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Issue 9: Entwined 28 October 2025 This issue takes a moment to revel in the science that surrounds us. Come walk the tangled paths less followed, who knows what you may come across! Editorial Unravelling the Threads: From the Editors-in-Chief & Cover Illustrator by Ingrid Sefton, Aisyah Mohammad Sulhanuddin & Anabelle Dewi Saraswati A word from the Editors-in-Chief, and fascinating insights into this issue's cover. Knot theory Knot Theory and Its Applications. Why Knot? by Ryan Rud Untangle the knot theory with Ryan to reveal the role of this mathematical marvel in our everyday life. Hugging Entwined: A Hug Story by Elise Volpato Embrace the physiology, psychology and cultural complexities of hugs, as Elise opens us up to their undeniable benefits. Geological time periods Enter . . . the Anthropocene? by Rita Fortune Rita digs into questions of how and where we can draw a line in the sand, in attempts to disentangle a new geological time period. Cosmic matter The Cosmos in Our Palms: A Reflection of Our Cosmic Origins by Mishen De Silva Gain a new appreciation with Mishen of how the beauty and mystery of the cosmos is not just among us, but within us. Humans of UniMelb Rewilding Our Cities with Dr Kylie Soanes by Ciara Dahl Uncover life behind and between the concrete jungle, as Ciara talks all things urban ecology with Dr Kylie Soanes. Brain connectome Conferring with Consciousness by Ingrid Sefton Me, myself and my brain - Ingrid traverses the neural paths that comprise the conscious experience. Journey of food The Life of Matcha by Kara Miwa-Dale Delicately grown, globally consumed: Kara evaluates the intersection of matcha's deep-rooted social importance with physical health and current trends. Gunpowder Ancient Asian Alchemy: Big Booms by Isaac Tian Aiming for immortality, landing at gunpowder? Isaac explores how a quest for life is fundamentally entangled in the alchemy of gunpowder. Classical biology Eyeballs, a Knife, and No Fear of God by Jess Walton Travel back in time with Jess to meet the early anatomists who helped pioneer the arduous and neverending human quest to seek answers from deep within ourselves. Literally speaking, that is. Axolotls Axolotl: The Little God of the Lake by Danny He Dive into the history, habitat, and hardhsips of your favourite frilly friends. Axolotls are so much more than a cute face, and time may be running out to save them. Camouflage Living Pixels by KJ Srivastava Uncovering the science behind camouflaging creatures that have no eyes makes this trick no less magical, as KJ reveals. Pacific Island futures Human-Cetacean Relations by Andrew Irvin Taking us to Tonga, Andrew tells a tale of a musician swimming between the worlds of communication, marine science and a future for Pacific Islands. Philosophy of science It’s Dangerous to Go Alone by Julia Lockerd Join Julia to debate the importance of epistemic and social relationships in the development of modern science. Perceptions of time Time Perception – The Chaos Binding Your World Together by Furqan Mohsin Spend a moment with Furqan considering how our perception of time strings us together, yet fundamentally pulls us apart.

Issue 8: Enigma 3 June 2025 This issue unspools the long-hidden threads in science. Come make sense of the puzzles and mysteries with us! Or perhaps, leave just as addled. Editorial Cracking the Code: A Word from the Editors-in-Chief by Ingrid Sefton & Aisyah Mohammad Sulhanuddin A word from our Editors-in-Chief. Facial recognition Friend or Foe?: The Mechanisms Behind Facial Recognition by Mishen De Silva What's in a face? Mishen walks us through the ingenious ways our brains make meaning of the faces we see everyday. Human evolution The Lost Link: A Mystery in Evolution by Eymi Gladys Carcamo Rodriguez The theory of human evolution conjures textbook timelines of ape to man, but as Eymi explores, biology has never been that simple. Celebrity culture Glowing Limelight, Fashioned Stars by Aisyah Mohammad Sulhanuddin Chronically online or not, society sure loves its stars. Aisyah investigates the messy sociology behind our relationships with celebrities in past decades. Astronomy Why Are We So Fascinated by Space? An Exploration of Human’s Fascination with Outer Space by Emily Cahill What make the night sky impossible to ignore? Emily uncovers how culture, commercialisation and science have fuelled our cosmic curiosity. Prehistoric predators Terror Birds: The Discovery of Prolific Hunters by Jason Chien Giant, flightless and carnivorous - Jason pieces together the rise of terror birds as fearsome apex predators Psychology A Psychological ‘Autopsy’ of Ludwig van Beethoven: Dissecting Genius and Madness by Kara Miwa-Dale Elusive and erudite, even beyond the grave. Dissect the inner world of Beethoven with Kara - when can we call genius, madness? Fungi Fungal Pac Man by Ksheerja Srivastava No matter how good of a gamer you are, Ksheerja proves why biosensensing fungi should be crowned as our worlds best Pac-Man player. Dreams In Your Dreams: Unpacking the Stories of Your Slumber by Ciara Dahl Where do our minds go every night? Ciara explores the mysterious science best theories behind dreaming Neurology Functional Neurological Disorder by Esme MacGillivray What if your nervous system just stopped working? Esme explains FND, and how it affects someone, beyond symptoms. Slime moulds Thinking Outside the Body: The Consciousness of Slime Moulds by Jessica Walton I think, therefore I am... a slime mould? Jess ponders whether this humble, single cell protist may exhibit conciousness without a brain. Psychadelics Life Story of a Drug by Elijah McEvoy From 'Bicycle Day' to brain receptors, Elijah takes us on a trip through the enigmatic origins, uses and psychadelic effects of LSD. Gut microbiome Microbic Mirror of The Self by Sarah Ibrahimi Microbes: Humanities greatest enemy or our best friend? Sarah explores the relationship between the gut microbiome and our health. Infantile amnesia Mental Time Travel: How Far Can I Remember? by Sophie Potvin Step inside the hippocampus, as Sophie illustrates the mechanisms of memory formation and our power to make the past come alive again. Consciousness A Headspace of One’s Own by Andrew Irvin At what point does a computer become conscious? Andrew delves into technology that blurs the line between artificial intelligence and the human brain. Prejudice in Science What Do Women Want? by Madeleine Kelly The question we should be asking is not what we know, but what we don't know about women.

< Back to Issue 4 Echidnas: Gentle Courters In The Competitive Animal Kingdom by Emily Siwing Xia 1 July 2023 Edited by Maddison Moore and Arwen Nguyen-Ngo Illustrated by Christy Yung When we think of animals or nature in competition, we picture aggression and savagery over resources such as food, territory and mates. Beyond aggression, however, the variety of animal behaviour associated with competition for resources is immense. A gentle form of competition is the bizarre mating ritual of our own unique Australian fauna: the echidna. Known as Tachyglossus Aculeatus and spiny anteaters, echidnas are quill-covered animals living in Australia and New Guinea. Since Australia is so isolated from other continents, our fauna has often been regarded by outsiders with an air of mystery and awe. To start with, echidnas are in the same family as the famed platypus, called monotremes (egg-laying mammals). Surviving monotreme species can only be found in Australia and New Guinea. The four species of echidnas, along with their duck-billed cousin, are the very few surviving members in this classification. Despite the similarities in their name and appearance in both being covered with hollow, spiny quills, these spiny anteaters are not actually closely related to the more well-known anteaters in the Americas on a genetic and evolutionary basis. Echidnas feed on a diet of ants and termites, using their electroreceptive beaks to find burrowing prey digging them out with their hind claws. These powerful claws are long and curved backwards, specially designed for digging. Funnily, when the British Museum received an echidna specimen, they switched the backward claws frontwards thinking that it was a mistake. As mentioned before, mating rituals can be a violent (even bloody) ordeal in nature. From barbed penises in cats and deadly fights for females in elephant seals, straight to sexual cannibalism in praying mantises, there seems to be endless examples of brutality in the animal world. However, behind these brutal images is another side of nature that seems gentle and even humorous at times: for example, the ritual of our spiny suitors. Echidna mating rituals begin with the formation of a mating train. From June to September in Australia, male echidnas mate by lining up — from their beak tips to their spiny bottoms — to follow behind one single female. These trains can have more than 10 males in line and last for days, even weeks, at a time. During the mating season, male echidnas may leave a train to join or form a different train behind another eligible female. Their mating efforts often lead males to travel for long distances, even beyond their own home ranges. If the males get interrupted and lose track of the female, they reform their train by picking up her scent with their snouts in the air. They are such determined suitors that it is extremely difficult for a female echidna to evade them. Usually, there is one male that remains through the long-winded process, and they get to mate with the female. The reason behind forming echidna trains is unknown, but scientists generally agree that it is correlated with some type of selection process. One theory is that it aids the female in weeding out all the weaker males by tiring them out until the last one remains. Another is that the female is waiting for the right male that she is interested in to get behind her. Either way, it is a process of determination and perseverance. In exceedingly rare occasions where there are still multiple suitors left at the end, the males dig a trench surrounding the female and compete through head bumping. Although there is still much not understood about head bumping due to its scarce occurrence, it is generally considered an echidna social behaviour that serves to maintain dominance. Head bumps are generally only given by dominant echidnas to subordinate echidnas who haven’t recognised their dominance status and moved away. This rarely happens and is a relatively peaceful affair compared to conflicts in other animals. The winner of the mating head bumping ritual then digs until the previously mentioned trench is deep enough for him to be below the female so they can mate through their cloacas. 23 days after copulation, the female lays a soft-shelled leathery egg into a temporary pouch where it continues to incubate for 10 more days when a tiny puggle (a baby echidna or platypus) hatches. The puggle drinks milk from the female’s special mammary hairs until it is capable of feeding itself and has fully covered spines and fur. At last, the matured echidna leaves their mother’s burrow to live independently. The mating rules and practices amongst echidnas are a demonstration of patience and courtesy. This contrasts with the general public misconception of nature being merciless, which is characterised by the brutal competition for food, social status and mating opportunities. Although they are in the same competition for a mate, the lines of waddling echidnas are polite, organised and humorous. Behind the mask of brutality, nature continues to have its pleasant secrets. References Morrow G, Nicol SC. Cool Sex? Hibernation and Reproduction Overlap in the Echidna. PLoS One. 2009 Jun 29;4(6):e6070. Echidna [Internet]. AZ Animals. [cited 2023 Jun 22]. Available from: https://a-z-animals.com/animals/echidna/ Anne Marie Musser. Echidna | Britannica [Internet]. 2023 [cited 2023 Jun 22]. Available from: https://www.britannica.com/animal/echidna-monotreme Echidna trains: explained [Internet]. Australian Geographic. August 6, 2021 [cited 2023 Jun 22]. Available from: https://www.australiangeographic.com.au/topics/wildlife/2021/08/echidna-trains-explained/ Lindenfors P, Tullberg BS. Evolutionary aspects of aggression the importance of sexual selection. Adv Genet. 2011;75:7–22. Warm Your Heart With Videos of ‘Echidna Love Trains’ [Internet]. Atlas Obscura. September 1, 2017. [cited 2023 Jun 22]. Available from: http://www.atlasobscura.com/articles/echidna-love-trains Previous article Next article back to MIRAGE

< Back to Issue 6 Proprioception: Our Invisible Sixth Sense by Ingrid Sefton 28 May 2024 Edited by Subham Priya Illustrated by Jessica Walton What might constitute a sixth sense? Perhaps, it involves possessing a second sight or superhuman abilities. A classic example of this would be Spider-Man and his ‘spidey-sense’ — an instinctual warning system that alerts him to imminent danger. Enhancing his reflexes and agility, his sixth sense enables him to evade threats with precision. Turns out Spider-Man is not the sole bearer of a ‘spidey sense’. While we may not be scaling walls anytime soon, we too possess a special sense that unconsciously guides our movements. It might sound peculiar, but knowing your arm is indeed your own arm involves a unique form of sensory processing. Considered by neuroscientists as our own ‘sixth sense’, proprioception is our own way of helping the brain to understand the position of our body and limbs in space (Sherrington, 1907). Consider a typical scenario: your first sip of coffee in the morning. Eyes shut, you savour your latte before the day begins. Such a simple act, yet impossible without proprioception. With closed eyes, how do you know where your mouth is? How do you gauge the position of your arm to ensure the coffee cup reaches your lips? Proprioception seamlessly transmits information about muscle tension, joint position, and force to the brain, making drinking your coffee an automatic and coordinated process. Proprioception operates on principles akin to those guiding our other senses. Specialised cells, known as receptors, are found in each sensory organ and receive information from the environment. Receptors in your eyes capture visual information, while those in your ears detect auditory stimuli. This sensory information is transduced through signals to the central nervous system – through the spinal cord and to the brain – where it’s integrated and processed to determine an appropriate response. Analogously, proprioceptive information is mediated by proprioceptors, a unique type of receptors located in your muscles and joints (Proske & Gandevia, 2012). Unlike our other senses, proprioception does not rely on input from the external environment. Rather, it provides feedback to the brain about what the body itself is doing. Changes in muscle tension and the position of our joints are relayed to the brain, ensuring awareness of the body’s whereabouts at any given moment. One implication of this ‘internal’ feedback loop is that proprioception never turns ‘off’. When you cover your ears, you experience silence. If you hold your nose, you can block out the smell. Yet even when still, in motion, or unconscious, your brain continuously receives proprioceptive input. Imagine this in the context of going to bed each night. What exactly prevents you from falling out of bed, once asleep? While most senses are subdued when sleeping, proprioception remains active, informing the brain about the slightest changes in the position of the body. This ensures a perpetual awareness of our body in space – and luckily for us, stops us from rolling out of bed (Proske & Gandevia, 2012). It can be hard to appreciate what our proprioceptive system allows us to do, given its unconscious nature and integration with our other senses. Rare neurological disorders affecting proprioception highlight just how critical this sense is in our daily lives. The case of Ian Waterman – now known as ‘the man who lost his body – offers profound insights into the significance of proprioception (McNeill et al., 2009). Following a fever in 1971 at age 19, a subsequent auto-immune reaction destroyed all his sensory neurons from the neck down–a condition termed ‘neuronopathy’. Despite retaining his intact motor functions, Waterman lost all proprioceptive abilities, rendering him unaware of his body's position in space. Although the viral infection’s initial effect was that of immobility, this loss was not due to paralysis. Rather, it was Waterman’s lack of control over his body that inhibited his ability to move. Sitting, walking, and manipulating objects became impossible tasks as a result of the absence of any proprioceptive feedback from the body. Remarkably, Waterman has been able to teach himself precise strategies to walk and function with a degree of normality (Swain, 2017). Yet, all movement requires concerted planning and relies entirely on vision to compensate for the unconscious proprioceptive processing. In the absence of any light, Waterman is unable to see his limbs, thus restricting his ability to move. An understanding of the molecular mechanisms underlying proprioception remains somewhat of a mystery compared to that of our other senses. However, recent genetic advancements are paving the way for the development of novel therapies aimed at neurological and musculoskeletal disorders (Woo et al., 2015). A study involving two young patients with unique neurological disorders affecting their body awareness revealed a mutation in their PIEZO2 gene (Chesler et al., 2016). Both individuals experienced significant challenges with balance and movement, coupled with progressive scoliosis and deformities in the hips, fingers, and feet. The PIEZO2 gene typically encodes a type of mechanosensitive protein in cells, r esponsible for generating electrical signals in response to alterations in cell shape (Coste et al., 2010). Mutations to this gene prevent signal generation and render the neurons incapable of detecting limb or body movement. These findings firmly establish PIEZO2 as a critical gene for facilitating proprioception in humans, a sense that is crucial for bodily awareness. PIEZO2 mutations have also been implicated in genetic musculoskeletal disorders (Coste et al., 2010). Joint problems and scoliosis experienced by the patients in a study suggest that proprioception may also indirectly guide skeletal development. These insights into the role of the PIEZO2 gene in proprioception and musculoskeletal development open up promising avenues for understanding and treating neurological and musculoskeletal disorders. It’s more than fitting to regard proprioception as our sixth sense. The capacity of our nervous system to seamlessly process vast amounts of information from our joints and muscles, all without any conscious effort on our part, is truly remarkable. So, the next time you have that eyes-shut first sip of coffee, give yourself a pat on the back. With your sixth sense at play, you’re clearly a superhero! References Chesler, A. T., Szczot, M., Bharucha-Goebel, D., Čeko, M., Donkervoort, S., Laubacher, C., Hayes, L. H., Alter, K., Zampieri, C., Stanley, C., Innes, A. M., Mah, J. K., Grosmann, C. M., Bradley, N., Nguyen, D., Foley, A. R., Le Pichon, C. E., & Bönnemann, C. G. (2016). The Role of PIEZO2 in Human Mechanosensation. N Engl J Med , 375 (14), 1355-1364. https://doi.org/10.1056/NEJMoa1602812 Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010). Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science , 330 (6000), 55-60. McNeill, D., Quaeghebeur, L., & Duncan, S. (2009). IW - “The Man Who Lost His Body”. In (pp. 519-543). https://doi.org/10.1007/978-90-481-2646-0_27 Proske, U., & Gandevia, S. C. (2012). The Proprioceptive Senses: Their Roles in Signaling Body Shape, Body Position and Movement, and Muscle Force. Physiological Reviews , 92 (4), 1651-1697. https://doi.org/10.1152/physrev.00048.2011 Sherrington, C. S. (1907). On the proprio-ceptive system, especially in its reflex aspect. Brain , 29 (4), 467-482. Swain, K. (2017). The phenomenology of touch. The Lancet Neurology , 16 (2), 114. https://doi.org/10.1016/S1474-4422(16)30389-1 Woo, S. H., Lukacs, V., de Nooij, J. C., Zaytseva, D., Criddle, C. R., Francisco, A., Jessell, T. M., Wilkinson, K. A., & Patapoutian, A. (2015). Piezo2 is the principal mechanotransduction channel for proprioception. Nature Neuroscience , 18 (12), 1756-1762. https://doi.org/10.1038/nn.4162 Previous article Next article Elemental back to

< Back to Issue 9 Rewilding Our Cities with Dr Kylie Soanes by Ciara Dahl 28 October 2025 Illustrated by Jess Walton Edited by Arwen Nguyen-Ngo When you think of nature, I bet the last things that come to mind are skyscrapers, freeways and footpaths. Welcome to the hidden world of urban ecology! I recently spoke to urban ecologist and prolific science communicator Dr Kylie Soanes about the challenges of conserving wildlife in urban environments, and what drives her to protect nature in our cities. Dr Kylie Soanes is determined to protect wildlife in our urban environments. (1) A research fellow at the University of Melbourne, Soanes describes herself as “your friendly neighbourhood wildlife scientist” on a mission to “save nature in cities and towns.” Her projects range from designing rope bridges to help endangered possums cross busy roads, to installing floating wetlands that bring biodiversity back to our urban waterways. Cities are a bustling weave of people and places, but where does nature belong in all of that chaos? That’s the question Soanes has dedicated much of her career to exploring. Like many of us, she grew up in a classic urban environment, longing to get into the wild. Her passion for learning about the natural world eventually grew into a career studying ecology and conservation at university. There is a common assumption that nature doesn't belong in cities. However, Soanes emphasises that cities are a “perfect place for people to connect with nature; there’s heaps of amazing biodiversity here”, adding that “it doesn't always have to look like the pristine natural conditions for it to be valuable”. She emphasises that communicating this message is the "first real step" in shifting mindsets. Soanes notes that urban ecology is often more about working with people than with science, explaining that “there are still people in this space that need to use it." Urban ecologists must be skilled collaborators, working with communities and experts across disciplines – from architects and engineers, to social scientists and artists – to reach solutions that balance the needs of nature and people. But what happens when communities don't feel seen by urban plans? A recent effort to protect swamp wallaby habitat along the Merri Creek Trail by diverting pedestrian traffic was met with concern from the community about personal safety (2). Cases like these highlight the challenges urban ecologists face every day when trying to make space for nature in our cities. Soanes argues that it is critical for urban ecologists to discuss “social risks and social justice, to make sure that we're not changing cities in a way that makes it worse for people". Public outcries like these often stem from communities that are faced with “a decision that they think that they weren't involved in”. The biggest tool in an urban ecologist's belt is community consultation, "so that everybody is brought along on the journey and we can make the right call for everyone." Some of Soanes’ favourite work is not just about protecting nature in cities, but putting it back. She speaks about creating new habitats in urban spaces, such as floating wetlands that transform bleak industrial wastelands into thriving ecosystems, or even rooftop gardens that reclaim space for nature. One of the most exciting areas of urban ecology includes restoring locally extinct species. Soanes cites the example of the endangered Key’s Matchstick Grasshopper, which was reintroduced to Royal Park in 2022 to restore the local population and support a healthy ecosystem (3). Often, such projects are overlooked in urban areas. She explains how they are frequently “put in the too hard basket”; but there is now a shift in focus towards “physically reintroducing species once we know that all the things that they need are there". So, where can we find some of Melbourne’s most exciting urban ecology projects? You can spot the floating wetlands in various locations along the Yarra River (4), and native wildflower meadows planted on roadsides throughout the city (5). Ever spotted those wooden boxes on trees around Melbourne’s gardens? They’re not decorations – they’re artificial hollows providing safe places for wildlife to nest (6). Additionally, “lots of councils are really embracing water sensitive urban design" by installing "miniature wetlands that slow rainwater down and clean it up before it hits our stormwater system" (7). The City of Melbourne has installed floating wetlands in the Yarra River since 2022. (4) Soanes also emphasises how cultural values and knowledge can be woven into urban ecology projects. She points to the revitalised Moonee Ponds Creek as an example, noting “it has a calendar for the Wurundjeri seasons and a beautiful cultural trail.” Projects like these offer valuable opportunities for communities to connect not only with nature, but with culture. So, how can we make our own homes more wildlife-friendly? Soanes encourages asking, “What can I add to make living here easier for species other than me? ”. It could be as simple as planting a few more native plants in your garden. As the warmer months approach, placing birdbaths or shallow water trays outside can help wildlife keep cool, “especially as our cities become hotter and drier”. Outside of her work as a researcher, Soanes has a strong social media presence, using it as a platform to share her conservation messages with the wider public. She emphasises that science communication is "about making your messages and your science accessible not just to the broader public, but to the people making decisions". Dr Kylie Soanes platforms her conservation messages on social media. (8) Soanes argues that "showcasing and celebrating those stories of success" gives people "hope that they can make change in their area", while inspiring councils and urban land managers to apply similar solutions. She acknowledges that wildlife conservation can feel "very heavy” at times but stresses “it is important to show that there are all these options out there.” "There are so many other people that want the same things, or would like to see their neighbourhood become a little bit better for nature," she adds. "I think almost everybody cares about nature – it just doesn't always look like wearing khaki and carrying binoculars at all times." A big thank you to Dr Kylie Soanes for taking the time to speak with us and shed light on the fascinating world of urban ecology. To keep up with her work, follow her on Instagram @drkyliesoanes or explore her research and projects at kyliesoanes.com . References Soanes K. Dr Kylie Soanes [Internet]. Dr Kylie Soanes. [cited 2025 Oct 18]. Available from: https://kyliesoanes.com/ Paul M. A “balancing act” as council votes to fence dogs out of park, sparking safety concerns [Internet]. ABC News. 2025 Aug 21. Available from: https://www.abc.net.au/news/2025-08-21/merri-creek-dog-fence-swamp-wallaby-coburg-victoria/105675854 City of Melbourne. Melbourne jumps at the chance to bring back the grasshopper [Internet]. City of Melbourne. 2022 [cited 2025 Oct 18]. Available from: https://www.melbourne.vic.gov.au/media/melbourne-jumps-chance-bring-back-grasshopper Balance Enviro. Yarra River Floating Wetlands – Balance Enviro Solutions [Internet]. 2022. Available from: https://balanceenviro.com.au/project/yarra-river-floating-wetlands/ City of Melbourne. Wildflower meadows and rare blooms boost biodiversity in Melbourne [Internet]. Vic.gov.au . 2024 [cited 2025 Oct 18]. Available from: https://www.melbourne.vic.gov.au/news/wildflower-meadows-and-rare-blooms-boost-biodiversity-melbourne#meadows Arthur Rylah Institute. Use of nest boxes in Victoria [Internet]. 2020. Available from: https://www.ari.vic.gov.au/research/people-and-nature/use-of-nest-boxes-in-victoria Melbourne Water. Constructed wetlands | Melbourne Water [Internet]. 2022. Available from: https://www.melbournewater.com.au/building-and-works/stormwater-management/options-treating-stormwater/constructed-wetlands Soanes K. Dr Kylie Soanes [Instagram page]. Instagram. [cited 2025 Oct 18]. Available from: https://www.instagram.com/drkyliesoanes/?hl=en Previous article Next article Entwined back to

By Gavin Choong < Back to Issue 3 Love and Aliens By Gavin Choong 10 September 2022 Edited by Khoa-Anh Tran and Niesha Baker Illustrated by Ravon Chew Next Neither Daniel Love nor Brendan Thoms were Australian citizens, but they were both recognised as First Nations Australians by law. Under legislation, “aliens” who commit crimes with a sentence of over a year may be removed from the country. (1) Due to their non-citizenship, the then Minister for Home Affairs Peter Dutton classified these men as aliens and tried to deport them after they were convicted of serious crimes. This attempt failed. The High Court of Australia ruled, in the hotly contested landmark decision of Love v Commonwealth, that Indigenous Australians could not be considered aliens under Australian law because of the “spiritual connection” they hold with the lands and waters of the country we live in. (1) Effectively, this barred the deportation of Love and Thoms but also sent astronomical ripples through the fabric of our nation’s legal framework. This year, major challenges to the decision made in Love v Commonwealth have arisen. Of the arguments put forward, some protest the judicial activism of the judges – that is, them going above and beyond written law to produce a fairer ruling. For example, many contend the term spiritual connection bears no actual legal meaning. However, with a history dating back upwards of seventy-thousand years, two hundred and fifty languages and eight hundred dialects, complex systems of governance, deeply vested religious and spiritual beliefs, and a profound understanding of land, it would be ignorant to argue this rich culture should simply be disregarded in the face of the law. This article adopts a scientific lens and delves into an empirical basis for the spiritual connection Aboriginal Australians share with country, traversing from Dreamtime to spacetime and beyond. THE DREAMING: FROM NOTHING, EVERYTHING From nothing came everything. Nearly fourteen billion years ago, a zero-volume singularity held, tightly, all the energy, space, and time from our current universe. In the moment of creation, temperature and average energies were so extreme all four fundamental forces which shape the universe, as we know it, acted as one. Cosmological inflation followed, allowing for exponential expansion and rapid cooling. Within a picosecond, the four fundamental forces of nature – gravity, electromagnetism, weak interactions, and strong interactions – emerged independently. These forces interacted with matter, resulting in the formation of elementary particles now coined quarks, hadrons, and leptons. For twenty more minutes, elementary particles coupled to form subatomic particles (protons, neutrons) which in turn underwent nuclear fusion to create simple early atoms such as hydrogen and helium. From nothing, came everything. In an eternal present, where there had once been flat and barren ground, Ancestral and Creator spirits emerged from land, sea, and sky to roam the Earth. As they moved, man and nature – mountains, animals, plants, and rivers – were birthed into existence. Once these spirits had finished, instead of disappearing, they transformed into the world they had created, existing in sacred sites such as the night sky, monolithic rocks, and ancient trees. The Dreaming is a First Nations peoples’ understanding of the world and its creation. Importantly, it is an event which cannot be fixed in time – “it was, and is, everywhen,” continuing even today. Countless retellings have caused Dreamtime tales to diverge slightly, leading communities of Aboriginal Australians to identify with different variations of similar stories. (2) These fables refer to natural worldly features and sacred sites, whilst also incorporating favourable values such as patience, humility, and compassion. An example is the tale of the Karatgurk, told by the Wurundjeri people of the Kulin nation, about seven sisters representing what we now consider as the Pleiades star constellation. (3) The Karatgurk These seven sisters once lived by the Yarra River, where Melbourne now stands. They alone possessed the secret of fire, carrying live coals at the end of their digging sticks. (Crow ("trickster, cultural hero, and [another] ancestral being") called the sisters over claiming he had discovered tasty ant larvae. (3) The women began scouring, only to find viscious snakes underneath the dirt which they beat using their digging sticks. As they did so, the live coals flew off and were stolen by Crow who brought fire to mankind. The Karatgurk sisters were swept into the sky, with their glowing fire sticks forming the Pleiades star cluster. In theory, the extreme physical reactions occurring minutes after the Big Bang, paired with hyper-rapid cosmic inflation, should have resulted in a completely homogeneous universe with an even distribution of all existing matter and energy. Cosmological perturbation theory explains, however, that micro-fluctuations in material properties create gravitational wells resulting in the random grouping of matter. These aggregations formed the first stars, quasars, galaxies, and clusters throughout the next billion years. It took, however, another ten billion years for the solar system to form. Similar to Saturn’s planetary rings, the early Sun had its own rotating, circumstellar disc composed of dust, gas, and debris. According to the nebular hypothesis, over millions of years, enough particulates coagulated within the Sun’s spinning disc to form small, primordial planets. Early Earth was a hellish fire-scape as a result of constant meteoric bombardment and extreme volcanic activity. The occasional icy asteroids which collided with Earth deposited large amounts of water, vaporising upon contact – as our planet began to cool, these gaseous deposits condensed into oceans, and molten rock solidified into land mass. In the blink of an eye, early traces of modern humans fluttered into existence at the African Somali Peninsula. They were a nomadic people, travelling westwards and then north through modern day Egypt and into the Middle East. Ancestral Indigenous Australians were amongst the first humans to migrate out of Africa some 62,000 to 75,000 years ago. While other groups travelled in different directions filling up Asia, Europe and the Americas, ancestral Indigenous Australians took advantage of drastically lower sea levels during that time to travel south, as, back then, mainland Australia, Tasmania, and Papua New Guinea formed a single land mass (Sahul) while South-East Asia formed another (Sunda). In spite of this, the wanderers still had to possess the requisite sea-faring skills to traverse almost ninety kilometres of ocean. When the last ice age ended 10,000 years ago, rising waters from melting ice caps covered many of the terrestrial bridges early humans had once journeyed over. This severing allowed Indigenous Australians to foster culture and tradition in their very own passage of time, uninterrupted and independent until a British fleet of eleven ships approached Botany Bay thousands of years later. Significant parts of Australia’s coast were also submerged due to ice age flooding. As coastal Indigenous Australians observed this phenomenon, they recognised its significance through their tales. The Gimuy Walubara Yidinji, traditional custodians of Cairns and the surrounding district, are one of the many groups which reference coastal flooding in their geomythology. Gunya and the Sacred Fish Gunyah, who had lived on Fitzroy Island, went out to hunt for fish one day. Spotting a glimmer in the water, he plunged a spear towards it only to find he had attacked the sacred black stingray. The stingray beat its wing-like fins, causing a great, unending storm. Gunyah fled from the rapidly rising sea and managed to find refuge in a clan living on the cliffs of Cairns. Together, they heated huge rocks in a fire and threw them far into the sea. The pacific was once again pacified, and the Great Barrier Reef created. Isaac Newton proposed, in Principia Mathematica, that the strength of the force of gravity between two celestial bodies would be proportional to both of their masses. At the beginning of the twentieth century, Albert Einstein refined this concept with the theories of Special and General Relativity. His mathematical models suggested time and space were woven into a four-dimensional canvas of spacetime, and the presence of massive objects such as black holes and stars created gravitational wells which distorted spacetime. Within these distortions, bodies closer to large masses would conceive time and space differently than those further away. This unique phenomenon, for example, means astronauts living onboard the International Space Station age fractionally slower relative to us grounded on Earth. Einstein was also able to find that as the velocity of any given body increased to that near the speed of light, it would gain an almost-infinite mass and experience a drastically slowed perception of time relative to their surroundings. These once inconceivable findings had monumental implications in the sphere of theoretical physics, with two examples below. (4, 5) Dark Matter ‘Visible’, baryonic matter humanity is familiar with makes up less than a fifth of the known universe, with a hypothetical ‘dark’, non-baryonic matter comprising the rest. Dark matter lies between and within galaxies, driving baryonic matter to aggregate, forming stars and galaxies. As it cannot be detected using electromagnetic radiation, gravitational lensing provides the strongest proof of its existence. Gravitational lensing occurs when there is an interfering body between us, here on Earth, and a given target. As per Einstein’s relativity, the interfering body has mass which will bend space and therefore distort the image we receive of the target. There exists a mathematically proportional relationship between mass and distortion – the more massive an interfering body, the greater the distortion. Scientists performed calculations but found that the levels of distortion they observed correlated to masses much greater than that of the interfering body. Dark matter accounts for this invisible and undetectable missing mass. String Theory At its core, quantum physics deals with interactions at the atomic and subatomic level. This body of work has borne unusual findings – including that light can act both as a particle and wave, that we may never identify a particle’s position and momentum simultaneously with complete certainty, and that the physical properties of distant entangled particles can fundamentally be linked. On paper, however, there has been great difficulty reconciling quantum physics with relativity theory, as the former deals with interactions which occur in “jumps…with probabilistic rather than definite outcomes”. (4) String theory, however, seeks to settle this tension by proposing the universe is comprised of one-dimensional vibrating strings interacting with one another. This theoretical framework has already bore fascinating fruit – it has been hypothesised that the universe has ten dimensions (nine spatial, one temporal) and during the Big Bang, a “symmetry-breaking event” caused three spatial dimensions to break from the others resulting in an observable three-dimensional universe. (5) On 21 September 1922, astronomers in Goondiwindi, Queensland, used a total solar eclipse to successfully test and prove Einstein’s theory of relativity. Aboriginal Australians present believed they were “trying to catch the Sun in a net”. (6) Western academics were far from the only ones who sought to explain natural phenomena. From the ancient Egyptians to Japanese Shintoists and South American Incas, many civilisations of the past revered the Sun and Moon, having been enthralled by the two celestial bodies. Indigenous Australians were one such people, wanting to understand why the sun rose and set, how moon cycles and ocean tides were related, and what exactly were the rare solar and lunar eclipses. Such occurrences had a mystical property about them, reflected in a rich collection of traditional tales which looked to illuminate these astronomical observations. (7) Walu the Sun-woman Told by the Yolngu people of Arnhem Land, Walu lights a small fire every morning to mark that dawn has arrived. She paints herself with red and yellow pigment with some spilling onto the clouds to create sunrise. Walu lights a bark torch and carries it across the sky from East to West, creating daylight. Upon completing her journey, she extinguishes her torch and travels underground back to the morning camp in the East. While doing so, she provides warmth and fertility to the very Earth surrounding her. Ngalindi the Moon-man Told by the Yolngu people of Arnhem Land, “water fill[s] Ngalindi as he rises, becoming full at high tide”. (6) When full, he becomes gluttonous and decides to kill his sons because they refuse to share their food with him. His wives seek vengeance by chopping off his limbs, causing water to drain out. This is reflected by a waning moon and ebb in the tides. Eventually, Ngalindi dies for three days (New Moon) before rising once again (waxing Moon). Bahloo and Yhi Told often by the Kamilaroi people of northern New South Wales, Yhi (Sun-woman) falls in love with Bahloo (Moon-man) and tries to pursue him across the sky. However, he has no interest in Yhi and refuses her advances. Sometimes, Yhi eclipses Bahloo and tries to kill him in a fit of jealously, but the spirits holding up the sky intervene allowing Bahloo to escape. In 1788, British colonists prescribed the fictitious doctrine of terra nullius which treated land occupied by Indigenous peoples as “territory belonging to no-one,” susceptible to colonisation. (8) It is apparent, however, that Indigenous Australians did and still do belong, having a greater, more unique, and nuanced relationship to our lands and waters than we can ever hope to have. This article shows that as detailed and prescriptive our modern scientific understanding is, First Nations peoples will have an equally if not richer perspective, woven through their stories, languages, and practices. To argue that the spiritual connection Indigenous people share with country is not recognised by law would be wilfully making the same mistake our early settlers made two and a half centuries ago. It would be allowing the continuance of intergenerational trauma and suppression. For those reasons, despite the assertive legal challenges being brought against Love v Commonwealth, its judgement must be upheld. References 1. Love v Commonwealth; Thoms v Commonwealth [2020] HCA 3. 2. Stanner WE. The Dreaming & other essays. Melbourne (AU): Black Inc.; 2011. 3. Creation Stories [Internet]. Victoria: Taungurung Lands & Waters Council [cited 2022 Apr. Available from: https://taungurung.com.au/creation-stories/ 4. Powell CS. Relativity versus quantum mechanics: the battle of the universe [Internet]. The Guardian; 2015 Nov 4 [cited 2022 Apr 17]. Available from: https://www.theguardian.com/news/2015/nov/04/relativity-quantum-mechanics-universe-physicists 5. Wolchover N. String theorists simulate the Big Bang [Internet]. Live Science; 2011 Dec 14 [cited 2022 Apr 17]. Available from: https://www.livescience.com/17454-string-theory-big-bang.html 6. Hamacher DW. On the astronomical knowledge and traditions of Aboriginal Australians [thesis submitted for the degree of Doctor of Philosophy]. [Sydney]: Macquarie University; 2011. 139 p. 7. Mathematics, moon phases, and tides [Internet]. Melbourne: University of Melbourne [cited 2022 Apr 17]. Available from: https://indigenousknowledge.unimelb.edu.au/curriculum/resources/mathematics,-moon-phases,-and-tides 8. Mabo v Queensland (No 2) [1992] HCA 23. Previous article Next article alien back to

< Back to Issue 9 It’s Dangerous to Go Alone by Julia Lockerd 28 October 2025 Illustrated by Jason Chien Edited by Luci Ackland It’s safe to say that as a species, we have done a fair bit of thinking over the years. From microbes to mammals, to mapping the stars, we have always searched for ways to make meaning of the world and its many mysteries. Every day, the amount of knowledge possessed grows, building on the ideas we learn from each other. But what is knowledge without someone to know it? And how can we build a reliable foundation upon which to amass this knowledge? Many modern philosophers take a ‘what’s mine is mine’ approach to epistemology – the development of knowledge – with ideas like trust and collaboration altogether excluded from the recipe for ‘good science’ (1). Philosopher John Locke suggests that an ‘autonomous knower’ (2) – that’s you! – should only accept input from someone existing outside the self if she already possesses empirical evidence confirming that input is true (3). That is to say, don’t believe anything you read online, or in a book, or hear from your friend, or your professor alone. Basically, don’t believe the sky is blue unless you can look outside and see it for yourself. This seems like a hard way to live and makes it nearly impossible to make any headway on scientific advancement. If there is truly no way to build on previous knowledge, how do we measure anything at all? When considering scientific disciplines, the (presumably brooding) ‘autonomous knower’ must give up her lone wolf life and finally make some friends. This is not only for her emotional benefit, but also because science simply cannot occur without it. Epstein (2006) argues that the three main drivers of scientific collaboration are as follows: 1. The topic demands it. This applies to fields such as cognitive psychology, where the topic is an amalgam of different specialisations. 2. To gain a new perspective. Researchers interviewed by Epstein highlighted how collaboration helps them gain new approaches and techniques. 3. To provide additional knowledge. Although it’s all well and good to assert you should only believe what you can prove yourself (looking at you, Locke), collaboration is crucial to avoid ‘reinventing the wheel’ every time you want to learn something new (4). This last reason, by its very nature, proves that, despite my best efforts, no one person can possess the whole of human understanding by herself. Thus, the ‘many-headed knower’ makes her appearance on stage. This version of the knower exists as an alternative to Locke’s Autonomous Knower, where multiple individuals can share fragments of a greater epistemic idea. Without it, whole scientific disciplines can be reasoned away as no single person possesses the evidence to prove the scientific idea exists (2). For example, many medical devices could not be realised without input from both clinicians and engineers. If knowledge cannot be shared between these two groups, MedTech might cease to exist at all. With the multiheaded knower by your side, you can now solve scientific conundrums with the power of friendship (or, begrudging teamwork if it’s 11.59pm and you’re still working on that group project due at 12.00am). To fully grasp how systems of collaboration function, we need to investigate the interpersonal relationships that make up the heads of the knower. Generally, these relationships are of two kinds: Moral and Epistemic trust. Returning to our old friend, the multi-headed knower, epistemic trust allows multiple heads to exist, while moral trust in social bonds between researchers keeps her many heads attached. Epistemic trust involves the acceptance of knowledge provided by an external source as true. While trustworthiness often evokes a sense of superior moral value, epistemic trust has far more to do with the perceived competency of the individual providing information. Wagenknecht calls these relationships ‘Epistemic Dependence’ (5). The word dependence here is interesting, as it reveals a certain vulnerability in the relationship between researchers. Wagenknecht likens it to someone asking for directions in a foreign city. Simply, it is a blind trust that one's partner knows the way to go and is capable of leading them there. But where does this trust come from? If trust were truly blind, I could justify my lab results with a simple ‘Trust me bro,’ and my supervisor would go ‘Fantastic. Nobel prize for you.’ Unfortunately, this isn’t how it works, and my career trajectory will (probably) look a little more complicated. It is instead proposed that there are ‘shades of trust and distrust’ that can be influenced by external modifiers, such as accurate conduct of experiments, analysis of results, and epistemic authority. In this model, trust is a dynamic concept that builds or deteriorates between trustees over a chain of interactions (5). If a series of interactions is positive and trust is progressively built up, at some point, an asymptotic limit of trust will be reached. However, the level of epistemic trust between any two researchers is high but never complete, even when there is no reason to doubt the other's testimony. This is good news for Locke, as there still might be a space in which his autonomous knower can exist in happy isolation. Moral trust, the far less popular younger brother of Epistemic trust, is the scrappy underdog in the world of scientific relationships. It is argued that morality shouldn’t even get a seat at the big kids' table, as there is no place for it in scientific collaboration (2). This raises the ever-devious question: why not lie? A little fudge of the numbers could make you the next Elizabeth Holmes, minus the jail time and general disgrace (6). To find an answer, I turn to T.M. Scanlon’s ‘What We Owe Each Other’ (7). Specifically, in chapter five, he discusses the ever-sexy ‘structure of moral contractualism’. Scanlon explores a set of moral requirements that must be accepted or rejected based on the concern we hold for another's well-being, their own personal values, and perspective. Simply, academic falsification is rare because one researcher owes it to another to give a truthful testimony. Returning to the analogy of being lost in a foreign city, what keeps the locals from sending a tourist in the wrong direction out of laziness or fun? I argue that it is the acceptance of a moral principle out of concern for another person's well-being. Immanuel Kant believed lying was always wrong, in every situation (a stance I’m sure made him suuuuuuuuper fun to be around) (8). If this is true, the structure of scientific collaboration must surely crumble in the absence of moral trust (9). Interestingly, Scanlon discusses the place of ‘impersonal values’ in the development of moral code. This relates to reasons for adherence to a moral code that does not pertain to the well-being or status of any one individual. He uses the preservation of the Grand Canyon as an example. We do not deface the Grand Canyon because it would harm any particular group of people, and we cannot argue that this principle is 'what we owe to others', as the canyon doesn't have any personal feelings (that we know of). Instead, only the value we have tied to the land itself stops us from turning it into the biggest lazy river in the world (7). In the context of research, not only do we owe it to each other to adhere to truthfulness, but we also owe it to science as a concept. Essentially, if you’re not doing science with a pure and truthful heart, you’re not doing science at all. Someone needs to tell Dr. Evil about this. As scientific communities have relied more and more on each other to produce collaborative results, science as a whole has become somewhat of a team sport. I argue that while epistemic and moral are two different forms of trust – or even the same form of trust applied to different issues – they both contribute to the social basis of scientific collaboration. Trust in itself is a purely social concept; just as knowledge cannot exist without a 'knower', trust cannot exist without two people, between whom that trust can exist. Therefore, whether you subscribe to the idea that moral trust has any place in scientific collaboration, it is indisputable that there is a social level to any interaction between researchers. This is to say nothing about the more 'frivolous' aspects of collaboration in which personal opinions, egos, and attitudes have been anecdotally proven to affect the quality of collaborative work. Science, at its core, is about understanding. It makes sense that we can’t even get off the ground if we don't start by understanding each other. References 1. J. Locke. An Essay concerning Human Understanding. www.gutenberg.org , 1689. Available: https://www.gutenberg.org/files/10615/10615-h/10615-h.htm 2. J. Hardwig. The Role of Trust in Knowledge. The Journal of Philosophy . 1991;88(12):693. doi: 10.2307/2027007 3. R. W. Grant. John Locke on Custom’s Power and Reason’s Authority. The Review of Politics. 2012;74(4) 607–629.doi: 10.2307/23355688. Available: https://www.jstor.org/stable/23355688 4. S. Epstein. Making Interdisciplinary Collaboration Work. Available: https://www.cs.hunter.cuny.edu/~epstein/papers/collaboration.pdf . [Accessed: Mar. 29, 2024] 5. S. Wagenknecht. Facing the Incompleteness of Epistemic Trust: Managing Dependence in Scientific Practice. Social Epistemology . 2014;29(2):160–184. doi: 10.1080/02691728.2013.794872 6. E. Fricker. Testimony and Epistemic Autonomy. The Epistemology of Testimony . 2006:225–245. doi: 10.1093/acprof:oso/9780199276011.003.0011 7. T. M. Scanlon. What We Owe to Each Other. 1998. Available: https://www.hup.harvard.edu/file/feeds/PDF/9780674248953_sample.pdf 8. T. L. Carson. Kant and the Absolute Prohibition against Lying. Lying and Deception . 2010:67–87. doi: 10.1093/acprof:oso/9780199577415.003.0004 9. Immanuel Kant. An Answer to the Question: What is Enlightenment? by Immanuel Kant 1784. Marxists.org , 1798. Available: https://www.marxists.org/reference/subject/ethics/kant/enlightenment.htm Previous article Next article Entwined back to

< Back to Issue 4 PT by Saachin Simpson 1 July 2023 Edited by Caitlin Kane, Rachel Ko and Patrick Grave Illustrated by Jolin See 'Pt' (medical abbreviation for ‘patient’) recounts a patient visit on an early-morning ward round at Footscray Hospital in my first placement as a second-year medical student. The line “I came to hospital with my innocence” was actually said by the patient and stuck with me, eventually inspiring this poem, which I wrote in a Narrative Medicine class run by Dr Fiona Reilly and Dr Mariam Tokhi. The poem depicts a dramatic rise and fall in tension during the patient visit. It is bookended by soulless technical medical abbreviations that exemplify patient notes on electronic medical records. Pt Pt alert and oriented, sitting upright in chair. Breathing comfortably, responsive to questions. Bilat basal creps, bilat pitting oedema to knee. Pt gazes out window at the opposite concrete wall Pt’s cataracts suddenly shimmer, a sorcerer’s crystal ball. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt’s power becomes apparent in his mighty ocular grip Pt’s lungs echo black tattered sails of a ramshackle timber ship. “I came to hospital with my innocence” Professional, qualified eyes dart from computer To patient And back. “and now I muse on dark and violent tricks” Med student looks at intern looks at reg looks at consultant. Feet shuffle, lips purse Pretending not to hear. “Your poisons gift no remedy, your words fat and hollow” Like a serpentine hiss, his derision rings through sterile air 5-step Therapeutic Guidelines for Reassurance (vol 23.4, updated 2023) does little for his despair. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt to await GEM. Frusemide 40mmHg. Cease abx. Refer physio. Refer OT. Call family. For d/c Monday. Previous article Next article back to MIRAGE

< Back to Issue 7 Neuralink: Mind Over Matter? by Kara Miwa-Dale 22 October 2024 edited by Weilena Liu illustrated by Aisyah Mohammad Sulhanuddin What if I told you that you could control a computer mouse with just your thoughts? It sounds like something straight out of a sci-fi movie, doesn’t it? But this isn’t fiction… Welcome to the brain-computer interface, a device which is able to record and interpret neural activity in the brain, enabling direct communication between your mind and a computer. Tech billionaire Elon Musk founded ‘Neuralink’, a company developing coin-sized brain-chips that can be surgically inserted into the brain using a robot. Neuralink made headlines a few months ago by successfully implanting their brain-chip, dubbed ‘Telepathy’, into their first trial patient, Noland Arbaugh. While there were a few technical glitches, it seems to be working relatively well so far. Noland has been able to regain some of the autonomy that he lost following a devastating spinal cord injury. He is even able to play video games with a superhuman-like reaction speed, thanks to the more direct communication route between the Neuralink implant and his computer. But it doesn’t stop there; Elon Musk’s ultimate vision is to have millions of people using Neuralink in the next 10 years, not only to restore autonomy to those with serious injuries, but to push the boundaries of what the human brain is capable of. He thinks that Neuralink will allow us to compete with AI and vastly improve our speed and efficiency of communication, which is ‘pitifully slow’ in comparison to AI. Neuralink implants may seem like an incredible leap in scientific technology, but what will happen if they become normalised in our society? Let’s imagine for a moment … Jade, April 7th 2044 Shoving my jacket into my bag, I dart out of the hospital and pull onto the main road in my Tesla. As I speed past the intersection, I see a giant advertisement plastered on a sleek building: ‘Neuralink: Seamless Thoughts, Limitless Possibilities’. When I signed up to get a Neuralink implant, all I’d thought about were the infinite possibilities of how it would change my life – not what could go wrong. I wish I could say that I was brainwashed into getting a Neuralink, or that I had no choice in the matter. But the truth? I got an implant so that I could be ‘ahead of the crowd’ and because I was so frustrated at feeling inadequate compared to the other doctors at my hospital. When I graduated medical school, at the top of my class, people told me that I would do ‘great things’ and ‘change the world’. I followed the standard path, landing my first job and climbing the ranks one caffeine-fuelled shift at a time. I loved my job. Every time I saved a life, it felt like all my effort had paid off. Then Neuralink happened. I still remember the day Dr Maxwell - a doctor I worked with - proudly announced that he’d ‘bitten the bullet’ and gotten the implant. Over the coming weeks, we watched in awe: his diagnoses were quicker and more accurate than any human could imagine, and he went home as energetic as he’d arrived. Now, the extra hours I spent figuring out tricky cases were no longer a representation of my work ethic, but a symptom of my inadequacy compared to the Neuralink-enhanced doctors. One by one, my colleagues signed up for the implant. I hated the thought of having something foreign nestled in my brain, recording my brain’s neurons every second of the day. I told myself I wouldn’t let peer pressure get to me. But, as I watched those around me get promoted while I continued to work endless days, the frustration started to build. One afternoon, the department head came into my office to tell me that they were reconsidering the renewal of my contract. I wasn’t ‘keeping up’ with my Neuralink-enhanced colleagues. “We respect your personal decision, of course,” she said with hollow politeness. I wasn’t keen on being pressured into it, but at the same time, I genuinely believed that the implant would improve my life. When I told my friends and family about getting an implant, they were concerned. They tried to list all the things that could go wrong, but I came up with enough reasons to convince myself that it was the right decision. Once they saw how incredible the Neuralink device was, I thought, they would want one too. *** I’m jolted back to reality as the car veers slightly left, and I manually yank the wheel to correct it. Perhaps my implant glitched for a second… *** Everything changed after I had my Neuralink implanted. I was the only person in my family who had one, although a couple of friends did. At first, I felt invincible. The phenomenal speed with which I was able to come up with previously challenging diagnoses was thrilling. I was able to process enormous amounts of data and draw connections that I had never been able to before. It was addictive to feel that I was working at my full potential, using my newfound ‘superpower’ to save more lives than ever. About a month in, my thoughts began racing uncontrollably, until I felt like I was drowning in a flood of information. Sometimes, the input was so overwhelming that my head pounded and I struggled to breathe. My thoughts didn’t even feel like mine anymore. Family and friends started to grow more and more distant from me. This device was stuck inside my brain like superglue, and sometimes I just wanted to dig it right out of my skull. When I asked the doctor about removing it, he looked at me and smirked, “Why on earth would you want to get rid of such a game-changing device? Neuralink’s the new normal, honey. Get used to it.” *** A honk startles me as a car zooms past, nearly colliding with mine. I turn into a quieter street to regain my composure. But then – suddenly – thoughts of accelerating the car bombard my mind – so loud that I can barely hear myself think. The speedometer rises from 60 to 80 to 100 km an hour. I desperately try to disconnect my Neuralink from the car, to manually override the system – anything that will slow the car down. I start pushing random buttons hoping that I will get some kind of response. A red light flashes on my dashboard. ERROR. SIGNAL DISRUPTED BY UNKNOWN USER. I look up and meet the panicked eyes of a woman pushing a man in a wheelchair. Noah, April 7th 2044 The sun makes its final, glorious descent below the horizon, painting a beautiful array of pinks and oranges across the sky. I take a deep breath as Sophia, my support worker, pushes me along the road. We’re on our way to the grocery store, just in time for the end of day specials, which are all I can afford right now. Since my accident, I’ve tried my best to appreciate what I have, but it isn’t easy. Some days, I’m filled with rage as I struggle to complete daily tasks that I did on autopilot before my accident – back when I wasn’t confined to a wheelchair. It’s been hard to come to terms with this new body that I’m stuck with, and all the ways it seems to betray me. I miss the simple things – going to the grocery store by myself or playing board games with friends. But most of all, I miss working as an architect. I loved seeing my clients’ faces light up as they imagined the memories they would make in the new homes I had designed. This sense of satisfaction was taken from me the moment I was paralysed from the neck down. It’s why I’m so desperate to get a Neuralink implant. I would get one right this second if they weren’t so expensive. The Neuralink device isn’t covered by my insurance because the government claims that it wouldn’t be ‘cost effective’. While it won’t restore movement in my arms and legs, this implant would give me some precious freedom back. Maybe if I keep saving and take out a loan, I’ll have just enough to cover it and get my life back … *** “God, these Tesla drivers think they own the road!” I chuckle at Sophia, as a Tesla races towards the crossing in this 40km zone. As we begin to cross the road, I realise that the Tesla is showing no signs of slowing down. The car swerves violently, hurtling towards us without mercy. Sophia’s face pales as she frantically tries to push me out of the road. I squeeze my eyes shut, bracing for impact. Bibliography: Cernat, M., Borțun, D., & Matei, C. (2022, April). Human-Computer Interaction: Ethical Perspectives on Technology and Its (Mis) uses. In International Conference on Enterprise Information Systems (pp. 338-349). Cham: Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-39386-0_16 Fridman, Lex. (Host). (2024, August 3rd). Elon Musk: Neuralink and the Future of Humanity (No 438). [Audio podcast episode]. In Lex Fridman Podcast. https://lexfridman.com/elon-musk-and-neuralink-team/ Jawad, A. J. (2021). Engineering ethics of neuralink brain computer interfaces devices. Perspective , 4 (1). https://doi.org/10.23880/abca-16000160 Oravec, B. Neurotechnology, Ethical Privacy, and Information Technology. Knighted , 36. https://www.mga.edu/arts-letters/docs/knighted-journal/Issue-6.pdf#page=37 Youssef, N. O. A., Guia, V., Walczysko, F., Suriyasuphapong, S., & Moslemi, C. (2020). Ethical concerns and consequences of Neuralink. Natural Science. https://rucforsk.ruc.dk/ws/files/75503337/NIB3_Group1_Neuralink.pdf Previous article Next article apex back to

< Back to Issue 8 Life Story of a Drug by Elijah McEvoy 3 June 2025 Edited by Weilena Liu Illustrated by Aisyah Mohammad Sulhanuddin From the mythical visions of church goers who took mushrooms in the infamous ‘Good Friday Experiment’ to the extreme self-reflection of those ‘tripping’ off the traditional South American hallucinogenic tea Ayahuasca (1,2), humans have been painting the extraordinary narratives of psychedelics for thousands of years in thousands of settings. Put simply, psychedelics are a class of psychoactive drugs that can alter your thoughts and senses, inducing wild experiences not thought possible in your brain’s ground state (3). One of the most famous of these drugs is LSD. ‘Lucy in the Sky with Diamonds’ is said to have inspired entire Beatles albums and shown Steve Jobs “that there’s another side to the coin” of life (4,5). LSD is also a psychedelic that stands as an enigma in many regards. It is both naturally derived and synthetically created. It has been tested in psychological therapy and psychological warfare. Even the ‘trips’ experienced by its users entail both unexplainable hallucinations and scientifically proven phenomena. While being lesser understood, the stories of LSD’s enigmatic origins, uses and effects are just as interesting as those that come from its users. The Origins Lysergic Acid Diethylamide (LSD) or ‘acid’ for short is a semi-synthetic chemical compound with humble biological beginnings. LSD is derived from a class of alkaloid metabolite molecules that are naturally produced by the fungus commonly known as ergot. Ergot fungi are members of the parasitic genus Claviceps , which have been infecting staple crops and shaping society long before acid came to distort shapes in the eyes of its users (6). Epidemics of ergotism, a disease caused by these ergot alkaloids after ingesting contaminated crops, swept across Middle Age Europe and led to the deaths of tens of thousands of people (7). Despite credible arguments to the contrary, some historians have even suggested that the Salem Witch Trials may have been sparked by a form of this disease known as convulsive ergotism. Not only were the environmental conditions in 1691 Salem reported to be optimal for ergot growth in the town’s rye, but convulsive ergotism also induces distinct muscle contractions, paranoia and audiovisual hallucinations (8). These symptoms all would have given credit to the claims of bewitchment made by the young girls that instigated the accusations of witchcraft in the town. Aside from death and dark magic, this fungus has also been used as an effective therapeutic across several eras of history. It’s use as a medication for childbirth was recorded as early as 1100 BCE in China, with midwives using ergot or it’s alkaloids to reduce bleeding during birth, expedite delivery or induce an abortion (6,7). It wasn’t until modern pharmacology advanced in the 20th century that scientists began to chemically characterise these ergot alkaloids and use them as the basis to create potent drugs. The story of how LSD was first created and consumed is one that has been immortalised in history books and unofficial holidays. Dr Albert Hoffman, a Swiss biochemist working for the pharmaceutical company Sandoz, first synthesised LSD in 1938 as the 25th substance in a series of lysergic acid derivatives being evaluated by the company (9). Initial testing of this compound indicated it had no unique pharmacological uses beyond those of pre-existing ergot alkaloid derived drugs (9). However, Hoffman couldn’t shake the nagging feeling that LSD-25 had more to offer. After making another batch of the compound 5 years later, Hoffman’s suspicions grew stronger when he was forced to leave the lab early after entering a “dream-like state… [with] a kaleidoscope-like play of colours” (9). A few days later, in a moment that demonstrated both admirable scientific curiosity and blatant rejection of OH&S, Hoffman took a large dose of LSD himself and set in for a trip of a lifetime (9). Like all good scientists, he recorded his experience in a journal, writing at 3pm on 19 April 1943: “visual distortions, symptoms of paralysis, desire to laugh” (9). Hoffman’s notes for the day stopped there. The Uses April 19th has come to be celebrated as ‘Bicycle Day’, commemorating the seemingly endless and surreal bike ride home Hoffman undertook after this self-experimentation. However, a wacky trip was not the only thing that followed this discovery. After Hoffman distributed the drug to his superiors to try for themselves, LSD was sold on the market by Sandoz under the name Delysid. This drug was employed by psychiatrists throughout the 1950s as a treatment for alcoholism or simply ‘psychotherapy-in-a-pill’ for patients suffering psychological trauma (10,11). LSD not only garnered therapeutic interest from scientists but also more nefarious intrigue from the CIA. Seeking to get an upper hand in the department of mental warfare during the Cold War, the CIA bought up 40,000 doses of LSD from Sandoz and performed a variety of unethical experiments on unknowing prisoners, heroin addicts and even other CIA agents in an attempt to understand the drug’s potential for ‘mind control’ under the MKUltra project (12). Moving into the 60s, LSD’s use amongst budding leaders of the Hippie and Yippie movements gave the drug its countercultural status. Harvard Professor Timothy Leary, who was dismissed from his position due to experimenting (literally) with LSD, promoted the drug as an agent of revolution that allowed the youth of America to “turn on, tune in, drop out” (10) of repressive society. Due to its increasing association with these disruptive movements and eventual outlawing by the US government in 1966 (11), acid’s place in culture shifted out of labs and psychologist offices and into illicit recreational usage by experimental hippies and enlightened artists. The Trip Whether accompanied by an experienced monitor or listening to some soothing vinyl records yourself, the experience of taking LSD is predictably unpredictable. ‘Dropping acid’ is unique in that only micrograms of the drug are enough to elicit a palpable psychedelic experience (13), with most users diluting the dosage on tabs of blotting paper or sugar cubes (11). Following consumption, it takes as little as 1.5 hours for LSD to cross the blood-brain barrier, dilate the pupils and bring users to the peak intensity of the drug’s psychological effects (13). The bizarre experiences perceived by those ‘tripping’ on LSD is rooted in a now well-characterised receptor binding interaction in the brain. The nitrogen-based chemical groups of the LSD molecule first anchor themselves within the 5-HT2A serotonin receptors found in the synapses of neurons (14). While the serotonin neurotransmitter typically helps regulate brain activities like mood and memory, LSD binding instead causes the activation of distinct intracellular cascades within these brain cells (3). The importance of this interaction was demonstrated in experiments that proved blocking this receptor can cancel the acid trip all together (3). Recent studies that have further characterised the chemical structure of this interaction have also shown that 5-HT2A forms a lid-like structure that locks LSD into this receptor protein’s binding site and sets the user in for a long trip (14). From these individual cellular interactions, LSD ignites a burst of brain activity. Modern brain scanning technology has revealed that LSD first disrupts the capacity of the thalamus to filter and pass on sensory stimuli from the body to the cortex of the brain. Upon injection of LSD, patient’s brains demonstrated both an overflow of information running between the thalamus and posterior cingulate cortex and restriction of signals going to the temporal cortex (15). Not only does LSD modify the brain’s ability to sort out important stimuli from the outside world, but this small molecule has also been found to temporarily form new connections between different parts of the brain. Hoffman’s recount of how “every sound generated a vividly changing image” (9) on the first Bicycle Day can be explained by the increased connectivity of the brain’s visual cortex on LSD. This causes areas of the brain responsible for other senses or emotions to become involved in creating the images perceived in the user’s head, causing visual hallucinations and geometric distortion that have no basis in real stimuli coming from the eyes (16). In contrast, Hoffman’s feeling of being “outside [his] body” (9) likely came from decreased connectivity between the parahippocampus and retrosplenial cortex, two regions of the brain responsible for cognition. This severance has been correlated with the greater meaning that those tripping on LSD find in objects, events or music along with their characteristic ‘ego dissolution’ (16). This is a phenomenon where users no longer see the world through the lens of their own ‘self’ and instead feel an increased sense of unity with everything around them (17). Very Hippie ideas with a very scientific explanation. The Comedown and Beyond The float back down from the peak of an LSD trip takes up to 10 hours and leaves its users with a variety of stories and outcomes. Contrary to the fearmongering of parents and politicians, LSD does not leave holes in the brain, does not lead to addiction and has not directly led to the death of anyone as a result of overdosage (3). While the risk of a ‘bad trip’ and the feelings of severe anxiety, fear and despair that come with it may be traumatic, these are typically experienced when taking LSD in unsupportive environments without proper mental preparation (13). In fact, when LSD is taken in a manner closer to the controlled ritual practices surrounding psychedelics of old (3), acid is suggested to have long-lasting positive impacts on the user’s attitude and personality (13). It is these experiences that have rejuvenated the field of LSD research from its abrupt stop in the 60s. Modern investigations have picked up where these scientists left off and are evaluating the potential of utilising LSD-assisted therapy to alleviate anxiety and depression. Studies have focused particular attention on addressing these mental health conditions in those suffering from life-threatening illnesses like cancer (18). While some of these experiments lack the controls or data to make strong generalised conclusions, several studies have demonstrated that patients supplied with LSD reported lasting decreases in anxiety surrounding their condition, greater responsiveness to their families and improved quality of life (3,18). All of this is not to promote LSD as a harmless wonder drug. While rare, LSD has been linked to Hallucinogen Persisting Perception Disorder, a condition in which people experience distressing ‘flashbacks’ to the effects and experiences of past psychedelic trips in a normal setting. Additionally, the changes in visual perception, emotion and thought while one is tripping can also cause users to make reckless decisions in dangerous situations (18). However, continuing to wage war against controlled experiments and supervised therapeutic trials with LSD only serves to limit the attempts of scientists in better understanding the balance between this drug’s risks and benefits. While our trip through the life of LSD may end here, there is still much to explore. The greater story of how we use it, how we view it and how it fits into our society is far from over. References Illing S. Vox. 2018 [cited 2024 Oct 23]. The brutal mirror: what the psychedelic drug ayahuasca showed me about my life. Available from: https://www.vox.com/first-person/2018/2/19/16739386/ayahuasca-retreat-psychedelic-hallucination-meditation Majić T, Schmidt TT, Gallinat J. Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences? J Psychopharmacol. 2015 Mar 1;29(3):241–53. Nichols DE. Psychedelics. Barker EL, editor. Pharmacol Rev. 2016 Apr 1;68(2):264–355. Gilmore M. Beatles’ Acid Test: How LSD Opened the Door to “Revolver” [Internet]. Rolling Stone. 2016 [cited 2024 Oct 23]. Available from: https://www.rollingstone.com/feature/beatles-acid-test-how-lsd-opened-the-door-to-revolver-251417/ Hsu H. The Lingering Legacy of Psychedelia. The New Yorker [Internet]. 2016 May 17 [cited 2024 Oct 23]; Available from: https://www.newyorker.com/books/page-turner/the-lingering-legacy-of-psychedelia Haarmann T, Rolke Y, Giesbert S, Tudzynski P. Ergot: from witchcraft to biotechnology. Molecular Plant Pathology. 2009 Jul;10(4):563–77. Schiff PLJ. Ergot and Its Alkaloids. American Journal of Pharmaceutical Education. 2006 Oct 15;70(5):98. Woolf A. Witchcraft or Mycotoxin? The Salem Witch Trials. Journal of Toxicology: Clinical Toxicology. 2000 Jan;38(4):457–60. Hofmann A. How LSD Originated. Journal of Psychedelic Drugs. 1979 Jan 1;11(1–2):53–60. Massari P. Harvard Griffin GSAS News. 2021 [cited 2024 Sep 28]. A Long, Strange Trip | The Harvard Kenneth C. Griffin Graduate School of Arts and Sciences. Available from: https://gsas.harvard.edu/news/long-strange-trip Stork CM, Henriksen B. Lysergic Acid Diethylamide. In: Wexler P, editor. Encyclopedia of Toxicology (Third Edition) [Internet]. Oxford: Academic Press; 2014 [cited 2024 Sep 28]. p. 120–2. Available from: https://www.sciencedirect.com/science/article/pii/B9780123864543007442 Stuff You Should Know. Did the CIA test LSD on unsuspecting Americans? - Stuff You Should Know [Internet]. [cited 2024 Aug 25]. (Stuff You Should Know). Available from: https://www.iheart.com/podcast/1119-stuff-you-should-know-26940277/episode/did-the-cia-test-lsd-on-29468397/ Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A. The Pharmacology of Lysergic Acid Diethylamide: A Review. CNS Neurosci Ther. 2008 Nov 11;14(4):295–314. Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, et al. Crystal structure of an LSD-bound human serotonin receptor. Cell. 2017 Jan 26;168(3):377. Sample I. Study shows how LSD interferes with brain’s signalling. The Guardian [Internet]. 2019 Jan 28 [cited 2024 Nov 10]; Available from: https://www.theguardian.com/science/2019/jan/28/study-shows-how-lsd-messes-with-brains-signalling Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, et al. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences. 2016 Apr 26;113(17):4853–8. Sample I. LSD’s impact on the brain revealed in groundbreaking images. The Guardian [Internet]. 2016 Apr 11 [cited 2024 Nov 10]; Available from: https://www.theguardian.com/science/2016/apr/11/lsd-impact-brain-revealed-groundbreaking-images Liechti ME. Modern Clinical Research on LSD. Neuropsychopharmacol. 2017 Oct;42(11):2114–27. Previous article Next article Enigma back to

< Back to Issue 8 A Psychological ‘Autopsy’ of Ludwig van Beethoven: Dissecting Genius and Madness by Kara Miwa-Dale 3 June 2025 Edited by Steph Liang Illustrated by Ashlee Yeo ‘No great mind has ever existed without a touch of madness.’ – Aristotle Preface This is not an autopsy in the traditional sense. No scalpels or specimen jars will be involved. Instead, it is an autopsy of the mind – a retrospective exploration of the inner world of the great classical composer, Ludwig van Beethoven. Beethoven was considered a genius for revolutionising Western classical music with his emotionally powerful, structurally innovative, and highly complex compositions. He broke from convention, pioneered new musical forms, and continued to create masterpieces even after becoming completely deaf. Drawing upon insights from genetics, neuroscience, psychiatry, and anthropology, alongside the testimonies of Beethoven’s peers, we will piece together an understanding of how genius, creativity and mental affliction may be intertwined. Was Beethoven’s genius a product of madness, a triumph over it, or something different altogether? The Subject Name: Ludwig van Beethoven Occupation: Composer Age at Death: 56 Reason for Autopsy : To investigate the elusive connection between creativity, mental disorder, and the mysterious concept of genius I. The Witnesses: Testimonies from the Living To those that knew him, Beethoven was a paradox. One friend called him “half crazy”, noting violent outbursts, erratic moods and obsessive tendencies (1). Others saw him as “merry, mischievous, full of witticisms and jokes” (2). His talent and creative genius, however, were never in doubt. The poet Goethe, who met him in 1812, wrote: “Beethoven’s talent amazed me. However, he is an utterly untamed personality” (3). Based on Beethoven’s letters and accounts from friends, modern psychiatrists suspect that he may have lived with bipolar disorder (4). Yet, there is no way to be sure. Like the mind itself, Beethoven resists full understanding – a genius shaped by forces we may never fully comprehend. II. The Geneticist How can DNA offer insight into Beethoven’s genius? Often described as the blueprint of life, DNA offers fascinating insights into human potential – highlighting our predispositions, vulnerabilities, and even talents. However, it only tells part of the story. In 2023, an international team of scientists sequenced the DNA of five authenticated locks of Beethoven’s hair (5). Not long after, another group of researchers used this data to calculate a polygenic score estimating his genetic predisposition for beat synchronisation, a trait believed to be linked to musicality (6). Polygenic scores add up the small effects of many different genes to estimate someone’s likelihood of expressing a complex trait – like musical ability. Because these traits are influenced by many different genes working together, polygenic scores can be a helpful tool in exploring their biological basis. Curiously, Beethoven’s polygenic score for beat synchronisation was surprisingly low, implying that he wasn’t predisposed to have a strong sense of rhythm. Does this mean that Beethoven defied his own biology? Not necessarily. Polygenic scores have significant limitations. They don’t account for environmental influences – like the years of rigorous musical training that Beethoven underwent – or complex gene-gene and gene-environment interactions. Additionally, these scores are based on modern genetic datasets, so applying them to someone from the 18th century can reduce the reliability of the interpretation. That said, the story becomes even more fascinating when we consider research linking polygenic risk scores for psychiatric conditions – such as bipolar disorder and schizophrenia – to creativity. One large study found that people with a higher genetic risk for these conditions were overrepresented in artistic and creative jobs, although the association was small (7). This doesn’t mean that mental illness causes creativity, or that all creative people have a mental disorder, but it hints at a complex biological overlap. III. The Psychiatrist How does one make a psychiatric diagnosis from the grave? It is an impossible task, and an imprecise science, but we can draw inferences from historical accounts of a person’s behaviour. Beethoven seemed to exhibit behaviours consistent with bipolar disorder, a mental health condition characterised by extreme mood swings that include emotional highs (mania or hypomania) and lows (depression). Letters written by Beethoven himself, along with observations from friends, may provide some insight. He was notably “prone to outbursts of anger, baseless suspicions, quarrels and reconciliations, fruitless infatuations, physical ills, changes of residences…and the hiring and firing of servants" (1). One friend remarked that ‘he composes, or was unable to compose, according to the moods of happiness, vexation or sorrow’, suggesting that his creative output fluctuated with his shifting emotional state (1). Individuals with bipolar disorder experience manic or hypomanic episodes marked by elevated mood, increased energy, rapid thought processes, reduced inhibition, and heightened confidence (8). These episodes may enhance creative thinking by promoting divergent thinking – the ability to generate novel ideas or unusual associations (9). Research shows that the medial prefrontal cortex, a brain region active during divergent thinking, is typically engaged during manic states (10). While it would be inappropriate to assign a clinical diagnosis based solely on anecdotal evidence, it is possible to speculate that Beethoven’s prolific composing periods might have corresponded to manic or hypomanic episodes. But how can we distinguish a clinical mood disorder from mere bursts of creative inspiration or genius? The U-shaped curve hypothesis offers one explanation, proposing that the relationship between ‘madness’ and genius is not linear (11). Mild to moderate expressions of bipolar disorder may actually enhance creativity by promoting divergent thinking, whereas severe illness can be debilitating and reduce creative output. This raises the possibility that Beethoven experienced a less severe form of bipolar disorder – one that fueled rather than hindered his musical brilliance. Building on this, psychological research also suggests that people in creative occupations tend to score higher on measures of ‘openness to experience’ (12). This personality trait describes the extent to which a person is curious, imaginative, and receptive to new ideas or unconventional beliefs. Studies have suggested that openness to experience is elevated among individuals with bipolar disorder compared to controls with no mood disorder (13,14). It is possible that Beethoven’s creative genius was influenced, at least in part, by the interplay between his personality and traits associated with bipolar. However, it is important to acknowledge the very real challenges of living with mental illness and to avoid romanticising the condition as a source of artistic inspiration. IV. The Anthropologist Cultural narratives - like the ‘mad genius’ and ‘tortured artist’ tropes - have long romanticised and distorted the relationship between mental illness and creative brilliance. However, contemporary understandings of mental health increasingly challenge the idea that extraordinary creativity requires psychological suffering. Beethoven’s life was marked by adversity. His father, believed by some to be abusive, enforced a strict practice regime for his music lessons and struggled with alcoholism – an affliction that would later cast a shadow over Beethoven’s own life. During Beethoven’s mid-twenties, he began to lose his hearing, becoming completely deaf by around 44. Yet, he continued to compose innovative symphonies, relying only on the music in his mind. Did Beethoven’s suffering fuel his brilliance? While some studies suggest a link between bipolar disorder and heightened creativity, it would be a mistake to suggest that mental illness is a prerequisite for genius. Many highly creative individuals have no history of mental illness at all. So why, then, does the ‘mad genius’ stereotype continue to endure? During Beethoven’s era – the Romantic period – suffering was often glorified as a source of artistic inspiration. Mental illness was poorly understood, and the emotional extremes exhibited by artists with mood disorders were frequently mistaken for signs of genius. Emotional intensity and instability were often seen as sources of inspiration for genius works of art. It wasn’t until the 20th century that bipolar was formally recognised as a mental illness. It is hard to say, based solely only on historical records, whether Beethoven experienced a mental health condition, or was simply an emotionally intense and unconventional individual. What we define as ‘normal’ or ‘abnormal’ behaviour is complex and deeply influenced by the social and cultural norms of the time. V. The Final Verdict So, what can we conclude from this evidence? Was Beethoven a genius because of his madness? Or in spite of it? Perhaps these are the wrong questions. Such binaries oversimply a reality that is far more nuanced. They invite us to reconsider our definitions of ‘normality’, ‘illness’ and ‘genius’. It is important to acknowledge the very real and devastating challenges associated with mental illness. Yet, it’s also true that some traits associated with conditions like bipolar disorder – such as divergent thinking – may intersect with creativity in complex ways. Rather than viewing these conditions purely as deficits, we might ask: could some features of mental disorder be better understood as extreme expressions of the broader, messier spectrum of human cognition and emotion? In the end, Beethoven remains an enigma – not because he was ‘mad’, but because he was unknowable and defied neat categorisation. Perhaps that is what genius truly is: not a clinical condition, or a byproduct of suffering, but a mystery that transcends explanation. References 1. Hershman DJ. Manic depression and creativity. Prometheus Books; 2010 Oct 5. 2. Bezane C. Bipolar Geniuses: Ludwig Van Beethoven [Internet]. Chicago: Conor Bezane; 2016 Mar 15. https://www.conorbezane.com/thebipolaraddict/thebipolaraddictbipolar-geniusesbeethoven/ 3. Carnegie Hall. Friends of Beethoven [Internet]. New York: Carnegie Hall; 2020 Mar 19 [cited 2025 May 31]. https://www.carnegiehall.org/Explore/Articles/2020/03/19/Friends-of-Beethoven 4. Erfurth A. Ludwig van Beethoven—a psychiatric perspective. Wiener Medizinische Wochenschrift. 2021;171(15):381-90. https://doi.org/10.1007/s10354-021-00864-4 5. Begg TJA, Schmidt A, Kocher A, Larmuseau MHD, Runfeldt G, Maier PA, et al. Genomic analyses of hair from Ludwig van Beethoven. Current Biology. 2023;33(8):1431-47.e22. https://doi.org/10.1016/j.cub.2023.02.041 6. Wesseldijk LW, Henechowicz TL, Baker DJ, Bignardi G, Karlsson R, Gordon RL, et al. Notes from Beethoven’s genome. Current Biology. 2024;34(6):R233-R4. https://doi.org/10.1016/j.cub.2024.01.025 7. Power RA, Steinberg S, Bjornsdottir G, Rietveld CA, Abdellaoui A, Nivard MM, et al. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience. 2015;18(7):953-5. https://doi.org/10.1038/nn.4040 8. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5-TR . 5th ed, text revision. Washington, DC: American Psychiatric Association; 2022. 9. Forthmann B, Kaczykowski K, Benedek M, Holling H. The Manic Idea Creator? A Review and Meta-Analysis of the Relationship between Bipolar Disorder and Creative Cognitive Potential. International Journal of Environmental Research and Public Health. 2023;20(13):6264. https://www.mdpi.com/1660-4601/20/13/6264 10. Mayseless N, Eran A, Shamay-Tsoory SG. Generating original ideas: The neural underpinning of originality. NeuroImage. 2015;116:232-9. https://doi.org/10.1016/j.neuroimage.2015.05.030 11. Richards R, Kinney DK, Lunde I, Benet M, Merzel AP. Creativity in manic-depressives, cyclothymes, their normal relatives, and control subjects. Journal of abnormal psychology. 1988;97(3):281. 12.Feist GJ. A meta-analysis of personality in scientific and artistic creativity. Personality and social psychology review. 1998;2(4):290-309. 13. Matsumoto Y, Suzuki A, Shirata T, Takahashi N, Noto K, Goto K, et al. Implication of the DGKH genotype in openness to experience, a premorbid personality trait of bipolar disorder. Journal of Affective Disorders. 2018;238:539-41. https://doi.org/10.1016/j.jad.2018.06.031 14. Middeldorp CM, de Moor MHM, McGrath LM, Gordon SD, Blackwood DH, Costa PT, et al. The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry. 2011;1(10):e50-e. https://doi.org/10.1038/tp.2011.45 Previous article Next article Enigma back to

< Back to Issue 9 Axolotl: The Little God of the Lake by Danny He 28 October 2025 Illustrated by Saraf Ishman Edited by Ciara Dahl Creation “When the fifth sun was created, it did not move. The god of the wind carved a destructive path through the realm, slaying all other gods to induce the Sun into movement. Xolotl, guide for the dead, escaped his sacrifice by transforming into an invulnerable salamander. Eventually, even he was captured. Upon his sacrifice, the Sun began its course. Thus began the time of man.” - Author’s creative interpretation of Aztec mythology. The otherworldly biology of the axolotl ( Ambystoma mexicanum) attracted fascination among the Aztecs, who named it after the god of fire and lightning (1). They believed the shapeshifting god Xolotl took many forms, from a chimera depicted as a dog-headed man, to a skeleton, to a deformed monster with reversed feet (1). He was a renowned shapeshifter who would guide the dead on their journey to the afterlife (1). Centuries on, the axolotl would transform from a feared deity to a beloved icon and subject of scientific marvel. Fascination “Auguste Dumeril lounged by the lake. The humidity of Lake Xochimilco was beginning to take its toll. He had recently been informed of a marvellous reptile, one that resided exclusively in the canals of ancient Aztec, capable of regrowing limbs and organs including its brain. He wondered of the scientific possibilities of studying such a creature. A self-regenerating invertebrate could fascinate the scientific community and make wonderful contributions to medicine. This creature is to be taken back home to Paris” - Imaging a day with French Zoologist August Dumeril. The axolotl exhibits many biological peculiarities. Cousin of the tiger salamander ( Ambystoma tigrinum) , it has evolved over millions of years to take advantage of the bountiful resources of the Mexican basins (2). It remains in its juvenile, tadpole-like form throughout its adulthood, retaining its gills and breathing through its skin (2). The animal’s near perfect regeneration and its potential application for medical research fascinated scientists. French zoologist Auguste Dumeril was the first to conduct research on the axolotl after discovering it during his expedition to Mexico (3). Decades later, proteins were discovered which enabled the miraculous processes of complete, scar-free regeneration of an injured axolotl (4). Scientists continue to research methods in which the axolotl’s regeneration can facilitate trauma care and cancer research (4, 5). Conservation “Pedro set his spade down, straw hat clutched close to his chest. His eyes fixated on the water before him. Just below the surface, he had thought something had moved along the river bank. It had been many years since he had last seen an axolotl. The Méndez Rosas had been working as Chinamperos for generations. The axolotl had been a welcome sight for his forefathers, now it is a sign of hope for Lake Xochilmilco.” - an interview with Pedro, a 7th generation Chinamperos (7). Chinampas are large man-made farming islands created by the Aztecs (6). The capital city was built upon an island on a vast lake using a series of complex canals to prevent their city from flooding (6). Chinamperos use the lake's nutrient-rich soil to grow crops and create a self-sustaining system resilient to pests and disease (6). Productive chinampas ensure greater food security for Mexico City. A perfect symbiosis between water and land, a healthy chinampa cannot be without a healthy body of water (6). As chinampas grow they become refuge for wildlife such as the axolotl (6). As axolotls breathe through their skin, their presence indicates excellent water quality and hence a healthy chinampa (6). However, this once thriving ecosystem is now under threat from urbanisation. Drainage of the lake has resulted in the range of chinampas being limited to Lake Xochilmilco (6). Pollution and climate change has altered the landscape, while expansion of the city has resulted in the loss of precious wetlands (6). These changes have driven axolotls to critical endangerment. A once venerated and sacred creature has been neglected and buried by the relentless incursion of human civilisation (6). It is now a race against time to save the wild axolotls as few remain in Lake Xochilmilco (2). As urbanisation continues to bear down upon the chinampas, calls have been made to protect these dwindling areas of refuge (2). The fate of the axolotl is yet to be determined, but it is certain that the loss of another species will continue to set a dangerous precedent for the conservation of our ecosystems. Aztec mythology describes the god represented by the axolotl as the caretaker of his underworld kingdom and a guide for lost souls (1). Perhaps it is now important for us to take care of the axolotl as Xolotl has taken care of us. References Spence L. Mexico and Peru [Internet]. Senate; 1994. Accessed September 29, 2025. https://archive.org/details/mexicoperu00spen The Editors of Encyclopaedia Britannica. Axolotl. Britannica . July 20, 1998. Updated 27 August, 2025. Accessed September 29, 2025. https://www.britannica.com/animal/axolotl Reiß C. Cut and Paste: The Mexican Axolotl, Experimental Practices and the Long History of Regeneration Research in Amphibians, 1864-Present. Front Cell Dev Biol . 2022;10:786533. doi:10.3389/fcell.2022.786533 Huang L, Ho C, Ye X, Gao Y, Guo W, Chen J, et al. Mechanisms and translational applications of regeneration in limbs: From renewable animals to humans. Ann Anat . 2024;255:152288. doi:10.1016/j.aanat.2024.152288 Suleiman S, Schembri-Wismayer P, Calleja-Agius J. The axolotl model for cancer research: a mini-review. J BUON . 2019;24(6):2227–31. Accessed September 29, 2025. https://www.researchgate.net/publication/338630505_The_axolotl_model_for_cancer_research_a_mini-review The Editors of Encyclopaedia Britannica. Chinampa. Encyclopaedia Britannica . July 20, 1998. Updated 26 May, 2017. Accessed September 29, 2025. https://www.britannica.com/topic/chinampa Nature on PBS. Wild axolotls are being saved by... nuns and Aztec gardens? | WILD HOPE. Youtube. September 12, 2023. Accessed September 29, 2025. https://www.youtube.com/watch?v=NL0ad3jBWRI&t=808s Previous article Next article Entwined back to