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< Back to Issue 4 Talking to Yourself: The Biology of Hallucinations by Lily McCann 1 July 2023 Edited by Arwen Nguyen-Ngo and Yasmin Potts Illustrated by Zhuominna Ma What is consciousness? No small question. To this day it hasn’t been entirely satisfied. Consider a conversation: There are voices from the outside, stimuli that talk to all the sensory receptors that we have. They pass on messages to our fingertips that we are touching something cold; they tell our eyes that we are seeing certain wavelengths of light; and they tell the cochlea of our ears what sounds we are hearing. The sensory circuits of our bodies bring these words from outside and turn them inward, presenting them to the centre of our consciousness: Here - this is what we are experiencing. This is what we are taking from the world outside. But already, at the base of this consciousness, an idea of the world has been established. The central experience of our mind is built upon prediction: we are constantly conjuring up an estimate of how the outside world will be. The ‘Predictive Processing’ model of consciousness states that it is the conversation between this predictive perception of the world and the feedback from our sensory experience that defines what it is to feel consciousness (1). In 1971, Nature published the conclusions of a study titled, ‘Preliminary Observations on Tickling Oneself’ (2). In this experiment, a device was used to compare the experience of being tickled by an experimenter to the experience of tickling oneself, and both were compared to the intermediate of passively following the experimenter’s arm as they tickled the participant. The study concluded that the action of tickling oneself produced no effect as the planned action of tickling cancelled out the sensation of being tickled; the lack of an action in the case of the experimenter tickling the subject’s hand, allowed for a full ‘tickle’ sensation. Interestingly, the third process of passively following the tickling action was rated at a level in between these two responses. This showed that it was not the action of tickling alone that cancelled out the sensation of the stimulus as tickling, but that a knowledge of the tickle, a prediction of it, were enough to reduce the effect. This experiment reflects the idea that it is not just our planned actions and our sensory perception that drive consciousness, but that it is prediction that has a core place in driving experience. For centuries, hallucinations have been recognised as distortions of our sense of being conscious in the world. In 1838, Esquirol wrote in his ‘Mental Maladies: A Treatise On Insanity’ that the experience of a hallucination is “a thorough conviction of the perception of a sensation, when no external object, suited to excite this sensation, has impressed the senses.” (3) Anything that distorts our ‘perception’ or ‘sensation’ can therefore give rise to a hallucination. This can occur in the context of infection, psychosis, delirium, use of certain drugs - and the aptly named ‘exploding head syndrome’. Contrary to popular opinion, hallucinations are not a feature of psychotic disorders alone. In fact, analysis has shown that no single aspect of schizophrenia-related hallucinations is specific to this disease (4). In 2000, the idea of the ‘Tickling’ study was elaborated with respect to hallucinations in an investigation comparing the experience of self-produced and externally implemented stimuli for those who both did and did not suffer from hallucinations. It was shown in this study that for participants with hallucinatory disorders, there was a breakdown in the ability to differentiate between stimuli produced externally and internally (5). This study is in line with a certain theory of hallucination purported by Frith, who suggests in his discussion of positive symptoms of schizophrenia that the foundation of hallucination is a “fault in the system which internally monitors and compares intentions and actions” (6). There is another interesting theory that describes hallucinations as memories released from suppression. The authors suggest that the hallucination itself is a cacophony of memory signals set loose, where normally they are shut out of our conscious mind. One study described auditory hallucinations in those with hearing loss as an “uninhibition syndrome”. They argued that in the cases studied, a lack of sensory auditory input seemed to “uninhibit neuronal groups storing auditory memory” (7). The brain is an incredibly complex organ and theories regarding consciousness and hallucinations abound. The question of greatest practical importance is what part of the process of hallucinations can we understand and therefore, what can be targeted when we are called to treat this system in a medical setting. Recent investigations have linked various molecules, receptors and genes to hallucinatory disorders or states, whilst imaging studies demonstrate networks and regions of the brain activated during hallucinations. Investigation of certain receptor-modulating drugs has revealed the place of certain molecules in delusion and sensation; and the association of certain genes to hallucination-prone phenotypes has established a genetic cause for susceptibilities to hallucination. This research yields molecular and genetic targets for therapies that can help reduce the burden of hallucinations on an individual. It is a remarkable faculty of our minds, the ability to create a world - or aspects of the world - for ourselves and convince our own consciousness that it is real. Hallucinations reveal the capacity of the human brain for imagination; they show that all we experience is indeed creative, merely restricted by what we see as truth. But the grounding fact of knowing what is real is essential to functioning in society. Losing the ability to check our own creative experience of consciousness is exceedingly frightening and disempowering. Anything that helps us to maintain the right balance of conversation between the experiences we create and those we feel allow us to maintain a sense of self in the world. Elucidating the biology behind these conversations and the effects of hallucination itself can bring us closer to a definition of consciousness. References Hohwy J, Seth A. Predictive processing as a systematic basis for identifying the neural correlates of consciousness. Philosophy and the Mind Sciences. 2020;1(2). 3. https://doi.org/10.33735/phimisci.2020.II.64 Weiskrantz L, Elliot J, Darlington C. Preliminary observations on tickling oneself. Nature. 1971 Apr 30. 230: 598–599 https://doi.org/10.1038/230598a0 Esquirol J. Mental maladies: A treatise on insanity. France: Wentworth Press; 2016 Waters F, Fernyhough C. Hallucinations: A systematic review of points of similarity and difference across diagnostic classes. National Library of Medicine. 2016 Nov 21. doi: 10.1093/schbul/sbw132 Blakemore S.J, Smith J, Steel R, Johnstone E.C. The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: Evidence for a breakdown in self-monitoring. Psychological Medicine. 2000 Oct 17. 30(5): 1131-9. https://doi.org/10.1017/S0033291799002676 Frith C. The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychological Medicine. 1987 Aug. 17(3): 631-648. Doi: 10.1017/s0033291700025873 Goycoolea, M., Mena, I. and Neubauer, S. (2006) ‘Spontaneous musical auditory perceptions in patients who develop abrupt bilateral sensorineural hearing loss. an uninhibition syndrome?’, Acta Oto-Laryngologica, 126(4), pp. 368–374. doi:10.1080/00016480500416942. Previous article Next article back to MIRAGE

< Back to Issue 8 Why Are We So Fascinated by Space? An Exploration of Human’s Fascination with Outer Space by Emily Cahill 3 June 2025 Edited by Weilena Liu Illustrated by Saraf Ishmam I have always been enamoured by the stars. Sitting on the beach after sunset, staring up at the sky, has always given me this hopeful, grateful feeling - for what I have, and for what’s to come. It has made me wonder, why do I feel this way? Why do I feel hope instead of fear, staring into the great darkness? Is it pure curiosity or is it curated by society? Culture encompasses the ideas, customs, and manifestations that we hold regarding space. Films have been the leading presentation of outer space for many entertainment industries around the world and make visuals of space accessible for many. Many commercials, whether for global or local companies, feature advertising set in or about outer space, filling magazines, billboards and television ad breaks. From astronomy to geology to botany, many scientific fields are involved in outer space research and centre around the universe to seek answers. Culture, the entertainment industry, commercialization, and science could all be contributing factors to this fascination, and may have just as great an impact as innate curiosity. Culture Throughout time, there has been a leap from admiration to exploration of outer space. Myths and folktales about outer space and the stars have existed for centuries. The constellations were defined by humans based on patterns associated with these myths and folktales (1). Perhaps space is something that has connected all humans regardless of where and when because it has always existed for us to admire. From folktales to automated rocket ships, the human desire to explore launched our voyages in space. From designing caravans to traverse the countryside, to building boats to cross the sea, to assembling submarines to travel to the bottom of the ocean, humans have always created whatever they need to explore the unknown. The ‘father of modern rocketry’ Konstantin Tsiolkovsky said, “The Earth is the cradle of humanity, but one cannot live in a cradle forever” (2). These inspiring words align with many scientists and space exploration companies like NASA, emphasizing the importance of space travel to satisfy curiosity. There are also underlying cultural reasons that push space exploration. The 1961 Apollo space mission was presented as an opportunity to discover the unknown, but in fact was for another reason. Apollo Astronaut Frank Borman said, “Everyone forgets that the Apollo programme wasn’t a voyage of exploration or scientific discovery, it was a battle in the Cold War, and we were Cold War warriors. I joined to help fight a battle in the Cold War and we’d won” ( Hollingham , 2023). Pop culture also has a large influence on how we see outer space. Katy Perry and Gayle King went to space just a few months ago, heralding female astronauts, but at the same time, reinforcing the growing idea of space tourism. Entertainment Perhaps the most common and tangible depiction of outer space - other than gazing at the sky itself - is in films. Star Wars was and continues to be a cultural phenomenon, even garnering the distinction of a global holiday on the 4th of May. The films Gravity (2013), Interstellar (2014), and The Martian (2015) centre around heroes in unbelievably intense scenarios trying to solve problems to better the human race. The success of these films may be due to the strength of the actors and writing alone, but is more likely due to the dueling feelings of fear and hope that accompany the setting of outer space. The deep sea and outer space are both settings where films have thrived, potentially because of the human instinct for curiosity, and in turn, the impulse to root for and care about the characters. Given the influence of entertainment on culture, if these movies depicted space as a scary, dangerous, and outlandish environment, we might not feel as excited or positive about space. Both our conceptions of the unknown and the influence of the entertainment industry shape our perceptions of outer space. Interstellar is praised by critics for its ability to let us see ourselves as the protagonist - solving impossible puzzles and searching for the answers to life - while reflecting the emotionally beautiful and terrifying landscape of human existence in outer space (4). Commercialization For decades, advertisements have featured outer space as a setting or main theme for the storyline. Some ads are even filmed in space. In 2001, Pizza Hut sent an astronaut in a rocketship with a camera and a pizza, becoming the first commercial actually shot in space (5). Olay and Girls Who Code collaborated in a 2020 Super Bowl commercial with Katy Kouric, Taraji P. Henson, Busy Phillps, and Lilly Singh with the tagline “make space for women” (6). Madonna Badger - the COO of the advertising agency that ran the Olay commercial - said that space gives us somewhere to escape to in the midst of tough times: “W e’re living in pretty anxious times. When things on Earth become so stressful, there’s something about space that gives us permission to dream” (5). The CCO of Walmart, Jane Whiteside echoed Badger, saying, “It’s a really strange time to be an earthling right now. There’s this interesting confluence of extreme anxiety and a sense of optimism that somehow, we’re going to figure things out.” He said, “Space is the epitome of that. It’s unbridled optimism” (5). The 2020 Super Bowl Walmart commercial centered around a Walmart delivery person dropping off groceries to aliens on another planet. Outer space is on our televisions and devices as the setting for some of the biggest advertisements, for the biggest companies, suggesting a sense of importance and grandeur. Science The hunt to answer the questions “Where do we come from?”, “Are we alone in the universe?”, and “What is out there?” is another factor that may drive our fascination with space. Not only do we enjoy admiring it, but we also want to gain something from it. Scientists say that these questions can potentially be answered, and fields like paleontology, geology, botany, and chemistry work together to answer them. One of the current driving forces of this research is the search for another planet that can support human life if Earth becomes uninhabitable (7). Climatologists are able to learn more about Earth’s climate from the climate of other planets and gain natural resources that benefit our planet. Mars’ climate has undergone drastic changes, including the presence of water and the loss of atmospheric gases - changes we can learn from using paleontology and geology to discover how organisms on Mars may have adapted (7). Whether launching into space or stargazing, humans continue to look up into the sky - whether for a defined reason or not, it will continue to remain a mystery. References 1. National Sanitation Foundation. (2012). What are Constellations? National Radio Observatory. https://public.nrao.edu/ask/what-are-constellations/ 2. NASA. (2015). The Human Desire for Exploration Leads to Discovery. https://www.nasa.gov/history/the-human-desire-for-exploration-leads-to-discovery/ 3. Hollingham R. Apollo: How Moon missions changed the modern world. BBC. 2023 May. https://www.bbc.com/future/article/20230516-apollo-how-moon-missions-changed-the-modern-world 4. Scott A.O. Off to the Stars, With Grief, Dread and Regret. New York Times. 2014 Nov. https://www.nytimes.com/2014/11/05/movies/interstellar-christopher-nolans-search-for-a-new-planet.html 5. Zelaya I. Why Outer Space Is a Go-To Theme for Super Bowl 2020 Ads. Adweek (Super Bowl Commercials). 2020 Jan. https://www.adweek.com/brand-marketing/why-outer-space-is-a-go-to-theme-for-super-bowl-2020-ads/ 6. Spacevertising: The Super Bowl And The 15 Best Outer-Space Ads You Need To See Right Now Orbital Today (Features). 2024 Feb. https://orbitaltoday.com/2024/02/14/spacevertising-super-bowl-and-15-best-outer-space-commercials-you-need-to-see-right-now/ 7. Horneck, G. (2008). Astrobiological Aspects of Mars and Human Presence: Pros and Cons. Hippokratia Quarterly Medical Journal, 1, 49-52. https://pmc.ncbi.nlm.nih.gov/articles/PMC2577400/ Previous article Next article Enigma back to

< Back to Issue 8 Thinking Outside the Body: The Consciousness of Slime Moulds by Jessica Walton 3 June 2025 Edited by Han Chong Illustrated by Ashlee Yeo Imagine yourself as an urban planner for Tokyo’s public transport system in 1927. Imagine mapping out the most efficient paths through dense urban sprawl, around obstructing rivers and mountains. And imagine meticulously designing the most efficient possible model, after years of study and expertise… only to find your design prowess, 83 years later, matched by a slime mould: a creature with no eyes, no head nor limbs, nor nervous system. Of course, this is anachronistic. For one, the Tokyo railroad system developed over time, not all at once. But it was designed to meet the needs of the city and maximise efficiency. Yet in 2010, when researchers exposed the slime mould Physarum polycephalum to a plate mimicking Tokyo city (with population density represented by oat flakes) it almost exactly mimicked the Tokyo railroad system (1). This became one of the most iconic slime mould experiments, ushering in a flood of research about biological urban design asking the question: Could a slime mould, or other similar organisms, map out human cities for us? But a slime mould doesn’t know what cities are. They’re single-celled organisms; they don’t understand urban planning, or public transport, or humans. They are classified as protists, largely because we’re not sure how else to categorise them, not because they’re particularly ‘protist-y.’ They have no brain and are single-celled for most of their life; so they can’t plan routes, have preferences, or make memories. Right? Except, perhaps they can. Slime moulds are extremely well-studied organisms because they exhibit precisely these behaviours. But how do they think? And what does it mean— to think ? Slime moulds have evidenced memory and learning. The protoplasm network they form is really just one huge cell that eventually develops into a plasmodium, growing and releasing spores. While plasmodial slime moulds (like P. polycephalum ) do this during reproduction, cellular slime moulds (dictyostelids) are able to aggregate together into one cell like this when food is scarce or environments are difficult (meaning they must be able to detect and evaluate if these things are true). Most slime mould behaviour is understood through cell signalling and extracellular interaction mechanisms; responding to chemical gradients using receptors along their membrane, which signal to the cells to move up the concentration gradient of a chemoattractant molecule and away from a chemorepellent. This makes sense; bacteria (like almost every other living organism) do this all the time and it’s the chief way that they make decisions . But what about memory and preferences? What about stimuli beyond the immediate detected chemicals? Slime moulds can, for example, anticipate repeated events and avoid simple traps to reach food hidden behind a U-shaped barrier (2,3). These are beyond input-to-output; something more complex must be happening. Something conscious? Thinking ? The idea of consciousness requiring complex neuronal processes is becoming rapidly outdated as we observe patterns of thinking in organisms that, according to classical definitions, really should not be able to. Using the slime mould as an example, Sims and Kiverstein (2022) argue against the ‘neurocentric’ assumption that an organism must have a brain to be cognisant. Instead, P. polycephalum is suggested to exhibit spatial memory, with cognition being suggested to sometimes include external elements (3). They showed it may undergo simple, habitual learning and hypothesised it uses an oscillation-based mechanism within the cell (3). Similarly, oscillator units along the slime mould’s extending tendrils oscillate at a higher frequency at higher concentrations of food source molecules (like some tasty glucose), signalling to the slime mould to move in that direction (4). Sims and Kiverstein (2022) also posit that the slime trail left by slime mould could function as an external memory mechanism. They found that P. polycephalum avoids slime trails as they represent places it has already been; suggesting a method of spatial memory (4). This was further proved as not a pure input-output response by showing that the avoidance response could be overridden when food is placed on or near slime trails (5). They suggest that the slime mould was able to balance multiple inputs, including oscillation levels and slime trail signals, exhibiting simple decision-making. Should we count these processes as thinking ? This topic is debated by philosophers as much as biologists. Sims and Kiverstein (2022) use the Hypothesis of Extended Cognition, being that mind sometimes extends into the environment outside of the brain and body, to argue firmly that it does count. But at the end of the day, despite understanding the chemical and electrical processes between neurons signalling and the cellular makeup of the brain, we still don’t understand how electrical signals through a series of axons make the leap to complex consciousness. Rudimentary and external cognition pathways, as seen with the slime mould, may also be an evolutionary link in the building blocks to more complex, nerve-based consciousness and decision making (3). We don’t yet understand the phenomena inside our own skulls—how can we hope to define it across all other organisms? Slime moulds clearly have something beyond simple chemical reactions. This begs the question: Aren't our own minds also fundamentally just made of simple chemical reactions? And if a slime mould is able to evaluate multiple inputs, how wonderfully complex must such processes be inside (and outside) a sea anemone, a cockroach or a cat? There’s no way to know what such a consciousness would look like or feel like to our frame of reference. When a slime mould, moving as a network around an agar plate, ‘looks up’ (or an equivalent slime mould action) and perceives unfathomable entities, how does it process that? What does the slime mould think of us? Bibliography 1. Kay R, Mattacchione A, Katrycz C, Hatton BD. Stepwise slime mould growth as a template for urban design. Sci Rep. 2022 Jan 25;12(1):1322. 2. Saigusa T, Tero A, Nakagaki T, Kuramoto Y. Amoebae Anticipate Periodic Events. Phys Rev Lett. 2008 Jan 3;100(1):018101. 3. Sims M, Kiverstein J. Externalized memory in slime mould and the extended (non-neuronal) mind. Cognitive Systems Research. 2022 Jun 1;73:26–35. 4. Reid CR, Latty T, Dussutour A, Beekman M. Slime mold uses an externalized spatial “memory” to navigate in complex environments. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17490–4. 5. Reid CR, Beekman M, Latty T, Dussutour A. Amoeboid organism uses extracellular secretions to make smart foraging decisions. Behavioral Ecology. 2013 Jul;24(4):812–8. Previous article Next article Enigma back to

< Back to Issue 6 Cosmic Carbon Vs Artificial Intelligence by Gaurika Loomba 28 May 2024 Edited by Rita Fortune Illustrated by Semko van de Wolfshaar “There are many peculiar aspects of the laws of nature that, had they been slightly different, would have precluded the existence of life” - Paul Davies, 2003 Almost four billion years ago, there was nothing but an incredibly hot, dense speck of matter. This speck exploded, and the universe was born. Within the first hundredth of a billionth of a trillionth of a trillionth second, the universe began expanding at an astronomical rate. For the next 400 million years, the universe was made of hydrogen, helium, and a dash of lithium – until I was born. And thus began all life as you know it. So how did I, the element of life, the fuel of industries, and the constituent of important materials, originate? Stars. Those shiny, mystical dots in the night sky are giant balls of hot hydrogen and helium gas. Only in their centres are temperatures high enough to facilitate the collision of three helium-4 nuclei within a tiny fraction of a second. I am carbon-12, the element born out of this extraordinary reaction. My astronomical powers come from my atomic structure; I have six electrons, six protons, and six neutrons. The electrons form teardrop shaped clouds, spread tetrahedrally around my core, my nucleus, where the protons and neutrons reside. My petite size and my outer electrons allow my nucleus to exert a balanced force on other atoms that I bond with. This ability to make stable bonds makes me a major component of proteins, lipids, nucleic acids, and carbohydrates, the building blocks of life. The outer electrons also allow me to form chains, sheets, and blocks of matter, such as diamond, with other carbon-12 atoms. Over the years of evolution, organic matter buried in Earth formed fossil fuels, so I am also the fuel that runs the modern world. As if science wasn’t enough, my spiritual significance reiterates my importance for the existence of life. According to the Hindu philosophy, the divine symbol, ‘Aum’ is the primordial sound of the Cosmos and ‘Swastika’, its visual embodiment. ‘Alpha’ and ‘Omega’, the first and last letters of the Greek alphabet, represent the beginning and ending, that is the ‘Eternal’ according to Christian spirituality. When scientists photographed my atomic structure, spiritual leaders saw the ‘Aum’ in my three-dimensional view and the ‘Swastika’ in my two-dimensional view. Through other angles, the ‘Alpha’ and ‘Omega’ have also been visualised (Knowledge of Reality, 2001). I am the element of life, and within me is the divine consciousness. I am the beginning and I am the end. My greatness has been agreed upon by science and spirituality. In my absence, there would be no life, an idea humans call carbon chauvinism. This ideology and my greatness remained unquestioned for billions of years, until the birth of Artificial Intelligence. I shaped the course of evolution for humans to be self-conscious and intelligent life forms. With the awareness of self, I aspired for humans to connect back to the Cosmos. But now my intelligent toolmakers, aka humans, are building intelligent tools. Intelligence and self-consciousness, which took nature millions of years to generate, is losing its uniqueness. Unfortunately, if software can be intelligent, there is nothing to stop it becoming conscious in the future. Soon, the earth will be populated by silicon-based entities that can compete with my best creation. Does this possibility compromise my superiority? A lot of you may justifiably think so. The truth is that I am the beginning. Historically, visionaries foresaw asteroid attacks as the end to human life. These days, climate change, which is an imbalance of carbon in the environment, is another prospective end. Now, people believe that conscious AI will outlive humans. Suggesting that I will not be the end; that my powers and superiority will be snatched by AI. So the remaining question is, who will be the end? I could tell you the truth, but I want to see who is with me at the end. The choice is yours. References Davies, P. (2003). Is anyone out there? https://www.theguardian.com/education/2003/jan/22/highereducation .uk Knowledge of Reality (2001). Spiritual Secrets in the Carbon Atom . https://www.sol.com.au/kor/11_02.htm Previous article Next article Elemental back to

< Back to Issue 2 Discovery, Blue Skies... and Partisan Bickering? Is the era of bipartisan science dead? Do we discover for discovery’s sake? And what happens when optimistic scientific vision meets cold political reality? Journeying from Cambridge, Massachusetts to Melbourne, Australia and tackling everything from deadlocked appropriations bills and economic mandates to the scientist-politician and the prospect of discovery, this feature tries to shine a light on all those questions, as it ponders what it really means to do science in the age of politics. by Andrew Lim 10 December 2021 Edited by Ethan Newnham & Sam Williams Illustrated by Friday Kennedy The chalk dust hangs in the air. Blackboards scrawled with inheritance trees, genetic disease rates and historical minutiae about a long-deceased Oxford don … they all stand still for a moment. As he walks out, the freshman class surrounds the professor (a man once unironically described as “the rock star of biology”), pestering him with incessant questions. Ambling into the sunny fall day, they are joined by more and more – he cracks a joke about being a “photos kind of guy” and lets them take the obligatory selfie. Image 1: Dr Eric Lander teaching freshman biology at MIT in 2012. Looking at the scene, it’s hard to believe that we find here a future member of the Cabinet of the United States. Surely such individuals come from the corridors of Congress or the halls of big business, not this leafy, academic and somewhat-secluded corner of Cambridge, Massachusetts, between an apple tree descended from Isaac Newton’s in the garden and a prototype solar car down the hall. And almost certainly this man, who once steeled himself for a “rather monastic” pure mathematics career and whose main claim to fame was in mapping out the human genome, cannot be the one who someday will be asked to bridge science and politics in what appears an ever more divided union. But he is. In 2021, this very professor, Dr Eric Lander, will be sworn in as Director of the Office of Science and Technology Policy (OSTP), charged by President Joe Biden with maintaining “the long-term health of science and technology” and “guarantee[ing] that [their] fruits … are fully shared”. The mandate belies a time where science increasingly seems to live in the world of partisan political bickering. And so, in an exciting new series of features beginning with this very article, we at OmniSci Magazine are sitting down with those shaping the colliding worlds of science and public service across Australia and around the globe to ask: In a time when Dr Lander’s appointment is heralded by the White House slogan “Science is Back” and Australia sees thirteen Science Ministers in ten years, can science still straddle the political divide, or is the era of bipartisan science dead? What does it mean to discuss national science in an era of international research? And how should scientists and policymakers alike navigate this brave new political world? If not very scientific, it perhaps befits the political side of this feature to begin with the apocryphal. It has been said that The Right Honourable William Ewart Gladstone, the famed four-term 19th-century Liberal Prime Minister of the United Kingdom, was once attending a demonstration by the physicist Michael Faraday, who had just made his first forays into electricity. After the show, Gladstone went to the back of the room to have a word with the inventor: “It’s all very curious, Mr Faraday,” he murmured, “but does it have any practical use?”. The scientist did not miss a beat: “Well, sir,” he responded, “I suspect one day you shall tax it!” Image 2: President John F Kennedy speaking at Rice University in Houston, Texas in September 1962 It’s an old joke that, to many, sums up the cold-hearted and transactional relationship between science and politics. But those of a more optimistic bent would disagree. They would point to the golden age of space exploration, when, over half a century ago, on a sunny September Houston morning, President John F Kennedy famously declared that the United States would “go to the Moon in this decade”. That day, he offered a vision for his country to “set sail on this new sea because there is new knowledge to be gained”, promising an open mandate to learn more about the universe around us, with no reason beyond the sheer wonder of exploration. It was a promise to a nation – one that appeared to transcend party politics. Indeed, it was ironically under the presidency of Richard M Nixon, the man whose campaign had accused Kennedy in 1960 of mass electoral fraud, that Apollo 11 landed on the moon, with Nixon transformed into the man who promised to “not drift, nor lie at anchor…with man's epic voyage into space”. But if overflowing bipartisan support for research as a sheer quest for knowledge was once the case, it certainly seems at odds with political reality today. Both sides of the political aisle seem deeply concerned with the economics of science rather than the prospect of discovery. In Australia, upon the appointment of The Honourable Richard Marles MP as Shadow Minister for Science, Opposition Leader the Honourable Anthony Albanese MP described him as “shadow minister for jobs, jobs and more jobs”. The Shadow Minister himself then highlighted science and technology as key to “micro-economic reform” for Australia. Mere months later, upon The Honourable Melissa Price MP’s appointment as Minister for Science, Prime Minister the Honourable Scott Morrison MP spoke of her portfolio encompassing science and technology “right across the economy, both in civil and defence uses”. To many, this speaks to a wider concern – the neglect of esoteric “blue skies” research (pursuing discovery for discovery’s sake) in favour of scientific research with immediate short-term economic impact. you never quite know what a scientific discovery will lead to or when it’ll be useful (or indeed, vital!) for society. I don’t think our State or Federal Governments are doing enough to fund this kind of science and research, in everything from medical research to physics to studying our threatened species. It needs to be valued a lot more.” Representatives from the Victorian branches of the Australian Labor Party and the Liberal Party of Australia did not respond to our request for comment. It's a trend that Ellen Sandell MP, Deputy Leader of the Victorian Greens, has watched with growing concern. In an exclusive email interview with OmniSci Magazine, she expressed her dismay at the state of “blue skies” science: “Basic research - or the study of science to better understand our world, even if we don’t know where it will lead - is incredibly important. I think the pandemic has shown us just how valuable our scientists are, and Image 3: Ellen Sandell MP on the floor of Victorian Parliament. Image 4: Dr Amanda Caples, Lead Scientist of Victoria However, Lead Scientist of Victoria Dr Amanda Caples, one of the key figures in the Victorian Government’s engagement with research, rejects Sandell’s contention. In her discussion with us, Dr Caples spoke of “an ‘and’ conversation rather than choosing one form of research over another…[a discussion about] hav[ing] a good mix of pure and applied research”. She went on: “most pure research has a purpose or use-case in mind – it’s just not typically driven by commercial interests and the applications are not always evident at the outset. The policy outcome that the Victorian Government is seeking to achieve is to mobilise research knowledge to make it available for use in the economy and community more broadly… Applying the brains of the research community to the problems of industry – and I suggest also of government – is not a novel concept. It is the approach of successful innovation clusters from Cambridge UK to Boston and to Israel. It underpins future industries and high-value jobs, attracts talent and supports service industries. We can do it here in Melbourne too!”. Nonetheless, with all these swirling worries, it’s no surprise that the days of blue-skies research investment seem an enchanting vision – the best that humanity can be, boldly seeking out new frontiers of understanding and knowledge. Yet if exciting, perhaps it is but a mirage. A mere two months after the rhetorical highs of his Houston address, in a White House Cabinet Room meeting not declassified until some 40 years later, Kennedy confided in NASA Administrator James E Webb that if he couldn’t find a practical, political use for the research, “we shouldn't be spending this kind of money, because I'm not that interested in space”. A year after that, as poll numbers and public support for his scientific venture started to wane, Kennedy’s language became sharper. He bluntly told Webb that “we’ve got to wrap around in this country, a military use for what we’re doing and spending in space.” Even in this, space research’s golden age, amidst his lofty rhetoric of human adventure, Kennedy had his eye on the polls, the politicians and the price tags. Image 5: President Biden announcing his plans to form ARPA-H, flanked by Vice President Kamala Harris and Speaker Nancy Pelosi. President Biden and Dr Lander appear to be thinking similarly – at least in terms of searching for a large-scale, popular science mandate that the public will buy into. In the wake of a pandemic, their area of concern seems almost too obvious: health. In his April address to a Joint Session of Congress, President Biden announced his plan to develop an “Advanced Research Projects Agency for Health [ARPA-H]…to develop breakthroughs to prevent, detect, and treat diseases like Alzheimer’s, diabetes, and cancer.” Invoking his son Beau, who died of brain cancer in 2015, he announced increased funding to “end cancer as we know it”, declaring that there was “no more worthy investment…nothing that is more bipartisan…[and] it’s within our power to do it”. A cure for cancer. A man on the moon. Striking, almost visceral promises designed to address the worries of their generation: from national defence in the Cold War to public health amidst a pandemic. It’s something that both Sandell and Caples seem focussed on too. Sandell believes that a continued and increasing emphasis on health research is the way forward for Victoria: “Melbourne is a centre for excellence when it comes to medical research, so the state government has a role in supporting and encouraging this to ensure we maintain that position.” Likewise, Caples thrusts mRNA research into focus, listing one of her key priorities as “driv[ing the] development of frontier technologies such as quantum computing and mRNA.” But to her, the story is not just about the lessons from the pandemic itself, but also about how we rebuild. As she told us, “Nations around the world are investing in science, technology and innovation as they rebuild economies impacted by the coronavirus pandemic. This is because global policymakers understand that a high performing science and research system benefits the broader economy.” This narrative of science as the springboard out of COVID echoes a letter President Biden wrote to Dr Lander upon his appointment, describing science’s power to forge “a new path in the years ahead – a path of dignity and respect, of prosperity and security, of progress and common purpose”. Yet, especially for our stateside counterparts, lofty rhetoric seems no guarantee of avoiding an ugly partisan fight. Just a few years after a Trump White House considered science agency cuts en masse, the issue of funding is back on the congressional table. And it’s not all going well. In the USA, almost all budget laws for federal government agencies, departments and programs begin life as appropriations bills – bills that determine how much money is to be allocated (or “appropriated”) to parts of the government. However, this year, an ongoing Senate deadlock has seen Congress unable to pass any appropriations bills whatsoever. To avert a government shutdown (where no agencies have any money and no federal programs can operate), a stopgap continuing resolution has been implemented, temporarily freezing spending at previous levels, allowing the government to keep operating. On October 18, Senator Patrick Leahy (D-VT), Chair of the Senate Appropriations Committee, announced nine appropriations bills to break the logjam and fund the government (including crucial research agencies) through the 2022 fiscal year. Given the political situation, the bills have been riddled with earmarks – unrelated “pork barrel” projects designed to win over wavering votes (the most famous example of this being a $400 million “Bridge to Nowhere” in Alaska, funded inside a 2005 housing, transport and urban development bill). In just one case of this, $64 million has been carved out of the National Oceanographic and Atmospheric Administration (NOAA) for additional “special projects”. Yet despite these concessions, the bills look to be dragged through a long political battle. In a statement released as Leahy announced his plans, Senator Richard Shelby (R-AL), Vice Chair of the Committee, lambasted them as “partisan spending bills…[and] a significant step in the wrong direction”, vowing to oppose them. On 3rd December 2021, a week before this article’s publication, Congress passed another stopgap continuing resolution following a night of political brinksmanship that brought the government within hours of being defunded and shut down. Regardless, at the time of writing, all appropriations bills remain unpassed and the battle rages on into 2022. It’s a confrontational attitude – and one that seems to not be going anywhere anytime soon. After all, closer to home, we’ve seen university education funding become a political football, with Shadow Education Minister the Honourable Tanya Plibersek MP promising a Labor Party election platform predicated on undoing what she characterises as Morrison government “economic vandalism”. But it’s not all bad news. In her responses, Sandell describes herself as “worried about the hyper-partisan nature of politics at the moment but…buoyed by how science and evidence has been at the heart of our response to the pandemic in Australia, at least here in Victoria.” She sees the issue of a partisan approach to scientific advice as stemming from a greater problem: the non-existence of the scientist-politician. In her words, “When I entered State politics, I was shocked to discover less than 10% of politicians had any form of post-high-school scientific training. I think that’s a real loss for our Parliament and our society…I hope that the pandemic has shown the population and Governments the value of listening to evidence, and that this rubs off into other areas of policy-making.” But she refuses to tie the power of “this scientific type of thinking” to her own values. In her experience, a scientific mode of thinking invites “politicians of all persuasions” to work to integrate their ideology with evidence. A fiscally conservative scientist-politician is just as possible as a social-justice-minded and progressive one – the policies produced might well be different, but the base evidence is constant. Caples is similarly optimistic: “Regardless of politics, the foundational principles of science remains [sic] the same - which is to expand our knowledge of the natural world, to progress society and develop innovations to meet its challenges. While debates – political or otherwise – might take place on the peripheries of scientific learning, these tenets remain the same to build the evidence base.” After all, the pitch Webb made in his 1963 meeting with Kennedy relied not on social justice, progressivism nor Cold War tactics. It was so much simpler: “man [is] looking at three times what he’s never looked at before… and he understands the Universe just looking at those three things…these are going to be finite things in terms of the development of the human intellect. And I predict you are not going to be sorry, no Sir, that you did this.” Image 6: Vice President Kamala Harris administering the oath of office to Dr Eric Lander, as his wife Lori watches on. That notion of the lasting good that discovery can do – its place as a rung on the ladder of human progress, in so many ways beyond the governance of a single place or a single point in time – is a sentiment that echoes on through the decades. In June 2020, while being sworn in, Lander took some time to ruminate about the text on which he was swearing his oath of office. He told Vice President Kamala Harris about the particular page of the Mishnah (a Jewish text compiled from oral tradition) he had used, which discusses “a very special concept in Jewish tradition called Tikkun Olam, the repairing of the world…it says we don’t have to finish the work, but we may not refrain from doing that work…[it] speaks in many ways to the work of this administration, of repairing the world, building back better.” Caples’ final comments to OmniSci Magazine touch a similar note – “as a lapsed pharmacologist, I look at my work through the lens of a receptor-ligand binding model. Where the receptor is the problem that needs to be solved (or the opportunity to be pursued) and my role is to build the ligand that holds together long enough to bind to the receptor and effect change. The ligand of course has to have the right composition and 3-dimensional structure to be effective, that is people and governance framework.” Sandell agrees: “With the big challenges our world is facing - from climate change to pandemics - scientists are needed now more than ever. And for those thinking about going into policy-making, make sure you keep an open mind, look at the evidence and collaborate with others. Our world needs policy-makers who have a genuine desire to solve some of the big problems of our time, not people who are just in it for themselves. Don’t get discouraged by what you might see in Question Time or the depressing nature of politics at times - we need good, curious people from all walks of life to join politics to improve the tenor of debate and ultimately improve our world.” The consensus from all three? Yes – every day of the week, politics seems dirtier, and the policy problems seem greater than ever before. They may not be issues we can finish in our lifetimes – the solutions we create may not work, the “ligands” may not “bind”, forever. Yet because we might well fail is no reason to “refrain from doing that work”; no reason for “good, curious people” not to try. But, to the man who we began with – that energised professor in Building 26 at MIT – such philosophical musings are all yet to come. There, Dr Lander cracks a caustic quip about his students, reminding them that only a few centuries before, people thought their brains were only there to vent heat. It’s almost ironic to consider that his job will eventually hinge on a handful of brains and egos on Capitol Hill. Tikkun Olam: repairing the world. It appears to be the gallant ambition of saints. Or maybe the quixotic endeavour of fools. So complicated it hardly seems worth the effort. Throughout this magazine, you have read stories of science’s remarkable ability to create patterns amidst chaos, find the quantitative inside the qualitative and build order amidst disorder. These pages provide the opposite – offering no data to extrapolate, no empirical test to conduct, no nice charts and graphs to view. Just a messy, complicated ball of disordered contradictions. It was Aristotle who suggested that democracy was inherently dangerous – that this bubbling cauldron of ideas and ideals, pragmatism and ideology, could not be entrusted to the ballot box. And, indeed, the notion that everything would be easier should we just “follow the science”, as though science was some monolithic entity with its own set of ideologies, seems tempting from time to time. But the questions raised here – of immediate benefits weighed against blue-sky thinking; of hard-to-sell science pondered alongside popular mandates; of political leanings measured next to scientific impartiality – don’t fit nicely into our boxes of conservative and liberal; left and right; moderate and progressive. They are far too complex, far too nuanced and far too important to be rendered into a three-word slogan, a thirty-word answer, or even a three-thousand-word feature article. And maybe – just maybe - that’s why they matter. Andrew Lim is an Editor and Feature Writer with OmniSci Magazine. Image Credits (in order): Michael C. ’16, from “Eric Lander, spring rolls, and the New York Times” in MIT Admissions Blog Sept 6, 2012; Robert Knudsen. White House Photographs. John F. Kennedy Presidential Library and Museum, Boston; The Office of Ellen Sandell MP; The Office of the Lead Scientist of Victoria; Melina Mara/The Washington Post; Official White House Photo by Cameron Smith, accessed via the Library of Congress. Previous article back to DISORDER Next article

< Back to Issue 2 Building the Lightsaber Some of the most iconic movie gadgets are the oldest ones. For this issue we look at how the lightsaber was brought to life. by Manthila Ranatunga 10 December 2021 Edited by Sam Williams and Tanya Kovacevic Illustrated by Rohith S Prabhu Star Wars : A New Hope was a massive success when it hit cinemas back in 1977. It was a groundbreaking sensation in the field of science fiction movies and computer generated imagery (CGI) in films. What really caught many fans’ eyes was, of course, the lightsaber. Also referred to as a “laser sword”, it is described as “an elegant weapon, for a more civilised age”. Now in our civilised age, we have decided to replicate this dangerous weapon. Lightsabers have already been built by a few enthusiasts. For this piece, we will be focusing on Hacksmith Industries’ lightsaber build from 2020 , as it is the closest to the real deal. Fig. 1. “Hacksmith Industries’ latest lightsaber build”, Hacksmith Industries, 4000° PLASMA PROTO-LIGHTSABER BUILD, 2020. Hacksmith Industries was founded by James Hobson, an engineer who builds real-life versions of film and video game gadgets. After multiple attempts, the team managed to fabricate a retractable, plasma-based lightsaber. However, this is not a real lightsaber, but more-so a protosaber in the Star Wars universe. We will get back to this point later on. How do they work? Let us first talk about how lightsabers work in the movies. A lightsaber consists of three parts: the hilt, the Kyber crystal and the blade itself. Similar to a traditional sword, the hilt is the handle and is made of a durable metal such as aluminium. It contains the Kyber crystal, which is a rare crystal found in the Star Wars universe and is the power source of the lightsaber. Moving onto the more interesting part, the blade is a beam of plasma. Often called “the fourth state of matter”, it is created by heating gas up to temperatures as high as 2,500 degrees celsius. A battery inside the hilt activates the crystal. The produced plasma is then focused through a lens and directed outwards. An electromagnetic field, essentially a force field, generated at the hilt contains the plasma in a defined beam and directs it back into the hilt. The crystal absorbs the energy and recycles it. Hence lightsabers are extremely energy-efficient, allowing Jedi Knights to use them for their whole lifetimes. Fig. 2. Robert W. Schönholz, Blue Lightsaber, c.2016. Of course, the lightsaber breaks the laws of physics. Electromagnetic fields do not work as they do on fictional planets like Coruscant. Energy-dense power sources such as Kyber crystals do not exist in real life, which leads us to the protosaber. In Star Wars lore, a protosaber is a lightsaber with an external power source. It was the predecessor to the lightsaber when Kyber crystals could not be contained inside the hilt. Since real-life high energy sources cannot be squished into the hilt, Hacksmith Industries' lightsaber build is reminiscent of the early protosaber. The build The engineers at Hacksmith Industries settled on liquefied petroleum gas (LPG) as the power source, the same gas used for home heating systems and barbecues. This gas is fed through the brass and copper hilt, and is burnt continuously to keep producing plasma. To form the beam shape of the blade, they incorporated laminar flow of gas. Ever seen videos of “frozen” water coming out of taps like this ? Laminar flow occurs when layers of fluid molecules, in this case LPG, flow without mixing. In this instance, a smooth beam is created. Unlike actual lightsabers, the beam does not return to the hilt to be absorbed. Of course, to be a lightsaber, it has to function like one, too. The plasma is extremely hot, reaching up to 2,200 degrees celsius. Therefore, it can cut through metal and other objects much like we see in the movies. This also means contact with the blade can lead to serious or even fatal injuries. The external power supply is in the form of a backpack, with mounted LPG canisters and electronics for assistance. Overall, the build looks, feels and works like a real lightsaber, which makes it a pretty accurate replica. However, we do not have the Force or ancient Jedi wisdom, so there are some notable imperfections in the design. Fig. 3. “Finished lightsaber build”, Hacksmith Industries, 4000° PLASMA PROTO-LIGHTSABER BUILD, 2020. Colours Lightsabers come in a variety of colours, each reflecting the wielder's moral values in Star Wars canon. Blue, for example, represents justice and protection. Green, blue and red are the most commonly seen in the movies, but lightsabers also come in purple, orange, yellow, white and black. If you did high school science, you may remember mixing bunsen burner flames with salts to produce colours. The same principle applies here; salts can be mixed in with plasma to colour the blade. For example, Strontium Chloride gives a red colour, so you can finally live out your Sith fantasies. Fig. 4. “Lightsaber colours by mixing salts”, Hacksmith Industries, 4000° PLASMA PROTO-LIGHTSABER BUILD, 2020. Improvements The downside of using plasma is that we cannot fight with it. Blades would pass right through each other without clashing. To fix this, a metal rod that can withstand high temperatures, such as Tungsten, could form the blade with a beam of plasma around it. However, this means the lightsaber would not be retractable, which defeats the purpose. To keep the blade coloured, salts have to be continuously fed through the hilt. This can be done with another pressurised canister along with the LPG, although it requires extra space. Despite the imperfections, the protosaber by Hacksmith Industries is the closest prototype to a real-life lightsaber. With constantly evolving technology, we will be able to build a more compact model that more closely resembles those in the movies. Makers all around the world are building cool movie gadgets like the lightsaber, so keep a lookout for your favourite ones. You never know what the nerds may bring! References 1. Amy Tikkanen, “Star Wars”, Britannica, published April 10, 2008, https://www.britannica.com/topic/Star-Wars-film-series. 2, 4, 7. Hacksmith Industries, “4000° PLASMA PROTO-LIGHTSABER BUILD (RETRACTABLE BLADE!)”, October 2020, YouTube video, 18:15, https://www.youtube.com/watch?v=xC6J4T_hUKg. 3. Joshua Sostrin, “Keeping it real with the Hacksmith”, YouTube Official Blog (blog), November 12, 2020, https://blog.youtube/creator-and-artist-stories/the-hacksmith-10-million-subscribers/. 5. Daniel Kolitz, “Are Lightsabers Theoretically Possible?”, Gizmodo, published August 10, 2021, https://www.gizmodo.com.au/2021/08/are-lightsabers-theoretically-possible/. 6. Richard Rogers, “Lightsaber Battery Analysis”, Arbin Instruments: News, published October 3, 2019, https://www.arbin.com/lightsaber-battery-analysis/. 8. Phil Edwards, “Star Wars lightsaber colors, explained”, Vox, published May 4, 2015, https://www.vox.com/2015/5/31/8689811/lightsaber-colors-star-wars. Previous article back to DISORDER Next article

< Back to Issue 8 Fungal Pac Man by Ksheerja Srivastava 3 June 2025 Edited by Rita Fortune Illustrated by Esme MacGillivray We live in a world where a fungus would probably beat you at Pac-Man. While playing, the average person just follows the dots, but fungi are playing a whole different game. Despite no central brain, they navigate complex mazes, optimise routes, and even communicate across vast networks. To do so, fungi use such efficient strategies that scientists are studying them as a means to improve everything from city planning to biosensors. Nature has been perfecting pathfinding long before we put a quarter in the arcade. The elongated bodies of fungi, known as mycelia, build vast and complex networks. These structures emerge from natural algorithms - specifically, a process called collision-induced branching (1). In this process, new growth divides into new paths upon meeting an obstacle. When fungal hyphae hit a wall (literally or figuratively), they don’t just stop; they branch out, adapt, and keep moving. Traditional path-finding algorithms like Depth-First Search (DFS) or Breadth-First Search (BFS) methodically crawl through paths, moving step by step without reacting to obstacles (2). Fungi, on the other hand, adjust on the fly, often landing on the most resource-efficient routes way faster. Imagine reaching a junction in Pac-Man and instead of choosing just one path, Pac-Man splits into two, each clone taking a different route to cover more ground. This is exactly why fungal networks often end up looking eerily like optimised transport systems, such as railway lines or power grids! (3) Some fungi aren’t just clever in how they grow - they can quite literally compute. Certain species, like Basidiomycete fungi, communicate through spikes of electrical activity pulsing through their mycelial networks, processing information in ways surprisingly reminiscent of neural systems (4). What makes them even more intriguing is their hypersensitivity to the world around them. These organisms can detect subtle shifts in their environment - both chemical and physical. It’s like they’ve memorised every path they’ve taken, so when a new pellet appears on the far side of the board, they don’t need to search blindly. They already know the fastest way there, no matter where the original Pac-Man started. Endophytic fungi, fungi that live inside plants without causing harm, have been used to create biosensors - devices that can detect environmental contaminants like pollutants or pesticides (5). When these fungi encounter harmful chemicals, they react, making them perfect for monitoring things like toxins in the environment. Scientists have even developed yeast-based biosensors to specifically detect chemicals like tebuconazole, a common pesticide (6). Fungi don’t stop at chemistry and computations. It turns out they’re mechanically perceptive too. In one study, oyster fungi incorporated into fungal insoles responded to compressive stress, hinting at applications in wearable tech or even seismic sensing systems (7). Mycelium-based composites also exhibit unique patterns of electrical activity as moisture levels shift, making them promising candidates for humidity-responsive technologies. As if that weren’t enough, some fungi have the incredible ability to glow in the dark, a phenomenon known as bioluminescence. This natural light can be harnessed in special sensors, which use the glow to indicate the presence of specific substances. Essentially, when the fungi detect certain chemicals, they light up, providing an easy way to spot pollutants or toxins (8). These properties make fungi wildly efficient. No random turns, no wasted loops, just constant feedback powering smarter decisions. They know where they’ve been, sense what’s coming, and find the fastest route every time. It’s Pac-Man with a built-in optimisation engine, and that’s exactly how fungi behave in the wild. How well do you think you’d do against this version of Pac-Man? Probably not great. Let’s face it: they’re not only outsmarting us, they’re doing it with no brain at all. As we look toward smarter and more sustainable technologies, fungi might just be the key to a new era of bio-inspired computing and environmental monitoring. Researchers are already tapping into their natural brilliance to create more efficient systems for everything from biosensors to sustainable materials. The next time you see a mushroom, remember: it’s not just a fungus, it’s part of a vast, intelligent network playing the ultimate game of survival, one optimised move at a time. In a world where efficiency and adaptability are paramount, fungi might just be the unsung heroes we need to help us solve some of the biggest challenges ahead. References Asenova E, Lin HY, Fu E, Nicolau DV, Nicolau DV. Optimal Fungal Space Searching Algorithms. IEEE Trans Nanobioscience. 2016 Oct;15(7):613-618. doi: 10.1109/TNB.2016.2567098. Epub 2016 May 13. PMID: 27187968. Hanson KL, Nicolau DV Jr, Filipponi L, Wang L, Lee AP, Nicolau DV. Fungi use efficient algorithms for the exploration of microfluidic networks. Small. 2006 Oct;2(10):1212-20. doi: 10.1002/smll.200600105. PMID: 17193591. Asenova E, Fu E, Nicolau Jr DV, Lin HY, Nicolau DV. Space searching algorithms used by fungi. InBICT'15: Proceedings of the 9th EAI International Conference on Bio-inspired Information and Communications Technologies (formerly BIONETICS) 2016. European Alliance for Innovation. Adamatzky A. Towards fungal computers. Interface focus. 2018 Dec 6;8(6):20180029. Khanam Z, Gupta S, Verma A. Endophytic fungi-based biosensors for environmental contaminants-A perspective. South African Journal of Botany. 2020 Nov 1;134:401-6. Mendes F, Miranda E, Amaral L, Carvalho C, Castro BB, Sousa MJ, Chaves SR. Novel yeast-based biosensor for environmental monitoring of tebuconazole. Applied Microbiology and Biotechnology. 2024 Dec;108(1):10. Nikolaidou A, Phillips N, Tsompanas MA, Adamatzky A. Reactive fungal insoles. InFungal Machines: Sensing and Computing with Fungi 2023 Sep 17 (pp. 131-147). Cham: Springer Nature Switzerland. Singh S, Kumar V, Dhanjal DS, Thotapalli S, Singh J. Importance and recent aspects of fungal-based biosensors. InNew and Future Developments in Microbial Biotechnology and Bioengineering 2020 Jan 1 (pp. 301-309). Elsevier. Previous article Next article Enigma back to

Thinking of joining the OmniSci committee? We spoke to Aisyah, who incorporates her love for design into illustrations, events and social media at OmniSci, and shares her advice for those interested in getting involved (just do it!). Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator. Meet OmniSci Designer & Committee Member Aisyah Mohammad Sulhanuddin Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator interviewed by Caitlin Kane What are you studying? I am studying the Bachelor of Science in geography, now in my final year. Do you have any advice for younger students? It’s alright to not know what you’re doing. But on the flipside, if you do feel you know what you’re doing, be very aware that could change in the next few years. Always be open to new options. What first got you interested in science? When I was a kid, my parents encouraged me to ask questions about the world. I also had my own little book of inventions… if there was a problem somewhere, even if it was with the most outlandish invention, I would seek a way to solve that problem. That idea of being able to figure out how the world works is very fascinating to me. How did you get involved with OmniSci? During lockdown, I saw on the bulletin an expression of interest for a new magazine. I’d just entered uni, wanted to try everything and thought why not, it seems like such a great opportunity. And it is! What is your role at OmniSci? I’ve done a lot of graphic design and I’m going to return for this issue in that role. I’ve basically collaborated with writers to make art that looks good, goes with my style and can convey what they want to say in their article. I’m also in the committee for OmniSci, and have been since last year. Within that, I’ve put multiple hats on: I’ve enjoyed organising multiple events for the club, and helping out with social media. Social events have had a great turnout this year, which is awesome. A new year is always a new opportunity for more people to learn about the magazine. What is your favourite thing about contributing at OmniSci so far? I’ve really enjoyed the graphics side of things. I love creating and it’s really awesome to be able to put art to something text-based. It’s interpretation… You’re bound by what the article says and what the science says, but there is freedom within to express something. I definitely enjoy being able to put my creativity into promotion [as a committee member]. Doing it in a way that’s aesthetically pleasing—it matters to me when things look nice! Do you have any advice for people thinking of getting involved, especially more on the committee side? Yes—do it! Come and join… If you’re interested, feel free to come along because no role should be too daunting for you, and there is always opportunity to make the role fit how you want, it’s quite flexible. Can you give us a sneak peak of what you're working on this issue? If there’s a lot to come, maybe you can just tell us where you’re up to in the process. I’ll be working on the design and looking forward to collaborating with the writer as to how to convey their article properly. In the future, I’m looking forward to being able to create more content for OmniSci—really looking forward to that. What do you like doing in your spare time (when you're not contributing at OmniSci)? A range of things—I like to read, edit photos, do graphic design of random illustrations. I also crochet, do a bit of arts and crafts on the side, and take a whole lot of photos. Which chemical element would you name your firstborn child (or pet) after? Wait, let me pull up the periodic table! Let’s see… Neon. Feels like a great name for a child or an animal. Like calling your kid Jaz or Jet. It’s very snazzy! Do you have anything else you’d like to share with the OmniSci community? Stay looking on our Facebook page! Keep in touch and always keep on communicating, consuming and learning more about science, because that’s how the world progresses honestly. See Aisyah's designs Should We Protect Our Genetic Information? The Rise of The Planet of AI Maxing the Vax: why some countries are losing the COVID vaccination race What’s the forecast for smallholder farmers of Arabica coffee? The Ethics of Space Travel Space exploration in Antarctica The Mirage of Camouflage FINAL Big Bang to Black Holes: Illusionary Nature of Time

< Back to Issue 7 Fossil Markets: Under the Gavel, Under Scrutiny by Jesse Allen 22 October 2024 edited by Zeinab Jishi illustrated by Jessica Walton At the crossroads between science and commerce, the trade in fossils has "developed into an organised enterprise" over the course of the twentieth century. With greater investment and heated competition between museums and private collectors, fossils increasingly took their place alongside “art, furniture, and fine wine” (Kjærgaard, 2012, pp.340-344). Fast forward to the twenty-first century, and this trend shows no signs of abating. On the contrary: as of 10 July 2024, a near-complete stegosaurus skeleton - nicknamed ‘Apex’ - was discovered by a commercial palaeontologist in Colorado, and was later purchased by “hedge-fund billionaire” Ken Griffin for US$44.6 million (Paul, 2024). This makes it the single most expensive dinosaur skeleton ever sold, eclipsing the previous record set in 2020 for a T-Rex named ‘Stan’, who was snapped up for US$31.8 million (Paul, 2024). These sales came with their fair share of criticism and controversy, reigniting the long-standing debate about how fossils should be handled, and where these ancient remains rightfully belong. Fossils (from the Latin fossilus , meaning ‘unearthed’) are the “preserved remains of plants and animals” which have been buried in sediments or preserved underneath ancient bodies of water, and offer unique insights into the history and adaptive evolution of life on Earth (British Geological Survey, n.d.). Their value is by no means limited to biology, however: they are useful for geologists in correlating the age of different rock layers (British Geological Survey, n.d.), and reveal the nature and consequences of changes in Earth’s climate (National Park Service, n.d.). Though new discoveries are being made all the time, fossils are inherently a finite resource, which cannot be replaced. This is part of what makes the fossil trade so lucrative, but the forces of limited supply and high demand have also led to the emergence of a dark underbelly. Cases of fossil forgery go back “as far as the dawn of palaeontology itself” in the late 18th and 19th centuries (Benton, 2024). The latest “boom in interest" is massively inflating prices and “fuelling the illicit trade” in fossils (Timmins, 2019). Whereas the US has a ‘finders-keepers’ policy, according to which private traders have carte blanche to dig up and sell any fossils they find, countries such as Brazil, China, and Mongolia do not allow the export of specimens overseas (Timmins, 2019). Sadly, this does little to prevent illegal smuggling; the laws are sometimes vague, and enforcement can be difficult when no single government agency is responsible for monitoring palaeontological activities (Winters, 2024). According to David Hone, a reader in zoology at Queen Mary University of London, “not every fossil is scientifically valuable”; but they are all “objects…worthy of protection,” and too many “scientifically important fossils appear briefly on the auction house website” before “vanish[ing] into a collector’s house, never to be seen again” (Hone, 2024). Museums, universities, and other scientific organisations are finding it more and more difficult to “financially compete with wealthy, private purchasers” as they are simply being priced out of the market (Paul, 2024). As sales become less open to expert scrutiny, the risk of forgery and price distortions become greater. It also has negative implications for future research. Private collectors might give access to one scientist, but not allow others to corroborate their findings. If the fossils aren’t open to all, many institutions simply won’t examine the items in private collections as a matter of principle. (Timmins, 2019). The general public also loses out in a world where dinosaur fossils are reduced to expensive conversation pieces. As Hone writes, “we might never dig up another Stegosaurus, or never find one nearly as complete as [Apex].” Having waited 150 million years to be unearthed, this latest fossil is one of many that may not see the light of day for a very long time. Bibliography Benton, M. (2024, September 5). Modern palaeontology keeps unmasking fossil forgeries – and a new study has uncovered the latest fake . The Conversation. https://theconversation.com/modern-palaeontology-keeps-unmasking-fossil-forgeries-and-a-new-study-has-uncovered-the-latest-fake-223501 British Geological Survey. (n.d.). Why do we study fossils? British Geological Survey. https://www.bgs.ac.uk/discovering-geology/fossils-and-geological-time/fossils/ Hone, D. (2024, June 10). The super-rich are snapping up dinosaur fossils – that’s bad for science . The Guardian. https://www.theguardian.com/commentisfree/article/2024/jun/10/super-rich-dinosaur-fossils-stegosaurus-illegal-trade-science Kjærgaard, P. C. (2012). The Fossil Trade: Paying a Price for Human Origins. Isis , 103 (2), 340–355. https://doi.org/10.1086/666365 National Park Service. (n.d.). The significance of fossils . U.S. Department of the Interior. https://www.nps.gov/subjects/fossils/significance.htm Paul, A. (2024, July 18). Stegosaurus 'Apex' sold for nearly $45 million to a billionaire . Popular Science. https://www.popsci.com/science/stegosaurus-skeleton-sale/ Timmins, B. (2019, August 8). What’s wrong with buying a dinosaur? BBC News. https://www.bbc.com/news/business-48472588 Winters, G.F. (2024). International Fossil Laws. The Journal of Paleontological Sciences , 19 . https://www.aaps-journal.org/Fossil-Laws.html Previous article Next article apex back to

Issue 6: Elemental 28 May 2024 This issue explores the building blocks that comprise the world we live in. Our talented writers braved the elements - have a read below! Editorial by Ingrid Sefton & Rachel Ko A word from our Editors-in-Chief. Fire and Brimstone by Jesse Allen The world has long been subject to the fury of fire and volcanic eruptions. Technology to predict seismic activity may allow us to tame this elemental force. Hidden in Plain Sight: The dangerous chemicals in our everyday products by Kara Miwa-Dale Drink bottles, tinned food, receipts: a recipe for disaster? Interviewing A/Prof Mark Green, Kara exposes the hidden dangers of endocrine disrupting chemicals. A Frozen Odyssey: Shackleton’s Trans-Antarctic Expedition by Ethan Bisogni A pursuit of knowledge and a testament to survival, Ethan navigates the enthralling legacy of Sir Ernest Shackleton's Trans-Antarctic Expedition. Everything, Everywhere, All at Once: The Art of Decomposition by Arwen Nguyen-Ngo Arwen breaks down the intricacies of decomposition, leading us to consider the fundamental power not only in creation, but destruction. Out of our element by Serenie Tsai Following the industrial revolution, humankind has exploited and degraded the Earth's natural resources. Serenie shows how nature resists, maintaining the capacity to restore what humans have destroyed. Cosmic Carbon Vs Artificial Intelligence by Gaurika Loomba Carbon constitutes life and death, shaping conscious human existence. What threat could AI hold to the power of this element? Proprioception: Our Invisible Sixth Sense by Ingrid Sefton Our mysterious, yet omnipresent sixth sense - proprioception is the reason we know where our body and limbs are, even in the dark. A Brief History of the Elements: Finding a Seat at the Periodic Table by Xenophon Papas There's hydrogen and helium, then lithium, beryllium - or is there? The periodic table we know today was not always so, as Xen recounts.

issue 3 : alien 10 September 2022 This issue is about exploring all things exotic, unfamiliar, unknown. Dive into the column and feature articles by our talented writers below! columns The Body, Et Cetera “Blink and you’ll miss it”: A Third Eyelid? By Rachel Ko This article unpacks the fascinating evidence for evolution reflected within our very own eyes, connecting us to our reptilian ancestors. Chatter Belly bugs: the aliens that live in our gut By Lily McCann In this issue we explore how microbes influence our health and emotions, and what this means for our concept of identity. Humans of UniMelb In conversation with Paul Beuchat By Renee Papaluca I caught up with Paul Beuchat to learn more about his research journey and his potentially ‘alien’ methods of teaching. Our Past, Present & Future Waving Hello to the Aliens By Reah Shetty Our interaction with the idea of aliens has evolved. The question is how far have we come and how far will we go? Science Books Believing in aliens... A science? By Juulke Castelijn I wasn’t expecting to be persuaded of the existence of life beyond the confines of Earth. Ethics in Science The Ethics of Space Travel By Monica Blasioli Being the beginning of research into the impacts of space travel, can turning space travel into monopoly truly be justified? Wonders of the Landscape Space exploration in Antartica By Ashleigh Hallinan What makes Antarctica special when it comes to meteorite discovery? Science in the Age of Politics Hope, Humanity and the Starry Night Sky By Andrew Lim This second feature in the ‘Science in the Age of Politics’ series considers the importance of the stars, and scientific diplomacy, amidst rising global tensions. features Death of the Scientific Hero By Clarisse Sawyer How do we teach scientific history without promoting historical bigots? Mighty Microscopic Warriors! By Gaurika Loomba Equipped with a plethora of signalling chemicals and cells with different features, our heroic immune system fights wars daily without us realising it. Love and Aliens By Gavin Choong The First Nations’ perspectives are profound, and must be recognised by the Australian legal system. Existing in an Alien World: Navigating Neurodiversity in a System Built for Someone Else By Hazel Theophania Autism isn’t some inscrutable mystery - we’re people, and learning how we operate will help dismantle the barriers built up around us. AI and a notion of 'artificial humanity' By Mia Horsfall We still consider AI as other (or 'alien') to us, but ideal utility would be gained from toeing the precarious line between humanity and machine.

< Back to Issue 8 Life Story of a Drug by Elijah McEvoy 3 June 2025 Edited by Weilena Liu Illustrated by Aisyah Mohammad Sulhanuddin From the mythical visions of church goers who took mushrooms in the infamous ‘Good Friday Experiment’ to the extreme self-reflection of those ‘tripping’ off the traditional South American hallucinogenic tea Ayahuasca (1,2), humans have been painting the extraordinary narratives of psychedelics for thousands of years in thousands of settings. Put simply, psychedelics are a class of psychoactive drugs that can alter your thoughts and senses, inducing wild experiences not thought possible in your brain’s ground state (3). One of the most famous of these drugs is LSD. ‘Lucy in the Sky with Diamonds’ is said to have inspired entire Beatles albums and shown Steve Jobs “that there’s another side to the coin” of life (4,5). LSD is also a psychedelic that stands as an enigma in many regards. It is both naturally derived and synthetically created. It has been tested in psychological therapy and psychological warfare. Even the ‘trips’ experienced by its users entail both unexplainable hallucinations and scientifically proven phenomena. While being lesser understood, the stories of LSD’s enigmatic origins, uses and effects are just as interesting as those that come from its users. The Origins Lysergic Acid Diethylamide (LSD) or ‘acid’ for short is a semi-synthetic chemical compound with humble biological beginnings. LSD is derived from a class of alkaloid metabolite molecules that are naturally produced by the fungus commonly known as ergot. Ergot fungi are members of the parasitic genus Claviceps , which have been infecting staple crops and shaping society long before acid came to distort shapes in the eyes of its users (6). Epidemics of ergotism, a disease caused by these ergot alkaloids after ingesting contaminated crops, swept across Middle Age Europe and led to the deaths of tens of thousands of people (7). Despite credible arguments to the contrary, some historians have even suggested that the Salem Witch Trials may have been sparked by a form of this disease known as convulsive ergotism. Not only were the environmental conditions in 1691 Salem reported to be optimal for ergot growth in the town’s rye, but convulsive ergotism also induces distinct muscle contractions, paranoia and audiovisual hallucinations (8). These symptoms all would have given credit to the claims of bewitchment made by the young girls that instigated the accusations of witchcraft in the town. Aside from death and dark magic, this fungus has also been used as an effective therapeutic across several eras of history. It’s use as a medication for childbirth was recorded as early as 1100 BCE in China, with midwives using ergot or it’s alkaloids to reduce bleeding during birth, expedite delivery or induce an abortion (6,7). It wasn’t until modern pharmacology advanced in the 20th century that scientists began to chemically characterise these ergot alkaloids and use them as the basis to create potent drugs. The story of how LSD was first created and consumed is one that has been immortalised in history books and unofficial holidays. Dr Albert Hoffman, a Swiss biochemist working for the pharmaceutical company Sandoz, first synthesised LSD in 1938 as the 25th substance in a series of lysergic acid derivatives being evaluated by the company (9). Initial testing of this compound indicated it had no unique pharmacological uses beyond those of pre-existing ergot alkaloid derived drugs (9). However, Hoffman couldn’t shake the nagging feeling that LSD-25 had more to offer. After making another batch of the compound 5 years later, Hoffman’s suspicions grew stronger when he was forced to leave the lab early after entering a “dream-like state… [with] a kaleidoscope-like play of colours” (9). A few days later, in a moment that demonstrated both admirable scientific curiosity and blatant rejection of OH&S, Hoffman took a large dose of LSD himself and set in for a trip of a lifetime (9). Like all good scientists, he recorded his experience in a journal, writing at 3pm on 19 April 1943: “visual distortions, symptoms of paralysis, desire to laugh” (9). Hoffman’s notes for the day stopped there. The Uses April 19th has come to be celebrated as ‘Bicycle Day’, commemorating the seemingly endless and surreal bike ride home Hoffman undertook after this self-experimentation. However, a wacky trip was not the only thing that followed this discovery. After Hoffman distributed the drug to his superiors to try for themselves, LSD was sold on the market by Sandoz under the name Delysid. This drug was employed by psychiatrists throughout the 1950s as a treatment for alcoholism or simply ‘psychotherapy-in-a-pill’ for patients suffering psychological trauma (10,11). LSD not only garnered therapeutic interest from scientists but also more nefarious intrigue from the CIA. Seeking to get an upper hand in the department of mental warfare during the Cold War, the CIA bought up 40,000 doses of LSD from Sandoz and performed a variety of unethical experiments on unknowing prisoners, heroin addicts and even other CIA agents in an attempt to understand the drug’s potential for ‘mind control’ under the MKUltra project (12). Moving into the 60s, LSD’s use amongst budding leaders of the Hippie and Yippie movements gave the drug its countercultural status. Harvard Professor Timothy Leary, who was dismissed from his position due to experimenting (literally) with LSD, promoted the drug as an agent of revolution that allowed the youth of America to “turn on, tune in, drop out” (10) of repressive society. Due to its increasing association with these disruptive movements and eventual outlawing by the US government in 1966 (11), acid’s place in culture shifted out of labs and psychologist offices and into illicit recreational usage by experimental hippies and enlightened artists. The Trip Whether accompanied by an experienced monitor or listening to some soothing vinyl records yourself, the experience of taking LSD is predictably unpredictable. ‘Dropping acid’ is unique in that only micrograms of the drug are enough to elicit a palpable psychedelic experience (13), with most users diluting the dosage on tabs of blotting paper or sugar cubes (11). Following consumption, it takes as little as 1.5 hours for LSD to cross the blood-brain barrier, dilate the pupils and bring users to the peak intensity of the drug’s psychological effects (13). The bizarre experiences perceived by those ‘tripping’ on LSD is rooted in a now well-characterised receptor binding interaction in the brain. The nitrogen-based chemical groups of the LSD molecule first anchor themselves within the 5-HT2A serotonin receptors found in the synapses of neurons (14). While the serotonin neurotransmitter typically helps regulate brain activities like mood and memory, LSD binding instead causes the activation of distinct intracellular cascades within these brain cells (3). The importance of this interaction was demonstrated in experiments that proved blocking this receptor can cancel the acid trip all together (3). Recent studies that have further characterised the chemical structure of this interaction have also shown that 5-HT2A forms a lid-like structure that locks LSD into this receptor protein’s binding site and sets the user in for a long trip (14). From these individual cellular interactions, LSD ignites a burst of brain activity. Modern brain scanning technology has revealed that LSD first disrupts the capacity of the thalamus to filter and pass on sensory stimuli from the body to the cortex of the brain. Upon injection of LSD, patient’s brains demonstrated both an overflow of information running between the thalamus and posterior cingulate cortex and restriction of signals going to the temporal cortex (15). Not only does LSD modify the brain’s ability to sort out important stimuli from the outside world, but this small molecule has also been found to temporarily form new connections between different parts of the brain. Hoffman’s recount of how “every sound generated a vividly changing image” (9) on the first Bicycle Day can be explained by the increased connectivity of the brain’s visual cortex on LSD. This causes areas of the brain responsible for other senses or emotions to become involved in creating the images perceived in the user’s head, causing visual hallucinations and geometric distortion that have no basis in real stimuli coming from the eyes (16). In contrast, Hoffman’s feeling of being “outside [his] body” (9) likely came from decreased connectivity between the parahippocampus and retrosplenial cortex, two regions of the brain responsible for cognition. This severance has been correlated with the greater meaning that those tripping on LSD find in objects, events or music along with their characteristic ‘ego dissolution’ (16). This is a phenomenon where users no longer see the world through the lens of their own ‘self’ and instead feel an increased sense of unity with everything around them (17). Very Hippie ideas with a very scientific explanation. The Comedown and Beyond The float back down from the peak of an LSD trip takes up to 10 hours and leaves its users with a variety of stories and outcomes. Contrary to the fearmongering of parents and politicians, LSD does not leave holes in the brain, does not lead to addiction and has not directly led to the death of anyone as a result of overdosage (3). While the risk of a ‘bad trip’ and the feelings of severe anxiety, fear and despair that come with it may be traumatic, these are typically experienced when taking LSD in unsupportive environments without proper mental preparation (13). In fact, when LSD is taken in a manner closer to the controlled ritual practices surrounding psychedelics of old (3), acid is suggested to have long-lasting positive impacts on the user’s attitude and personality (13). It is these experiences that have rejuvenated the field of LSD research from its abrupt stop in the 60s. Modern investigations have picked up where these scientists left off and are evaluating the potential of utilising LSD-assisted therapy to alleviate anxiety and depression. Studies have focused particular attention on addressing these mental health conditions in those suffering from life-threatening illnesses like cancer (18). While some of these experiments lack the controls or data to make strong generalised conclusions, several studies have demonstrated that patients supplied with LSD reported lasting decreases in anxiety surrounding their condition, greater responsiveness to their families and improved quality of life (3,18). All of this is not to promote LSD as a harmless wonder drug. While rare, LSD has been linked to Hallucinogen Persisting Perception Disorder, a condition in which people experience distressing ‘flashbacks’ to the effects and experiences of past psychedelic trips in a normal setting. Additionally, the changes in visual perception, emotion and thought while one is tripping can also cause users to make reckless decisions in dangerous situations (18). However, continuing to wage war against controlled experiments and supervised therapeutic trials with LSD only serves to limit the attempts of scientists in better understanding the balance between this drug’s risks and benefits. While our trip through the life of LSD may end here, there is still much to explore. The greater story of how we use it, how we view it and how it fits into our society is far from over. References Illing S. Vox. 2018 [cited 2024 Oct 23]. The brutal mirror: what the psychedelic drug ayahuasca showed me about my life. Available from: https://www.vox.com/first-person/2018/2/19/16739386/ayahuasca-retreat-psychedelic-hallucination-meditation Majić T, Schmidt TT, Gallinat J. Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences? J Psychopharmacol. 2015 Mar 1;29(3):241–53. Nichols DE. Psychedelics. Barker EL, editor. Pharmacol Rev. 2016 Apr 1;68(2):264–355. Gilmore M. Beatles’ Acid Test: How LSD Opened the Door to “Revolver” [Internet]. Rolling Stone. 2016 [cited 2024 Oct 23]. Available from: https://www.rollingstone.com/feature/beatles-acid-test-how-lsd-opened-the-door-to-revolver-251417/ Hsu H. The Lingering Legacy of Psychedelia. The New Yorker [Internet]. 2016 May 17 [cited 2024 Oct 23]; Available from: https://www.newyorker.com/books/page-turner/the-lingering-legacy-of-psychedelia Haarmann T, Rolke Y, Giesbert S, Tudzynski P. Ergot: from witchcraft to biotechnology. Molecular Plant Pathology. 2009 Jul;10(4):563–77. Schiff PLJ. Ergot and Its Alkaloids. American Journal of Pharmaceutical Education. 2006 Oct 15;70(5):98. Woolf A. Witchcraft or Mycotoxin? The Salem Witch Trials. Journal of Toxicology: Clinical Toxicology. 2000 Jan;38(4):457–60. Hofmann A. How LSD Originated. Journal of Psychedelic Drugs. 1979 Jan 1;11(1–2):53–60. Massari P. Harvard Griffin GSAS News. 2021 [cited 2024 Sep 28]. A Long, Strange Trip | The Harvard Kenneth C. Griffin Graduate School of Arts and Sciences. Available from: https://gsas.harvard.edu/news/long-strange-trip Stork CM, Henriksen B. Lysergic Acid Diethylamide. In: Wexler P, editor. Encyclopedia of Toxicology (Third Edition) [Internet]. Oxford: Academic Press; 2014 [cited 2024 Sep 28]. p. 120–2. Available from: https://www.sciencedirect.com/science/article/pii/B9780123864543007442 Stuff You Should Know. Did the CIA test LSD on unsuspecting Americans? - Stuff You Should Know [Internet]. [cited 2024 Aug 25]. (Stuff You Should Know). Available from: https://www.iheart.com/podcast/1119-stuff-you-should-know-26940277/episode/did-the-cia-test-lsd-on-29468397/ Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A. The Pharmacology of Lysergic Acid Diethylamide: A Review. CNS Neurosci Ther. 2008 Nov 11;14(4):295–314. Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, et al. Crystal structure of an LSD-bound human serotonin receptor. Cell. 2017 Jan 26;168(3):377. Sample I. Study shows how LSD interferes with brain’s signalling. The Guardian [Internet]. 2019 Jan 28 [cited 2024 Nov 10]; Available from: https://www.theguardian.com/science/2019/jan/28/study-shows-how-lsd-messes-with-brains-signalling Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, et al. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences. 2016 Apr 26;113(17):4853–8. Sample I. LSD’s impact on the brain revealed in groundbreaking images. The Guardian [Internet]. 2016 Apr 11 [cited 2024 Nov 10]; Available from: https://www.theguardian.com/science/2016/apr/11/lsd-impact-brain-revealed-groundbreaking-images Liechti ME. Modern Clinical Research on LSD. Neuropsychopharmacol. 2017 Oct;42(11):2114–27. Previous article Next article Enigma back to