< Back to Issue 2 Hiccups Evolution might be a theory, but if it’s evidence you’re after, there’s no need to look further than your own body. The human form is full of fascinating parts and functions that hold hidden histories - from the column that brought you a deep-dive into ear wiggling in Issue 1, here’s an exploration of why we hiccup! by Rachel Ko 10 December 2021 Edited by Katherine Tweedie and Ashleigh Hallinan Illustrated by Gemma Van der Hurk Hiccups bring a special brand of chaos to a day. It’s one that lingers, rendering us helpless and in suspense; a subtle, internal chaos of quiet frustration that forces us to drop what we’re doing to monitor each breath – in and out, in and out – until the moment they abruptly decide to stop. It’s an experience we’ve all had – one that can hit anyone at any time – and for most of us, hiccups are a concentrated episode of inconvenience; best ignored, and overcome. Yet, despite our haste to get rid of them when they interrupt our day, hiccups seem to have mystified humans for generations. Historically, the phenomenon has been the source of many superstitions, both good and bad. A range of cultures associate them with the concept of remembrance: in Russia, hiccups mean someone is missing you (1), while an Indian myth suggests that someone is remembering you negatively for the evils you have committed (2). Likewise, in Ancient Greece, hiccups were a sign that you were being complained about (3), while in Hungary, they mean you are currently the subject of gossip. On a darker note, a Japanese superstition prophesises death to one who hiccups 100 times. (4) Clearly, the need to justify everything, even things as trivial as hiccups, has always been an inherent human characteristic, transcending culture and time. As such, science has more recently made its attempt at objectively identifying a reason behind the strange phenomenon of hiccups. After all, if you take a step back and think about it, hiccups are indeed quite strange. Anatomically, hiccups (known scientifically as singultus) are involuntary spasms of the diaphragm (5): the dome-like sheet of muscle separating the chest and abdominal cavities. (6) The inspiratory muscles, including the intercostal and neck muscles, also spasm, while the expiratory muscles are inhibited. (7) These sudden contractions cause a rapid intake of air (“hic”), followed by the immediate closure of the glottis or vocal cords (“up”). (8) As many of us have probably experienced, a range of stimuli can cause these involuntary contractions. The physical stimuli include anything that stretches and bloats the stomach, (9) such as overeating, rapid food consumption and gulping, especially of carbonated drinks. (10) Emotionally, intense feelings and our responses to them, such as laughing, sobbing, anxiety and excitement, can also be triggers. (11) This list is not at all exhaustive; in fact, the range of stimuli is so large that hiccups might be considered the common thread between a drunk man, a Parkinson’s disease patient and anyone who watches The Notebook. The one thing that alcohol, (12) some neurological drugs (13) and intense sobbing (14) do have in common is that they exogenously stimulate the hiccup reflex arc. (15) This arc involves the vagal and phrenic nerves that stretch from the brainstem to the abdomen which cause the diaphragm to contract involuntarily. (16) According to Professor Georg Petroianu from the Herbert Wertheim College of Medicine, (17) many familiar home remedies for hiccupping – being scared, swallowing ice, drinking water upside down – interrupt this reflex arc, actually giving these solutions a somewhat scientific rationale. While modern research has successfully mapped out the process of hiccups, their purpose is still unclear. As of now, the hiccup reflex arc and the resulting diaphragmatic spasms seem to be effectively useless. Of the existing theories for the function of hiccups, the most prominent seems to be that they are a remnant of our evolutionary development, (18) essentially ‘vestigial’; in this case, a feature that once served our amphibian ancestors millions of years ago, but now retain little of their original function. (19) In particular, hiccups are believed to be a relic of the ancient transition of organisms from water to land. (20) When early fish lived in stagnant waters with little oxygen, they developed lungs to take advantage of the air overhead, in addition to using gills while underwater. (21) In this system, inhalation would allow water to move over the gills, during which a rapid closure of the glottis – which we see now in hiccupping – would prevent water from entering the lungs. It is theorised that when descendants of these fish moved onto land, gills were lost, but the neural circuit for this glottis closing mechanism was retained. (22) This neural circuit is indeed observable in human beings today, in the form of the hiccup central pattern generator (CPG). (23) CPGs exist for other oscillating actions like breathing and walking, (24) but a particular cross-species CPG stands out as a link to human hiccupping: the neural CPG that is also used by tadpoles for gill ventilation. Tadpoles “breathe” in a recurring, rhythmic pattern that shares a fundamental characteristic feature with hiccups: both involve inspiration with closing of the glottis. (25) This phenomenon strengthens the idea that the hiccup CPG may be left over from a previous stage in evolution and has been retained in both humans and frogs. However, the CPG in frogs is still used for ventilation, while in humans, the evolution of lungs to replace gills has rendered it useless. (26) Based on this information, it seems hiccupping lost its function with time and the development of the human lungs, remaining as nothing more than an evolutionary remnant. However, we cannot discredit hiccupping as having become entirely useless as soon as gills were lost. Interestingly, hiccupping has only been observed in mammals – not in birds, lizards or other air-breathing animals. (27) This suggests that there must have been some evolutionary advantage to hiccupping at some point, at least in mammals. A popular theory for this function stems from the uniquely mammalian trait of nursing. (28) Considering the fact that human babies hiccup in the womb even before birth, this theory considers hiccupping to be almost a glorified burp, intended to remove air from the stomach. This becomes particularly advantageous when closing the glottis prevents milk from entering the lungs, aiding the act of nursing. (29) Today, we reduce hiccups to the disorder and disarray they bring to our day. But, next time you are hit with a bout of hiccups, take a second to find some calm amidst the chaos and appreciate yet another fascinating evolutionary fossil, before you hurry to dismiss them. After that, feel free to eat those lemons or gargle that salty water to your diaphragm’s content. References Sonya Vatomsky, "7 Cures For Hiccups From World Folklore," Mentalfloss.Com, 2017, https://www.mentalfloss.com/article/500937/7-cures-hiccups-world-folklore. Derek Lue, "Indian Superstition: Hiccups | Dartmouth Folklore Archive," Journeys.Dartmouth.Edu, 2018, https://journeys.dartmouth.edu/folklorearchive/2018/11/14/indian-superstition-hiccups/. Vatomsky, "7 Cures For Hiccups From World Folklore". James Mundy, "10 Most Interesting Superstitions In Japanese Culture | Insidejapan Tours," Insidejapan Blog, 2013, https://www.insidejapantours.com/blog/2013/07/08/10-most-interesting-superstitions-in-japanese-culture/. Paul Rousseau, "Hiccups," Southern Medical Journal, no. 88, 2 (1995): 175-181, doi:10.1097/00007611-199502000-00002. Bruno Bordoni and Emiliano Zanier, "Anatomic Connections Of The Diaphragm Influence Of Respiration On The Body System," Journal Of Multidisciplinary Healthcare, no. 6 (2013): 281, doi:10.2147/jmdh.s45443. Christian Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," Bioessays no. 25, 2 (2003): 182-188, doi:10.1002/bies.10224. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. John Cameron, “Why Do We Hiccup?,” filmed for TedEd, 2016, TED Video, https://ed.ted.com/lessons/why-do-we-hiccup-john-cameron#watch. Monika Steger, Markus Schneemann, and Mark Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," Alimentary Pharmacology & Therapeutics 42, no. 9 (. 2015): 1037-1050, doi:10.1111/apt.13374. Lien-Fu Lin, and Pi-Teh Huang, "An Uncommon Cause Of Hiccups: Sarcoidosis Presenting Solely As Hiccups," Journal Of The Chinese Medical Association 73, no. 12 (2010): 647-650, doi:10.1016/s1726-4901(10)70141-6. Steger, Schneemann and Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," 1037-1050. Unax Lertxundi et al., "Hiccups In Parkinson’s Disease: An Analysis Of Cases Reported In The European Pharmacovigilance Database And A Review Of The Literature," European Journal Of Clinical Pharmacology 73, no. 9 (2017): 1159-1164, doi:10.1007/s00228-017-2275-6. Lin and Huang, "An Uncommon Cause Of Hiccups: Sarcoidosis Presenting Solely As Hiccups," 647-650. Peter J. Kahrilas and Guoxiang Shi, "Why Do We Hiccup?" Gut 41, no. 5 (1997): 712-713, doi:10.1136/gut.41.5.712. Steger, Schneemann and Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," 1037-1050. Georg A. Petroianu, "Treatment Of Hiccup By Vagal Maneuvers," Journal Of The History Of The Neurosciences 24, no. 2 (2014): 123-136, doi:10.1080/0964704x.2014.897133. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Cameron, “Why Do We Hiccup?” Michael Mosley, "Anatomical Clues To Human Evolution From Fish," BBC News, published 2011, https://www.bbc.com/news/health-13278255. Michael Hedrick and Stephen Katz, "Control Of Breathing In Primitive Fishes," Phylogeny, Anatomy And Physiology Of Ancient Fishes (2015): 179-200, doi:10.1201/b18798-9. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Pierre A. Guertin, "Central Pattern Generator For Locomotion: Anatomical, Physiological, And Pathophysiological Considerations," Frontiers In Neurology 3 (2013), doi:10.3389/fneur.2012.00183. Hedrick and Katz, "Control Of Breathing In Primitive Fishes," 179-200. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Daniel Howes, "Hiccups: A New Explanation For The Mysterious Reflex," Bioessays 34, no. 6 (2012): 451-453, doi:10.1002/bies.201100194. Howes, "Hiccups: A New Explanation For The Mysterious Reflex," 451-453. [1] Howes, "Hiccups: A New Explanation For The Mysterious Reflex," 451-453. Previous article back to DISORDER Next article

By Hazel Theophania < Back to Issue 3 Existing in an Alien World: Navigating Neurodiversity in a System Built for Someone Else By Hazel Theophania 10 September 2022 Edited by Breana Galea and Ruby Dempsey Illustrated by Janna Dingle Next Content warnings: Ableism, mental illness. Have you ever read something that just makes everything click into place? For me, it was that autism is characterised by a difficulty in forming and understanding ‘second-order representations’1. Let me explain: A ‘first order representation’ is the face value, the direct interpretation of an object or event. A ‘second order representation’ is the underlying meaning, the non-literal association with an object or event. Autistic people struggle with the latter. Allistic (non-autistic) people don’t, and for them it’s intrinsic in a large part of communication – nonverbal cues and gestures, sarcasm, undertones, passive aggression, politeness and more complex events like communication of social hierarchy all take place beneath the veneer of explicit communication. They rely on the ability to interpret another’s actions based on extrapolating their perspective. Rather than being automatic for autistic people, doing so is a learned, active behaviour, and one that is taxing to maintain and use. Reading this explanation was epiphanous for me for two reasons: it concisely explained why I and other autistic people I knew had such trouble navigating and communicating in social interactions, and it clarified why conflict and miscommunication arose so frequently. It contextualised and validated the way I experience and understand the world. Autistic communication is direct, predominantly using first order representation. It doesn’t soften effect or hide meaning with subtext; conversely it has difficulty picking up on inference and implication from others. So many times I have answered questions or followed instructions ‘incorrectly’, because I’ve addressed the words and not the implied meaning underneath. Much of boundary setting and emotional communication in social relationships is implicit - are they ‘acting’ interested? Does it ‘feel’ like they are reciprocating? Can you ‘tell’ that they want to be friends? - inability and difficulty in reading those complex second order representations makes navigating those situations painful and confusing. These struggles and anxieties make it much harder for autistic individuals to make and maintain friendships (3). Sedgewick and Pellicano (3) found that both autistic girls and boys report weaker friendships with more conflict than their neurotypical peers. They experience more victimisation, autistic girls especially, from bullying and other relational aggression, and experience far more insecurity around their friendships. The authors identify “both autistic and neurotypical girls alluded to wanting to fit in, but in different ways.” The neurotypical girls in the study were more concerned with securing a place in the social hierarchy – appearing cool and fitting in with the popular crowd - whether through dating or other means. For the autistic girls it was about finding people who actually accepted them as themselves; fitting in was not about adhering to social expectations, but about finding friends where they didn’t have to. Bury and Hedley (5) found much the same issues in analysing the problems autistic people face in the workplace. While the work itself was no more trouble for autistic individuals than their neurotypical counterparts, navigating the social aspects of a workplace drastically increased the stress and drain on autistic employees. Issues can arise from relative trivialities like dealing with food or birthday wishes, up to serious conflicts that jeopardise their employment. The same communication and relational issues that lead to autistic individuals struggling socially can have more serious consequences when the miscommunication and conflict arise when interacting with an authority, such as a boss or supervisor. Problems stem from unclear instructions, not adhering to unwritten or unspoken rules (social and otherwise), interrupting and socialising at wrong times – everything that relies on being able to determine and pick up on implicit communication. In other words, being autistic has career consequences. Now, having anxiety or depression aren’t intrinsic to being autistic (6). They’re not part of the same dysfunction in development. However, something about being expected to negotiate a minefield of implicit communication that others grasp intuitively leads to an extreme coincidence of autism with both anxiety and depression. The social ostracism and punishment for violating rules you’ve never been taught casts a slight shadow over every interaction. The starkly increased incidences of bullying and victimisation autistic youth go through may also contribute to mental illness. Mayes, Murray and their team7 write: “It is quite possible that youth with ASD (youth with Autism Spectrum Disorder (ASD) ) face considerable challenges during the transition from childhood to adolescence. Social difficulties and awareness of being different from others, especially during the teen years, may lead to problems with anxiety, depression, or hostility.” They reported anxiety in autistic children ranging from 67% to 79% depending on the severity of their traits, and depression affecting between 42% and 54% likewise – in comparison to anxiety occurring in 8% of children and adolescents8 and depression in 5% of children, 17% of adolescents13, and 5% of adults12 overall. Similar figures are reported by Susan White and her colleagues in their meta-analysis “Anxiety in children and adolescents with autism spectrum disorders”. The social deficits autistic individuals endure lead to social anxiety by increasing the likelihood of negative interactions9 and then that anxiety makes interaction with others more difficult, perpetuating the cycle. It’s clear there’s an issue here. Despite no biological link, autistic people suffer far greater rates of depression and anxiety than their neurotypical counterparts. They find friendships more taxing, worrying, and less fulfilling due to impossible unrealistic expectations of allistic communication and understanding. They’re far more likely to be the target of bullying and victimisation than their neurotypical counterparts. Autistic adults suffer in their careers and employment due to a lack of accommodation and recognition. But it doesn’t have to be this way. Growing up neurodivergent shouldn’t be traumatic. Existing as an autistic person shouldn’t be fraught with conflict. I don’t know how we will get to that point. It feels like there are a hundred facets to the issue, each their own problem and needing their own solution. That being said, all solutions need to stem from an understanding of autism and autistic individuals. So, what does it mean to be autistic and how can we navigate those communicative differences? The social aspect of autism arises from a deficit in ‘Theory of Mind’, which is the capacity to interpret and conceptualise another’s thoughts, beliefs, emotions, and intentions (1, 2, 9, 10). Second order representations are the events in which Theory of Mind is used to interpret their meaning – and so a disorder in Theory of Mind development affects the ability of an individual to use and understand those second order representations. Essentially: autistic individuals struggle to interpret and conceptualise other people’s thoughts, beliefs, emotions and intentions. What does that mean for communication? As mentioned earlier, it leads to this a twofold miscommunication between autistic and allistic people, where autistic people don’t see meaning where it is, and allistic people see meaning where it isn’t. This is known as the ‘double empathy problem’ (2). But it isn’t just a communication deficit on the part of the autistic person – the disconnect is due to two entirely different communication styles. Allistic people use second order representations readily and frequently. They’re able to infer other’s perspectives with ease and conversation is based around these assumptions. Gestures, body language and inference are used to convey meaning and assess receptiveness. If the wrong assumptions are made, it can lead to ‘fragmenting’, where there is a cost to getting it wrong and the conversation is disrupted (2). It may not be relationship-damaging every time, but people do pick up on misread cues or intentions and often the only indication a mistake has been made is given through those same implicit communications. The creation of a shared understanding is known as ‘intersubjectivity’ (1, 2). Allistic intersubjectivity is managed through these second order representations, where the shared understanding is outlined and defined implicitly. Autistic people don’t have the same ability to interpret second order representations, so rather than probing or assessing what others have in common, they essentially have to guess. As a result, autistic people can seem appear egotistical or self-interested (2) when they spontaneously talk about an interest of theirs, or suddenly change the topic of conversation. In actuality, they’re trying to find common ground. Because finding that initial mutuality is harder, autistic individuals also place far less of a social cost on getting it wrong (2) and so while intersubjectivity may be harder to initially reach, there’s far less penalty for trying and failing. If these bids for connection are reciprocated, it can creates a “rich intersubjective space for shared understanding” (2). These two elements of autistic communication come together to form a coherent communication style. Heasman writes “The generous assumption of common ground and the low demand for coordination are more than two isolated features; they potentially fit together into a functional system that allows rich forms of social relating” (2). The autistic communication style only appears to be dysfunctional when “[placed] against the cultural backdrop of neurotypical norms and expectations” (2). Another way to look at that is that autistic people don’t need ‘extra’ accommodation or compensation compared to allistic people – allistic people just have all their needs already met. They’re already accommodated for, but it’s such a cultural norm that it’s not even perceived as being so. A metaphor for the two types of communication is that of an allistic person and an autistic person trying to set up fishing rods along a river. The allistic person knows where the fish are - perhaps from reading the movement of the water - and sets up all their poles in that spot. The autistic fisherperson has no such information and sets up their rods all up and down the river to try to find themwhere the fish are. Once they’ve got a few bites and know where the fish are, great! They can move all their rods and set up in whatever spot they’ve found. They just don’t have the same ability to determine where to set up in the first place. They’re not any worse at fishing (i.e., communicating) – they just have trouble knowing where to start. Autism is only a disability in an environment that doesn’t support it. As Bury noted, the only deficits in the workplace are from a lack of social accommodation – autistic individuals don’t struggle with the work itself. In fact, both Bury and Hurley-Hanson and her co-authors report that autistic individuals perform better in a multitude of areas: they have greater problem-solving, pattern-recognition and decision-making skills and a greater tolerance for repetition (5, 11). And that’s great! It’s wonderful to be recognised for the talents you have and the effort you put in. But it shouldn’t have to be justified that autistic people deserve employment and equitable treatment. It’s depressing to have your life and experience boiled down to your marketability and employability. But there is still a disconnect between autistic and allistic people. The perception of autistic people as defective rather than different prevents the integration and acceptance of autistic people into the social space and workforce. To work towards an autism-friendly society, education and awareness of the ways communication and understanding differ in neurodivergent individuals need to be ubiquitous. The hardships autistic people face aren’t because we’re autistic – they’re because everyone else isn’t. Instead of us continuing to assimilate to an allistic worldview, perhaps it’s time to meet us halfway and learn how we operate instead. References Frith, U. (1989) A new look at language and communication in autism. Heasman, B. (2018) Neurodivergent intersubjectivity: Distinctive features of how autistic people create shared understanding. Sedgewick, F., Pellicano, E., (2018) ‘It’s different for girls’: Gender differences in the friendships and conflict of autistic and neurotypical adolescents. Happé, F., Leslie, A. (1989) Autism and ostensive communication: The relevance of metarepresentation Bury, S. et al. (2020) Workplace Social Challenges Experienced by Employees on the Autism Spectrum: An International Exploratory Study Examining Employee and Supervisor Perspectives White, W. et al. (2009) “Anxiety in children and adolescents with autism spectrum disorders.” Mayes, S.D., Calhoun, S.L., Murray, M.J. et al. (2011) Variables Associated with Anxiety and Depression in Children with Autism. Bernstein, G. A., & Borchardt, C. M. (1991). Anxiety disorders in childhood and adolescence: A critical review. Journal of the American Academy of Child and Adolescent Psychiatry Bellini, S. (2004) Social Skill Deficits and Anxiety in High-Functioning Adolescents With Autism Spectrum Disorders. Focus on Autism and Other Developmental Disabilities. Brewer, N, Young, RL & Barnett, E 2017, ‘Measuring Theory of Mind in Adults with Autism Spectrum Disorder’ Hurley-Hanson, A. (2020) ‘Autism in the Workplace’, Palgrave Macmillan Institute of Health Metrics and Evaluation. Global Health Data Exchange (GHDx) Selph, S. (2019) Depression in Children and Adolescents: Evaluation and Treatment Previous article Next article alien back to

< Back to Issue 8 Fungal Pac Man by Ksheerja Srivastava 3 June 2025 Edited by Rita Fortune Illustrated by Esme MacGillivray We live in a world where a fungus would probably beat you at Pac-Man. While playing, the average person just follows the dots, but fungi are playing a whole different game. Despite no central brain, they navigate complex mazes, optimise routes, and even communicate across vast networks. To do so, fungi use such efficient strategies that scientists are studying them as a means to improve everything from city planning to biosensors. Nature has been perfecting pathfinding long before we put a quarter in the arcade. The elongated bodies of fungi, known as mycelia, build vast and complex networks. These structures emerge from natural algorithms - specifically, a process called collision-induced branching (1). In this process, new growth divides into new paths upon meeting an obstacle. When fungal hyphae hit a wall (literally or figuratively), they don’t just stop; they branch out, adapt, and keep moving. Traditional path-finding algorithms like Depth-First Search (DFS) or Breadth-First Search (BFS) methodically crawl through paths, moving step by step without reacting to obstacles (2). Fungi, on the other hand, adjust on the fly, often landing on the most resource-efficient routes way faster. Imagine reaching a junction in Pac-Man and instead of choosing just one path, Pac-Man splits into two, each clone taking a different route to cover more ground. This is exactly why fungal networks often end up looking eerily like optimised transport systems, such as railway lines or power grids! (3) Some fungi aren’t just clever in how they grow - they can quite literally compute. Certain species, like Basidiomycete fungi, communicate through spikes of electrical activity pulsing through their mycelial networks, processing information in ways surprisingly reminiscent of neural systems (4). What makes them even more intriguing is their hypersensitivity to the world around them. These organisms can detect subtle shifts in their environment - both chemical and physical. It’s like they’ve memorised every path they’ve taken, so when a new pellet appears on the far side of the board, they don’t need to search blindly. They already know the fastest way there, no matter where the original Pac-Man started. Endophytic fungi, fungi that live inside plants without causing harm, have been used to create biosensors - devices that can detect environmental contaminants like pollutants or pesticides (5). When these fungi encounter harmful chemicals, they react, making them perfect for monitoring things like toxins in the environment. Scientists have even developed yeast-based biosensors to specifically detect chemicals like tebuconazole, a common pesticide (6). Fungi don’t stop at chemistry and computations. It turns out they’re mechanically perceptive too. In one study, oyster fungi incorporated into fungal insoles responded to compressive stress, hinting at applications in wearable tech or even seismic sensing systems (7). Mycelium-based composites also exhibit unique patterns of electrical activity as moisture levels shift, making them promising candidates for humidity-responsive technologies. As if that weren’t enough, some fungi have the incredible ability to glow in the dark, a phenomenon known as bioluminescence. This natural light can be harnessed in special sensors, which use the glow to indicate the presence of specific substances. Essentially, when the fungi detect certain chemicals, they light up, providing an easy way to spot pollutants or toxins (8). These properties make fungi wildly efficient. No random turns, no wasted loops, just constant feedback powering smarter decisions. They know where they’ve been, sense what’s coming, and find the fastest route every time. It’s Pac-Man with a built-in optimisation engine, and that’s exactly how fungi behave in the wild. How well do you think you’d do against this version of Pac-Man? Probably not great. Let’s face it: they’re not only outsmarting us, they’re doing it with no brain at all. As we look toward smarter and more sustainable technologies, fungi might just be the key to a new era of bio-inspired computing and environmental monitoring. Researchers are already tapping into their natural brilliance to create more efficient systems for everything from biosensors to sustainable materials. The next time you see a mushroom, remember: it’s not just a fungus, it’s part of a vast, intelligent network playing the ultimate game of survival, one optimised move at a time. In a world where efficiency and adaptability are paramount, fungi might just be the unsung heroes we need to help us solve some of the biggest challenges ahead. References Asenova E, Lin HY, Fu E, Nicolau DV, Nicolau DV. Optimal Fungal Space Searching Algorithms. IEEE Trans Nanobioscience. 2016 Oct;15(7):613-618. doi: 10.1109/TNB.2016.2567098. Epub 2016 May 13. PMID: 27187968. Hanson KL, Nicolau DV Jr, Filipponi L, Wang L, Lee AP, Nicolau DV. Fungi use efficient algorithms for the exploration of microfluidic networks. Small. 2006 Oct;2(10):1212-20. doi: 10.1002/smll.200600105. PMID: 17193591. Asenova E, Fu E, Nicolau Jr DV, Lin HY, Nicolau DV. Space searching algorithms used by fungi. InBICT'15: Proceedings of the 9th EAI International Conference on Bio-inspired Information and Communications Technologies (formerly BIONETICS) 2016. European Alliance for Innovation. Adamatzky A. Towards fungal computers. Interface focus. 2018 Dec 6;8(6):20180029. Khanam Z, Gupta S, Verma A. Endophytic fungi-based biosensors for environmental contaminants-A perspective. South African Journal of Botany. 2020 Nov 1;134:401-6. Mendes F, Miranda E, Amaral L, Carvalho C, Castro BB, Sousa MJ, Chaves SR. Novel yeast-based biosensor for environmental monitoring of tebuconazole. Applied Microbiology and Biotechnology. 2024 Dec;108(1):10. Nikolaidou A, Phillips N, Tsompanas MA, Adamatzky A. Reactive fungal insoles. InFungal Machines: Sensing and Computing with Fungi 2023 Sep 17 (pp. 131-147). Cham: Springer Nature Switzerland. Singh S, Kumar V, Dhanjal DS, Thotapalli S, Singh J. Importance and recent aspects of fungal-based biosensors. InNew and Future Developments in Microbial Biotechnology and Bioengineering 2020 Jan 1 (pp. 301-309). Elsevier. Previous article Next article Enigma back to

< Back to Issue 10 Contingent Realities - the (Ph)ailure of a (Ph)act by Edmond Sim 2 June 2026 Illustrated by Eric Wang Edited by Rita Fortune "What is true for you is true for you, and what is true for me is true for me" – Protagoras sneered (1). “I cannot but agree” – Plato replied, terse and tight-lipped. They were bitter ideological enemies. Whilst Protagoras sold a world built entirely on human perception, Plato demanded absolute, unchanging facts: forms and realities that existed independently of human viewing (2). For millennia, the discipline of physics sided vehemently with him. The entire enterprise of the physical sciences was a crusade to banish the ‘will’ of anthropomorphic gods and heroes, to uncover the definitive and rational "facts" behind the universe. The pursuit of logos, rather than mythos. Eight years following Plato’s death, a student of his, Zeno of Citium, established the Stoic school, spreading the belief that the universe operated due to reason (logos), was monistic (i.e. one interconnected physical system governed by consistent laws), and operated on cause and effect (3). This belief in determinism (the idea that events in the future had been determined by a chain of past occurrences) reached its zenith in the Scientific Revolution of the 17/18th centuries. Fact: repeatable, reversible and reliable We will start with an easy question: what is a fact? I would argue that a statement is a fact if it: (i) stems from a pre-existing state of affairs in the world; and (ii) is singular, i.e. is restricted to reality, of which there is one. This is described in perhaps the most incomprehensible quotation of mankind by Aristotle (4). “To say that that which is, is not, and that which is not, is, is a falsehood; therefore, to say that which is, is, and that which is not, is not, is true” (4). ‘Pre-existing’ requires a past. For something to already be there, waiting for us to see it, it can't have just spawned from the void. Every 'is' requires a 'why'. This relentless search for the chain of cause and effect reached its extreme in the 18th century with the French polymath, Pierre-Simon Laplace. His proposal of a hypothetical entity, now famously known as Laplace’s Demon, served as the ultimate thought experiment for the deterministic worldview that dominated the Scientific Revolution. Imagine a massive, omnipresent intellect – a demon. If this intelligence knew the exact location and force of each single atom in the universe right now, it would know everything. Uncertainty would vanish. The past and the future would be simultaneously now (5). A rock does not "choose" to roll; rather it rolls because gravity acts upon its mass. Similarly, in a deterministic universe, you do not "choose" to act. Your current physical state was caused by the state of the universe one second ago. That state was caused by the state one year ago, which was caused by the state of the universe before you were born, stretching all the way back to the initial conditions of the Big Bang. We conclude: there only exists one unique solution that maps space to time. Two different pasts never merge into the exact same future. Two identical presents never split into different futures. ‘c’ is a constant (crisis): Classical mechanics, in all its beautiful and symmetrical mathematics, provides us this shocking revelation that reality may be deterministic, and that free will is an illusion, a fiction within the slow march of time (7). Occam’s razor (that is, that the simplest explanation is usually the correct one) is seemingly disproven through two fundamental flaws within the classical framework. Firstly, the speed of light (denoted as c) is unique because it stays the same regardless of how fast you are moving. James Clerk Maxwell discovered that electric and magnetic fields are perfectly synced; a ripple in an electric field creates a magnetic one, and that magnetic ripple in turn regenerates the electric field. This continuous loop creates an electromagnetic wave, which we see as light. The speed of this wave is determined by two fundamental properties of empty space: how easily it allows electric and magnetic fields to form and spread. As these properties of the vacuum itself never change, light always travels at the exact same speed, whether you are racing toward the light source or standing perfectly still. The immediate consequences of forcing light to travel at a constant value are rather disturbing. Consider the unfortunate events of a German salary worker in the early 20th century: It was another miserable, grey day in Germany. Albert was staring out the window of a Deutsche Bahn train that was currently four hours late, thinking that his day couldn’t get any worse. CRACK. Lightning strikes the metal frame of the train car, right at the front. Albert jumps, spilling his lukewarm coffee. But before he can even dry off his trousers, a second lightning bolt strikes the very back of the train. He spills his coffee over his shirt. Albert has to get off the train at the next stop, Bern, to get to his job working at the Swiss Patent office. As he dries off his clothes on the platform, he observes an express train that runs straight through the station. Lightning, particularly vicious today, strikes both the front and end of the train carriage at the exact same time. When he was sitting inside the moving carriage, the light from the front strike had reached his eyes first because he was moving toward it. Remember, the speed of light remains constant even in his moving carriage. But now, standing completely still on the damp Bern platform, the light from both strikes on this new express train reached him exactly simultaneously (9). The man on the platform and the passengers on the train would fundamentally argue on the chronological order of events in the universe. Yet the frightening fact was neither of them was wrong (10). (This assumes that the Deutsche-Bahn moves at speeds close to the speed of light, however due to strikes from the train worker union, it would be a challenge for the train to move at a non-zero speed at all.) Recall our first condition for the definition of fact – the existence of a pre-existing past. Yet, if two observers cannot even agree on "when” an event took place, this condition fails. Fact, it seems, depends entirely on how fast you go. Bohr-ing reality is fundamentally uncertain. The second deviation from naive Laplace was the discovery of the hollow atom. Rutherford used the analogy of planets (the electrons) orbiting a star (the nucleus) seemingly never straying from their tidy, well-defined and circular orbits. Electromagnetism prevented this model from being taken seriously. Any particle that possesses charge must release energy when accelerated. Now, imagine a satellite that constantly releases energy each orbit around Earth. Naturally, the satellite will fall into the Earth. The same would occur to the electron. It would spiral into the nucleus in less than a fraction of a picosecond. Every atom in the universe would instantly implode. Two independent theories then arose almost simultaneously following this discovery. In 1925-26, the landmark papers of Heisenberg’s matrix mechanics (which uses matrices to calculate important quantum properties) and Schrödinger’s wave mechanics (an equation that relates a quantum state to its energy) attempted to provide reasons as to why energy did not disappear from the electron’s orbit (11). Breaking with the tradition of presenting the quantum ‘ghost’ of randomness, quantum mechanics actually provides a more deterministic theory than one may realise. Akin to Laplace’s demon, Schrödinger’s equation describes the time evolution of a quantum system: given an initial quantum state, we can make a definite and certain prediction of what that quantum state will be at any later time (12). This is a very intangible concept and would likely be poorly understood, so let me demonstrate this by way of an example of a coin toss. Imagine a coin spinning rapidly on a table. If you try and guess whether it’s showing heads or tails at that specific microsecond, you probably can’t. It’d be too blurry. However, the blur itself is not random. The way the coin spins, its momentum, its wobble, the friction against the table is governed by strict, unbreakable rules. If you know exactly how the coin was flicked (the initial quantum state), Schrödinger’s formula can predict with 100% certainty exactly what that "blur" will look like five seconds from now, ten days from now, or one hundred years from now. The deterministic nature of quantum mechanics is that the blur itself evolves predictably. The infamous and rather misrepresented "quantum randomness" only applies at the very end, when you finally get fed up and slap your hand down on the coin, forcing it to be either heads or tails (the measurement) (13). The issue, therefore, with this notion of fact under a quantum lens is the lack of a singular outcome. Time evolution is a well-defined function, yet outcome can only be predicted probabilistically. Therefore, we fail yet again the second condition of fact. Fact is – the friends we made along the way? An ongoing unresolved issue in quantum theory is how to explain the two conflicting ways in which systems evolve. Unobserved states evolve smoothly, yet exhibit discontinuous jumps into an outcome when measured. The infamous “Wigner’s Friend” paradox provides an example (14). Suppose your friend is inside a sealed lab watching a spinning coin. In their perspective, when they stop the coin and read its face, its state collapses into a singular outcome. In the shivering cold, you curse that you had to be the one to stand outside. According to the rules of quantum mechanics, because you haven’t seen the coin face, the smooth, unbroken evolution is still happening. You get sick of suffering in the name of science, so you rush into the laboratory and ask your friend what the coin landed on. At that moment, the superposition abruptly collapses for you. Facts no longer appear grounded in an objective, observer-independent past. Instead, they become relational, contingent upon who is observing the system. Worse still, facts seem capable of multiplying: different observers may legitimately describe different realities. This forms the basis for Rovelli’s Relational Quantum Mechanics (15). In RQM, an object (like an electron, a coin, or a cat) does not inherently "possess" properties like position or momentum in isolation. Instead, those properties only exist when two physical systems interact. Asking "Where is the particle right now?" when nothing is looking at it is a grammatically incorrect question, equivalent to asking “What is the sound of one hand clapping?" The property of "position" only truly comes into meaning if there exists a detector for which the electron interacts with (16). Any interaction is essentially an exchange of information between two systems. Rovelli formalises this by proposing two foundational postulates. First, there is a finite limit to the relevant information one system can extract from another. Second, it is always possible to extract new information (17). At first glance, these seem at odds: how can you continually extract new data if the total capacity is capped? The consequence of this tension is what we traditionally call "collapse", but RQM reframes it simply as an update of relative information. If you have maxed out the information capacity of a system — for instance, by pinning down the spinning coin’s exact momentum — then asking a new question about its position forces the system to "forget" old information to make room for the new. This directly yields Heisenberg’s uncertainty principle. If we wish to keep using the word "fact" in our theory of modern physics, we must redefine it. Facts are no longer global, pre-existing truths built into a singular reality. Instead, they are by nature local, inherently plural, and entirely dependent on the relationship between the watcher and the watched. Protagoras peers down, then looks up at Plato with a bright-eyed grin. "As I was saying,” References Plato. Theaetetus. Waterfield R, translator. London: Penguin Classics; 1987. Plato. The Republic. Lee D, translator. 2nd ed. London: Penguin Books; 2003. Sellars J. Stoicism. Berkeley: University of California Press; 2006. Aristotle. Metaphysics. Ross WD, translator. Oxford: Clarendon Press; 1924. Laplace PS. A Philosophical Essay on Probabilities. Truscott FW, Emory FL, translators. New York: John Wiley & Sons; 1902. University of Oxford. The Eddington Number. Oxford: University of Oxford. 2020. https://www.maths.ox.ac.uk/about-us/life-oxford-mathematics/oxford-mathematics-alphabet/e-eddington-number Mastin L. Determinism. The Basics of Philosophy. 2008. https://www.philosophybasics.com/branch_determinism.html Einstein A. Relativity: The Special and the General Theory. Lawson RW, translator. New York: Henry Holt and Company; 1920. Norton JD. The Relativity of Simultaneity. Pittsburgh: University of Pittsburgh. 2022. https://www.pitt.edu/~jdnorton/teaching/HPS_0410/chapters/Special_relativity_rel_sim/ Norton JD. Einstein for Everyone. Pittsburgh: University of Pittsburgh. 2022. https://www.pitt.edu/~jdnorton/teaching/HPS_0410/chapters/Special_relativity_clocks_rods/ Heisenberg W. Über quantentheoretische Umdeutung kinematischer und mechanischer Beziehungen. Z Phys. 1925;33(1):879-93. Nave R. Schrödinger Equation [Internet]. Atlanta: Georgia State University. 2017. http://hyperphysics.phy-astr.gsu.edu/hbase/quantum/schr.html Ismael J. Quantum Mechanics. Stanford: Stanford Encyclopedia of Philosophy. 2021. https://plato.stanford.edu/entries/qm/ Wigner EP. Remarks on the mind-body question. In: Good IJ, editor. The Scientist Speculates. London: Heinemann; 1961. p. 284-302. Rovelli C. Relational quantum mechanics. Int J Theor Phys. 1996;35(8):1637-78. Laudisa F, Rovelli C. Relational Quantum Mechanics. Stanford: Stanford Encyclopedia of Philosophy. 2021. https://plato.stanford.edu/entries/qm-relational/ Rovelli C. Helgoland. Segre E, Carnell S, translators. New York: Riverhead Books; 2021. Previous article back to Fact & Fiction Next article

< Back to Issue 4 From the Editors-in-Chief by Caitlin Kane, Rachel Ko, Patrick Grave, Yvette Marris 1 July 2023 Edited by the Committee Illustrated by Gemma van der Hurk Scirocco, summer sun, shimmering on the horizon. Salt-caked channels spiderweb your lips, scored by rivulets of sweat. Shifting, hissing sands sting your legs. You are the explorer, the adventurer, the scientist. A rusted spring, you heave forward, straining for each step, hauling empty waterskins. ----- The lonely deserts of science provide fertile ground for mirages. An optical phenomenon that appears to show lakes in the distance, the mirage has long been a metaphor for foolhardy hopes and desperate quests. The allure of a sparkling oasis just over the horizon, however, is undeniable. The practice of science involves both kinds of stories. Some scientists set a distant goal and reach it — perhaps they are lucky, perhaps they have exactly the right skills. Other scientists yearn to crack a certain problem but never quite get there. In this issue of OmniSci Magazine, we chose to explore this quest for the unknown that may be bold, unlucky, or even foolhardy: chasing the ‘Mirage’. Each article was written entirely by a student, edited by students, and is accompanied by an illustration that was created by a student. We, as a magazine, exist to provide university students a place to develop their science communication skills and share their work. If there’s a piece you enjoy, feel free to leave a comment or send us some feedback – we love to know that our work means something to the wider world. We’d like to thank all our contributors — our writers, designers, editors, and committee — who have each invested countless hours into crafting an issue that we are all incredibly proud of. We’d also like to thank you, our readers; we are incredibly grateful that people want to read student pieces and learn little bits from the work. That’s enough talking from us until next issue. Go and read some fantastic student writing! Previous article Next article back to MIRAGE

< Back to Issue 9 Knot Theory and Its Applications. Why Knot? by Ryan Rud 28 October 2025 Illustrated by Saraf Ishmam Edited by Elijah McEvoy Knot theory is a theoretical study in mathematics, where your brain thinks of an imaginary knot, and manipulates it to your heart’s desire. Yes, the kind of knot you are probably thinking of now, it might be a shoelace, a knot in a piece of string or some utility knot. Good job, but it’s missing one detail: the knot needs to be tied at its ends. Think of this as a string with both ends tied together so that it can’t come undone when you play with it. Now you can pull at and twist this knot, as long as you don’t break it. Congratulations, you now understand the basics of knot theory. (1) So why should we care about a niche field of maths that you will probably never use in your everyday life? Well, the first answer to that is simply ‘for the love of the game’. For some people problem-solving is an endless endeavour that satisfies an urge to understand and be intellectually stimulated. But that’s not for everyone. So then we remember all the times when random elements of pure mathematics became essential when applied to seemingly unrelated topics. Such as how number theory became applied to information transmission, cryptography and computing. (2) How quaternions made for more efficient digital transformations in computer science. (3) Or how graph theory was used to strongly conjecture that any two people have 6 degrees of separation between each other. (4) Although we may not routinely ponder these discoveries, it is because of the works of pure mathematicians that we can admire certain facts that we could not prove otherwise or appreciate how they silently helped to make all the digital devices in your homes. But before we get into the applications, it is good to be familiar with some general terminology. That knot which you pictured earlier with its ends tied is called a standard knot. In 1867 Lord Kelvin thought of the revolutionary idea that what we know as elements - the ones made of protons and neutrons - are actually types of standard knots. (5) He wasn’t right, but it inspired his assistant Peter Guthrie Tait to begin the rigorous study of knots and we have been trying to find applications ever since. Here are the first knots in the greater sequence of the periodic table of knots (see cover image for more!): Figure 1. An ordered table of the first 15 prime knots. (6) There are knots made from one piece of string (prime knots) and knots made from multiple knots joined end-to-end (composite knots) (Fig.2b). There are also links, where two closed knots are combined without gluing the string (Fig.2a). Understanding any further implications of this terminology is not necessary here, but it may help to have a visual understanding of them for the next part. Figure 2. a) Showcasing types of mathematical links; unlink on the left, Hopf link in the centre and whitehead link on the left. b) Demonstrating how two prime knots are combined into a composite knot. c) Demonstrating chirality in trefoil knots, notice the overlapping pattern. Lastly, like many things in mathematics we need a way to systematically and efficiently describe how we manipulate the knots. Luckily, Kurt Reidemeister had the pleasure of providing us with a knot-manipulating moveset in the 1930s through rigorous proofs.These are the legal set of moves that can be done to a knot without changing the knot structure. If we were to cut the knot, twist or untwist the string and then reattach the ends, this is called a crossing switch and it changes the knot. Again, this is not an extensive course but it helps to know of the terminology and visualise it. Feel free to do more research into the details of these topics using the references below! Figure 3. A depiction of the Reidemeister moves. DNA and knot theory Deoxyribonucleic acid (DNA) is the most important and relevant knotting molecule. Each cell nucleus contains (on the millionth order) DNA that is regularly knotting, coiling and compressing to fit into this tight space. However, the best application of knot theory is to the closed end, circular DNA in bacteria. During DNA replication, the unwinding of DNA at one end creates immense torsional strain on the other side of the loop, which is enough supercoiling that prevents replication and leads to cell death.To counter this, bacteria utilise an enzyme known as type II topoisomerase which makes double-stranded cuts in the DNA, followed by a rearrangement of the tangle and reconnecting of the strands, a crossing switch! Without this adaptation, all cellular life would have evolved differently. If you gave this DNA to a mathematician and asked which position in the DNA would be best for this enzyme to cut with the intent of untangling, they could spend a lifetime performing Reidemeister moves and contemplating, never knowing where or how many cuts to make. In contrast to our world’s best mathematicians, topoisomerase is incredibly efficient in where it cuts. We have yet to understand what mechanism allows for such accurate cuts, but practical research into topoisomerase could potentially help knot theorists solve the immensely inscrutable question of the minimum number of crossing switches to simplify any knot. Furthermore, if an understanding of the mechanisms for topoisomerases in bacteria and humans is possible, then humanity can access a new form of control over DNA. It has been speculated that there are possible uses of topoisomerases to inhibit cancer growth, or as a revolutionary way to treat bacterial disease. While we do not have this intel right now, this is one of the ways knot theory could be integral to applied sciences and given time and research funding, it can prove itself useful. (7-8) Knots in chemistry So what other molecules can form knots? Chemists have been creating molecules which involve the basic knots and links since the 1960s (see Fig 4), when topological isomerism was discovered and characterised. Topological isomers are chemicals that are similar in many properties, but differ in spatial arrangement. We can think of it like chirality for knots (see Fig 2c). Chirality is the property of an object not being the same as its mirror image, like a right and left hand. Subsequently, these molecules were made through a technique called ‘templating’, where a metal ion or some template structure was used to produce a desired product, based on how the template interacts with the reactants. There is also another category of knot called a ravel (Fig 4h), where a knot has multiple strings connected at vertices. Altogether, the study of topological isomerism and templating techniques have been advanced by the experimental desire to produce these beautiful molecules. This then indirectly contributes to the production of new molecules and drugs that can go on to have real world impacts. (9) Figure 4. a) The first molecular trefoil knot produced in 1989. c) The first molecule pentafoil knot produced in 2011. d) First molecular Borromean rings, a type of link produced in 2004. f) The first molecule solomon link produced in 2013. h) The first molecular ravel produced in 2011. (9) The recent breakthrough in knot theory I admit, progress in knot theory is slow and perhaps you did not find the scientific revelation of knot theory here that you were hoping for. But that does not mean that current research is ineffective. As recent as June of this year, there was a groundbreaking proof. Think back to the prime and composite knots (scroll up if you have to). Prime knots have an unknotting number, which is the number of crossing changes needed to simplify it to the unknot, similar to what the topoisomerase does. If we merge two prime knots into a composite knot, it can be easily seen that it takes as many crossing switches to simplify the composite, as it does the crossing switches for the sum of the primes. In other words, to untangle a composite knot, you cut and reglue it as many times as the prime knots that make it up. Now, the breakthrough was a proof that it is possible to untangle some composite knots through less crossing switches than the sum of its prime knots. This may seem bleak, but it disproves a widely believed conjecture and now theorists are one step closer to solving the question of the minimum number of crossing switches needed to simplify a knot. (10) Conclusion I will end this with a quote from Dr Arunima Ray, a mathematician that specialises in knot theory and low-dimensional topology at the University of Melbourne, and a dear professor of mine. Hopefully this is just more proof (pun intended) that the work us mathematicians do is tangible: “I had never imagined that mathematics could be used to describe something so abstract as knot theory, but to me the appeal was its tangibility. No matter who you are, there really is something in mathematics for you.” References Pencovitch M. What’s not to love? [Internet] Mathematics Today . 2021. Available from: https://ima.org.uk/17434/whats-knot-to-love/ Koblitz N. A course in number theory and cryptography . 2nd ed. Springer Science & Business Media; 1994. Jeremiah. Understanding quaternions. 3D Game Engine Programming [Internet]. June 25, 2012. Available from: https://www.3dgep.com/understanding-quaternions/ Zhang L, Tu W. Six degrees of separation in online society [Internet]. Research Gate. 2009. Available from: https://www.researchgate.net/publication/255614427_Six_Degrees_of_Separation_in_Online_Society Wilson RM. Holograms tie optical vortices in knots. Physics Today. 2010. https://doi.org/ 10.1063/1.3366639 Li M, Wang T, Kau A, George W, Petrenko A. Knots. Brilliant. 2025 [Internet]. Available from: https://brilliant.org/wiki/knots/ Catherine. All tangled up: an introduction to knot theory [Internet]. Gleammath. April 28, 2021. Available from: https://www.gleammath.com/post/all-tangled-up-an-introduction-to-knot-theory Skjeltorp AT, Clausen S, Helgesen G, Pieranski P. Knots and applications to biology, chemistry and physics. In: Riste T, Sherrington D, editors. Physics of Biomaterials: Fluctuations, Selfassembly and Evolution. Dordrecht: Springer Netherlands; 1996. p.187–217. https://doi.org/10.1007/978-94-009-1722-4_8 Horner KE, Miller MA, Steed JW, Sutcliffe PM. Knot theory in modern chemistry [Internet]. Chemical Society Reviews. 2016;45(23). Available from: https://durham-repository.worktribe.com/output/1394834 Brittenham M, Hermiller S. Unknotting number is not additive under connected sum [Internet]. Arxiv . 2025. Available from: https://arxiv.org/html/2506.24088v1 Previous article Next article Entwined back to

< Back to Issue 2 The Evolution of Science Communication In the current age of social media, users hold far more autonomy over the posts and information which they share online. However, this was not always the case, with the media once being far more regulated, and restricted for only certain individuals. With users now having far more power over content posted online, how does this impact the information which others receive about the COVID-19 pandemic? by Monica Blasioli 10 December 2021 Edited by Khoa-Anh Tran & Yen Sim Illustrated by Rachel Ko Trigger warning: This article mentions illness, and death or dying. Since the beginning of the pandemic in March 2020, science communication has started to evolve in ways never before seen across the globe. There appears to be an endless amount of infographics, Facebook posts, and YouTube and TikTok videos… including some with dancing doctors. Information not only about the COVID-19 virus, but countless diseases and scientific concepts, is available in more casual, accessible language at only the touch of a button. Any questions which you might have about science or your body can be answered through a quick Google search. In this sense, science communication is now far more rapid, as well as more accessible than in research papers (which always seem like they are written in a foreign language at times). However, the downside of having vast amounts of information available is that it can create challenges in determining the validity of what is being presented. In previous years, science communication was typically limited to the more typical forms of media, such as in a newspaper or a magazine, or even through a television interview. These were typically completed by professionals in the field, such as a research scientist or a medical doctor. When looking at the 1920 Influenza outbreak, many citizens at that time would have received their information from printed newspapers and posters on bulletin boards, as seen below. Image 1, [1] Somewhat similar to today's age, there were signs displaying the importance of mask-wearing, and newspapers explaining the closures of schools and shops, the distribution of vaccines, and reports of death rates. These messages were, and still are, created and approved by larger institutions, governments and medical professionals, particularly doctors. As seen on the (left / right / below / above), doctors are urging people to not become complacent, despite a recent drop in influenza cases. This is rather similar to current newspaper or television news reports - only in reference to COVID-19, instead of influenza. Image 2, [2] There were, of course, still groups which were uncertain about the scientific evidence being provided by journalists, doctors and government officials at this time. In November of 1918, it was declared that “the epidemic of [influenza] disease is practically over,” with mask laws being relaxed. However, only a few days later, the previous mask laws were reintroduced with a spike in Influenza cases. As unpacked in Dr Dolan’s research [3], the “Anti-Mask League” formed and protested in response to this back track, claiming that masks were unsanitary, unnecessary, and stifling their freedom. As this was during the early 20th century, the league advertised their protests in local newspapers, with reports that hundreds of San Francisco residents were fined for not abiding by mask rules, often due to their alliance with the Anti-Mask League. The San Francisco Anti-Mask League is one of the most renowned and infamous groups of its time, with smaller-scale groups also questioning the science being communicated. This type of conflicting information surrounding mask issues, and the opinion that they restrict personal freedoms, have incited similar responses throughout history. However, resistance by anti-mask groups has not existed on such an influential and global scale, as it has during the current COVID-19 pandemic. With the rise of the age of “new media,” including platforms such as Instagram and Facebook, individuals now have far more autonomy over their role in the media, meaning that they yield a lot more power over the information others are receiving. Almost anybody can interpret scientific material online and upload it in a video of them dancing to some music on TikTok, spreading information to potentially hundreds of thousands of viewers across the globe. In many ways this new found autonomy and power can be quite beneficial. Australian Doctor Imogen Hines uses her platform on TikTok, alongside her medical education and current scientific research, to break down medical treatments and mistruths, particularly surrounding the COVID-19 pandemic. These videos use simple language and straight-forward analogies, “humanising” the often intimidating figures in the medical field, and allowing the general public to be well-informed about scientific concepts. For example, Dr Imogen breaks down the research surrounding long term side effects of vaccines using a milkshake analogy! https://www.tiktok.com/@imi_imogen1/video/7027448207823211777?is_copy_url=1&is_from_webapp=v1&lang=en On the other hand, this phenomenon can have pretty serious ramifications, with many individuals feeling rightfully confused about what the truth really is, when there appears to be so many versions of it posted across the internet. Following a rather controversial study on Ivermectin as a treatment for COVID-19, the internet was soon buzzing with excitement about the prospect of a drug that many believed could replace the need for a vaccine. Despite numerous gaps in the original study, and countless further studies refuting Invermectin’s ability to treat COVID-19, many social media users are continuing to spread this myth online. Both governments and hospitals alike have been accused of hiding a seemingly “good” cure from their citizens. In Texas, a group of doctors won a legal case which allowed Texas Huguley Hospital to refuse administering Ivermectin to a COVID-19 infected Deputy Sheriff. This sparked outrage on Facebook, with users and the Sheriff’s wife demanding greater freedoms over their medical treatments, instead of just relying on the judgement of doctors and hospital staff. In this instance, the misinformation surrounding Ivermectin is not only influencing individuals to seek out futile treatments, but it is also spreading mistrust with the science and medical communities, who work incredibly hard to protect the world, particularly over the past two years. Despite Ivermectin being used in a clinical setting to treat parasitic (not viral) infections in humans for a number of years now, it can be extremely dangerous for individuals to have complete power over their medical treatments. The dosage and timing of treatment is crucial in ensuring success. Just like with everyday medications such as paracetamol, taking Ivermectin in high doses is risky. A COVID-19 infected woman from Sydney who read about Ivermectin on social media took a very high dosage of the drug after purchasing it from an online seller, which resulted in severe diarrhea and vomiting. In order to combat some of this misinformation, a number of social media platforms are “fact checking” posts or providing warnings on posts with keywords, such as ‘COVID-19’ or ‘vaccination.’ On Instagram, each post with these keywords will contain a banner at the bottom inviting users to visit their “COVID-19 Information Centre,” which provides a list of information supported by WHO and UNICEF about how vaccines are of high-standard, well-researched, and generally resulting in mild side effects. In addition, on Facebook, posts identified to be spreading mistruths will provide users with websites explaining the truth, before they can access the original posts. However, these warnings and fact-checks can only go so far. Posts blindly supporting the use of Ivermectin, falsely reporting side effects of vaccines, and arguing that masks cannot block virus particles still circulate the internet. Often those most vulnerable in the community are at risk of being led astray with misinformation. In principle, evidence-based, concise, easy-to-understand science communication is essential to break down the barrier between research and the general public, ensuring that citizens are well-informed and more comfortable about the world around them. In the situation of a public health crisis such as the COVID-19 pandemic, this communication is crucial in ensuring that all citizens can remain well-informed, safe and healthy. Misinformation and dodgy studies can not only lead people astray, but also cost them their health and wellbeing. References: 1. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 2. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 3. Brian Dolan, Unmasking History: Who Was Behind the Anti-Mask League Protests During the 1918 Influenza Epidemic in San Francisco? Perspectives in Medical Humanities (San Francisco: UC Medical Humanities Consortium, 2020) Previous article back to DISORDER Next article

< Back to Issue 5 Three-Parent Babies? The Future of Mitochondrial Donation in Australia Kara Miwa-Dale 24 October 2023 Edited by Yasmin Potts Illustrated by Aisyah Mohammad Sulhanuddin Mitochondria are the ‘powerhouse of the cell’. Sound familiar? This fact was likely drilled into you during high school biology classes (or by looking at memes). Beyond this, you may not have given mitochondria a second thought - but you should! This organelle has been at the centre of some heated parliamentary debates relating to mitochondrial donation. This new IVF technology, which aims to prevent women from passing on mitochondrial disease, will reshape Australia’s approach to genetic and reproductive technologies. Mitochondrial donation was legalised in Australia last year when ‘Maeve’s Law’ was passed in the Senate. This law reform has generated a minefield of social and ethical questions that are yet to be fully answered. What is mitochondrial disease? Mitochondria are the small but mighty structures found in all our cells (except red blood cells) that produce more than 90% of the energy used by our bodies (Cleveland Clinic, 2023). This organelle is vital for the functioning of important organs such as the heart, brain and liver (Cleveland Clinic, 2023). Mitochondria also have their own DNA, with a relatively small genome size of 37 genes (Garcia et al., 2017), compared to the 20,000 genes in our nuclear DNA (Nurk et al., 2022). Mitochondrial disease refers to a group of disorders in which ‘faulty’ mitochondria results in a range of symptoms such as poor motor control, developmental delay, seizures and cardiac disease (Mito Foundation, 2023). Half of the cases of mitochondrial disease are caused by mutations in mitochondrial DNA. These mutations are transmitted through maternal inheritance, which means that all the mitochondria in your cells are passed on from your biological mother (Mito Foundation, 2023). It is believed that about 1 in 200 people have a mutation in their mitochondrial DNA, with 1 in 5000 people having some form of mitochondrial disease (Mito Foundation, 2023). There is currently no cure for this group of conditions. How does mitochondrial donation work? Mitochondrial donation, also known as Mitochondrial Replacement Therapy (MRT), is an IVF technology which aims to prevent women from passing on mitochondrial disease to their children. For individuals with mitochondrial disease, this technology is currently the only way to have biological children without the risk of passing on their disease. MRT is used to create an embryo containing the nuclear DNA from two parents, in addition to mitochondrial DNA from an egg donor. This process involves taking the nuclear DNA from an embryo (created using the mother’s egg and father’s sperm) and inserting it into a donor egg which contains healthy mitochondria (NHMRC, 2023). The child will still inherit all of their unique characteristics, such as hair colour, through the nuclear DNA of their prospective parents. Therefore, it would be impossible to tell that an individual had been conceived through MRT simply by looking at them. Challenges in defining parenthood. Children conceived through MRT have been popularly referred to in the media as ‘three-parent babies’ since the technique creates an embryo containing DNA from three different individuals. However, this label is inaccurate and misleading. It suggests that all three parents make an equal contribution to the identity of the child, when in fact mitochondrial donors contribute only 0.1% of the child’s total genetic material. So, technically the term ‘2.002-parent babies’ would be more accurate! Under Australian law, mitochondrial donors will not have legal status as parents since their genetic contribution is not thought to influence the unique characteristics of the child. However, there are some concerns about the potential psychological impacts on children conceived through MRT, as the definition of parenthood is becoming increasingly blurry. It is possible that children conceived through mitochondrial donation will regard their mitochondrial donor as significant to their identity, considering how different their life may have looked without them. As researchers learn more about the function of mitochondria, we may indeed find that mitochondrial DNA has a greater influence on a person’s characteristics than we once thought. More recent studies have linked mitochondrial DNA to athletic performance (Maruszak et al., 2014), psychiatric disorders (Sequeira et al., 2012), and ageing (Wallace, 2010). Should mitochondrial donors remain anonymous? If mitochondrial donors contribute such a tiny amount of DNA to a child, and do not influence any of their personal characteristics, should they be obligated to disclose their identity to the recipient? Australia no longer allows egg or sperm donors to remain anonymous in order to protect the rights of individuals to know their biological origins. Yet, in the case of mitochondrial donation, there is a much smaller proportion of DNA involved. Some experts have compared mitochondrial donation to organ donation, in the sense that the donation also provides someone with the organ (or organelle) that enables them to live a healthy life, without altering their unique characteristics. It has therefore been argued that mitochondrial donation should be treated in a similar way to organ donation, allowing donors to remain anonymous. Considering that donated eggs are often in low supply, permitting anonymous donors may provide a way of improving the availability of donor eggs. It is likely that Australia will follow the lead of the UK by permitting anonymous donation. Are we ‘playing God’ by altering the genome? By making heritable changes to an individual’s genome, we are heading into new and potentially dangerous territory. Opponents of mitochondrial donation have voiced fears about the ‘slippery slope’ between trying to eradicate mitochondrial disease and taking this technology too far into the realm of ‘designer babies’. Considering that mitochondrial donation does not involve making any changes to nuclear DNA, and can only be used for medical reasons, these statements seem a bit sensationalist. However, there are some genuine reasons to be concerned about the safety of this technology and its implications for the future of humankind. While MRT is generally considered to be safe based on clinical research, there are still some uncertainties about its efficacy in clinical practice. For example, clinical research has found that there is a chance of ‘carry-over’ of unhealthy mitochondria during the MRT process (Klopstock, Klopstock & Prokisch, 2016). If this carry-over occurs, there is a potential for the numbers of unhealthy mitochondria to gradually increase as the embryo develops, essentially undoing all the hard work of creating an embryo free from mitochondrial disease. However, the percentage of carry-over is usually less than 2% and is likely to become lower as the technology advances (Klopstock, Klopstock & Prokisch, 2016). Unfortunately, we won’t know about any negative long-term impacts of MRT until we are able to observe the development of children conceived through this technology. However, adults over the age of 18 cannot be forced to participate in a study, which makes it more challenging to track long-term outcomes. An important consideration is the privacy and autonomy of these individuals - that they are not over-medicalised or viewed as some sort of ‘spectacle’ to the public. The future of mitochondrial donation in Australia. ‘Maeve’s Law’ was named in honour of Maeve Hood, a cheerful 7-year-old who was diagnosed with a rare mitochondrial disease at 18 months old. The law was passed with the aim of preventing the transmission of mitochondrial disease in Australia, which affects around fifty families each year. This revolutionary law permits the creation of a human embryo containing genetic material from three people and allows heritable changes to be made to the genome (although under strict guidelines). Such practices were previously illegal in Australia due to understandable concern that these technologies could be destructive in the wrong hands. Maeve’s Law introduces an exception to these prohibitions solely for the purpose of preventing serious mitochondrial disease. While MRT is no longer illegal in Australia, Maeve’s Law does not authorise the immediate use of MRT in clinical practice. The law outlines a two-stage approach in which the technology will be implemented, provided that clinical trials are successful. This initiative will be conducted by Monash University through the mitoHOPE (Healthy Outcomes Pilot and Evaluation) program, for which they received $15 million in funding (Monash University, 2023). Stage 1, which is expected to last around ten years, will involve clinical research aimed at improving MRT techniques and validating its safety. After an initial review, mitochondrial donation may become available in a clinical practice setting in Stage 2. Mitochondrial donation is an exciting technology which provides hope to the many Australians touched by the devastating effects of mitochondrial disease. However, it is important that more research is conducted into its safety and efficacy, as well as the long-term implications of its use. As is often the case with groundbreaking technologies such as this, the laws and policies lag behind the science. The passing of Maeve’s Law is only the start of what will be a long journey to the successful implementation of mitochondrial donation in Australia. The next ten years will be crucial in setting a precedent for how our society approaches the use of other novel genetic technologies in healthcare. The question is no longer ‘should we use mitochondrial donation?’ but ‘how can we implement this technology in a safe and ethical way?’ References Cleveland Clinic. (2023). Mitochondrial Diseases . https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases Garcia, I., Jones, E., Ramos, M., Innis-Whitehouse, W., & Gilkerson, R. (2017). The little big genome: The organization of mitochondrial DNA . Frontiers in Bioscience (Landmark Edition), 22, 710. Klopstock, T., Klopstock, B., & Prokisch, H. (2016). Mitochondrial replacement approaches: Challenges for clinical implementation . Genome Medicine, 8(1), 1-3. Maruszak, A., Adamczyk, J. G., Siewierski, M., Sozański, H., Gajewski, A., & Żekanowski, C. (2014). Mitochondrial DNA variation is associated with elite athletic status in the Polish population. Scandinavian Journal of Medicine & Science in Sports, 24(2), 311-318. Mito Foundation. (2023). Maybe Mito Patient Factsheet. https://www.mito.org.au/wp-content/uploads/2019/01/Maybe-Mito-Patient-Factsheet1.pdf Mito Foundation. (2023). Mitochondrial Disease: The Need For Mitochondrial Donation . https://www.mito.org.au/wp-content/uploads/2019/01/Brief-mitochondrial-donation-2.pdf Monash University. (2023). Introducing Mitochondrial Donation into Australia. The mitoHOPE Program. https://www.monash.edu/medicine/mitohope National Health and Medical Research Council. (2023). Mitochondrial Donation. https://www.nhmrc.gov.au/mitochondrial-donation Nurk, S., Koren, S., Rhie, A., Rautiainen, M., Bzikadze, A. V., Mikheenko, A., & Phillippy, A. M. (2022). The complete sequence of a human genome . Science, 376(6588), 44-53. Sequeira, A., Martin, M. V., Rollins, B., Moon, E. A., Bunney, W. E., Macciardi, F., & Vawter, M. P. (2012). Mitochondrial mutations and polymorphisms in psychiatric disorders. Frontiers in Genetics, 3, 103. Wallace, D. C. (2010). Mitochondrial DNA mutations in disease and aging. Environmental and Molecular Mutagenesis, 51(5), 440-450. Wicked back to

By Yvette Marris Behind the Mask By Yvette Marris 23 March 2022 Edited by Tanya Kovacevic Illustrated by Quynh Anh Nguyen It would be hard to write about A Year in Science without the obligatory COVID article. We hear constantly about the stresses of being a frontline healthcare worker, the signs and symptoms of long COVID, and the endless vaccine scepticism. I’d like to tell a slightly different story. During the COVID pandemic, other infections didn’t just take a holiday and cancers didn’t just stop growing. More ordinary illness and injury continued behind the headlines. As a consequence of the pandemic, healthcare workers are additionally dealing with an abundance of patients, delays with diagnosis and some very complex medical cases. Megan Gifford worked in a hospital that didn’t primarily treat COVID-19 patients, but still had to adapt to the constant changing of rules, regulations and policies put in place to protect staff and patients alike from the virus. Now at the Peter MacCallum Cancer Centre in Melbourne, Gifford spoke to me about her experiences working at Townsville University Hospital in the only bone marrow transplant ward servicing a large population across regional Queensland. Gifford experienced the stress and burden of trying, not only to assuage their own anxieties but to also provide current, up-to-date information to patients and deliver high quality care. There were the frustrations of unavoidable logistical problems like border closures, stay-at-home orders, preventing access to crucial materials and patient transport. There was heartbreak of watching transplant patients deteriorate mentally, as their will to persist with treatments began to fade. Pathologists and haematologists also found themselves facing an unprecedented logistical nightmare, including re-allocation of diagnostic equipment and protective equipment for mass COVID testing. Access to essential biomedical material like blood and plasma became increasingly difficult and many suffered as a result. While pandemic consequences like long COVID and the increased prevalence of affective disorders, like depression and anxiety, are well documented in media and academia, post-traumatic stress disorder (PTSD) hasn’t gotten the same amount of attention. Statistics and anecdotes alike are staggering, both for patients and healthcare workers. With stressors like an unprecedented number of critically ill patients, capricious disease progressions, high mortality, and ever-changing treatment guidelines the world was sympathetic to healthcare workers’ struggles (3). Yet with the lockdowns and restrictions over, it would be naïve to think everything would just return to normal. It was found that 29% of healthcare workers had clinical or sub-clinical symptoms of PTSD (1), and that this figure was significantly higher for healthcare workers directly treating COVID patients (2). Gifford recalled anecdotes of “patients suffering anxiety attacks when they smell the hospital alcohol rub and hear the familiar beeping of the various equipment”. Even beyond the mental health scope, logistical issues like delayed learning for medical students or the backlog of elective procedures is still placing an enormous burden on healthcare workers, despite the immediate threat seemingly behind us. But to say that everything remains in shambles would frankly be insulting to healthcare workers, who are working tirelessly to deliver good quality healthcare. The speed at which pathologists and scientists have adapted to limited resources and supply shortages, and the way in which doctors and frontline workers have shifted their style of care and developed new problem-solving skills, are exceptional and should not go unnoticed or unappreciated. Importantly, the COVID-19 pandemic and its ripple effects have brought centre stage the consequences of under-resourced healthcare centres in a way that affected all people, irrespective of geography, class or reputation. The reality is that the conditions in which many metropolitan hospitals found themselves in, with never enough staff or supplies, is a condition that some hospitals experienced long before COVID-19 ever appeared, particularly in rural settings. To say that every dark cloud has a silver lining would be horribly cliché, but in this case, there may be truth to it. This edition of A Year in Science is a chance for us to reflect on all that COVID-19 has called attention to and decide to do something about it. References Carmassi C, Foghi C, Dell’Oste V, Cordone A, Bertelloni CA, Bui E, et al. PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic. Psychiatry Research. 2020 Oct;113312. Janiri D, Carfì A, Kotzalidis GD, Bernabei R, Landi F, Sani G. Posttraumatic Stress Disorder in Patients After Severe COVID-19 Infection. JAMA Psychiatry. 2021 Feb; Johnson SU, Ebrahimi OV, Hoffart A. PTSD symptoms among health workers and public service providers during the COVID-19 outbreak. Vickers K, editor. PLOS ONE. 2020 Oct 21;15(10):e0241032. Previous article Next article

Ever thought about whether we could build the Iron Man suit? We cannot replicate it exactly, but we can find some workarounds to build parts of it with currently available technology. With the exponential growth of technology, we are getting closer and closer to building the Iron Man suit. Cinema to Reality Can We Build the Iron Man Suit? By Manthila Ranatunga We see cool and fancy gadgets in movies every now and then. How can we bring them to reality? For this issue, we take a look at the Iron Man suit. Edited by Breana Galea, Ashleigh Hallinan & Tanya Kovacevic Issue 1: September 24, 2021 Illustration by Gemma Van der Hurk Warning: Iron Man (2008) spoilers When Marvel Studios released Iron Man in 2008, it was all the rage among comic book fans, film geeks and engineers alike. The Iron Man suit is one of the coolest and most iconic gadgets in film history. A generation of mechatronics engineers were inspired after watching Tony Stark build the suit, myself included. Now we wonder whether we could build it with today’s technology. So, the question remains: can we build the Iron Man suit? We are talking about the Mark III suit, the gold and hot-rod red one. Unfortunately, replicating the suit is impossible; the laws of physics would not allow it. However, we can make some compromises and find some workarounds to build the suit’s most defining systems. The Power Source We can all agree the most vital part of the suit is the power source. After all, it gave Mr Stark the idea for the suit. The suit is powered by an arc reactor, which is essentially a fusion reactor (1). These produce power using nuclear fusion, the same way the sun and stars burn as enormous balls of fire. We are talking about reactions between atoms which are the building blocks of everything. Atoms contain a cluster of even smaller particles inside. Collectively they form the nucleus, so you can see where nuclear fusion comes from. Now, where are we going with this? Well, when nuclear fusion occurs, heat energy is produced (2). Nuclear fusion was chosen as the suit’s power source due to the colossal amount of energy it produces. With the palm of your hand acting as a size guide, nuclear fusion is one of the highest energy density methods available. Sounds too good to be true, right? Correct. To replicate the conditions required, a reactor would need to be heated to 150 million degrees Celsius (3) - 10 times hotter than the sun’s core! Imagine that on your chest! Unsettling, to say the least. Mr Stark’s arc reactor is self-sustaining and can power the suit for hours, or even days. But with modern technology, fusion reactors consume more energy than they produce (4). Consequently, recreating an arc reactor of the same size and energy output is currently impossible. Nevertheless, there are workarounds to create a partially functioning arc reactor. Massachusetts Institute of Technology (MIT) has been working on a fusion reactor called the ‘Alcator C-Mod’ for the past 20 years (5). Their goal has been to reduce their size while maintaining power output. Typical fusion reactor size ranges from three to nine metres in diameter, but MIT has managed to reduce theirs to about one. Assuming fusion reactors are net-positive energy producing and well heat-insulated, we can assemble the Alcator C-Mod into our own arc reactor. There are many more factors that are too complicated for us and thus we will ignore them. Instead of being placed on the chest, it can be a giant backpack! The Flight System Now, why do we need so much power? Well, the flight system consumes the bulk of it, which leads to the next point. In the movie, Iron Man flies using the repulsors on his gloves and boots. They are not gas turbines like jet engines. The suit does not carry fuel – how could it? It does not have any storage compartments. The fuel must come from outside of the suit. Here is a hint: it is everywhere, yet invisible at the same time... Air! Helicopters fly by pushing air downwards with their rotors. This works according to Isaac Newton’s third law, which states that any force will have an equal and opposite reaction. By pushing air downwards, the helicopter goes upwards. Iron Man does not have a giant rotor, so how did he solve this? Get ready for another round of physics! Repulsors use muon beams to control flight as needed. Muons are particles smaller than atoms. They exist in the Earth’s upper atmosphere (6), but can also be created at large research facilities. For now, let us assume Mr Stark has a way to produce them on his own; remember, he is a billionaire! The muon beams are ignited using plasma made by the heating of air. To produce this on-demand, the suit draws power from the arc reactor for heating and the suction of air. The repulsor beams are then created, ready for flight! Muons have a short lifespan - about a millionth of a second. In real life, muon storage is not a viable option; they must be generated on the spot. Muon creation occurs in particle accelerators (7). These are long tubes for accelerating and making particles collide at high speeds. You may have heard of the Large Hadron Collider in Switzerland, a particle accelerator that is 27km long. Through efforts to miniaturise them, researchers at the SLAC National Accelerator Laboratory have designed one only 30 centimetres in size (8). Ignoring some laws of physics and with a few billion dollars, we can fabricate this into our own repulsors. Keep in mind - the suit’s hands and feet are smaller than 30 centimeters. Our gloves and boots will be longer and bulkier. The Future So there we have it - a semi-reasonable arc reactor and a flight system. Fun to explore the possibilities of current technology, right? But we must also consider the ethics of building such a deadly weapon. Yes - the Iron Man suit is a weapon. In the wrong hands, this technology would not be so exciting. Centuries or even decades from now, scientific breakthroughs may allow the replication of the suit. When that happens, as humans, it will be necessary to contemplate the moral consequences of such an advancement. Here we have only examined two principal systems of the suit. The rest is up to you! Traverse your mind and create your own semi-realistic Iron Man suit. As we saw here, the Iron Man suit is not far off from our time. Who knows what the future holds? References 1, 3, 4. Trevor English, “How Does Iron Man's Arc Reactor Work?” Interesting Engineering. Published June 26, 2020. https://interestingengineering.com/how-does-iron-mans-arc-reactor-work . 2. Matthew Lanctot, “DOE Explains...Nuclear Fusion Reactions.” U.S. Department of Energy. Accessed August 30, 2021. https://www.energy.gov/science/doe-explainsnuclear-fusion-reactions . 5. Earl Marmar, “Alcator C-Mod tokamak”. Plasma Science and Fusion Center - Massachusetts Institute of Technology. Accessed August 31, 2021. https://www.psfc.mit.edu/research/topics/alcator-c-mod-tokamak 6. Paul Kyberd, “How a ‘muon accelerator’ could unravel some of the universe’s greatest mysteries”. The Conversation. Published February 20, 2020. https://theconversation.com/how-a-muon-accelerator-could-unravel-some-of-the-universes-greatest-mysteries-131415 . 7. Seiichi Yamamoto, “First images of muon beams”. EurekAlert! Published February 3, 2021. https://www.eurekalert.org/news-releases/836969 . 8. Tibi Puiu, “Particle accelerator only 30cm in size is hundred times faster than LHC”. ZME Science. Published November 6, 2014. https://www.zmescience.com/science/physics/particle-accelerator-faster-lhc-5334/ .

< Back to Issue 10 Dating Isn’t Physics – Opposites Don’t Attract by Elva Assisan 2 June 2026 Illustrated by Jessica Walton Edited by Cady Jacobson The opposites attract trope has a history of being very popular in our media, appearing quite literally everywhere from Pride and Prejudice by Jane Austen to 10 Things I Hate About You by Gil Junger. Its popularity is undoubtedly a result of the conflict and passion that this dynamic brings to a narrative. Popular culture portrays high contrast couples as those with more exciting, balanced and emotionally fulfilling lives. However, while it often looks like “you bring me out of my shell” when an introvert and extrovert meet in the beginning, it often ends in arguments about going out and staying in. Despite how popular the trope is, science suggests that opposites, in fact, do not attract. The ‘Similarity Attraction Affect’ theory proposes that individuals feel more attracted to those who are similar in attitudes (1). When people encounter those with similar attitudes, they feel affective attractions. They find that their interactions are smoother and therefore more enjoyable. Even in daily life, individuals find that they have more satisfying interactions with those that they have similarities with. When another person shares similar opinions or behaviours, it creates feelings of acceptance and emotional security. This validation strengthens self-esteem and encourages emotional closeness (1), as successful long-term relationships are usually built on compatibility and mutual understanding, rather than dramatic contrast. In addition to similarity increasing feelings of acceptance due to shared values, similarity has also been found to make communication easier. Couples who share values and lifestyles generally experience fewer misunderstandings and conflicts, as they approach situations in much the same way. If two people agree on major life decisions, such as family expectations, finances, and future goals, decision making becomes less stressful (2). On the other hand, relationships with more extreme differences become more exhausting over time as more major issues have to be resolved. Montoya, Horton and Kirchner conducted a meta-analysis examining attraction and found that both actual and perceived similarity significantly increased interpersonal attraction (3). Essentially, people are more likely to enjoy spending time with those who remind them of themselves by having shared humour, hobbies, and values. Building on this, it is not just about having similarities with another person, but having a dynamic where you are invited to act on your core traits and behaviours. For example, dominant people prefer to interact with partners who invite them to be dominant, and submissive people prefer to interact with partners who invite them to be submissive. When people have different qualities which work in conversation, that same mutual understanding is found. Another example of this is having an organised partner who remembers appointments, while the spontaneous partner ensures life contains fun, instead of colour-coded spreadsheets. Individuals are also naturally drawn to environments and relationships that reinforce their self-concept and worldview (4). Indeed, the idea that opposites attract may actually originate from this notion of complementarity. Importantly, the claim that similarity matters does not mean couples have to be the exact same. Healthy relationships still require individuality, compromise, and respect for differences. Minor differences can improve relationships by encouraging personal development and preventing boredom (2). While the idea that “opposites attract” sounds romantic and makes great material for movies, psychological research suggests that similarity is usually what keeps relationships alive, particularly once the excitement wears off. Ultimately, successful relationships are less about finding your complete opposite and more about finding someone whose weirdness matches your own closely enough that neither of you end up arguing about how to load the dishwasher every night. References Byrne D. An Overview (and Underview) of Research and Theory within the Attraction Paradigm. Journal of Social and Personal Relationships . 1997; 14 (3):417–431. doi:10.1177/0265407597143008 Luo S, Klohnen EC. Assortative Mating and Marital Quality in Newlyweds: A Couple-Centered Approach. Journal of Personality and Social Psychology . 2005; 88 (2):304–326. doi:10.1037/0022-3514.88.2.304 Montoya RM, Horton RS, Kirchner J. Is actual similarity necessary for attraction? A meta-analysis of actual and perceived similarity. Journal of Social and Personal Relationships . 2008; 25 (6):889–922. doi:10.1177/0265407508096700 Dryer DC, Horowitz LM. When do opposites attract? Interpersonal complementarity versus similarity. Journal of Personality and Social Psychology . 1997; 72 (3):592–603. doi:10.1037/0022-3514.72.3.592 Previous article back to Fact & Fiction Next article

< Back to Issue 6 Hidden in Plain Sight: The dangerous chemicals in our everyday products by Kara Miwa-Dale 28 May 2024 Edited by Zeinab Jishi Illustrated by Semko van de Wolfshaar Water bottles, lipsticks, receipts, and tinned food cans. Have you ever considered what may be lurking in these seemingly harmless daily essentials? These items all contain bisphenol A (BPA), a common endocrine-disrupting chemical (EDC). EDCs are chemicals that mimic or interfere with the endocrine system, which is responsible for producing and releasing hormones that regulate important processes in the body such as growth, metabolism, and reproduction (The Endocrine Society & IPEN, 2024). Upon being released into the bloodstream, hormones travel to their target tissues and organs, where they influence key biological functions. Hormones have specific receptors on their surface which bind to matching receptors on their target tissue. The endocrine system is an incredible feat of nature. It creates widespread and long-lasting changes throughout the body via an intricately controlled web of interactions between tiny molecules. However, a small change can be enough to tip this finely regulated balance into disarray. BPA is a type of bisphenol, which is one class among many other types of EDCs, such as phthalates, perfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs). BPA has a similar chemical structure to oestrogen, an important hormone involved in both male and female reproductive systems. This enables BPA to ‘mimic’ oestrogen; essentially tricking oestrogen receptors into activating in the absence of oestrogen. BPA is known to cause a wide range of negative health impacts, such as reproductive, metabolic, and neurological issues (The Endocrine Society & IPEN, 2024). But don’t just take my word for it. The toxicity of BPA has been debated over many decades, ever since it was first linked to health issues in the 1970s. It has been challenging to generate evidence relating to the toxicity of BPA, given the ethical concerns of deliberately exposing people to EDCs. As a result, scientists have mainly used animal models, alongside studies examining the correlation between EDC exposure and disease, to investigate the action of BPA. Research strongly indicates that elevated exposure to BPA is correlated with poorer egg quality and higher miscarriage rates in women, alongside a reduction in sperm count in men (Matuszczak et al., 2019). BPA is also a known obesogen (a hormone which disrupts metabolism, increasing risk for obesity), supported by a recent study indicating the odds of adult obesity rise by 15% for every 1 nanogram/mL increase in the concentration of their urinary BPA (Wu et al., 2020). Even more concerningly, BPA has been found to have epigenetic effects, which are heritable chemical modifications to DNA which regulate how genes are turned on and off. Scientists were able to demonstrate these epigenetic effects by exposing rats to BPA and allowing them to breed for multiple generations. In this study, rates of obesity and reproductive disease were increased in all subsequent generations of rats, despite only the first generation being directly exposed to BPA (Manikkam et al. 2013). Considering that BPA has been used commercially since the 1950s, it is probable that these epigenetic effects have been compounding in humans with each passing generation. Without intervention, the consequences of ongoing BPA exposure are likely to intensify. It is deeply concerning that BPA remains ubiquitous in the community, with more than 7 million tonnes produced each year (Manzoor et al., 2022). Given its presence in a multitude of everyday products, BPA exposure is essentially impossible to avoid. Detectable levels of BPA are present in nearly all children and adults, and even developing foetuses (Calafat et al., 2004). Mounting evidence for the toxicity of BPA is prompting scientists to call for greater measures in preventing harmful exposure to BPA and other EDCs. What is being done by policy makers to address this issue? I sat down with A/Prof Mark Green, an Associate Professor in Reproductive Biology at the University of Melbourne, to discuss the current research around EDCs and the measures that can be taken to protect the public from their damaging effects. Are BPA-free labels just illusions of safety? There has been a shift towards manufacturing products labelled ‘BPA-free’, such as BPA-free water bottles. This sounds great on the surface: purchase the ‘BPA-free’ water bottle and sleep well knowing that you’re taking proactive action to protect your health. Unfortunately, these efforts may be in vain. As companies manufacturing EDC-containing items have a vested interest in their products being approved as safe, many of these ‘BPA-free’ products are simply being replaced with other bisphenols (e.g. bisphenol F, or BPF), which are suspected to have similar or even worse effects compared to BPA (Wiklund & Beronius, 2022). Fortunately, some countries have started looking towards more holistic ways of regulating suspected EDCs, as noted by A/Prof Green: ‘A positive step forward is that the USA and EU are starting to think about regulating whole classes of chemicals, rather than individual chemicals.’ Introducing this new approach will help to ensure that manufacturers can’t simply switch to a similar (but unregulated) chemical when one is banned. Redefining toxicity: Does the dose make the poison? Another key issue is the current way that EDCs are evaluated for toxicity. A historical principle of toxicology (which has later been challenged) is the idea that ‘the dose makes the poison’. This theory proposes that substances with ‘toxic’ properties only cause us harm if we are exposed to a certain ‘threshold’ amount. In other words, if someone is exposed to five times the amount of a chemical, they will observe five times as much of an effect on their health. However, scientists have found that many EDCs don’t behave in this way. There are some instances where lower doses may, in fact, lead to more severe effects. As A/Prof Green aptly puts, there may be no such thing as a ‘safe dose’ for some EDCs. Blind spots in EDC regulatory testing: Are vulnerable populations overlooked? Regulatory testing procedures often underestimate the negative impact of EDCs by disregarding how hormones affect people differently throughout the lifespan. Embryonic development is a critical period in which exposure to EDCs can have disproportionately large impacts on health compared to exposure in adults. Choi and colleagues (2016) studied the consequences of BPA exposure on developing cattle embryos and observed that even short-term exposure had concerning repercussions on their development and metabolism. Nost testing procedures fail to take these endpoint measures into account. A/Prof Green pointed to examples of toxicology testing in which ‘rates of death and tumours in adult male rats were used as an end point measure to define toxicity, which had nothing to do with more subtle effects on reproduction’. Context matters: Navigating EDC regulation in the real world Another factor to consider is that these individual EDCs don’t exist in a vacuum; the reality is that we are exposed to a ‘soup’ of many different chemicals every day. A/Prof Green noted the inefficiency of testing individual chemicals for endocrine-disrupting properties: ‘Historically a lot of these EDCs have been studied individually, but we don’t know what happens with all the different compounds when they go together, and which combinations are worse. Investigating EDC mixtures is a big gap of knowledge.’ In isolation, small doses of EDCs may not result in any adverse impacts on human health. That said, the interaction of many EDCs may have severe consequences (Conley et al., 2021). These interactions may explain the conflicting evidence surrounding EDCs, where some studies reveal significant effects and others do not. A/Prof Green is currently investigating the impacts of EDC mixtures on human health in relation to the ‘exposome’, which is the cumulative effect of the environmental exposures we encounter throughout our lives (e.g. chemicals, air pollutants, radiation, food). He hopes that a better understanding of these complex interactions will allow us to make more informed decisions about how to regulate EDCs. Paving the path towards a healthier future Unfortunately, the economic interests of companies producing EDC-containing products compete with the implementation of necessary policies. Given the suspected epigenetic effects of EDCs like BPA, taking a more cautious but proactive approach in regulating EDCs seems to be a wise course of action. The burden created by EDCs is huge, with attributable annual disease costs estimated to be $340 billion USD in the USA, and $217 billion USD in the EU (Malits et al., 2022). What can we do as consumers? Are we resigned to bathing in a cocktail of EDCs, awaiting our descent into a dystopian nightmare reminiscent of ‘The Handmaid’s Tale’? Despite the disheartening reality of EDCs, there is room for hope. Scientists are working hard to find safer alternatives to materials containing EDCs, and a growing number of chemicals are facing bans or stricter regulation. The first step in mitigating the negative consequence of these chemicals is increasing awareness about EDCs and reducing our personal exposure to them. Here are 5 tips from A/Prof Green that can help you to avoid unnecessary exposure to EDCs: 1. Don’t drink from plastic water bottles, especially if they have been left in a hot environment. 2. Don’t reheat food in plastic containers - use a microwave-safe bowl or plate instead. When storing leftover food, let it cool before transferring to plastic containers. 3. Try to reduce consumption of tinned foods, as these are lined with plastic resins. 4. Avoid handling receipts, as these are covered in BPA. 5. Ventilate your home and avoid perfumes or sprays with strong smells – these often contain EDCs. To encourage governments and industrial regulators to enforce stronger legislation and tighter controls on EDCs, it is essential to empower consumers and advance scientific research. While our direct influence on policy decisions may be limited, as consumers, we possess the power to drive positive change, promoting public health not only in the present but for generations to come. For some more information, check out these great resources about EDCs: https://www.yourfertility.org.au/everyone/drugs-chemicals https://endocrinedisruption.org/ https://www.ewg.org/ References Calafat, A. M., Kuklenyik, Z., Reidy, J. A., Caudill, S. P., Ekong, J., & Needham, L. L. (2005). Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environmental Health Perspectives , 113 (4), 391-395. https://doi.org/10.1289/ehp.7534 Choi, B. I., Harvey, A. J., & Green, M. P. (2016). Bisphenol A affects early bovine embryo development and metabolism that is negated by an oestrogen receptor inhibitor. Scientific Reports , 6 (1), 29318. https://doi.org/10.1038/srep29318 Conley, J. M., Lambright, C. S., Evans, N., Cardon, M., Medlock-Kakaley, E., Wilson, V. S., & Gray Jr, L. E. (2021). A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat. Environment International , 156 , 106615. https://doi.org/10.1016/j.envint.2021.106615 Gore, A.C., La Merrill, M.A., Patisaul, H.B., and Sargis, R. (2024). Endocrine Disrupting Chemicals: Threats to Human Health. The Endocrine Society and IPEN. https://ipen.org/sites/default/files/documents/edc_report-2024-final-compressed.pdf Malits, J., Naidu, M., & Trasande, L. (2022). Exposure to endocrine disrupting chemicals in Canada: population-based estimates of disease burden and economic costs. Toxics , 10 (3), 146. https://doi.org/10.3390/toxics10030146 Manikkam, M., Tracey, R., Guerrero-Bosagna, C., & Skinner, M. K. (2013). Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PloS One , 8 (1), e55387. https://doi.org/10.1371/journal.pone.0055387 Manzoor, M. F., Tariq, T., Fatima, B., Sahra, A., Tariq, F., Munir, S., Khan, S., Ranhja, M. M. A. N., Sameen, A., Zeng, X., & Ibrahim, S.A. (2022). An insight into bisphenol A, food exposure and its adverse effects on health: A review. Frontiers in Nutrition , 9 . https://doi.org/10.3389/fnut.2022.1047827 Matuszczak, E., Komarowska, M. D., Debek, W., & Hermanowicz, A. (2019). The impact of bisphenol A on fertility, reproductive system, and development: a review of the literature. International Journal of Endocrinology , 2019 . https://doi.org/10.1155/2019/4068717 Wu, W., Li, M., Liu, A., Wu, C., Li, D., Deng, Q., Zhang, B., Du, J., Gao, X., & Hong, Y. (2020). Bisphenol A and the risk of obesity a systematic review with meta-analysis of the epidemiological evidence. Dose-Response , 18 (2). https://doi.org/10.1177/1559325820916949 Previous article Next article Elemental back to