessed September 4, 2025. https://cs.stanford.edu/people/eroberts/courses/ww2/projects/firebombing/detonation-and-combustion.htm 6. Britannica. Ammunition | Bullets, Shells & Cartridges. Britannica. 2025. Accessed September 25, 2025. https://www.britannica.com/technology/ammunition 7. Beyer G. How Did Gunpowder Change Warfare? TheCollector. 2025. Accessed October 4, 2025. https://www.thecollector.com/how-did-gunpowder-change-warfare/ 8. ICAN. History of Nuclear Weapons. ICAN. Accessed October 4, 2025. https://www.icanw.org/nuclear_weapons_history Previous article Next article Entwined back to

< Back to Issue 5 When Dark Matters Ingrid Sefton 24 October 2023 Edited by Celia Quinn Illustrated by Louise Cen To put it simply, the entire visible universe is huge. In the scheme of it, we really are just tiny dots on a floating rock, in a vast and constantly expanding cosmos. Yet, as it turns out, that’s not even close to the full story. All the visible objects, planets and galaxies contribute less than 15% of the mass in the universe. The other 85%? Nobody knows for certain, but it has a name. Dark matter. More can be said about what dark matter is not, than what it is. It isn’t the baryonic or “normal” matter such as protons, neutrons and electrons which comprise our visible world. It also isn’t antimatter, composed of subatomic particles with opposite charges to normal matter. Instead, dark matter interacts with normal matter in a manner entirely different to that of antimatter. It’s not a type of black hole, nor simply a form of radiation, or a type of massless particle. So, what can be conclusively said? Essentially, nothing. As the name suggests, dark matter emits no light and therefore is not visible in the way normal matter is, making it difficult to observe. In fact, dark matter has only been “observed” by way of its gravitational effects. Therefore, we know it must have mass in order to be able to interact with visible matter gravitationally. It’s also imperative for it to be big enough to cause the massive gravitational effects seen in galaxies (Lochner et al., 2005). Estimates place the mass-energy content of the cosmos as being composed of 26.8% dark matter, 68.3% dark energy and a relatively miniscule 4.9% normal matter (Greicius, 2013). The terms dark matter and dark energy are often thrown around somewhat interchangeably. However, they explain distinct aspects of observed gravitational and physical phenomena. Dark matter can be thought of as an invisible substance which is only seen through its effects on gravity - the unexplained gravitational forces that hold together rapidly rotating galaxies and stopping them from flying apart. Dark energy is then the force responsible for pushing these clusters of galaxies and the universe apart, accelerating the rate of expansion of the universe (NASA/WMAP Science Team, 2013). Given the lack of answers about what dark matter is, an interesting question to ponder is how its existence was even discovered. Swiss astronomer Fritz Zwicky was the first to propose the idea of “dark matter”. His observations of the Cloma galaxy cluster led him to suggest if individual galaxies within the cluster were only held together by the gravitational force of visible mass, the galaxies should fly apart due to their high velocity (American Museum of Natural History, 2000). He termed this mysterious force responsible for binding galaxy clusters together “dark matter”. It wasn’t until the 1970s that Vera Rubin became the first person to establish the existence of dark matter through her work with spiral galaxies. Spiral galaxies aren’t stationary. They rotate, with stars different distances from the centre moving in roughly circular orbits around this centre. The highest concentration of visible stars is found within the core region of a galaxy, leading to the assumption that the majority of mass, and therefore gravity, should also be concentrated there. An implication of this is the expectation that the farther a star is from this gravitational centre of a galaxy, the slower its projected orbital speed should be (American Museum of Natural History, 2000). However, alongside astronomer Kent Ford, Rubin made the puzzling observation that stars in both the centre and outer regions of any galaxy were moving at the same speed (American Museum of Natural History, 2000). Her calculations provided convincing observational evidence of Zwicky’s theory. The presence of a significant mass of invisible matter in the outer regions of a galaxy would create an even, spherical distribution of matter, gravitationally explaining the observed rotation of galaxies and their velocity distribution (NASA/WMAP Science Team, 2013). Fifty years later and experimental evidence still remains the only “proof” of dark matter we have, having been unable to directly detect dark matter. Despite this, a majority of scientists are confident in its existence. Rubin’s insight into the velocity distribution of galaxy rotation curves is amongst some of the most convincing observational evidence for the presence of dark matter. Also supporting its existence are the various discrepancies that arise in the process of gravitational lensing. Gravitational lensing occurs when an emitted source of light is deflected or distorted by the gravitational field of a large mass. Based upon the degree of deflection, the gravitational potential of the object can be calculated, alongside the amount of matter in the lensing object (Xenon Dark Matter Project, 2022). Yet, the strength of this gravitational lensing observed in many galaxy clusters is significantly greater than that calculated from visible matter alone. These inconsistencies point to the existence of unseen mass, or dark matter, as a convincing explanation for the observed lensing effects. It’s become clear that the standard model of physics, explaining the different particles and forces comprising the visible world, cannot be used in attempting to explain dark matter. In response, researchers are exploring a number of avenues to find hypothetical new particles. Amongst the most likely candidates for the composition of dark matter are two classes of particles: Weakly Interacting Massive Particles (WIMPs) and axions. WIMPs are distinguished as a class of particles created thermally in the early universe at very high temperatures, while axions originate predominantly from non-thermal mechanisms (Griest, 2002). Compared to WIMPS, or other known type of particles, axions would be thousands of times lighter but also significantly more abundant than WIMPs (Darling & Knight, 2022). Given the infinite potential to invent hypothetical substances that resolve the enigma of dark matter, experimentation to find these particles has significant challenges. Current research efforts are focused on the detection of such particles. More than a kilometre underground in Stawell, Victoria, the Stawell Gold Mine has been converted into an underground laboratory – one with no light, no noise, and no radioactivity to interfere with dark matter signals (Lippincott, 2023). Here, an experiment known as DAMA/Libra, which started in Italy in 1998, is being replicated. For two decades, what is suspected to be dark matter has been detected at the same time each year in Italy. The Stawell Lab is seeking to verify these results, operating below the equator to determine any potential effect of seasonal interference from the Earth (Darling & Knight, 2022). The research utilises the technology SABRE (Sodium iodide with Active Background REjection), which are sodium iodide crystals that emit flashes of light if a sub-atomic particle hits the nuclei of atoms within the crystals (Darling & Knight, 2022). Hence, if a particle of dark matter hits a nucleus, a tiny flash of light should be created. Simultaneously, researchers at the University of Western Australia have been working on the detection project ORGAN (Oscillating Resonant Group Axion), in order to determine the presence of axions (McAllister, 2022). Despite not having detected any dark matter signals thus far, such experimentation has still offered important insights. Not detecting dark matter within a certain mass range and level of sensitivity allows exclusion limits to be set around the possible characteristics of axions. This tells researchers where to stop looking and, instead, where they should be focusing their resources and efforts. Despite the disarray around “solving” the conundrum of dark matter, alongside its less than reassuring name, it’s not actually something that people should be scared about. The gravity that dark matter is responsible for enables our existence, with dark energy having allowed the expansion of the early universe to become what we see, and don’t see, today (Xenon Dark Matter Project, 2022). Detecting the presence of dark matter is about advancing our understanding of the size, structure, and future of the universe. Current research approaches may seem slightly haphazard, attempting to find something that has never been detected and may not even exist. But when pursuing strange cosmological phenomena beyond our understanding, taking a wild stab in the dark may be exactly what we need to do. References American Museum of Natural History (2000). Vera Rubin and Dark Matter . Retrieved September 1, 2023 from https://www.amnh.org/learn-teach/curriculum-collections/cosmic-horizons-book/vera-rubin-dark-matter Darling, A., & Knight, B. (August 20, 2022). The search for dark matter . ABC News. https://www.abc.net.au/news/2022-08-21/dark-matter-particle-physics-sabre-experiment-stawell-victoria/101113010 Greicius, T. (March 21, 2013). Planck Mission Brings Universe Into Sharp Focus. NASA. https://www.nasa.gov/mission_pages/planck/news/planck20130321.html Griest, K. (2002). WIMPs and MACHOs . In P. Murdin (Ed.), Encylopedia of Astronomy and Astrophysics: CRC Press. Lippincott, H. (August 9, 2023). Researchers dig deep underground in hopes of finally observing dark matter. The Conversation. https://theconversation.com/researchers-dig-deep-underground-in-hopes-of-finally-observing-dark-matter-211075 Lochner, J. C., Williamson, L., & Fitzhugh, E. (2005). Possibilities for Dark Matter. Retrieved August 29, 2023 from https://imagine.gsfc.nasa.gov/educators/galaxies/imagine/titlepage.html McAllister, B. (July 26, 2022). This Australian experiment is on the hunt for an elusive particle that could help unlock the mystery of dark matter. The Conversation. https://theconversation.com/this-australian-experiment-is-on-the-hunt-for-an-elusive-particle-that-could-help-unlock-the-mystery-of-dark-matter-187014 NASA/WMAP Science Team. (2013). WMAP produces new results . Retrieved September 13, 2023 from https://map.gsfc.nasa.gov/news/ Xenon Dark Matter Project. (2022). Dark Matter . Retrieved August 25, 2023 from https://xenonexperiment.org/partners/ Wicked back to

< Back to Issue 7 Neuralink: Mind Over Matter? by Kara Miwa-Dale 22 October 2024 edited by Weilena Liu illustrated by Aisyah Mohammad Sulhanuddin What if I told you that you could control a computer mouse with just your thoughts? It sounds like something straight out of a sci-fi movie, doesn’t it? But this isn’t fiction… Welcome to the brain-computer interface, a device which is able to record and interpret neural activity in the brain, enabling direct communication between your mind and a computer. Tech billionaire Elon Musk founded ‘Neuralink’, a company developing coin-sized brain-chips that can be surgically inserted into the brain using a robot. Neuralink made headlines a few months ago by successfully implanting their brain-chip, dubbed ‘Telepathy’, into their first trial patient, Noland Arbaugh. While there were a few technical glitches, it seems to be working relatively well so far. Noland has been able to regain some of the autonomy that he lost following a devastating spinal cord injury. He is even able to play video games with a superhuman-like reaction speed, thanks to the more direct communication route between the Neuralink implant and his computer. But it doesn’t stop there; Elon Musk’s ultimate vision is to have millions of people using Neuralink in the next 10 years, not only to restore autonomy to those with serious injuries, but to push the boundaries of what the human brain is capable of. He thinks that Neuralink will allow us to compete with AI and vastly improve our speed and efficiency of communication, which is ‘pitifully slow’ in comparison to AI. Neuralink implants may seem like an incredible leap in scientific technology, but what will happen if they become normalised in our society? Let’s imagine for a moment … Jade, April 7th 2044 Shoving my jacket into my bag, I dart out of the hospital and pull onto the main road in my Tesla. As I speed past the intersection, I see a giant advertisement plastered on a sleek building: ‘Neuralink: Seamless Thoughts, Limitless Possibilities’. When I signed up to get a Neuralink implant, all I’d thought about were the infinite possibilities of how it would change my life – not what could go wrong. I wish I could say that I was brainwashed into getting a Neuralink, or that I had no choice in the matter. But the truth? I got an implant so that I could be ‘ahead of the crowd’ and because I was so frustrated at feeling inadequate compared to the other doctors at my hospital. When I graduated medical school, at the top of my class, people told me that I would do ‘great things’ and ‘change the world’. I followed the standard path, landing my first job and climbing the ranks one caffeine-fuelled shift at a time. I loved my job. Every time I saved a life, it felt like all my effort had paid off. Then Neuralink happened. I still remember the day Dr Maxwell - a doctor I worked with - proudly announced that he’d ‘bitten the bullet’ and gotten the implant. Over the coming weeks, we watched in awe: his diagnoses were quicker and more accurate than any human could imagine, and he went home as energetic as he’d arrived. Now, the extra hours I spent figuring out tricky cases were no longer a representation of my work ethic, but a symptom of my inadequacy compared to the Neuralink-enhanced doctors. One by one, my colleagues signed up for the implant. I hated the thought of having something foreign nestled in my brain, recording my brain’s neurons every second of the day. I told myself I wouldn’t let peer pressure get to me. But, as I watched those around me get promoted while I continued to work endless days, the frustration started to build. One afternoon, the department head came into my office to tell me that they were reconsidering the renewal of my contract. I wasn’t ‘keeping up’ with my Neuralink-enhanced colleagues. “We respect your personal decision, of course,” she said with hollow politeness. I wasn’t keen on being pressured into it, but at the same time, I genuinely believed that the implant would improve my life. When I told my friends and family about getting an implant, they were concerned. They tried to list all the things that could go wrong, but I came up with enough reasons to convince myself that it was the right decision. Once they saw how incredible the Neuralink device was, I thought, they would want one too. *** I’m jolted back to reality as the car veers slightly left, and I manually yank the wheel to correct it. Perhaps my implant glitched for a second… *** Everything changed after I had my Neuralink implanted. I was the only person in my family who had one, although a couple of friends did. At first, I felt invincible. The phenomenal speed with which I was able to come up with previously challenging diagnoses was thrilling. I was able to process enormous amounts of data and draw connections that I had never been able to before. It was addictive to feel that I was working at my full potential, using my newfound ‘superpower’ to save more lives than ever. About a month in, my thoughts began racing uncontrollably, until I felt like I was drowning in a flood of information. Sometimes, the input was so overwhelming that my head pounded and I struggled to breathe. My thoughts didn’t even feel like mine anymore. Family and friends started to grow more and more distant from me. This device was stuck inside my brain like superglue, and sometimes I just wanted to dig it right out of my skull. When I asked the doctor about removing it, he looked at me and smirked, “Why on earth would you want to get rid of such a game-changing device? Neuralink’s the new normal, honey. Get used to it.” *** A honk startles me as a car zooms past, nearly colliding with mine. I turn into a quieter street to regain my composure. But then – suddenly – thoughts of accelerating the car bombard my mind – so loud that I can barely hear myself think. The speedometer rises from 60 to 80 to 100 km an hour. I desperately try to disconnect my Neuralink from the car, to manually override the system – anything that will slow the car down. I start pushing random buttons hoping that I will get some kind of response. A red light flashes on my dashboard. ERROR. SIGNAL DISRUPTED BY UNKNOWN USER. I look up and meet the panicked eyes of a woman pushing a man in a wheelchair. Noah, April 7th 2044 The sun makes its final, glorious descent below the horizon, painting a beautiful array of pinks and oranges across the sky. I take a deep breath as Sophia, my support worker, pushes me along the road. We’re on our way to the grocery store, just in time for the end of day specials, which are all I can afford right now. Since my accident, I’ve tried my best to appreciate what I have, but it isn’t easy. Some days, I’m filled with rage as I struggle to complete daily tasks that I did on autopilot before my accident – back when I wasn’t confined to a wheelchair. It’s been hard to come to terms with this new body that I’m stuck with, and all the ways it seems to betray me. I miss the simple things – going to the grocery store by myself or playing board games with friends. But most of all, I miss working as an architect. I loved seeing my clients’ faces light up as they imagined the memories they would make in the new homes I had designed. This sense of satisfaction was taken from me the moment I was paralysed from the neck down. It’s why I’m so desperate to get a Neuralink implant. I would get one right this second if they weren’t so expensive. The Neuralink device isn’t covered by my insurance because the government claims that it wouldn’t be ‘cost effective’. While it won’t restore movement in my arms and legs, this implant would give me some precious freedom back. Maybe if I keep saving and take out a loan, I’ll have just enough to cover it and get my life back … *** “God, these Tesla drivers think they own the road!” I chuckle at Sophia, as a Tesla races towards the crossing in this 40km zone. As we begin to cross the road, I realise that the Tesla is showing no signs of slowing down. The car swerves violently, hurtling towards us without mercy. Sophia’s face pales as she frantically tries to push me out of the road. I squeeze my eyes shut, bracing for impact. Bibliography: Cernat, M., Borțun, D., & Matei, C. (2022, April). Human-Computer Interaction: Ethical Perspectives on Technology and Its (Mis) uses. In International Conference on Enterprise Information Systems (pp. 338-349). Cham: Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-39386-0_16 Fridman, Lex. (Host). (2024, August 3rd). Elon Musk: Neuralink and the Future of Humanity (No 438). [Audio podcast episode]. In Lex Fridman Podcast. https://lexfridman.com/elon-musk-and-neuralink-team/ Jawad, A. J. (2021). Engineering ethics of neuralink brain computer interfaces devices. Perspective , 4 (1). https://doi.org/10.23880/abca-16000160 Oravec, B. Neurotechnology, Ethical Privacy, and Information Technology. Knighted , 36. https://www.mga.edu/arts-letters/docs/knighted-journal/Issue-6.pdf#page=37 Youssef, N. O. A., Guia, V., Walczysko, F., Suriyasuphapong, S., & Moslemi, C. (2020). Ethical concerns and consequences of Neuralink. Natural Science. https://rucforsk.ruc.dk/ws/files/75503337/NIB3_Group1_Neuralink.pdf Previous article Next article apex back to

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< Back to Issue 9 Conferring with Consciousness by Ingrid Sefton 28 October 2025 Illustrated by Heather Sutherland Edited by Steph Liang Down the rabbit hole Indulge me for a moment, will you? I value your opinion. Your opinion, as in, one which has arisen from your mind. I would assume. It would seem unusual to consider that, perhaps, your thoughts are not your own. Stranger still to ponder the possibility that they did not arise from your mind. I digress – or maybe not. For it is this dilemma which I wish to pick your brain on. The mind. The brain. You. Are they one and the same; entwined? What do you think? Again, assuming it is you thinking. Assuming you feel certain enough to agree with this. Really, with what certainty can we say anything? You may be wondering who “I” am. I am but you, of course! I kid, but not entirely. Think of me as the brain; your brain if you wish. An excellent name I gave myself, if you ask me. Before we spiral any deeper into this chasm that is consciousness – because that is what this is about, is that not what this, life, is all about? – I must disclose a few things. One, I do not expect you to have answers to these questions I pose. Because two. We do not have answers. I apologise that I have not come bearing the answers to our existence, that I have not yet unpicked these questions of “who?”, “how?”, “why?”. I come offering an alternative. I wish to present to you these entangled threads of consciousness: of what we currently know, of what we hope to know and of where we can proceed from here. Then it’s back to you. You get to decide what you think (again, with the thinking). Maybe, for you and the workings of your inner mind, consciousness and all it entails will be revealed in full clarity. Maybe not. You certainly won’t know unless you try. A brief neural memoir Many a Nobel prize has been awarded for discoveries relating to the nervous system: from the morphology of neurons (Golgi and Cajal 1906) and their electrical signalling properties (Eccles, Hodgkin and Huxley 1963), to the nature of information processing in the visual system (Hubel and Wiesel 1981) (1). Despite some obvious gaps remaining in what is known about the brain (ahem, that slight issue of consciousness), the field of neuroscience has rapidly progressed over the last century. Gone are the days of thinking I was nothing more than a cooling mechanism for the blood, as Greek philosopher Aristotle once believed (2). How dismissive of my intellect! I assure you, I have far more important things to be doing. Generating the experience of “you”, as one small matter. The techniques developed to study the brain have also rapidly advanced. It was not until the invention of microscopes in the 19 th century that the neuron doctrine even came about . Pioneered by Santiago Ramón y Cajal, this is the (now) well-accepted concept that the nervous system is made up of discrete cells known as neurons, challenging older theories which proposed a continuous neural network (3). Today, neuroscientists have the ability to appreciate my anatomical and functional complexity at a huge range of temporal and spatial resolutions. Whole-brain connectivity can be studied using functional magnetic resonance imaging (fMRI), while the electrical activity of single neurons can be recorded using patch-clamp electrode technology. Not to mention optogenetics, chemogenetics, viral transduction: while the available experimental techniques are still unable to address all our brainy questions, the field of neuroscience has never been in a better position to get closer to answers. The potential of neurons Neurons: those special, excitable cells that make up the squishy entity I seem to be. The mechanisms of how neurons detect, generate and transmit signals have been described in utmost precision. When I talk of excitable cells, I am not referring to a bunch of cheerful, eager neurons. Excitability, in this context, refers to the fact that neurons can respond to a sensory stimulus by generating and propagating electrical signals, known as action potentials. Clearly, I am made up of slightly more than two neurons cheerfully signalling to each other back and forth. Try 86 billion, between the cortex and cerebellum combined (4). Yet, despite our deep understanding of neural signalling mechanisms, this has yet to reveal an explanation for consciousness. Individual neurons in isolation, it would appear, don’t hold the answers we want. In turn, a focus of neuroscience research has been on the wider “neuronal correlates of consciousness”, the minimal neuronal mechanisms that are sufficient to generate a conscious experience (5). This relates broadly to the generation of consciousness itself, but also to studying the neural underpinnings of specific conscious experiences. For example, which collective neural substrates support the process of visual object recognition. This is often a focus of fMRI studies, which examine brain activity in an attempt to pin-point where in the brain a particular cognitive function may be performed. Fancy techniques aside, some of the most fundamental insights into my regional specialisations have arisen from careful observation following selective lesions or damage to the brain. The critical, yet specific role of Broca’s area in speech production was discovered in 1861 by surgeon Paul Broca’s observations of his patient “Tan”. Tan had lost his ability to produce meaningful speech, yet was still able to comprehend speech; Broca identified a lesion in Tan’s left frontal lobe post-mortem, drawing the conclusion that this region is selectively involved in speech production (6). But what does all of this show us? Perhaps the only thing that neuroscientists can agree on, is that conscious experience is fundamentally, in some way, somehow, related to my activity: the brain. In turn, the activity of the brain is related to the activity of neurons; firing and signalling and transforming information. A lot is known about neurons. Less can be said about specific cognitive functions, yet we can see correlations between the regional brain activity and particular conscious experiences. Here lies my problem. The elephant in the room. How do we get from individual neurons to conscious experience? A map with no destination Enter “The Connectome” and the Human Connectome Project: a collective attempt to map the neuronal connections of the human brain, in an effort to connect structure to function (7). And in turn, for our purposes, to ideally connect this to consciousness. The rationale is that by modelling and trying to “build” a brain using a bottom-up approach, we may therefore understand the mechanisms of how cognitive functions arise. I’m sure it will come as no surprise that this isn’t the simplest of tasks. To measure, record and model billions of neurons and synapses requires techniques, time, and resources that are incredibly hard to come by in sufficient quantities. Excitingly, scientists have recently managed to successfully map a whole brain. That is, of a fly (8). With 3016 neurons and 548000 synapses, this was no simple feat. In case you had forgotten my own complexity, however, let me remind you of my 86 billion neurons, and estimated 1.5 x10 14 total synapses in the cortex alone (4). Progress has also been made on the human front, nonetheless. It was recently announced that a cubic millimetre of human temporal cortex has been completely reconstructed using electron microscopy, involving 1.4 petabytes of electron microscopy data (1000 Terabytes or one quadrillion bytes) (9). One cubic millimetre down, approximately a million to go. Putting practicalities aside, let us suppose we do, one day, manage to map and model an entire human brain, in all its intricacies. What now? What does one actually do with this data, and how would this allow us to better understand how consciousness arises? Up until now, we have been following the train of thought that consciousness, somehow, results from the activity of neurons, yet does not arise from the activity of individual neurons. This leads us to the notion that perhaps consciousness is due to the collective, computational activity of neurons working together – that with enough complexity, and enough information processing, together this will lead to the first-person experience of being “you”. Does this actually make sense? You tell me. Wishful thinking and conscious rocks The notion that, at a certain level of complex neuronal signal processing, a first-person perspective of “being you” (i.e. consciousness) arises is often termed “strong emergence” or “magical emergence” (10). With what we currently know about the properties of neurons, there is fundamentally no reason why this should happen. The “property” of consciousness, which cannot be predicted from the principles of how individual neurons function, seemingly just emerges. Consciousness, therefore, must somehow be greater than the sum of its parts, only emerging when neurons interact as a wider network. Maybe, the answer to this is merely that we don’t understand the mechanisms of neurons as well as we think we do. It could be that we have missed a fundamental property of how neurons operate and upon discovery of this, it would suddenly be completely explicable how consciousness arises. Or maybe, computation and neural signalling is not all there is to it. An alternative line of thinking is that rather than consciousness being a property that “arises”, it is a basic constituent of the universe that is missing from our current model of standard physics (11). That is, consciousness has been present all along and exists in everything. The philosophical view of ‘panpsychism’ embraces this idea to the extreme, proposing that everything within the universe is, to some degree, conscious (12). As in yes, that rock over there might just be conscious. Other theories suggest that consciousness only emerges in a recognisable form in certain conditions or at some critical threshold; myself and all my neurons apparently being one such example of the “right” conditions. Theories of consciousness don’t just stop at computation and fundamental properties of the universe. Quantum physics, microtubule computations, electromagnetic fields; all have been proposed as part of this web of “why” (13). While some theories arguably veer more towards pseudoscience than well-founded scholarship, they all make one thing clear. At this stage, just about every idea remains fair game in the quest for answers. Pondering hard, or hardly pondering? The question of consciousness is far from limited to the field of neuroscience. Philosophers too have long wracked their brains in an attempt to rationalise and unpick this problem. What unites the work of neuroscientists and philosophers alike, along with the many theories of consciousness, is that nothing provides a satisfactory explanation for why consciousness should emerge from the activity of neurons. Philosopher David Chalmers has termed this the “hard problem”. “Why should physical processing give rise to a rich inner life at all? It seems objectively unreasonable that it should, and yet it does” (14). If consciousness is simply the result of high-level processing and the computational activity of neurons, why would we even need to be conscious? If all the brain is doing is computation, and thus everything can be done via computation, there would appear to be no purpose in having a subjective experience of being “you”. Whichever side of consciousness we may be inclined to take, computational, fundamental, or otherwise, the fact remains. We cannot seem to move beyond mere description, to explanation. We have not solved the “hard problem”. A final conundrum, and a sole certainty Physicist Emerson M Pugh once made the somewhat sceptical remark that “if the human brain were so simple that we could understand it, we would be so simple that we couldn't.” (15) Is the reason that we have yet to understand consciousness simply, frustratingly, that we are not meant to? Logical conundrums aside, I rest my case. I hope I have given you some food for thought, or at the very least, not set off too dramatic an existential crisis. Somewhere between the neural wirings of the brain and the experience of consciousness lies an answer, regardless of whether we are destined to find it out. Make of this what you will. And if nothing else, let me try reassuring you once again with the wisdom of René Descartes. “ Cogito, ergo sum ” “ I think, therefore I am ” (16). If you are here, and you are thinking, you are conscious. You, my friend, are you. References Nobel Prizes in nerve signaling. Nobel Prize Outreach. September 16, 2009. Accessed October 18, 2025. https://www.nobelprize.org/prizes/themes/nobel-prizes-in-nerve-signaling-1906-2000/ . Rábano A. Aristotle’ s “mistake”: the structure and function of the brain in the treatises on biology. Neurosciences and History . 2018;6(4):138-43. Golgi C. The neuron doctrine - theory and facts . 1906. p. 190–217. https://www.nobelprize.org/uploads/2018/06/golgi-lecture.pdf Herculano-Houzel S. The human brain in numbers: a linearly scaled-up primate brain. Front Hum Neurosci . 2009;3:31. doi: 10.3389/neuro.09.031.2009 Koch C, Massimini M, Boly M, Tononi G. Neural correlates of consciousness: progress and problems. Nature Reviews Neuroscience . 2016;17(5):307-21. Broca area . Encyclopedia Britannica; 2025. Accessed October 18, 2025. https://www.britannica.com/science/Broca-area Elam JS, Glasser MF, Harms MP, Sotiropoulos SN, Andersson JLR, Burgess GC, et al. The Human Connectome Project: A retrospective. NeuroImage . 2021;244. doi: 10.1016/j.neuroimage.2021.118543 Winding M, Pedigo BD, Barnes CL, Patsolic HG, Park Y, Kazimiers T, et al. The connectome of an insect brain. Science . 2023;379(6636). doi: 10.1126/science.add9330 Shapson-Coe A, Januszewski M, Berger DR, Pope A, Wu Y, Blakely T, et al. A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution. Science . 2024;384(6696). doi: 10.1126/science.adk4858 Chalmers D. Strong and Weak Emergence. In: Clayton P, Davies P. The Re-Emergence of Emergence: The Emergentist Hypothesis from Science to Religion . Oxford University Press; 2008. Kitchener PD, Hales CG. What Neuroscientists Think, and Don’t Think, About Consciousness. Frontiers in Human Neuroscience . 2022;16. doi: 10.3389/fnhum.2022.767612 Goff P, William Seager, and Sean Allen-Hermanson. Panpsychism . The Stanford Encyclopedia of Philosophy. Summer 2022. Seth AK, Bayne T. Theories of consciousness. Nature Reviews Neuroscience . 2022;23(7):439-52. doi: 10.1038/s41583-022-00587-4 Chalmers D. Facing up to the hard problem of consciousness . In: Shear J. Explaining Consciousness: The Hard Problem. MIT Press; 1997. Pugh GE. The Biological Origin of Human Values . Routledge & Kegan Paul; 1978. Descartes R. Principles of Philosophy . 1644. Previous article Next article Entwined back to

< Back to Issue 9 Rewilding Our Cities with Dr Kylie Soanes by Ciara Dahl 28 October 2025 Illustrated by Jess Walton Edited by Arwen Nguyen-Ngo When you think of nature, I bet the last things that come to mind are skyscrapers, freeways and footpaths. Welcome to the hidden world of urban ecology! I recently spoke to urban ecologist and prolific science communicator Dr Kylie Soanes about the challenges of conserving wildlife in urban environments, and what drives her to protect nature in our cities. Dr Kylie Soanes is determined to protect wildlife in our urban environments. (1) A research fellow at the University of Melbourne, Soanes describes herself as “your friendly neighbourhood wildlife scientist” on a mission to “save nature in cities and towns.” Her projects range from designing rope bridges to help endangered possums cross busy roads, to installing floating wetlands that bring biodiversity back to our urban waterways. Cities are a bustling weave of people and places, but where does nature belong in all of that chaos? That’s the question Soanes has dedicated much of her career to exploring. Like many of us, she grew up in a classic urban environment, longing to get into the wild. Her passion for learning about the natural world eventually grew into a career studying ecology and conservation at university. There is a common assumption that nature doesn't belong in cities. However, Soanes emphasises that cities are a “perfect place for people to connect with nature; there’s heaps of amazing biodiversity here”, adding that “it doesn't always have to look like the pristine natural conditions for it to be valuable”. She emphasises that communicating this message is the "first real step" in shifting mindsets. Soanes notes that urban ecology is often more about working with people than with science, explaining that “there are still people in this space that need to use it." Urban ecologists must be skilled collaborators, working with communities and experts across disciplines – from architects and engineers, to social scientists and artists – to reach solutions that balance the needs of nature and people. But what happens when communities don't feel seen by urban plans? A recent effort to protect swamp wallaby habitat along the Merri Creek Trail by diverting pedestrian traffic was met with concern from the community about personal safety (2). Cases like these highlight the challenges urban ecologists face every day when trying to make space for nature in our cities. Soanes argues that it is critical for urban ecologists to discuss “social risks and social justice, to make sure that we're not changing cities in a way that makes it worse for people". Public outcries like these often stem from communities that are faced with “a decision that they think that they weren't involved in”. The biggest tool in an urban ecologist's belt is community consultation, "so that everybody is brought along on the journey and we can make the right call for everyone." Some of Soanes’ favourite work is not just about protecting nature in cities, but putting it back. She speaks about creating new habitats in urban spaces, such as floating wetlands that transform bleak industrial wastelands into thriving ecosystems, or even rooftop gardens that reclaim space for nature. One of the most exciting areas of urban ecology includes restoring locally extinct species. Soanes cites the example of the endangered Key’s Matchstick Grasshopper, which was reintroduced to Royal Park in 2022 to restore the local population and support a healthy ecosystem (3). Often, such projects are overlooked in urban areas. She explains how they are frequently “put in the too hard basket”; but there is now a shift in focus towards “physically reintroducing species once we know that all the things that they need are there". So, where can we find some of Melbourne’s most exciting urban ecology projects? You can spot the floating wetlands in various locations along the Yarra River (4), and native wildflower meadows planted on roadsides throughout the city (5). Ever spotted those wooden boxes on trees around Melbourne’s gardens? They’re not decorations – they’re artificial hollows providing safe places for wildlife to nest (6). Additionally, “lots of councils are really embracing water sensitive urban design" by installing "miniature wetlands that slow rainwater down and clean it up before it hits our stormwater system" (7). The City of Melbourne has installed floating wetlands in the Yarra River since 2022. (4) Soanes also emphasises how cultural values and knowledge can be woven into urban ecology projects. She points to the revitalised Moonee Ponds Creek as an example, noting “it has a calendar for the Wurundjeri seasons and a beautiful cultural trail.” Projects like these offer valuable opportunities for communities to connect not only with nature, but with culture. So, how can we make our own homes more wildlife-friendly? Soanes encourages asking, “What can I add to make living here easier for species other than me? ”. It could be as simple as planting a few more native plants in your garden. As the warmer months approach, placing birdbaths or shallow water trays outside can help wildlife keep cool, “especially as our cities become hotter and drier”. Outside of her work as a researcher, Soanes has a strong social media presence, using it as a platform to share her conservation messages with the wider public. She emphasises that science communication is "about making your messages and your science accessible not just to the broader public, but to the people making decisions". Dr Kylie Soanes platforms her conservation messages on social media. (8) Soanes argues that "showcasing and celebrating those stories of success" gives people "hope that they can make change in their area", while inspiring councils and urban land managers to apply similar solutions. She acknowledges that wildlife conservation can feel "very heavy” at times but stresses “it is important to show that there are all these options out there.” "There are so many other people that want the same things, or would like to see their neighbourhood become a little bit better for nature," she adds. "I think almost everybody cares about nature – it just doesn't always look like wearing khaki and carrying binoculars at all times." A big thank you to Dr Kylie Soanes for taking the time to speak with us and shed light on the fascinating world of urban ecology. To keep up with her work, follow her on Instagram @drkyliesoanes or explore her research and projects at kyliesoanes.com . References Soanes K. Dr Kylie Soanes [Internet]. Dr Kylie Soanes. [cited 2025 Oct 18]. Available from: https://kyliesoanes.com/ Paul M. A “balancing act” as council votes to fence dogs out of park, sparking safety concerns [Internet]. ABC News. 2025 Aug 21. Available from: https://www.abc.net.au/news/2025-08-21/merri-creek-dog-fence-swamp-wallaby-coburg-victoria/105675854 City of Melbourne. Melbourne jumps at the chance to bring back the grasshopper [Internet]. City of Melbourne. 2022 [cited 2025 Oct 18]. Available from: https://www.melbourne.vic.gov.au/media/melbourne-jumps-chance-bring-back-grasshopper Balance Enviro. Yarra River Floating Wetlands – Balance Enviro Solutions [Internet]. 2022. Available from: https://balanceenviro.com.au/project/yarra-river-floating-wetlands/ City of Melbourne. Wildflower meadows and rare blooms boost biodiversity in Melbourne [Internet]. Vic.gov.au . 2024 [cited 2025 Oct 18]. Available from: https://www.melbourne.vic.gov.au/news/wildflower-meadows-and-rare-blooms-boost-biodiversity-melbourne#meadows Arthur Rylah Institute. Use of nest boxes in Victoria [Internet]. 2020. Available from: https://www.ari.vic.gov.au/research/people-and-nature/use-of-nest-boxes-in-victoria Melbourne Water. Constructed wetlands | Melbourne Water [Internet]. 2022. Available from: https://www.melbournewater.com.au/building-and-works/stormwater-management/options-treating-stormwater/constructed-wetlands Soanes K. Dr Kylie Soanes [Instagram page]. Instagram. [cited 2025 Oct 18]. Available from: https://www.instagram.com/drkyliesoanes/?hl=en Previous article Next article Entwined back to

The Intellectual’s False Dilemma: Art vs Science By Natalie Cierpisz The age-old debate once again resurfaces. How do art and science truly interact? Is one dependent on the other? How does the ‘art intellectual’ embrace science, and how does the ‘science intellectual’ embrace art? Is this all a meaningless debate anyway? Edited by Andrew Lim, Mia Horsfall & Hamish Payne Issue 1: September 24, 2021 Illustration by Casey Boswell The autumnal Melbourne wind whistles through the naked plane trees lining South Lawn, the sky is flat and grey. Two individuals who regard themselves and only themselves as ‘intellectual paragons’ are seated on a somewhat uncomfortable wooden bench, a perfect perch for people-watching, yet they are rather egotistical and notice only their own presence. One carefully places down their black coffee to light a hand-rolled cigarette; they are a liberal arts intellectual. As the wind grows stronger, the other tightly wraps a lab coat around themselves, and pushes a pair of wire-rimmed spectacles up their nose for the nth time. This would be our scientist. “So, are you still fooling around with your test tubes and pretty lights?” asks the liberal arts academic, cigarette hanging out the corner of their mouth. “If you mean, am I still investigating antiprotons using laser spectroscopy, then yes, indubitably so. How’s your fooling around with Hegel going?” replies the scientist, again pushing their glasses back up to a suitable height. The liberal arts intellectual is quick to retort the scientist’s trite remarks - they are in fact composing a Hegelian analysis of The Communist Manifesto, and not ‘fooling around’ by any means. The tension between the two self-professed intellectuals is building. The two appear to be fighting for dominance in their passive attacks on ego. So goes the age-old feud between the arts and the sciences. These two shallow characters play into the false dilemma that science and art are separate, distinct, alien. Two polar opposites. A total and unequivocal dichotomy. In all fairness, it is difficult to imagine many people will take this polarised a stance on the relationship between art and science. And now, as we delve into the complex relationship between the two domains, it should become clear that science and art are functionally interdependent (1), and considering art and science as totally separate is simply absurd. Let’s get back to our two feuding intellectuals. There seems to be much stereotypical disjunction between the two. But how does this translate to the true relationship between art and science? If the liberal arts intellectual and scientist were not so wrapped up in their self-interested ways, perhaps their gaze would slowly drift to the grandiose arches and imposing columns of the Old Quad. The harmonious form and mathematical ratios of these monuments are an enduring reminder of the architectural leaps and bounds made in the early 14th century, a blended pursuit of art and science. Ergo, we will head to one of the greatest paradigm shifts in Western history – the Renaissance. The Renaissance roughly spanned from the 14th to the 17th century and was a period of complete intellectual revolution – for both science and the arts (2). Everyone is familiar with Leonardo da Vinci, the great Renaissance artist. Less people know that he was also an inventor and a man whose artistic practice was heavily influenced by science (3). To ensure his paintings were as realistic as possible, Da Vinci dissected cadavers to better understand human anatomy, and studied optics and astronomy to perfect his use of space and form in paintings like The Last Supper. Likewise, scientists like Nicholas Copernicus and Galileo Galilei kickstarted a revolutionary paradigm shift towards the heliocentric model, their work in optics and astronomy being heavily reflected in artworks of the same era. Both science and art challenged what was for centuries prior considered the status quo. Source: Leonardo da Vinci, The Last Supper, 1498, tempera on gesso, pitch, and mastic, 460 cm × 880 cm, Wikipedia, https://en.wikipedia.org (4). This certainly isn’t a call for readers to head to the Melbourne General Cemetery and begin digging up specimens, nor to transfer to a double degree in fine arts and biomedicine. Instead, the point is more about how fruitful interaction between the two domains can be, and how one requires the other to flourish. Returning briefly to South Lawn, the snarky liberal arts intellectual continues looking bored and takes out their copy of The Myth of Sisyphus. Sitting directly opposite them the scientist has gone back to finishing the latest New Scientist podcast and calculating a quantum theory of gravity. We have seen that science can inspire art, but how can art inspire science? “The greatest scientists are artists as well.” (5) So said perhaps the most well-known scientist of the modern century. Not only did Albert Einstein develop the special and general theory of relativity (we won’t get into the mathematical specifics for both our sakes), he was also a talented violinist and pianist. Einstein often credited his artistic side for his success in science, testifying that, "the theory of relativity occurred to me by intuition, and music is the driving force behind this intuition. My parents had me study the violin from the time I was six. My new discovery is the result of musical perception.” (6) We have already seen how science prompts art to create new visions, and Einstein was no exception. His revolutionary ideas about space and time have been acknowledged as a prime artistic influence for Picasso’s arguably infamous Cubist style, as well as for the Surrealist art movement. (7) But the arts are not just confined to visual and musical expression. How about the area of expertise of our liberal arts friends? Liberal arts as they are known today, include sociology, literature, philosophy, psychology, politics, and more. The knowledge and, most importantly, critical thinking that is learnt through humanistic education is perhaps key to the future of science. As the world changes and evolves, humans must change and evolve with it, creating innovative solutions along the way. If we shift our focus to around the 1st century BCE, we will encounter what is widely regarded as the coining of the term artes liberales, or liberal arts. Roman statesman, scholar and writer Marcus Tullius Cicero wrote extensively about a wide array of topics, from politics and education to Stoic philosophy. “Artes liberales” roughly translates to “subjects worthy of a free person” - academic study that would enable one to actively participate in society (8). This curriculum consisted of a focus on seven key disciplines of rhetoric, geometry, grammar, music, astronomy, arithmetic, and logic. Liberal arts by nature are not the antithesis of science. From the crux of the artes liberales evolved the study of mathematics, physics, philology, history, and so on. Today we have reached a point where these seven disciplines have evolved and branched out so expansively that we have lost sight of the fact that our modern-day science and arts curriculums are sown from the same seed. Both science and art stem from the real world. Simply put, science is a lens into the study of this world and the inhabitants within it. Art is another lens into this complex system, providing a different but equally valuable perspective. Life is not binary, so neither should be our approach to studying it, and by virtue studying ourselves. Now is the time to embrace such transdisciplinary thinking. We need to bridge the gap between rigorous climate science facts and currently inadequate policy making, assess the ethics of the future of gene-editing, and ultimately become better thinkers. The combined intellectual strength of analytical thinking associated with science, where we learn how to test hypotheses, interpret data and draw valid conclusions; and the arts, where we learn critical thinking, how to develop arguments, how to understand a diverse audience, is necessary to keep humanity’s head above water as our world rapidly changes. Take for example the future of the CRISPR-Cas9 editing tool. This enzyme-based tool allows scientists to remove or add sections of DNA sequence in our genome, our code for life. With this ‘hand of God’ comes great responsibility. Collaboration needs to be made between scientific thinkers and humanistic thinkers to identify what type of robust legislation needs to be implemented to ensure ethical use of this tool. It is no longer a case of scientists working in isolation in underground bunkers. Scientists are making huge strides in research that extend to and greatly impact the wider community. Cases like CRISPR-Cas9 demand a lens from science and a lens from the arts in order to see the full picture – and in this case, to ensure the ethical and safe practise of a tool that has potential to save lives and improve individuals’ quality of life – but this only happens if science and art function in harmony. So back to you, the reader. Perhaps think about enrolling in that philosophy breadth subject next semester that your liberal arts friend raves about. Pick up that popular science book you have been eyeing off at Readings on Lygon St. Listen to that science podcast that keeps popping up on your Spotify homepage (The BBC’s The Infinite Monkey Cage is excellent). Pick up that paintbrush. Go visit Science Gallery Melbourne, a recent art scene addition affiliated with University of Melbourne – how fitting! This isn’t Romeo and Juliet, where you are either a Capulet or a Montague. Rather, this is a case of wave-particle duality, where an electron is both a wave and a particle, and you are both an artist and a scientist. As the typical Melbourne wind continues to pick up and the Old Arts clocktower strikes 7:00 pm, it appears the liberal arts intellectual just swapped their copy of The Myth of Sisyphus for the scientists’ copy of Brief Answers to the Big Questions. Looks like they’re making progress. References: 1. Richmond, Sheldon. “The Interaction of Art and Science.” The MIT Press 17, no. 2 (1984): 81-86. https://www.jstor.org/stable/1574993 . 2. History.com Editors. “Renaissance.” History.com. April 4, 2018. https://www.history.com/topics/renaissance/renaissance . 3. Powers, Anna. “Why Art is Vital to the Study of Science.” Forbes. July 13, 2020. https://www.forbes.com/sites/annapowers/2020/07/31/why-art-is-vital-to-the-study-of-science/?sh=7dfd8f8942eb . 4. Da Vinci, Leonardo. The Last Supper. 1498. Tempera on gesso, pitch, and mastic. 460 cm × 880 cm. Wikipedia. https://en.wikipedia.org . 5, 6. Root-Bernstein, Michelle. “Einstein On Creative Thinking: Music and the Intuitive Art of Scientific Imagination.” Psychology Today. March 31, 2010. https://www.psychologytoday.com/au/blog/imagine/201003/einstein-creative-thinking-music-and-the-intuitive-art-scientific-imagination . 7. Muldoon, Ciara. “Did Picasso know about Einstein?” Physics World. November 1, 2002. https://physicsworld.com/a/did-picasso-know-about-einstein/ . 8. Tempest, Kathryn. “Cicero’s Artes Liberales and the Liberal Arts.” Ciceronian on Line 4, no. 2 (2020): 479-500. https://doi.org/10.13135/2532-5353/5502 . Feynman, Richard, P. The Pleasure of Finding Things Out: The Best Short Works of Richard P. Feynman. New York: Basic Books, 2005. Science Gallery Melbourne. “Inspiring and Transforming Curious Minds.” Published 2021. https://melbourne.sciencegallery.com/what-we-do . White, Fiona. “Why art and science are better together.” The University of Sydney News. September 17, 2020. https://www.sydney.edu.au/science/news-and-events/2020/09/17/arts-and-science-better-together.html .