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From the Editors-in-Chief Issue 1: September 24, 2021 Images provided by the OmniSci Team Patrick Science is more than the ghostly green of life on agar, more than the dust-white scrawl on the blackboard, more than the speckled-ink sky that embraces our eggshell Earth; science is a way of viewing the world with curiosity and naked wonder. There is scholarship in science, but science has forever existed without scholarship. For many, the joy of science communication lies in reaching and nourishing the scientist within people; science communicators encourage people to see this different perspective and see it often. Likewise, the importance of science communication lies in making science accessible to all. Despite the rigor of trials, p-values, simulation, and the scientific method, there is no reason that scientific research should not reach all audiences. When populists conflate expertise with elitism, we know that we have failed to share science with the world. ‘Scientist’ is not shorthand for lab coat and goggles – it is a spark shared by every member of the human race. Felicity Our common belief in the importance of science communication continues to inform our vision and mission for OmniSci. We believe that creating a platform on which students can practice and hone their communication skills is the key to a future of responsible science communication. The skills we strive to spotlight and develop as a magazine extend not only to the written form, but to graphic art and photography, too. As a wholly student-run magazine, we aim to make our magazine accessible to readers from all skill levels and disciplines, encouraging a general interest in science from outside the field as well! Ultimately, our mission is to engage students and the general public with thoughtful, well-researched and balanced science topics, all the while providing a platform to help the science communicators of the future grow. Maya When deciding on a name for our magazine, we endeavoured to find a name that would encompass all fields of science. We decided to search for affixes derived from Latin and Greek. And what did we come across? Omnis, the Latin prefix meaning all. Of course, this perfectly suited our aspiration to be inclusive of every field of science. So we decided to combine omni and science together, finally shortening it to OmniSci; this directly led us to the theme for our first issue, “Science is Everywhere”. Every day we come across millions of phenomena that can be explained by science. For example, we would not be able to understand the amazing processes of gravitational pull and digestion without physics and chemistry, respectively. We are fortunate enough to be witnesses and beneficiaries of these amazing events. However, we are not privileged enough to understand how and why all of them occur. For our very first issue of OmniSci Magazine, we wanted to share with our readers a little more insight into the way our incredible world works. Have you ever wondered about how trees communicate with one another? Or have you ever been curious about the importance of sleep and its impact on dreams? These questions, amongst many others, will be answered in this issue, and we hope you enjoy discovering a little more, that science truly is everywhere. Sophie We couldn't conclude without acknowledging the incredible people who brought this magazine to life! Thank you to everyone who submitted photography and art for our National Science Week competition - we were stunned by the beautiful submissions, and honoured to be able to feature them in our first issue. A special thank you goes to Natalie Gibley from the University of Melbourne for her help in making the competition happen! We are especially grateful for the never-ending support, passion and enthusiasm of Dr Jen Martin. From Zoom calls and endless emails, to workshops on writing and editing, Dr Martin has been an invaluable mentor for our team, and an incredible champion for science communication among students at the University of Melbourne. Finally, thank you to our amazing writers, editors, graphics designers, social media and web development officers. We couldn't have asked for a better team of students to start on this journey with us, and we are so excited to see what we create in the future! Your editors-in-chief, Sophia, Maya, Patrick and Felicity Edited by Tanya Kovacevic

< Back to Issue 9 Living Pixels by KJ Srivastava 28 October 2025 Illustrated by Max Yang Edited by Nirali Bhagat We’ve all seen those hypnotic videos of colour-changing animals – a cuttlefish pulsing stripes across its body, a chameleon melting from green to gold, or an octopus vanishing into coral like a magician’s smoke bomb. Their skin shifts hues like it’s nothing. But how do they actually do that? Take starfish, for instance. They don’t seem to have eyes, yet somehow they “know” what their surroundings look like. Cephalopods, your octopuses, squids, and cuttlefish, go even further, creating patterns that match their environment with uncanny precision. How can they pull that off if they can’t even see any details around them? Seeing Without Eyes? A chromatophore is a specialised cell found in animals, and even some bacteria, that contains pigment or reflects light. You’ll find them across the animal kingdom: in fish, frogs, chameleons, and even in certain bacteria (yes, microbes get to have fun too). Depending on the species, chromatophores come in different flavours. Some are pigment-based, like those filled with melanin (the same as in human skin), while others use microscopic structures to bend and reflect light, acting like natural nanotech (1). Under white light, chromatophores are often classified by the colour they show off – red, brown, blue, green, and the iridescent in-betweens. In vertebrates like fish and reptiles, these cells sit in neat layers under the skin, filtering and bouncing light to produce a kaleidoscope of shades. Chromatophores 101: Nature’s Colour Cells In creatures like octopuses and cuttlefish, chromatophores are tiny, elastic sacs filled with pigment. These sacs are surrounded by radial muscle fibres which are wired to the nervous system. When the animal wants to display a colour, it sends a signal that contracts those muscles, pulling the pigment sac open like an umbrella. The expanded pigment becomes visible on the surface. Relax the muscle and the sac snaps shut – colour gone! So instead of pigment just sitting there passively, the cephalopod is actively controlling its skin colour with muscle contractions, at speeds fast enough to create those mesmerising rippling patterns. All these changes are actively, neurally controlled; they're not automatic like blushing. They're often voluntary, and dynamic, responding to things like light, mood, temperature, and stress (2). In fact, cephalopod chromatophores are sensitive to direct electrical stimulation. One study found that when researchers applied oscillating electrical patterns to the squid Sepioteuthis lessonia, the pigment sacs expanded and contracted in synchronised, wave-like patterns under 1.5Hz; essentially, we can rhythmically ‘play’ these cells like an instrument! (1) Chromatophores in vertebrates work a bit differently. Instead of opening and closing sacs, the pigment inside the cell moves around, spreading out when the colour needs to be more visible, clustering together when it doesn't. Still responsive, still cool, just a little less… flashy. Layers, Pigments, and Light Tricks Here’s where things get really interesting. Chromatophores aren’t all for show. They’re sensitive to light, chemistry, and electrical signals, which makes them incredibly valuable for science and technology! Some fish chromatophores, for example, visibly change colour in the presence of toxins like cholera and pertussis. They detect these threats in real time, with the colour change varying with concentration, meaning you can even tell how much of a toxin is there, not just whether it is present (3). That makes them powerful candidates for biosensors, living tools that can monitor environmental or biological conditions. Why is it a big deal? Unlike traditional sensors made of synthetic materials or inert components, chromatophore-based systems are made of living cells. They keep reacting, adapting, and functioning over time, giving them an edge in sensitivity, flexibility, and longevity (2). While chromatophores already act as living, colour-changing pixels, researchers are exploring how to use them in adaptive camouflage technologies. Imagine a bandage that shifts colour when it detects infection, the moment bacteria start to grow, not just after the infection has spread. Or ocean sensors that monitor salinity and pollution, while blending seamlessly into coral reefs so as not to disturb marine life. All of these possibilities are made an achievable reality by these remarkable sacs of pigment! These amazing cells offer a glimpse at what happens when evolution builds something both beautiful and functional. Next time you see a chameleon vanish into a leaf, or an octopus ripple with light like a living mood ring, take a second to think about what’s really going on under the surface. Behind every colour shift is a tiny symphony of biology and physics, all working together in real time. And the best part? It’s still magic. It doesn't stop being magic when we figure out how it works! References Lei Y, Chen W, Mulchandani A. Microbial biosensors. Analytica chimica acta . 2006;568(1-2):200-10. doi: 10.1016/j.aca.2005.11.065 Tan L, Schirmer K. Cell culture-based biosensing techniques for detecting toxicity in water. Current opinion in biotechnology . 2017;45:59-68. doi: 10.1016/j.copbio.2016.11.026 Plant TK, Chaplen FW, Jovanovic G, Kolodziej W, Trempy JE, Willard C, Liburdy JA, Pence DV, Paul BK. Sensitive-cell-based fish chromatophore biosensor. InBiomedical Vibrational Spectroscopy and Biohazard Detection Technologies 2004;5321;265-274. doi: 10.1117/12.528093 Kim T, Bower DQ, Deravi LF. Cephalopod chromatophores contain photosensitizing nanostructures that may facilitate light sensing and signaling in the skin. Journal of Materials Chemistry C . 2025;13(3):1138-45. doi: 10.1039/D4TC04333B Previous article Next article Entwined back to

< Back to Issue 4 Fool Me Once by Julia Lockerd 1 July 2023 Edited by Tanya Kovacevic and Elijah McEvoy Illustrated by Sonia Santosa I have rabies. I’m absolutely sure of it. I mean, I can't really tell, but that’s the silent killer, right? You don’t know you’re rabid till it’s all over, and you’re foaming at the mouth and biting your student tutor on the leg. Despite being completely safe here in Australia with its complete lack of rabies-having animals, I’m still pretty sure I’ve managed to catch it. Next week it will all be over for me and my tutor. Sorry, James. Of course, it’s not actually rabies that I’ve contracted, but a much more common condition: Medical Student Syndrome (1). Last week in my lectures, we learned all the ins, outs, and symptoms of the rabies virus. So, naturally, now we all have it. This health-related anxiety is a prime example of how our human brains can trick us into experiencing phantom symptoms. The same cognitive veil is used in clinical trials all over the world in order to test the efficacy of new drugs. We’ve all felt it. That moment when you question, ‘Is this real, or is my mind making its reality?’ We call this the placebo effect. The placebo effect is crucial to modern and historical experimental design. The ‘trickable’ nature of the human mind has changed the course of drug development as we know it. The effects’ success hinges on a patient's belief that they are receiving treatment for their ailment. The simple belief in a cure can often result in real physiological changes in an individual. This makes the placebo effect a very powerful tool in the development of new drugs for the market. In a placebo-controlled trial, half of the sample population will be blindly given a placebo, and the other half of the drug being tested. In order for a potential treatment to be considered effective, it must produce more significant results than the placebo group (2). We must improve our approach to designing and researching hypotheses. Can we use what we know about the placebo effect to make more accurate claims about modern pharmaceutical development? Well, in 2017, Dr. Sara Vanbheim of the Arctic University of Norway published a study that brought into consideration the possible effects of differing sexual characteristics on placebo efficacy (3). This idea could restructure the way experiments are designed going forward and potentially provoke a possible review of drugs already on the market. Is it possible that traditionally marginalised groups are underrepresented in the clinical trial process? Can we restructure experiments to be more inclusive? Are changes even really necessary? These questions were investigated through the compilation and calculation of placebo and nocebo effects on men and women over multiple previously conducted studies mostly centering around physical pain and the administration of analgesia. The term ‘nocebo’ defines the antithesis of a placebo (4), referring to adverse side effects a subject feels when given an inert version of the test drug. While placebos tend to have an analgesic effect, nocebos often cause negative effects or emotions when the subjects are told that they should expect/anticipate them. Before discussing any of these questions, it is worth noting that the Norwegian study focuses solely on classic sexual differences between cis-gender men and women. Though both keywords ‘gender’ and ‘sex’ were included in the study, research surrounding the specific effects of gender identity and gender-affirming therapies on placebos has not been thoroughly conducted as of 2023. It is with this focus that the following hypotheses are stated (3): “1) placebo responses would be stronger or more frequently observed in males than in females, 2) nocebo responses would be stronger or more frequently observed in females than in males, 3) verbally induced placebo responses would be more frequently observed in males than in females, and 4) conditioned nocebo responses would be more frequently observed in females than in males.” Results concluded that there was indeed a significant correlation between sex and placebo/nocebo effects when concerning pain relief. But what is truly fascinating is that while men received elevated levels of a placebo effect, such as reduced symptoms and analgesia, women were more susceptible to hyperalgesia and negative emotions. Those supposed ‘side effects’ appear to weigh more heavily on women (3). What does this say about how men and women process pain and information? The Norwegian study discusses the role of ‘psychophysiological mechanisms’ in pain pathways. Or, more simply, How stress and anxiety can affect the pain the brain perceives. In 8 of the 12 studies, men experienced significantly stronger analgesic effects from the placebo than women (3). It is plausible that men react more strongly to pain induced by stress hormones. This would explain why when taking a placebo, their anxiety level would decrease, and they would receive higher levels of analgesia than their female counterparts (3). Another study, upon which the Norwegian argument builds, investigates placebo delivery methods and their effect on perceived pain in men and women. In this study, men relied far more on verbal queues to provide analgesia, whereas women received a more significant effect from classic conditioning (5). These studies bring into question both the methodological and physiological effects of placebos on different sexes. What do these differences tell us about how men and women perceive the world? And what does this mean for the future of the placebo? The result of all of these studies is to show not whether placebos are bad or good, reliable or unreliable, but instead to highlight the differences in the physiological and psychological links when looking at different groups of people. At its core, a placebo is simply a trick of the brain, a psychological mirage. While the basis and reliability of placebos can be debated at length, their effect on the human brain teaches us something about ourselves societally. In all areas of medicine, the inclusion of people from all different backgrounds, genders, ethnicities, and ages is crucial so professionals know how to identify and treat various manifestations of a disease with grace and care. Now I know James responds better to verbal commands; I’ll be sure to tell him he has rabies the next time I see him. References Henning Schumann J. I contracted medical student syndrome. You probably will too. [Internet]. AAMC. [cited 2023 Jun 22]. Available from: https://www.aamc.org/news/i-contracted-medical-student-syndrome-you-probably-will-too Harvard Health Publishing. The power of the placebo effect - Harvard Health [Internet]. Harvard Health. Harvard Health; 2021. Available from: https://www.health.harvard.edu/mental-health/the-power-of-the-placebo-effect Vambheim S, Flaten MA. A systematic review of sex differences in the placebo and the nocebo effect. Journal of Pain Research. 2017 Jul;Volume 10:1831–9. National Cancer Institute NCI. Definition of nocebo effects [Internet]. www.cancer.gov . 2011. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/nocebo-effect Enck P, Klosterhalfen S. Does Sex/Gender Play a Role in Placebo and Nocebo Effects? Conflicting Evidence From Clinical Trials and Experimental Studies. Frontiers in Neuroscience. 2019 Mar 4;13. 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< Back to Issue 7 Interstellar Overdrive: Secrets of our Distant Universe by Sarah Ibrahimi 22 October 2024 edited by Hendrick Lin illustrated by Amanda Agustinus “Somewhere, something incredible is waiting to be known” - Carl Sagan Humanity's innate curiosity and desire of uncovering the unknown has been the spark for mankind's explorations since the beginning of time. From Columbus' expedition across the Atlantic to discover the New World, to Armstrong's first steps on the Moon's surface, we have experienced technological advancement at a lightning pace over the course of human history. Perhaps the most enthralling of these advances has been the scientific quest to unveil the true nature of our universe - the stars, the planets and the beings that exist within it and far beyond. And now, a novel and revolutionary tool has been developed to deepen our understanding of the cosmos. The James Webb Space Telescope (JWST) developed by NASA is the largest of its kind to ever be placed in space. Launched on Christmas Day in 2021 on board the Ariane 5 rocket, it travelled 1.5 million kilometres equipped with various high-resolution and high-sensitivity instruments, allowing scientists the ability to capture detailed infrared astronomical images of our old and distant universe (NASA, 2022a). In a matter of less than a year, the deepest infrared image known to mankind was produced. Named Webb's First Deep Field, it was unveiled by U.S. President Joe Biden on June 11th, 2022 at the White House, encapsulating never-before-seen perspectives of our universe. With this revelation, a new gateway has been opened into answering the countless questions of the early universe pondered by astrophysicists and the public alike. Confronting viewers with an array of contrasting colours and eccentric shapes, Webb’s First Deep Field can be hard to interpret ( figure 1 ). Figure 1. Webb’s First Deep Field: SMACS 07223 Note. From/Adapted from Webb’s First Deep Field: SMACS 07223 [photo] by James Webb Space Telescope. NASA, 2022b. https://webbtelescope.org/contents/media/images/2022/035/01G7DCWB7137MYJ05CSH1Q5Z1Z?page=1&keyword=smac Copyright 2022, NASA. But with a careful eye and some clever detective work, we can begin to decipher the secrets contained within. For example, the bright lights depicting what appear to be stars are rather entire galaxies, each a gateway to billions of stars. In addition, Webb’s Near-Infrared Camera (NIRCam) is able to capture distant galaxies with the sharpest focus to date, unravelling important features from their faint complexities. Appreciation for this image increases exponentially once we begin to comprehend the magnitude of its importance - it depicts the galaxy cluster, SMACS 0723, exactly as it looked 4.6 billion years ago! In other words, this image is a glimpse back to a time well before humans or any life forms existed. Amongst the myriad of initial images produced by JWST, one particular point of interest would be the Southern Ring Nebula illustrating the dying NGC 3132 star ( figure 2 ). This can be seen through the expulsion of its gases and outer layers, producing striking imagery through Webb’s NIRCam. Viewers may also notice the bright lights representing individual galaxies in the nebula's background - again, not to be mistaken as stars. JWST’s ability to capture such a pivotal point in the trajectory of a star's life is crucial in assisting scientists to calculate the volumes of gas and dust present, as well as their unique molecular compositions. Figure 2. Southern Ring Nebula captured by JWST Note. From/Adapted from Southern Ring Nebula [photo] by James Webb Space Telescope. NASA, 2022c. https://webbtelescope.org/contents/media/images/2022/033/01G70BGTSYBHS69T7K3N3ASSEB Copyright 2022, NASA. The efforts to produce such groundbreaking images and insights into the universe did not happen overnight. The Hubble Space Telescope, launched in 1990, was an important predecessor to the JWST. Whether it was confirming the existence of black holes, or the Nobel Prize winning discovery demonstrating the accelerating rate of expansion of the universe, the Hubble Space Telescope laid the foundations for the JWST to flourish. These marvellations revealed by the JWST would also not be possible without the efforts of countless scientists to improve the technological potential of the Hubble Telescope. As a result of these developments, JWST contains a larger primary mirror, deeper infrared vision, and is optimised for longer ultraviolet and visible wavelengths, all with the aim to increase the telescope’s ability to capture profound images of our universe. Nonetheless, a number of hypotheses relevant to matters such as dark energy, exoplanets, and infrared astrophysics remain unanswered. As a next step forward, the Nancy Grace Roman Space Telescope is set to launch in 2027 with the capacity to produce a panoramic view two hundred times greater than the infrared view generated by Hubble and JWST. The questions that continue to itch our minds remain limitless. As Einstein once lamented, "the more I learn, the more I realise how much I don't know”. There is still so much that remains to be discovered. However, the JWST illustrates that through collaborative scientific efforts, humankind can begin to unravel the many mysteries that govern our universe, one galaxy at a time. References NASAa. (2022, July 12). NASA’s Webb Delivers Deepest Infrared Image of Universe yet. https://www.nasa.gov/image-article/nasas-webb-delivers-deepest-infrared-image-of-universe-yet/ NASAb. (2022, July 11). Webb’s First Deep Field . Webb Space Telescope. https://webbtelescope.org/contents/media/images/2022/035/01G7DCWB7137MYJ05CSH1Q5Z1Z?page=1&keyword=smac NASAc. (2022, July 11). Southern Ring Nebula. Webb Space Telescope. https://webbtelescope.org/contents/media/images/2022/033/01G70BGTSYBHS69T7K3N3ASSEB Previous article Next article apex back to

By Juulke Castelijn < Back to Issue 3 Believing in aliens... A science? By Juulke Castelijn 10 September 2022 Edited by Tanya Kovacevic and Ashleigh Hallinan Illustrated by Quynh Anh Nguyen Next The question of the existence of ‘intelligent life forms’ on a planet other than ours has always been one of belief. And I did not believe. It was probably the image of a green blob with multiple arms and eyes squelching across the ground and emitting noises unidentifiable as any form of language which turned me off the whole idea. But a book I read one day completely changed my mind; it wasn’t about space at all, but about evolution. ‘Science in the Soul’ is a collection of works written by the inimitable Richard Dawkins, a man who has argued on behalf of evolutionary theory for decades. Within its pages, you will find essays, articles and speeches from throughout his career, all with the target of inspiring deep rational thought in the field of science. A single essay gives enough food for thought to last the mind many days, but the ease and magnificence of Dawkin’s prose encourages the devourment of many pages in a single sitting. The reader becomes engulfed in scientific argument, quickly and completely. Dawkins shows the fundamental importance of the proper understanding of evolution as not just critical to biology, but society at large. Take, for instance, ‘Speaking up for science: An open letter to Prince Charles,’ in which he argues against the modelling of agricultural practices on natural processes as a way of combating climate change. Even if agriculture could be in itself a natural practice (it can’t), nature, Dawkins argues, is a terrible model for longevity. Instead, nature is ‘a short-term Darwinian profiteer’. Here he refers to the mechanism of natural selection, where offspring have an increased likelihood of carrying the traits which favoured their parents’ survival. Natural selection is a reflective process. At a population level, it highlights those genetic traits that increased chances of survival in the past. There is no guarantee those traits will benefit the current generation at all, let alone future generations. Instead, Dawkins argues, science is the method by which new solutions to climate change are found. Whilst we cannot see the future, a rational application of a wealth of knowledge gives us a far more sensitive approach than crude nature. Well, perhaps not crude per se. If anyone is an advocate for the beauty and complexity of natural life, it is surely Dawkins. But a true representation of nature, he argues, rests on the appreciation of evolution as a blinded process, with no aim or ambition, and certainly no pre-planned design. With this stance, Dawkins directly opposes Creationism as an explanation of how the world emerged, a battle from which he does not shy away. Evolution is often painted as a theory in which things develop by chance, randomly. When you consider the complexity of a thing such as the eye, no wonder people prefer to believe in an intelligent designer, like a god, instead. But evolution is not dependent on chance at all, a fact Dawkins argues many times throughout his collection. There is nothing random about the body parts that make up modern humans, or any other living thing - they have been passed down from generation to generation because they enhanced our ancestors’ survival. The underlying logic is unrivalled, including by religion. But that doesn’t mean Dawkins is not a man of belief. Dawkins believes in the existence of intelligent extraterrestrial life, and for one reason above all: given the billions upon billions of planets in our universe, the chance of our own evolution would have to be exceedingly small if there was no other life out there. In other words, we believe there is life out there because we do not believe our own evolution to be so rare as to only occur once. Admittedly, it is not a new argument but it had not clicked for me before. Perhaps it was Dawkins’ poetic phrasing. At this stage it is a belief, underlined by a big ‘if’. How could we ever know if there are intelligent life forms on a planet other than Earth? Dawkins provides an answer here too. You probably won’t be surprised that the answer is science, specifically a knowledge of evolution. We do not have to discover life itself, only a sign of something that marks intelligence - a machine or language, say. Evolution remains our only plausible theory of how such a thing could be created, because it can explain the formation of an intelligent being capable of designing such things. We become the supporting evidence of life somewhere else in the universe. That’s satisfying enough for me. Previous article Next article alien back to

By Hazel Theophania < Back to Issue 3 Existing in an Alien World: Navigating Neurodiversity in a System Built for Someone Else By Hazel Theophania 10 September 2022 Edited by Breana Galea and Ruby Dempsey Illustrated by Janna Dingle Next Content warnings: Ableism, mental illness. Have you ever read something that just makes everything click into place? For me, it was that autism is characterised by a difficulty in forming and understanding ‘second-order representations’1. Let me explain: A ‘first order representation’ is the face value, the direct interpretation of an object or event. A ‘second order representation’ is the underlying meaning, the non-literal association with an object or event. Autistic people struggle with the latter. Allistic (non-autistic) people don’t, and for them it’s intrinsic in a large part of communication – nonverbal cues and gestures, sarcasm, undertones, passive aggression, politeness and more complex events like communication of social hierarchy all take place beneath the veneer of explicit communication. They rely on the ability to interpret another’s actions based on extrapolating their perspective. Rather than being automatic for autistic people, doing so is a learned, active behaviour, and one that is taxing to maintain and use. Reading this explanation was epiphanous for me for two reasons: it concisely explained why I and other autistic people I knew had such trouble navigating and communicating in social interactions, and it clarified why conflict and miscommunication arose so frequently. It contextualised and validated the way I experience and understand the world. Autistic communication is direct, predominantly using first order representation. It doesn’t soften effect or hide meaning with subtext; conversely it has difficulty picking up on inference and implication from others. So many times I have answered questions or followed instructions ‘incorrectly’, because I’ve addressed the words and not the implied meaning underneath. Much of boundary setting and emotional communication in social relationships is implicit - are they ‘acting’ interested? Does it ‘feel’ like they are reciprocating? Can you ‘tell’ that they want to be friends? - inability and difficulty in reading those complex second order representations makes navigating those situations painful and confusing. These struggles and anxieties make it much harder for autistic individuals to make and maintain friendships (3). Sedgewick and Pellicano (3) found that both autistic girls and boys report weaker friendships with more conflict than their neurotypical peers. They experience more victimisation, autistic girls especially, from bullying and other relational aggression, and experience far more insecurity around their friendships. The authors identify “both autistic and neurotypical girls alluded to wanting to fit in, but in different ways.” The neurotypical girls in the study were more concerned with securing a place in the social hierarchy – appearing cool and fitting in with the popular crowd - whether through dating or other means. For the autistic girls it was about finding people who actually accepted them as themselves; fitting in was not about adhering to social expectations, but about finding friends where they didn’t have to. Bury and Hedley (5) found much the same issues in analysing the problems autistic people face in the workplace. While the work itself was no more trouble for autistic individuals than their neurotypical counterparts, navigating the social aspects of a workplace drastically increased the stress and drain on autistic employees. Issues can arise from relative trivialities like dealing with food or birthday wishes, up to serious conflicts that jeopardise their employment. The same communication and relational issues that lead to autistic individuals struggling socially can have more serious consequences when the miscommunication and conflict arise when interacting with an authority, such as a boss or supervisor. Problems stem from unclear instructions, not adhering to unwritten or unspoken rules (social and otherwise), interrupting and socialising at wrong times – everything that relies on being able to determine and pick up on implicit communication. In other words, being autistic has career consequences. Now, having anxiety or depression aren’t intrinsic to being autistic (6). They’re not part of the same dysfunction in development. However, something about being expected to negotiate a minefield of implicit communication that others grasp intuitively leads to an extreme coincidence of autism with both anxiety and depression. The social ostracism and punishment for violating rules you’ve never been taught casts a slight shadow over every interaction. The starkly increased incidences of bullying and victimisation autistic youth go through may also contribute to mental illness. Mayes, Murray and their team7 write: “It is quite possible that youth with ASD (youth with Autism Spectrum Disorder (ASD) ) face considerable challenges during the transition from childhood to adolescence. Social difficulties and awareness of being different from others, especially during the teen years, may lead to problems with anxiety, depression, or hostility.” They reported anxiety in autistic children ranging from 67% to 79% depending on the severity of their traits, and depression affecting between 42% and 54% likewise – in comparison to anxiety occurring in 8% of children and adolescents8 and depression in 5% of children, 17% of adolescents13, and 5% of adults12 overall. Similar figures are reported by Susan White and her colleagues in their meta-analysis “Anxiety in children and adolescents with autism spectrum disorders”. The social deficits autistic individuals endure lead to social anxiety by increasing the likelihood of negative interactions9 and then that anxiety makes interaction with others more difficult, perpetuating the cycle. It’s clear there’s an issue here. Despite no biological link, autistic people suffer far greater rates of depression and anxiety than their neurotypical counterparts. They find friendships more taxing, worrying, and less fulfilling due to impossible unrealistic expectations of allistic communication and understanding. They’re far more likely to be the target of bullying and victimisation than their neurotypical counterparts. Autistic adults suffer in their careers and employment due to a lack of accommodation and recognition. But it doesn’t have to be this way. Growing up neurodivergent shouldn’t be traumatic. Existing as an autistic person shouldn’t be fraught with conflict. I don’t know how we will get to that point. It feels like there are a hundred facets to the issue, each their own problem and needing their own solution. That being said, all solutions need to stem from an understanding of autism and autistic individuals. So, what does it mean to be autistic and how can we navigate those communicative differences? The social aspect of autism arises from a deficit in ‘Theory of Mind’, which is the capacity to interpret and conceptualise another’s thoughts, beliefs, emotions, and intentions (1, 2, 9, 10). Second order representations are the events in which Theory of Mind is used to interpret their meaning – and so a disorder in Theory of Mind development affects the ability of an individual to use and understand those second order representations. Essentially: autistic individuals struggle to interpret and conceptualise other people’s thoughts, beliefs, emotions and intentions. What does that mean for communication? As mentioned earlier, it leads to this a twofold miscommunication between autistic and allistic people, where autistic people don’t see meaning where it is, and allistic people see meaning where it isn’t. This is known as the ‘double empathy problem’ (2). But it isn’t just a communication deficit on the part of the autistic person – the disconnect is due to two entirely different communication styles. Allistic people use second order representations readily and frequently. They’re able to infer other’s perspectives with ease and conversation is based around these assumptions. Gestures, body language and inference are used to convey meaning and assess receptiveness. If the wrong assumptions are made, it can lead to ‘fragmenting’, where there is a cost to getting it wrong and the conversation is disrupted (2). It may not be relationship-damaging every time, but people do pick up on misread cues or intentions and often the only indication a mistake has been made is given through those same implicit communications. The creation of a shared understanding is known as ‘intersubjectivity’ (1, 2). Allistic intersubjectivity is managed through these second order representations, where the shared understanding is outlined and defined implicitly. Autistic people don’t have the same ability to interpret second order representations, so rather than probing or assessing what others have in common, they essentially have to guess. As a result, autistic people can seem appear egotistical or self-interested (2) when they spontaneously talk about an interest of theirs, or suddenly change the topic of conversation. In actuality, they’re trying to find common ground. Because finding that initial mutuality is harder, autistic individuals also place far less of a social cost on getting it wrong (2) and so while intersubjectivity may be harder to initially reach, there’s far less penalty for trying and failing. If these bids for connection are reciprocated, it can creates a “rich intersubjective space for shared understanding” (2). These two elements of autistic communication come together to form a coherent communication style. Heasman writes “The generous assumption of common ground and the low demand for coordination are more than two isolated features; they potentially fit together into a functional system that allows rich forms of social relating” (2). The autistic communication style only appears to be dysfunctional when “[placed] against the cultural backdrop of neurotypical norms and expectations” (2). Another way to look at that is that autistic people don’t need ‘extra’ accommodation or compensation compared to allistic people – allistic people just have all their needs already met. They’re already accommodated for, but it’s such a cultural norm that it’s not even perceived as being so. A metaphor for the two types of communication is that of an allistic person and an autistic person trying to set up fishing rods along a river. The allistic person knows where the fish are - perhaps from reading the movement of the water - and sets up all their poles in that spot. The autistic fisherperson has no such information and sets up their rods all up and down the river to try to find themwhere the fish are. Once they’ve got a few bites and know where the fish are, great! They can move all their rods and set up in whatever spot they’ve found. They just don’t have the same ability to determine where to set up in the first place. They’re not any worse at fishing (i.e., communicating) – they just have trouble knowing where to start. Autism is only a disability in an environment that doesn’t support it. As Bury noted, the only deficits in the workplace are from a lack of social accommodation – autistic individuals don’t struggle with the work itself. In fact, both Bury and Hurley-Hanson and her co-authors report that autistic individuals perform better in a multitude of areas: they have greater problem-solving, pattern-recognition and decision-making skills and a greater tolerance for repetition (5, 11). And that’s great! It’s wonderful to be recognised for the talents you have and the effort you put in. But it shouldn’t have to be justified that autistic people deserve employment and equitable treatment. It’s depressing to have your life and experience boiled down to your marketability and employability. But there is still a disconnect between autistic and allistic people. The perception of autistic people as defective rather than different prevents the integration and acceptance of autistic people into the social space and workforce. To work towards an autism-friendly society, education and awareness of the ways communication and understanding differ in neurodivergent individuals need to be ubiquitous. The hardships autistic people face aren’t because we’re autistic – they’re because everyone else isn’t. Instead of us continuing to assimilate to an allistic worldview, perhaps it’s time to meet us halfway and learn how we operate instead. References Frith, U. (1989) A new look at language and communication in autism. Heasman, B. (2018) Neurodivergent intersubjectivity: Distinctive features of how autistic people create shared understanding. Sedgewick, F., Pellicano, E., (2018) ‘It’s different for girls’: Gender differences in the friendships and conflict of autistic and neurotypical adolescents. Happé, F., Leslie, A. (1989) Autism and ostensive communication: The relevance of metarepresentation Bury, S. et al. (2020) Workplace Social Challenges Experienced by Employees on the Autism Spectrum: An International Exploratory Study Examining Employee and Supervisor Perspectives White, W. et al. (2009) “Anxiety in children and adolescents with autism spectrum disorders.” Mayes, S.D., Calhoun, S.L., Murray, M.J. et al. (2011) Variables Associated with Anxiety and Depression in Children with Autism. Bernstein, G. A., & Borchardt, C. M. (1991). Anxiety disorders in childhood and adolescence: A critical review. Journal of the American Academy of Child and Adolescent Psychiatry Bellini, S. (2004) Social Skill Deficits and Anxiety in High-Functioning Adolescents With Autism Spectrum Disorders. Focus on Autism and Other Developmental Disabilities. Brewer, N, Young, RL & Barnett, E 2017, ‘Measuring Theory of Mind in Adults with Autism Spectrum Disorder’ Hurley-Hanson, A. (2020) ‘Autism in the Workplace’, Palgrave Macmillan Institute of Health Metrics and Evaluation. Global Health Data Exchange (GHDx) Selph, S. (2019) Depression in Children and Adolescents: Evaluation and Treatment Previous article Next article alien back to

< Back to Issue 2 Law and Order: Medically Supervised Injecting Centres Keeping people safe from the harms of drug use is an important public health goal, but some question the value of medically supervised injecting centres in improving health and community outcomes. by Caitlin Kane 10 December 2021 Edited by Tanya Kovacevic & Natalie Cierpisz Illustrated by Rachel Ko Medically supervised injecting centres (MSICs) are an exemption from the standard practices of law and order: instead of policing drug users, these facilities allow people to bring illegal drugs to dedicated, clean settings where they can legally inject themselves and receive medical care if required. Essentially, drugs like heroin and ice can be used in a safer environment often integrated with other health and welfare services. These centres aim to improve public health and amenity outcomes, but are criticised for facilitating drug use. Australia’s MSICs have been controversial since their inception. The first local MSIC opened in Kings Cross, Sydney in 2001, following a Vatican intervention to withdraw nuns and the arrest of a Reverend for opening a short-lived unsanctioned injecting facility (1,2). Local businesses and residents feared a nearby “safe haven for drug users” would accelerate rampant and disruptive public drug use and threatened last-minute legal action (3). The centre is still in operation and has now supervised more than one million injections without a single overdose fatality (1,4). Medical director Dr Marianne Jauncey explained how the Kings Cross centre saves lives in a discussion with the ABC this year (5). Yet before Australia’s second MSIC opened in Richmond, Melbourne in 2018, commentators continued to decry the proposition as accepting and passively encouraging drug use. Nationals MP Emma Kealy announced, "It sends the wrong message to our kids and effectively says we've given up on preventing drug use” (6). With consultation ongoing to establish a third Australian MSIC in the Melbourne city centre, it’s valuable to detangle the misconceptions around the effects of MSICs on communities and their value as public health tools. Much controversy around Australia’s MSICs centres on three concerns: the number of overdoses occurring on premises, the attraction of drug addicts to the areas, and the drain on public health resources. Examining the data collected by public health scientists demonstrates that these concerns are unfounded and supports the continued consideration of MSICs as effective public health interventions. WHAT EFFECT DO MSICS HAVE ON OVERDOSES? It’s critical to understand that MSICs are proposed for areas with heavy drug use, particularly use in public settings and causing medical emergencies like overdoses. At the turn of the millennium, the streets of Kings Cross were a major site of public drug use, overdoses, and ambulance callouts (7). In 2000, one spate of thirty-five Sydney overdoses, four fatal, occurred in a single twenty-four hour period (3). At the time, 10% of all drug overdoses in Australia occurred in Kings Cross (3). In response, the Kings Cross MSIC opened in 2001 following decades of mounting evidence in Europe. European drug injection centres had been operating since the 1970s, with growing official support through the 1990s in countries like the Netherlands, Switzerland, and Germany (2). Evaluations reported successful reductions in public nuisance, improved service access, and declining overdose deaths (2). Switzerland demonstrated annual overdose deaths halved in four years and a tenfold reduced chance of hospital admission in MSIC overdoses compared to overdoses on the streets (2,3). Similarly, the Richmond MSIC opened in 2018 as a response to the highest heroin death toll in sixteen years and record ice deaths in 2016, with the major drug market in Richmond considered the “epicentre of Melbourne’s heroin crisis” (8). It could be easy to criticise the overdoses occurring on the MSIC premises, but these overdoses predated the MSICs and prompted their opening after other strategies failed to address the crisis. As public health interventions, MSICs are most effective in areas with high densities of public drug use, like Kings Cross and Richmond, which is why these sites were chosen to house MSICs (7). A systematic review of studies covering a range of MSIC facilities, including Kings Cross, concluded that all facilities had a significant reduction in overdose deaths in their local area (9). Ambulance callouts for overdoses near Kings Cross decreased by 68% within six years of opening (9). In Richmond, emergency medical attendances to drug overdoses near the MSIC have decreased significantly. Only 30 of the 2657 overdoses treated at the MSIC in its first eighteen months led to ambulance attendance and there has been a 25% decrease in naloxone administration, a treatment for opioid overdose, by ambulances in the one kilometre radius of the MSIC (10). The impact of drug overdoses in these areas has been greatly mediated by the presence of the MSICs. In 2017, the Kings Cross MSIC celebrated one million injections with zero fatal overdoses (1). The lack of a single overdose death at these facilities despite the number of overdoses should be considered a mark of commendation (1,5,10,11). DO MSICS ATTRACT DRUG USERS TO THE AREA? A second concern is that MSICs attract drug addicts to the area in which they are situated. However, this misattribution of causality arises because MSICs are purposefully located in areas with pre- existing drug markets. Major drug markets create local hotspots of public injection as many drug users inject immediately to reduce withdrawal and avoid police attention (7). These areas of high public drug use became candidates for the establishment of MSICs because drug users already frequented the area. Before the MSIC opened, over 90% of ambulances attendances for overdoses in Kings Cross were within a 300 metre radius of the proposed MSIC location. The area was chosen for an MSIC because of the existing disruption caused by public drug use and overdose. Improving public amenity, such as decreasing encounters with discarded needles, drug injection and overdose, is one of the most important goals of MSICs (2,11). Despite initial outrage in Kings Cross, support for the centre among local businesses increased to 70% in 2005, and local perceptions were positive (11,12). Monitoring of the area found no increase in drug-related crime, dealing or loitering after the Kings Cross MSIC opened (11). This is also supported by more recent findings in 2017, that alongside improving local amenity and reducing ambulance callouts, the Kings Cross MSIC did not draw dealers and addicts to the area in a ‘honey pot’ effect (6). This was corroborated by a systematic analysis which found no increase in drug-related violence and crime related to MSICs in Sydney and Vancouver across the results of four studies (9). The same review concluded that MSICs do not promote drug use, crime, drug trafficking, or increase new drug users (9). Likewise, demand for the Richmond MSIC was created by the existing Richmond drug market and disruption to the community, with 46 of 49 local stakeholders found to support a proposed MSIC in a 2017 consultation (11). Alongside harm minimisation, one submission highlighted the “significant toll on health workers and members of the local community who have to deal with the aftermath of overdoses and for children to see people in public in such a terrible state” as motivating their support for establishing a Richmond MSIC (11). Since opening, concern that additional people would travel to use the centre was abated by findings that travel distance was a major reason for not attending the MSIC and residential information collected from Richmond MSIC users (10). Regarding public amenity, an evaluation found mixed results in its eighteen months of operation, with reduced sightings of public injections and incidents at the neighbouring school, but decreased perception of safety and community support for the MSIC (10). It remains to be seen how this trend develops with continued operation of the centre. DO MSICS DRAIN PUBLIC HEALTH RESOURCES? While the primary goal of MSICs is to reduce the harms associated with overdose and public drug injection, MSICs have broader public impact through integration with complementary social and medical services. People who inject drugs are subject to associated harms, ranging from increased risks of blood-borne diseases (HIV, HBV, HCV) and psychiatric disorders to homelessness, crime, and prostitution (2,10). This socially marginalised group often lacks adequate access to healthcare, despite the significantly increased risks of harm and death (9). Analysis of the Vancouver MSIC found the streamlined and preventative healthcare provided to drug users was quantifiably more effective and saved both millions of dollars and 920 years of life over 10 years (9). In 2008, an economic review of the Kings Cross MSIC determined that averted health costs alone made significant savings for the government, and the value of prevented deaths would pay for operating costs more than 30 times (13). Furthermore, unprecedented access to drug users can facilitate important research to investigate and validate public health issues and strategies. For example, a 2017 paper analysed the rates and severity of overdoses for illicit and prescription opioids with data from the Sydney MSIC, producing clinically salient research enabled by access to marginalised and vulnerable populations (14). Alongside reductions in ambulance callouts and overdose complications which are instead managed at the centre, MSICs can improve the reach and delivery of health and social services for drug users, including blood-borne disease screening, drug treatment and rehabilitation, and mental health counselling (9,10). Engagement with MSICs and integrated services promoted safer injecting practices, health and social service use, and entry to treatment programs. The overall proportion of MSIC-attending drug users in treatment programs was 93%, compared to 61% of first-time attendees at the facility, demonstrating the improved effectiveness of reaching drug users with healthcare programs (15). Across seven studies on drug user uptake of MSICs, 75% of drug users reported improvements in their behaviours regarding public amenity and safe injection (9). This effect was particularly strong for marginalised and at-risk attendees, like those who were homeless, Indigenous, had previously overdosed, and others with self-identified need (15). MSICs contribute massively to overall public health strategy, through both direct harm reduction and efficiently increasing access to existing services. BEYOND MEDICALLY SUPERVISED INJECTING CENTRES MSICs in Australia and across the world have been successful in achieving their objectives; reducing drug-associated harms and community exposure to public injection and overdose (9,12). The continued controversy around MSICs despite their established and validated success betrays widespread misunderstanding around the nature of addiction, the effective treatment and harm reduction for drug abuse. In 2017, despite the support of three coronial recommendations and the Australian Medical Association for a Richmond MSIC, MP Tim Smith asked, “Since when did we start rewarding people who break the law, since when did drug users become victims, we need to enforce the law" (6,8). Political discourse that distorts the goals of MSICs and distracts from their established efficacy only serves to stagnate evidence-based action and weaken Australia’s response to damaging drug use. While MSICs attract stagnating attention and controversy, public health issues around drug addiction and opioid dependency remain unaddressed (16). In Australia, prescription drug abuse causes ten times more overdose deaths than illicit drug abuse, and prescription opioids provides a pathway to the use of illegal opioids, like heroin and fentanyl (14,16). As seen in the 2017 investigation into the prevalence and consequences of opioid overdoses in the Kings Cross MSIC, prescription opioid injection is a significant form of harmful drug use (14). MSICs are a useful and effective tool to combat drug abuse, but are not intended to solve all drug-pertinent problems; they must be incorporated into broader public health and crime strategies (9). Drug abuse is a seriously complicated problem, so it makes sense to have misconceptions around the impacts of MSICs. Effective drug policy needs to consider MSICs as a component of a broader public health strategy and educate the public about responses to drug abuse. It’s critical for communities and decision-makers to stay informed and choose evidence-based strategies to address the public health and amenity goals around drug use. References: Alcohol and Drug Foundation. ‘Medically Supervised Injecting Centres - Alcohol and Drug Foundation’. Accessed 1 December 2021. https://adf.org.au/insights/medically-supervised-injecting-centres/. Dolan, Kate, Jo Kimber, Craig Fry, John Fitzgerald, David McDonald, and Franz Trautmann. ‘Drug Consumption Facilities in Europe and the Establishment of Supervised Injecting Centres in Australia’. Drug and Alcohol Review 19, no. 3 (2000): 337–46. https://doi.org/10.1080/713659379. Barkham, Patrick. ‘Sydney Gets Safe Haven for Drug Users’. The Guardian, 4 September 2000, sec. World news. https://www.theguardian.com/world/2000/sep/04/patrickbarkham. ‘20th Anniversary of Sydney’s Medically Supervised Injecting Centre’. Accessed 9 December 2021. https://www.uniting.org/blog-newsroom/newsroom/news-releases/20th-anniversary-of-sydney-s-medically-supervised-injecting-cent. The Kings Cross Supervised Injecting Facility Marks Its 20th Anniversary. ABC News, 2021. https://www.abc.net.au/news/2021-05-06/united-medically-supervised-injecting-centre-20th-anniversary/13332878. Carey, Adam. ‘“People Are Dying”: Trial of Safe Injecting Room Blocked by Andrews Government’. The Age, 7 September 2017. https://www.theage.com.au/national/victoria/people-are-dying-trial-of-safe-injecting-room-blocked-by-andrews-government-20170907-gycmiu.html. Uniting. ‘History of the Uniting Medically Supervised Injecting Centre’. Accessed 9 December 2021. https://www.uniting.org/community-impact/uniting-medically-supervised-injecting-centre--msic/history-of-uniting-msic. Willingham, Richard. ‘Renewed Calls for Safe Injecting Room as Victoria’s Heroin Death Toll Reaches 16-Year High.’ ABC News, 27 October 2017. https://www.abc.net.au/news/2017-10-27/spike-in-heroin-deaths-in-victoria-safe-injecting-rooms/9092660. Potier, Chloé, Vincent Laprévote, Françoise Dubois-Arber, Olivier Cottencin, and Benjamin Rolland. ‘Supervised Injection Services: What Has Been Demonstrated? A Systematic Literature Review’. Drug and Alcohol Dependence 145 (1 December 2014): 48–68. https://doi.org/10.1016/j.drugalcdep.2014.10.012. Department of Health. Victoria, Australia. ‘Medically Supervised Injecting Room Trial - Review Panel Full Report’. State Government of Victoria, Australia, 25 June 2020. http://www.health.vic.gov.au/publications/medically-supervised-injecting-room-trial-review-panel-full-report. Victoria, Parliament, Legislative Council, and Legal and Social Issues Committee. Inquiry into the Drugs, Poisons and Controlled Substances Amendment (Pilot Medically Supervised Injecting Centre) Bill 2017. East Melbourne, Vic: Victorian Government Printer, 2017. Salmon, Allison M., Hla-Hla Thein, Jo Kimber, John M. Kaldor, and Lisa Maher. ‘Five Years on: What Are the Community Perceptions of Drug-Related Public Amenity Following the Establishment of the Sydney Medically Supervised Injecting Centre?’ International Journal of Drug Policy 18, no. 1 (1 January 2007): 46–53. https://doi.org/10.1016/j.drugpo.2006.11.010. SAHA. ‘NSW Health Economic Evaluation of the Medically Supervised Injection Centre at Kings Cross (MSIC)’, August 2008. https://www.uniting.org/content/dam/uniting/documents/community-impact/uniting-msic/MSIC-Final-Report-26-9-08-Saha.pdf. Roxburgh, Amanda, Shane Darke, Allison M. Salmon, Timothy Dobbins, and Marianne Jauncey. ‘Frequency and Severity of Non-Fatal Opioid Overdoses among Clients Attending the Sydney Medically Supervised Injecting Centre’. Drug and Alcohol Dependence 176 (1 July 2017): 126–32. https://doi.org/10.1016/j.drugalcdep.2017.02.027. Belackova, Vendula, Edmund Silins, Allison M. Salmon, Marianne Jauncey, and Carolyn A. Day. ‘“Beyond Safer Injecting”—Health and Social Needs and Acceptance of Support among Clients of a Supervised Injecting Facility’. International Journal of Environmental Research and Public Health 16, no. 11 (January 2019): 2032. https://doi.org/10.3390/ijerph16112032. Fitzgerald, Bridget. ‘Drug Overdoses Killed More than 2,000 Australians for the Fifth Consecutive Year, Report Finds’. ABC News, 31 August 2020. https://www.abc.net.au/news/2020-08-31/more-than-2000-australians-lost-their-lives-due-to-overdose-2018/12612058. Previous article back to DISORDER Next article

< Back to Issue 6 Out of our element by Serenie Tsai 28 May 2024 Edited by Luci Ackland Illustrated by Louise Cen A land teeming with lush forestry and fresh air seems like a far reach from the current state of the world. Not too long ago, this was Earth’s reality. However, with the onset of industrialisation, and the subsequent exploitation of our natural resources, our environment rapidly deteriorated. We polluted our atmosphere and contaminated our waterways with oil and debris. Not only did we pose a threat to human health, we also risked the safety of our future. Experimenting with elements Not long after the Industrial Revolution, the use of nuclear energy arose as an alternative to fossil fuel to combat climate change. Society’s view on nuclear energy became contentious when the largest nuclear disaster to date occurred in Chernobyl in 1986. The explosion of the nuclear reaction caused hundreds to be afflicted by Acute radiation syndrome and many died within a few weeks from this disease (World Nuclear Association, 2022). Following the accident, a 30-kilometre exclusion zone around the power plant was enforced to prevent further contamination to humans. Yet unexpectedly, forest coverage has since increased 1.5 times over (Matsala et al., 2021). In the absence of humans, wildlife appears to be flourishing—in particular, grey wolves are thriving and have become the top predator in the exclusion zone (Itoh, 2018). There remains a lack of research surrounding the long-term implications of radiation on the health of wildlife (Itoh, 2018), good and bad. The negative effects of radiation are evident in the increase of cases of tumour growth and deformed beaks and claws in local birds (Itoh, 2018). The local flora were also negatively impacted with tree rings during the period of the incident indicating that radiation caused a reduction in tree growth (Mousseau et al., 2013). Natural disasters becoming more disastrous Similarly, the impacts of industrialisation have become especially discernible with the increasing severity of natural disasters; effects of which have been further compounded by climate change. Human activities such as the consumption of fossil fuels has played an overwhelming role in the increase of global temperatures, leading to more extreme weather conditions (Wuebbles & Jain, 2001, Nema et al., 2012). These higher temperatures have consequently amplified the intensity of droughts and fire seasons (Liu et al., 2010). Air pollution levels into some areas cause citizens to be perpetually smothered by smoke. Nature’s takeover As the foundation of Earth, nature has the capacity to reclaim areas that humans once inhabited. In Houtouwan, China, a once-thriving fishing village has now been overrun by vegetation. Almost every inch of the village has been camouflaged by vegetation—only mere silhouettes of the buildings remain amongst the greenery. It makes sense that an open area combined with abundant rain and shine would give way to overgrown vegetation; yet a Banyan tree elsewhere in China managed to slowly take root through even just the cracks of a brick floor. In Bangkok, a half-demolished shopping mall is now an oasis for aquatic life. This did not happen of its own accord; the mall was abandoned when it failed local regulations and was then flooded during monsoon season. Locals then introduced fish to prevent insects from breeding in stagnant waters and it has been flourishing ever since. Life is nothing without nature, yet there is a fine line between using nature’s resources for greater good or using it to our demise. There is a dire need to regulate the use of our finite resources. Nature thrives in abandoned places and has the potential to overcome human-inflicted disasters and outlive humanity. References Itoh, M. (2018). Wildlife in the Exclusion Zone in Chernobyl . 177–187. https://doi.org/10.1007/978-3-319-70757-0_11 Liu, Y., Stanturf, J., & Goodrick, S. (2010). Trends in global wildfire potential in a changing climate. Forest Ecology and Management , 259 (4), 685–697. https://doi.org/10.1016/j.foreco.2009.09.002 Matsala, M., Bilous, A., Myroniuk, V., Holiaka, D., Schepaschenko, D., See, L., & Kraxner, F. (2021). The Return of Nature to the Chernobyl Exclusion Zone: Increases in Forest Cover of 1.5 Times since the 1986 Disaster. Forests , 12 (8), 1024. https://doi.org/10.3390/f12081024 Mousseau, T. A., Welch, S. M., Chizhevsky, I., Bondarenko, O., Milinevsky, G., Tedeschi, D. J., Bonisoli-Alquati, A., & Møller, A. P. (2013). Tree rings reveal extent of exposure to ionizing radiation in Scots pine Pinus sylvestris. Trees , 27 (5), 1443–1453. https://doi.org/10.1007/s00468-013-0891-z Nema, P., Nema, S., & Roy, P. (2012). An overview of global climate changing in current scenario and mitigation action. Renewable and Sustainable Energy Reviews , 16 (4), 2329–2336. https://doi.org/10.1016/j.rser.2012.01.044 World Nuclear Association. (2022). Chernobyl Accident 1986 . World Nuclear Association. https://world-nuclear.org/information-library/safety-and-security/safety-of-plants/chernobyl-accident.aspx Wuebbles, D. J., & Jain, A. K. (2001). Concerns about Climate Change and the Role of Fossil Fuel Use. Fuel Processing Technology , 71 (1-3), 99–119. ScienceDirect. https://doi.org/10.1016/s0378-3820(01)00139-4 Previous article Next article Elemental back to

By Lily McCann < Back to Issue 3 Belly bugs: the aliens that live in our gut By Lily McCann 10 September 2022 Edited by Andrew Lim and Zhiyou Low Illustrated by Helena Pantsis Next Figure 1 (1): "Animalcules" The figures above may look exceedingly simple to you. Beautifully drawn, yes, but nothing particularly complicated —mere ovals and lines of black ink. If I told you that the drawings were 350 years old, your interest might be piqued by that fascination we hold for all historical relics. You might wonder what the images are attempting to portray. You would only be more confused, however, were I to describe them to you using the name they were known by to the artist: “animalcules”. (2) These drawings, penned by a Dutch draughtsman in the early 1680s, are the first known depictions of bacteria from inside a human body (2). They were discovered by a man called Anthonie van Leeuwenhoek in a sample taken from between his teeth. Leeuwenhoek had examined “animalcules” in various water samples before turning to saliva, analysing the shape and movements of the little cells beneath his microscope, which he made from hand-crafted glass mounted between plates of brass. It is now known that these “animalcules” are in fact bacteria, and that they are avid colonisers not only of our mouths but every other body surface, too. These single-celled organisms parted ways with animals some 2.7 billion years ago in evolution and could not appear any more alien to ourselves (3). Though simple in structure and function, they are capable of populating the most inhospitable and extraterrestrial of environments. In fact, Deinococcus radiodurans (pictured below) can survive for years in the harsh vacuum of space (4). Figure 2 (5): Deinococcus radiodurans Freaky, right? The evolutionary distance between bacteria and ourselves does not seem to deter them from entering into the most intimate of symbiotic relationships with us. Despite their alien-ness, despite billions of years of divergent evolution, we have not lost the ability to communicate with these distant relatives of ours. In fact, communication with bacteria is a daily and essential part of our lives. The reason we can still chat with these creatures is that they are made up of the same basic “stuff” that we are: genetic material made of sugars, phosphates and nitrogen bases to dictate our functions; proteins to carry out our cellular processes; membranes to hold us together. All these aspects form a common basis for language. Just as human languages consist of orally transmitted units of sounds that can be translated and understood, bacteria can impart signals in the form of particles that can be decoded and acted upon by our own cells. One example of this kind of dialogue is the production of molecules called short chain fatty acids by bacteria that digest plant materials in our gut. These bacteria impart their gratitude to us for supplying them with suitable foods by releasing short chain fatty acids, which in turn tell our gut not to worry, signalling our cells and instructing them to reduce inflammation, build up our gut wall and even help fix our blood pressure. These molecules can also travel to the brain, where they are thought to influence the release of various signals including that of the “feel-good” hormone serotonin. (6) There’s a whole world of dialogue beyond this often referred to as the gut-brain axis of health. Research into the area has revealed that signals produced by gut bacteria are extremely influential in a number of conditions including anxiety and Parkinson’s disease. These relationships often work both ways, giving rise to a strange “chicken-and-egg” situation: those who demonstrate symptoms of such conditions are found to carry altered gut bacterial populations, and altering gut bacteria can in turn change symptoms. For example, in a cruel experiment involving the separation of infant monkeys from their mothers, the stress caused by separation changed the distribution of bacteria colonies in the infants’ guts, whilst administering a certain bacteria often imparted to infants by their mothers was found to reverse the symptoms of this stress (7). The way that bacteria can change our very emotions has significant implications for our idea of personhood. What are we, if how we act depends on the alien cells we carry in our digestive tracts? Perhaps we ought to extend our definition of identity to include these little cells that are truly, it seems, a part of how we are—another organ of our body, even. Happily (for those of you who support the philosophy of a ‘growth mindset’), the way our gut influences our minds is subject to manipulation. And we do not need a scientist to isolate and administer a certain bacterial species to us in order to change it; evidence suggests that simply altering what we eat can have a profound influence. Dietary change is known to directly alter bacterial gut colonies, and the change shown to bring about the most harmonious of conversations with our gut is increasing our intake of dietary fibre. Flooding our gut community with plentiful fibre causes a rush of signals from bacteria that promote gut health, mental health and healthy ageing. In contrast, a low fibre diet can promote diabetes, cardiovascular problems and, for pregnant mothers, may compromise the neural functioning of a developing child (8). What does this mean for medicine? Can we harness the billion-year old dialogue between our cells and the aliens that colonise our gut for our own benefit? Can we coax these residents into a mutually beneficial relationship by approaching them in the right tone? These questions are gradually gaining popularity among the scientific community as trials of probiotic administration are explored in the context of treating illnesses from depression to gastrointestinal disorders (9). We are yet to see where such studies will lead us. When the outside world seems increasingly bleak, I find comfort in the fact that within us rumbles on the activity of an intricate and disinterested universe, completely alien to and yet an integral part of ourselves. Like farmers of a garden in times of shortage, we exist in a state of codependency with the world we nurture inside our bodies. If we foster a good relationship with its inhabitants, they can protect us from the afflictions of illness, sadness and madness that threaten our species day by day. References : 1. The Royal Society. Bacteria from Leeuwenhoek's mouth [Internet]. 2022 [cited 17 March 2022]. Available from: https://royalsocietypublishing.org/cms/asset/2bf20f9f-28e1-4126-bd7e-f92950899a2b/rstb20140344f03.jpg 2. Lane N. The unseen world: reflections on Leeuwenhoek (1677) ‘Concerning little animals’ | Philosophical Transactions of the Royal Society B: Biological Sciences [Internet]. Philosophical Transactions of the Royal Society B: Biological Sciences. 2022 [cited 17 April 2022]. Available from: https://royalsocietypublishing.org/doi/10.1098/rstb.2014.0344 3. Cooper G. The Origin and Evolution of Cells [Internet]. Ncbi.nlm.nih.gov. 2022 [cited 17 April 2022]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9841/#:~:text=The%20eukaryotes%20developed%20at%20least,is%20from%20present%2Dday%20eukaryotes 4. Cox M, Battista J. Deinococcus radiodurans — the consummate survivor. Nature Reviews Microbiology. 2005;3(11):882-892. 5. 5. The European Synchroton. Deinococcus radiodurans [Internet]. 2022 [cited 5 May 2022]. Available from: https://www.esrf.fr/UsersAndScience/Experiments/MX/Research_and_Development/Biology/Deinococcus_radiodurans 6. De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti D et al. Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified. PLoS ONE. 2013;8(10):e76993. 7. Bailey M, Coe C. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Developmental Psychobiology. 1999;35(2):146-155. 8. Buffington S, Di Prisco G, Auchtung T, Ajami N, Petrosino J, Costa-Mattioli M. Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016;165(7):1762-1775. 9. Kazemi A, Noorbala A, Azam K, Eskandari M, Djafarian K. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clinical Nutrition. 2019;38(2):522-528. 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< Back to Issue 2 Making sense of the senses: The 2021 Nobel Prize in Physiology or Medicine What do spicy food, menthol lozenges and walking around blindfolded have in common? They all activate protein receptors discovered by Professors David Julius and Ardem Patapoutian, the winners of the 2021 Nobel Prize in Physiology or Medicine. by Dominika Pasztetnik 10 December 2021 Edited by Breana Galea & Juulke Castelijn Illustrated by Casey Boswell Stimuli are changes to our environment, such as heat, cold and touch, that we recognise through our senses. We are all constantly bombarded with thousands of these stimuli from our surroundings. Despite this disorder, we are somehow able to perceive and make sense of the world. The protein receptors discovered by Professors Julius and Patapoutian make this possible. Located at the surface of the nerve cell, these receptors convert an external stimulus to an electrical signal. This signal then travels along nerve cells to the brain, allowing us to sense the stimulus. Based in California, Julius and Patapoutian are scientists in the fields of neuroscience and molecular biology. The main interest of their work has been identifying and understanding the protein receptors involved in detecting stimuli. For Julius, his major focus has been to identify the receptors involved in the sensation of pain (1). For Patapoutian, it has been to identify the protein receptors involved in detecting mechanical stimuli, such as touch (2). For their past 25 years of research, Julius and Patapoutian were awarded the Nobel Prize in Physiology or Medicine in October 2021. The Nobel Prize was founded by Alfred Nobel, a Swedish scientist also famous for inventing dynamite. Prior to his death in 1896, Nobel allocated most of his money to the first Nobel Prizes. Since 1901, the Nobel Prize has been annually bestowed on those who, in Nobel’s words, have “conferred the greatest benefit to mankind” in different fields (3). Notable past laureates of the Nobel Prize in Physiology or Medicine include Sir Alexander Fleming, Sir Ernst Chain and the Australian Howard Florey. They were awarded in 1945 for their discovery of the antibiotic penicillin (4). Sir Hans Krebs received the Nobel Prize in 1953 for his discovery of the citric acid cycle (5). Also known as the Krebs cycle, it is a series of reactions used to produce energy in our cells. TRPV1: spice it up It’s a rather chilly morning. You eye the packet of Shin Ramyun that’s been sitting in your pantry for weeks. Without a second thought, you prepare the noodles, adding all the soup powder. After a few mouthfuls, your eyes start streaming and your face matches the scarlet red of the now-empty packaging. The culprit is capsaicin, a substance in the chilli flakes added to the soup powder. It binds to a protein receptor embedded at the surface of the nerve cells in your mouth. Julius discovered this receptor in 1997, and called it TRPV1, which stands for transient receptor potential vanilloid type 1 (6). TRPV1 is a channel with a gate at either end that is usually closed (Figure 1, blue) (7). Capsaicin opens these gates, allowing ions, such as calcium, to move through TRPV1 and into the nerve cell (Figure 1, red). The nerve cell then signals to the brain, causing you to feel the searing heat in your mouth. TRPV1 is also found in your skin and can be activated by temperatures above 40°C, such as when you accidentally touch the kettle full of boiling water for your noodles (8). Figure 1. TRPV1 at the surface of a nerve cell. In the absence of capsaicin or at cool temperatures, TRPV1 is closed (blue). In the presence of capsaicin or at higher temperatures, TRPV1 opens, allowing ions to flow into the nerve cell (red). TRPM8: too cool for school On your way to uni, you notice your throat’s a bit sore from going overboard with karaoke the night before, so you pop a lozenge into your mouth. The soothing, cool sensation is thanks to menthol. It is a compound that binds to TRPM8, which stands for transient receptor potential melastatin 8. It is another receptor found on the nerve cells in your tongue, as well as on your skin (9). TRPM8 was separately discovered in 2002 by both Julius and Patapoutian (10). Like TRPV1, TRPM8 is a protein channel that is usually closed. In response to menthol or cool temperatures from 26 down to 8°C, TRPM8 opens and allows ions to enter the nerve cell, which then signals the cold sensation to your brain (11). PIEZO: peer pressure During your lunch break at uni, you and your mates decide to play blindfolded tag. Because, as we all know, that's what uni students do in their free time. In the first round, you have the misfortune of being chosen as ‘it’. Blindfolded, you walk around with your hands in front of you, trying to find your mates. Despite not being able to see anything, you can still walk and wave your arms and roughly know where your arms and legs are in space. This is due to a sense called proprioception. You lunge forward and nearly grab someone, only to feel their jacket brush your fingers. Both proprioception and the detection of light touch, such as of the jacket brushing your fingers, are made possible by another class of protein receptors called PIEZO2. Discovered by Patapoutian in 2010, its name comes from piesi, the Greek word for pressure (12). Like TRPV1 and TRPM8, PIEZO2 is an ion channel at the nerve cell surface. However, the structure of PIEZO2 is nothing like that of TRPV1 and TRPM8. PIEZO2 has three protruding blades, which form a dent, called a nano-bowl, in the outer surface of the cell (13). When the outside of the cell is prodded, the blades straighten and the nano-bowl flattens. This allows the channel in the centre of the PIEZO2 to open, so ions can flow into the nerve cell (Figure 2). The nerve cell then sends an electrical impulse to the brain, letting you know you’re failing at blindfolded tag. Figure 2. PIEZO at the surface of a nerve cell. When force is applied to the surface of the nerve cell, the PIEZO channel opens, allowing ions to move into the cell. Apart from being essential for playing blindfolded tag, PIEZO2 is also important in various other aspects of the human body’s functioning we often take for granted. For example, PIEZO2 prevents you from breathing in too much air (14). It is also present on the cells lining your digestive tract. PIEZO2 detects pressure exerted onto these cells by food, causing the cells to release hormones that help with digestion (15). Furthermore, PIEZO2 helps monitor the fullness of your bladder, saving you from embarrassment (16). If there is a PIEZO2, what about PIEZO1? Although it has a similar structure to PIEZO2, PIEZO1’s role is quite different. PIEZO1 handles the background maintenance required to keep your body healthy. This includes bone formation (17) and preventing your red blood cells from bursting (18). People with a particular mutated form of PIEZO1 have a reduced risk of getting malaria (19). Patapoutian found that this mutation causes red blood cells to shrivel, preventing the malaria parasite from infecting them. Many people living in malaria-affected areas, such as Africa, have this mutation. Therefore, knowledge regarding these receptors is improving our understanding of related diseases. Drug development Researchers are currently using information about the receptors discovered by Julius and Patapoutian to develop new drugs to treat various conditions. Knowing the identities and structures of these receptors is helping researchers design compounds that bind to them, either blocking or activating them. In this way, Julius and Patapoutian’s work is helping provide a “benefit to mankind”. For example, during a migraine, the TRPV1 channel opens more frequently in the nerve cells of the meninges, the envelope surrounding the brain (20). These nerve cells contain more TRPV1 at their surfaces. This causes the nerve cells to send more electrical signals to the brain and so increases the sensation of pain. Using a drug to block the TRPV1 receptor could reduce the number of these electrical impulses and lessen the pain associated with migraines. It’s been a busy day activating all these receptors, which, as it turns out, are part of your daily life as a uni student. So next time you eat chilli flakes, have a menthol lozenge or play blindfolded tag, you will know which tiny sensors to hold responsible for your pleasant — or unpleasant — experiences. Further reading Press release: The Nobel Prize in Physiology or Medicine 2021 The Nobel Prize in Physiology or Medicine 2021 - Advanced Information References: University of California San Francisco. “Biography of David Julius.” UCSF. Accessed November 10, 2021. https://www.ucsf.edu/news/2021/09/421486/biography-david-julius. Nobel Prize Outreach AB 2021. “Press release: The Nobel Prize in Physiology or Medicine 2021.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/press-release/. Nobel Prize Outreach AB 2021. "Alfred Nobel’s will." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/alfred-nobel/alfred-nobels-will/. Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1945.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1945/summary/ Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1953.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1953/summary/ Ernfors, Patrik, Abdel El Manira, and Per Svenningsson. "Advanced information." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/advanced-information/. Liao, M., E. Cao, D. Julius, and Y. Cheng. "Structure of the Trpv1 Ion Channel Determined by Electron Cryo-Microscopy." Nature 504, no. 7478 (Dec 5 2013): 107-12. doi: 10.1038/nature12822. Ernfors et al., “Advanced information.” McKemy, D. D. "Trpm8: The Cold and Menthol Receptor." In Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades, edited by W. B. Liedtke and S. Heller. Frontiers in Neuroscience. Boca Raton (FL), 2007. Ernfors et al., “Advanced information.” McKemy, Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Coste, B., J. Mathur, M. Schmidt, T. J. Earley, S. Ranade, M. J. Petrus, A. E. Dubin, and A. Patapoutian. "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels." Science 330, no. 6000 (Oct 1 2010): 55-60. doi: 10.1126/science.1193270. Jiang, Y., X. Yang, J. Jiang, and B. Xiao. "Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels." Trends in Biochemical Sciences 46, no. 6 (Jun 2021): 472-88. doi: 10.1016/j.tibs.2021.01.008. Nonomura, K., S. H. Woo, R. B. Chang, A. Gillich, Z. Qiu, A. G. Francisco, S. S. Ranade, S. D. Liberles, and A. Patapoutian. "Piezo2 Senses Airway Stretch and Mediates Lung Inflation-Induced Apnoea." Nature 541, no. 7636 (Jan 12 2017): 176-81. doi: 10.1038/nature20793. Alcaino, C., K. R. Knutson, A. J. Treichel, G. Yildiz, P. R. Strege, D. R. Linden, J. H. Li, et al. "A Population of Gut Epithelial Enterochromaffin Cells Is Mechanosensitive and Requires Piezo2 to Convert Force into Serotonin Release." Proceedings of the National Academy of Sciences of the United States of America 115, no. 32 (Aug 7 2018): E7632-E41. doi: 10.1073/pnas.1804938115. Marshall, K. L., D. Saade, N. Ghitani, A. M. Coombs, M. Szczot, J. Keller, T. Ogata, et al. "Piezo2 in Sensory Neurons and Urothelial Cells Coordinates Urination." Nature 588, no. 7837 (Dec 2020): 290-95. doi: 10.1038/s41586-020-2830-7. Li, X., L. Han, I. Nookaew, E. Mannen, M. J. Silva, M. Almeida, and J. Xiong. "Stimulation of Piezo1 by Mechanical Signals Promotes Bone Anabolism." Elife 8 (Oct 7 2019). doi: 10.7554/eLife.49631. Cahalan, S. M., V. Lukacs, S. S. Ranade, S. Chien, M. Bandell, and A. Patapoutian. "Piezo1 Links Mechanical Forces to Red Blood Cell Volume." Elife 4 (May 22 2015). doi: 10.7554/eLife.07370. Ma, S., S. Cahalan, G. LaMonte, N. D. Grubaugh, W. Zeng, S. E. Murthy, E. Paytas, et al. "Common Piezo1 Allele in African Populations Causes Rbc Dehydration and Attenuates Plasmodium Infection." Cell 173, no. 2 (Apr 5 2018): 443-55 e12. doi: 10.1016/j.cell.2018.02.047. Dux, M., J. Rosta, and K. Messlinger. "Trp Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches." International Journal of Molecular Sciences 21, no. 1 (Jan 4 2020). doi: 10.3390/ijms21010342. Previous article back to DISORDER Next article

New to science? New to Melbourne? New to OmniSci? Yes, yes and yes! We spoke to Jolin about joining OmniSci with an art background, growing through challenges, and her best local exhibit recommendations. Jolin is a designer at OmniSci and an exchange student from Singapore studying Psychology and Arts & Culture Management. For Issue 4: Mirage, she is contributing to our website, and to two articles as an illustrator. Meet OmniSci Designer Jolin See Jolin is a designer at OmniSci and an exchange student from Singapore studying Psychology and Arts & Culture Management. For Issue 4: Mirage, she is contributing to our website, and to two articles as an illustrator. interviewed by Caitlin Kane What are you studying? I am an exchange student doing psychology and arts management. Do you have any highlights of your uni career so far? Recently my friend showed me around campus. Parkville in particular is really pretty so I guess it would be a nice thing to romanticise your student life. I think that was one of the highlights. She showed me the secret garden at the Bioscience Building, which was really nice. It’s fun to just explore and stuff. What is your role at OmniSci and how would you explain it to someone? I am an illustrator. I guess using visual cues and using design processes to communicate text, communicate ideas. That’s how I would describe my role, or describe what I want to do when I illustrate. What first got you interested in science? I don’t know, I think this is my attempt to reconcile both arts and science. I feel like a lot of artists try to stay in their own little circles. Like if you’re doing art you just do art. If you’re doing theatre you only know how to do theatre and you never branch out to visual art or music or even psychology… But I think it is good to have many disciplines under your belt. You don’t have to be super good at every single thing, but I guess it helps in every single thing that you do if you have knowledge about everything else. Like you can transfer skills or knowledge from one discipline to another. I think that's very valuable. That’s what got me interested in science, because I'm not doing science in school, except psychology. Back at the management university where I’m from we do more managerial psychology, like HR and marketing, we don’t really do clinical psychology. It has been interesting, because here in UniMelb I am doing a clinical psych mod, which is very very different from what I do back home. Like the topics they choose to uncover are very different. It is expanding my knowledge, my horizons. And what stage are you up to in the process now? Just reading the first drafts, so familiarising myself with them. Trying to grasp the ideas, because I think a lot of them are beyond what I’ve ever known, so trying to grasp that first. How did you get involved with OmniSci? I heard about it first at O-Week. I met you [Editor-in-Chief Caitlin] at Southbank campus, so then we talked. I was planning on joining clubs but I didn’t know what club I wanted to join. This is one of the two clubs that I joined—I also joined the Bubble Tea Society. I just wanted to do something meaningful and nice while I’m here, rather than just travelling and having fun and everything. I thought it would be nice to get to know people and talk about our ideas and see how our perspectives are different, especially because I’m so far away. And also reconciling art and science. We always highlight the differences between science and art, but I thought that OmniSci would be an amazing place to create a bridge between that. I’ve also had ideas of starting my own communications channel about psychology facts, because a lot of things that I’ve learnt at school have been very useful in my own personal life. Perhaps this way of making science accessible through art would be helpful for the general public. There are people out there who want to share and impart the knowledge that they have. I thought OmniSci might be a nice place to start doing that. What is your favourite thing about contributing at OmniSci so far? I think having the opportunity itself is the best part. It takes a lot to start a magazine on your own, so to have that platform is a big thing. The accessibility, the opportunity given to put your work out there, or have your ideas made concrete and shared with everyone. I think that’s the best thing. Low barriers of entry! Can you share something you're excited about working on this issue? Collaborating with the writers! It’s one thing to work alone and develop your ideas, and it’s another to develop them with someone else. I’m really looking forward to exploring how my style can adapt to newer themes. What do you like doing in your spare time when you're not contributing at OmniSci? I like to go to book stores, art galleries, theatre…just a bunch of arts stuff. Do you have any recommendations for theatre, anything that you’ve seen recently? I was at Malthouse Theatre a few months back, and it was really good. I really recommend Malthouse. There’s a State Library Exhibition on fringe festivals in Australia . I really believe in fringe stuff, so I think that’s a really thought-provoking exhibition to reflect on what we define as “good” and “bad” art. I also went to watch Patroclus and Achilles at the UniMelb Shakespeare company. It’s important to support student theatre because that’s where future artists start out! Which chemical element would you name your firstborn child (or pet) after? Oh my god, it’s so painful…I’m going to go with Potassium, so I can nickname them K. I’ll call them K all the time, except when I’m mad—then I’ll call them Potassium. See Jolin's designs PT PT Real Life Replicants

< Back to Issue 5 When Dark Matters Ingrid Sefton 24 October 2023 Edited by Celia Quinn Illustrated by Louise Cen To put it simply, the entire visible universe is huge. In the scheme of it, we really are just tiny dots on a floating rock, in a vast and constantly expanding cosmos. Yet, as it turns out, that’s not even close to the full story. All the visible objects, planets and galaxies contribute less than 15% of the mass in the universe. The other 85%? Nobody knows for certain, but it has a name. Dark matter. More can be said about what dark matter is not, than what it is. It isn’t the baryonic or “normal” matter such as protons, neutrons and electrons which comprise our visible world. It also isn’t antimatter, composed of subatomic particles with opposite charges to normal matter. Instead, dark matter interacts with normal matter in a manner entirely different to that of antimatter. It’s not a type of black hole, nor simply a form of radiation, or a type of massless particle. So, what can be conclusively said? Essentially, nothing. As the name suggests, dark matter emits no light and therefore is not visible in the way normal matter is, making it difficult to observe. In fact, dark matter has only been “observed” by way of its gravitational effects. Therefore, we know it must have mass in order to be able to interact with visible matter gravitationally. It’s also imperative for it to be big enough to cause the massive gravitational effects seen in galaxies (Lochner et al., 2005). Estimates place the mass-energy content of the cosmos as being composed of 26.8% dark matter, 68.3% dark energy and a relatively miniscule 4.9% normal matter (Greicius, 2013). The terms dark matter and dark energy are often thrown around somewhat interchangeably. However, they explain distinct aspects of observed gravitational and physical phenomena. Dark matter can be thought of as an invisible substance which is only seen through its effects on gravity - the unexplained gravitational forces that hold together rapidly rotating galaxies and stopping them from flying apart. Dark energy is then the force responsible for pushing these clusters of galaxies and the universe apart, accelerating the rate of expansion of the universe (NASA/WMAP Science Team, 2013). Given the lack of answers about what dark matter is, an interesting question to ponder is how its existence was even discovered. Swiss astronomer Fritz Zwicky was the first to propose the idea of “dark matter”. His observations of the Cloma galaxy cluster led him to suggest if individual galaxies within the cluster were only held together by the gravitational force of visible mass, the galaxies should fly apart due to their high velocity (American Museum of Natural History, 2000). He termed this mysterious force responsible for binding galaxy clusters together “dark matter”. It wasn’t until the 1970s that Vera Rubin became the first person to establish the existence of dark matter through her work with spiral galaxies. Spiral galaxies aren’t stationary. They rotate, with stars different distances from the centre moving in roughly circular orbits around this centre. The highest concentration of visible stars is found within the core region of a galaxy, leading to the assumption that the majority of mass, and therefore gravity, should also be concentrated there. An implication of this is the expectation that the farther a star is from this gravitational centre of a galaxy, the slower its projected orbital speed should be (American Museum of Natural History, 2000). However, alongside astronomer Kent Ford, Rubin made the puzzling observation that stars in both the centre and outer regions of any galaxy were moving at the same speed (American Museum of Natural History, 2000). Her calculations provided convincing observational evidence of Zwicky’s theory. The presence of a significant mass of invisible matter in the outer regions of a galaxy would create an even, spherical distribution of matter, gravitationally explaining the observed rotation of galaxies and their velocity distribution (NASA/WMAP Science Team, 2013). Fifty years later and experimental evidence still remains the only “proof” of dark matter we have, having been unable to directly detect dark matter. Despite this, a majority of scientists are confident in its existence. Rubin’s insight into the velocity distribution of galaxy rotation curves is amongst some of the most convincing observational evidence for the presence of dark matter. Also supporting its existence are the various discrepancies that arise in the process of gravitational lensing. Gravitational lensing occurs when an emitted source of light is deflected or distorted by the gravitational field of a large mass. Based upon the degree of deflection, the gravitational potential of the object can be calculated, alongside the amount of matter in the lensing object (Xenon Dark Matter Project, 2022). Yet, the strength of this gravitational lensing observed in many galaxy clusters is significantly greater than that calculated from visible matter alone. These inconsistencies point to the existence of unseen mass, or dark matter, as a convincing explanation for the observed lensing effects. It’s become clear that the standard model of physics, explaining the different particles and forces comprising the visible world, cannot be used in attempting to explain dark matter. In response, researchers are exploring a number of avenues to find hypothetical new particles. Amongst the most likely candidates for the composition of dark matter are two classes of particles: Weakly Interacting Massive Particles (WIMPs) and axions. WIMPs are distinguished as a class of particles created thermally in the early universe at very high temperatures, while axions originate predominantly from non-thermal mechanisms (Griest, 2002). Compared to WIMPS, or other known type of particles, axions would be thousands of times lighter but also significantly more abundant than WIMPs (Darling & Knight, 2022). Given the infinite potential to invent hypothetical substances that resolve the enigma of dark matter, experimentation to find these particles has significant challenges. Current research efforts are focused on the detection of such particles. More than a kilometre underground in Stawell, Victoria, the Stawell Gold Mine has been converted into an underground laboratory – one with no light, no noise, and no radioactivity to interfere with dark matter signals (Lippincott, 2023). Here, an experiment known as DAMA/Libra, which started in Italy in 1998, is being replicated. For two decades, what is suspected to be dark matter has been detected at the same time each year in Italy. The Stawell Lab is seeking to verify these results, operating below the equator to determine any potential effect of seasonal interference from the Earth (Darling & Knight, 2022). The research utilises the technology SABRE (Sodium iodide with Active Background REjection), which are sodium iodide crystals that emit flashes of light if a sub-atomic particle hits the nuclei of atoms within the crystals (Darling & Knight, 2022). Hence, if a particle of dark matter hits a nucleus, a tiny flash of light should be created. Simultaneously, researchers at the University of Western Australia have been working on the detection project ORGAN (Oscillating Resonant Group Axion), in order to determine the presence of axions (McAllister, 2022). Despite not having detected any dark matter signals thus far, such experimentation has still offered important insights. Not detecting dark matter within a certain mass range and level of sensitivity allows exclusion limits to be set around the possible characteristics of axions. This tells researchers where to stop looking and, instead, where they should be focusing their resources and efforts. Despite the disarray around “solving” the conundrum of dark matter, alongside its less than reassuring name, it’s not actually something that people should be scared about. The gravity that dark matter is responsible for enables our existence, with dark energy having allowed the expansion of the early universe to become what we see, and don’t see, today (Xenon Dark Matter Project, 2022). Detecting the presence of dark matter is about advancing our understanding of the size, structure, and future of the universe. Current research approaches may seem slightly haphazard, attempting to find something that has never been detected and may not even exist. But when pursuing strange cosmological phenomena beyond our understanding, taking a wild stab in the dark may be exactly what we need to do. References American Museum of Natural History (2000). Vera Rubin and Dark Matter . Retrieved September 1, 2023 from https://www.amnh.org/learn-teach/curriculum-collections/cosmic-horizons-book/vera-rubin-dark-matter Darling, A., & Knight, B. (August 20, 2022). The search for dark matter . ABC News. https://www.abc.net.au/news/2022-08-21/dark-matter-particle-physics-sabre-experiment-stawell-victoria/101113010 Greicius, T. (March 21, 2013). Planck Mission Brings Universe Into Sharp Focus. NASA. https://www.nasa.gov/mission_pages/planck/news/planck20130321.html Griest, K. (2002). WIMPs and MACHOs . In P. Murdin (Ed.), Encylopedia of Astronomy and Astrophysics: CRC Press. Lippincott, H. (August 9, 2023). Researchers dig deep underground in hopes of finally observing dark matter. The Conversation. https://theconversation.com/researchers-dig-deep-underground-in-hopes-of-finally-observing-dark-matter-211075 Lochner, J. C., Williamson, L., & Fitzhugh, E. (2005). Possibilities for Dark Matter. Retrieved August 29, 2023 from https://imagine.gsfc.nasa.gov/educators/galaxies/imagine/titlepage.html McAllister, B. (July 26, 2022). This Australian experiment is on the hunt for an elusive particle that could help unlock the mystery of dark matter. The Conversation. https://theconversation.com/this-australian-experiment-is-on-the-hunt-for-an-elusive-particle-that-could-help-unlock-the-mystery-of-dark-matter-187014 NASA/WMAP Science Team. (2013). WMAP produces new results . Retrieved September 13, 2023 from https://map.gsfc.nasa.gov/news/ Xenon Dark Matter Project. (2022). Dark Matter . Retrieved August 25, 2023 from https://xenonexperiment.org/partners/ Wicked back to