< Back to Issue 2 The Evolution of Science Communication In the current age of social media, users hold far more autonomy over the posts and information which they share online. However, this was not always the case, with the media once being far more regulated, and restricted for only certain individuals. With users now having far more power over content posted online, how does this impact the information which others receive about the COVID-19 pandemic? by Monica Blasioli 10 December 2021 Edited by Khoa-Anh Tran & Yen Sim Illustrated by Rachel Ko Trigger warning: This article mentions illness, and death or dying. Since the beginning of the pandemic in March 2020, science communication has started to evolve in ways never before seen across the globe. There appears to be an endless amount of infographics, Facebook posts, and YouTube and TikTok videos… including some with dancing doctors. Information not only about the COVID-19 virus, but countless diseases and scientific concepts, is available in more casual, accessible language at only the touch of a button. Any questions which you might have about science or your body can be answered through a quick Google search. In this sense, science communication is now far more rapid, as well as more accessible than in research papers (which always seem like they are written in a foreign language at times). However, the downside of having vast amounts of information available is that it can create challenges in determining the validity of what is being presented. In previous years, science communication was typically limited to the more typical forms of media, such as in a newspaper or a magazine, or even through a television interview. These were typically completed by professionals in the field, such as a research scientist or a medical doctor. When looking at the 1920 Influenza outbreak, many citizens at that time would have received their information from printed newspapers and posters on bulletin boards, as seen below. Image 1, [1] Somewhat similar to today's age, there were signs displaying the importance of mask-wearing, and newspapers explaining the closures of schools and shops, the distribution of vaccines, and reports of death rates. These messages were, and still are, created and approved by larger institutions, governments and medical professionals, particularly doctors. As seen on the (left / right / below / above), doctors are urging people to not become complacent, despite a recent drop in influenza cases. This is rather similar to current newspaper or television news reports - only in reference to COVID-19, instead of influenza. Image 2, [2] There were, of course, still groups which were uncertain about the scientific evidence being provided by journalists, doctors and government officials at this time. In November of 1918, it was declared that “the epidemic of [influenza] disease is practically over,” with mask laws being relaxed. However, only a few days later, the previous mask laws were reintroduced with a spike in Influenza cases. As unpacked in Dr Dolan’s research [3], the “Anti-Mask League” formed and protested in response to this back track, claiming that masks were unsanitary, unnecessary, and stifling their freedom. As this was during the early 20th century, the league advertised their protests in local newspapers, with reports that hundreds of San Francisco residents were fined for not abiding by mask rules, often due to their alliance with the Anti-Mask League. The San Francisco Anti-Mask League is one of the most renowned and infamous groups of its time, with smaller-scale groups also questioning the science being communicated. This type of conflicting information surrounding mask issues, and the opinion that they restrict personal freedoms, have incited similar responses throughout history. However, resistance by anti-mask groups has not existed on such an influential and global scale, as it has during the current COVID-19 pandemic. With the rise of the age of “new media,” including platforms such as Instagram and Facebook, individuals now have far more autonomy over their role in the media, meaning that they yield a lot more power over the information others are receiving. Almost anybody can interpret scientific material online and upload it in a video of them dancing to some music on TikTok, spreading information to potentially hundreds of thousands of viewers across the globe. In many ways this new found autonomy and power can be quite beneficial. Australian Doctor Imogen Hines uses her platform on TikTok, alongside her medical education and current scientific research, to break down medical treatments and mistruths, particularly surrounding the COVID-19 pandemic. These videos use simple language and straight-forward analogies, “humanising” the often intimidating figures in the medical field, and allowing the general public to be well-informed about scientific concepts. For example, Dr Imogen breaks down the research surrounding long term side effects of vaccines using a milkshake analogy! https://www.tiktok.com/@imi_imogen1/video/7027448207823211777?is_copy_url=1&is_from_webapp=v1&lang=en On the other hand, this phenomenon can have pretty serious ramifications, with many individuals feeling rightfully confused about what the truth really is, when there appears to be so many versions of it posted across the internet. Following a rather controversial study on Ivermectin as a treatment for COVID-19, the internet was soon buzzing with excitement about the prospect of a drug that many believed could replace the need for a vaccine. Despite numerous gaps in the original study, and countless further studies refuting Invermectin’s ability to treat COVID-19, many social media users are continuing to spread this myth online. Both governments and hospitals alike have been accused of hiding a seemingly “good” cure from their citizens. In Texas, a group of doctors won a legal case which allowed Texas Huguley Hospital to refuse administering Ivermectin to a COVID-19 infected Deputy Sheriff. This sparked outrage on Facebook, with users and the Sheriff’s wife demanding greater freedoms over their medical treatments, instead of just relying on the judgement of doctors and hospital staff. In this instance, the misinformation surrounding Ivermectin is not only influencing individuals to seek out futile treatments, but it is also spreading mistrust with the science and medical communities, who work incredibly hard to protect the world, particularly over the past two years. Despite Ivermectin being used in a clinical setting to treat parasitic (not viral) infections in humans for a number of years now, it can be extremely dangerous for individuals to have complete power over their medical treatments. The dosage and timing of treatment is crucial in ensuring success. Just like with everyday medications such as paracetamol, taking Ivermectin in high doses is risky. A COVID-19 infected woman from Sydney who read about Ivermectin on social media took a very high dosage of the drug after purchasing it from an online seller, which resulted in severe diarrhea and vomiting. In order to combat some of this misinformation, a number of social media platforms are “fact checking” posts or providing warnings on posts with keywords, such as ‘COVID-19’ or ‘vaccination.’ On Instagram, each post with these keywords will contain a banner at the bottom inviting users to visit their “COVID-19 Information Centre,” which provides a list of information supported by WHO and UNICEF about how vaccines are of high-standard, well-researched, and generally resulting in mild side effects. In addition, on Facebook, posts identified to be spreading mistruths will provide users with websites explaining the truth, before they can access the original posts. However, these warnings and fact-checks can only go so far. Posts blindly supporting the use of Ivermectin, falsely reporting side effects of vaccines, and arguing that masks cannot block virus particles still circulate the internet. Often those most vulnerable in the community are at risk of being led astray with misinformation. In principle, evidence-based, concise, easy-to-understand science communication is essential to break down the barrier between research and the general public, ensuring that citizens are well-informed and more comfortable about the world around them. In the situation of a public health crisis such as the COVID-19 pandemic, this communication is crucial in ensuring that all citizens can remain well-informed, safe and healthy. Misinformation and dodgy studies can not only lead people astray, but also cost them their health and wellbeing. References: 1. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 2. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 3. Brian Dolan, Unmasking History: Who Was Behind the Anti-Mask League Protests During the 1918 Influenza Epidemic in San Francisco? Perspectives in Medical Humanities (San Francisco: UC Medical Humanities Consortium, 2020) Previous article back to DISORDER Next article

< Back to Issue 2 Spirituality and Science Science is limited by the philosophies which govern it. Common thinking is that science is a rigid, cold and largely academic field which sneers at the domain of spirituality. I posit that one must move beyond this point of view in order to do good science, and to find the true aims and values of the discipline. by Hamish Payne 10 December 2021 Edited by Irene Yonsuh Lee & Khoa-Anh Tran Illustrated by Quynh Anh Nguyen When I was fifteen, I thought that I could thwart my English teacher. He had given us homework that was simple enough; discuss with our families whether true altruism exists. I did not have this discussion with my household but instead hosted the debate in my head, coming to a measured conclusion. However, the privacy of my argumentation showed the next day when my teacher asked me to share. He immediately suggested that I had only been thinking by myself and had not welcomed others into my discussion. This is not my most interesting story, but it did teach me something important: every thought that I have had contains traces of me. Even when I am fiercely debating contrary viewpoints on a subject, even when I am having my most dissonant thoughts, it is my own voice against which I argue. Whenever I have drawn my pen across the page, I have been leaving my fingerprints in the ink. At the time, these traces of me made me very uncomfortable. I have always heard that the beauty in science is that it does not matter if it is considered in isolation or in consultation with others; its facts and its theorems are invariant. This vision of science as a haven for unchanging logic was popularised by Descartes. For the cartesian, the body is split from nature, allowing one to consider the latter more sterilely. But the mind is also split from the body, and our talents, ambitions and passions are split apart in our minds. This thinking for centuries has spurred enormous strides forward in physical technology and has made humanity feel in control of our environment largely because the cartesian divide heralds natural determinism wherein each phenomenon has a direct and exploitable cause[1]. However, there is no room for individual expression in the Cartesian framework – no place for perception, experience, or spirituality. Though my retelling is likely apocryphal, the story of Galileo serves in my mind as a symbol of this divide. From the instant Galileo sought to place the sun at the centre of our solar system, he toppled the heavens and was thus persecuted by the purveyors of spirituality. The persecution of both the scientist and his heliocentric principle barred faith and belief from the scientific process and hence placed reason and logic at its centre. Yet it should not be forgotten that the clergy of the Roman Inquisition paid Galileo in kind and forbad the scientist a spirit. But what are the consequences of taking such a divided view of nature? When I hear people talk about scientists today, they treat the scientist not as someone who lives but as someone who develops rules about life. Scientists must never strive for innate beauty, but for inert truth, guided by cold logic – even Oscar Wilde wrote that “the advantage of science is that it is emotionless”[2]. As a continuation of Galileo being branded apostate, the scientist has been stripped of the right to ambiguity in his explanations, and uncertainty in his world view. If science is not complete, it is deemed a failure. But this is ludicrous. Any scientist must know and accept that the cartesian split neglects certain aspects of the world – those properties of a system which emerge only when all its parts are combined. Moreover, nature still eludes science on a very deep level. For example, there is still no widely accepted philosophical explanation of quantum mechanics, no ability to predict the chaotic flow of a surging river, no profound understanding of the synchronisation of heart cells. Science is so woefully incomplete and incapable of dealing with the sheer scale of disorder in the world that most real-world systems must undergo several fundamental simplifications to be modelled, lest they take years to understand. And when things are cut apart, it becomes even more difficult to stitch them back into the complete picture. Then what remains of the aims of science if it is only an imitation of nature – a painting with no colours, shadows on the wall? When I ask myself this question, I find Feynman’s words echo back in my head: doing science is no more than thinking about “the inconceivable nature of nature”[3]. Science seeks to connect us with nature. It is not about disassembling it and organising it, splitting it into more and more isolated pieces, but about marvelling at the whole system, attempting to let it all sit in your mind - to look at the dancing shadows and understand what is casting them, enjoying the dance all the same. Likewise, in his book, Nonlinear Dynamics and Chaos, Steven Strogatz humorously lists life under the list of unexplored scientific domains[4]. He does not relegate, however, science to its usual, removed, and sterilised place in this. Instead, he suggests that nature is so complex, that one cannot help but marvel at it with no real hope of controlling or quantifying it. I argue that these two scientists are just as much talking about what it means to be spiritual as scientific. To be spiritual is to try relentlessly to understand our life and our world and their relationship, even as they mercurially shift and change. Simply put, spirituality arises from a profound connection with nature. For example, the unity of the mind and the natural world is the bedrock of Eastern mysticism. The discipline seeks to connect the two through considered meditation and direly avoids their division. Such is highlighted by the Buddhist philosopher Asvaghosha; “When the mind is disturbed, the multiplicity of things is produced, but when the mind is quieted, the multiplicity of things disappears.” Western religions similarly connect nature and the spirit. Polytheistic traditions like the ancient Greek and Roman ascribe to their gods an element of the world each to control. The communication of the individual with a god is thus the interaction of the individual with the natural world. Similarly, the God of Judaism, Christianity and Islam is often present in awesome acts of nature. Particularly in the oldest parts of the Bible, God is seen to communicate through natural disasters and great floods and great fish and plagues and pestilences. Whilst I must admit that this analysis is somewhat superficial, it certainly illustrates the place nature holds deep in our minds and mythology. In an overwhelming number of cases, nature begets spirituality. Science is likewise born of nature and, for me at least, is therefore spiritual. But the value in reclassifying science as something spiritual as well as logical is not argumentation for naught. The scientist who is spiritual and fully connected with nature is better equipped than any. Guarding the connection between the individual and nature as sacred allows us to question our world on a more fundamental, truer level. Take as an example a question I hear often in my studies of physics: “Why is this theorem true?” Whilst it sounds reasonable enough, this type of question leads its asker down a reductionistic rabbit hole, in pitting mathematics against nature. Instead of seeing mathematics as a tool to describe nature, nature is seen as a product of mathematics. The rich physical world is reduced into rigidly true or false statements when we know such dichotomies are severely inept in the real world. Perhaps the scientist who is more holistically, spiritually connected with nature would be prompted to ask instead: “How true is this theorem to the world?” One does not have to look far to see how this subtle shift in approach to science can be incredibly successful. A fundamental principle of quantum physics states that matter is simultaneously particle-like and wave-like. This ambiguity in physical explanation, which would not be allowed from a cartesian point of view, is acceptable because it matches completely what is observed rather than attempting to reduce nature into the language of mathematics. Werner Heisenberg even wrote that “we cannot speak about atoms in ordinary language”, demonstrating the need for scientific holism. Approaching scientific discovery from a spiritual perspective allows us to move beyond the constraints of a reductive language. Likewise, studying science increases our spiritual relationship with nature. Albert Camus, perhaps rather unknowingly, said much the same thing in his unpublished novel, La Mort Heureuse. The protagonist, Mersault, on the brink of his death, says of the red, sunset clouds: “When I was young, my mother told me that [the clouds] were the souls of the dead who were travelling to Heaven. I was amazed that my soul was red. Now I know that it’s more likely the promise of wind. But that’s just as marvelous.”[5] What is spiritual is natural. Intellectual curiosity is rooted in the physical world, even as it changes and develops, becomes completely chaotic and throws more and more unanswerable questions in our faces. Science persists not because it seeks to provide answers to all of life’s questions, but because it provokes the mind into deeper questioning and, in that, deeper connection with nature and its ineffable, uncapturable beauty. The most marvellous thing about taking this perspective is that the science I do becomes more personal and ignites a stronger passion. I no longer must worry about the traces of myself; they are a necessary part of my understanding of the world and have shown me that, although science is “emotionless” in its methodology, it should not be so in its execution. Science is not spiritual because it precludes knowledge that is born from blind faith, but because it pushes knowledge to somewhere that is deeply human and that is beyond faith. References: [1] Fritjof Capra. 2000. The Tao of Physics : An Exploration of the Parallels between Modern Physics and Eastern Mysticism. 35th Anniversary Edition. Boston: Shambhala. [2] Wilde, Oscar. (1890) 2018. The Picture of Dorian Gray. New York, Ny: Olive Editions. [3] Feynman, Richard. 1983. “Fun to Imagine with Richard Feynman.” Documentary. BBC. [4] Strogatz, Steven H. (2014) 2019. Nonlinear Dynamics and Chaos : With Applications to Physics, Biology, Chemistry, and Engineering. Second. Boca Raton: Crc Press. [5] Camus, Albert. (1971) 2010. La Mort Hereuse. Paris: Gallimard. Previous article back to DISORDER Next article

< Back to Issue 2 Hidden Worlds: a peek into the nanoscale using helium ion microscopy How do scientists know what happens at scales smaller than you can see using an optical microscope? One exciting method is the helium ion microscope which can be used to view cells, crystals and specially engineered materials with extreme detail, revealing the beauty that exists at scales too small to imagine! by Erin Grant 10 December 2021 Edited by Jessica Nguy and Hamish Payne Illustrated by Erin Grant The room is white, with three smooth walls and a fourth containing a small sample prep bench and high shelves. In the centre is a desk with three monitors. Next to it, occupying most of the space, is the microscope. Eight feet tall, a few feet wide, resting on an isolated floor surrounded by caution tape; “NO STEP” written in big block letters. Wires protrude from its tiered shape in orderly chaos. It is a clean, technological space; we are ready to explore science. A colleague and I are at the Materials Characterisation and Fabrication Platform of the University of Melbourne to finish off the last steps of a scientific paper I’ve been working on for many years. What I need, as the icing on the cake, is an image. What does my sample look like way down there, at the nanometre scale? Objects that are only nanometres in size are very hard to imagine when we’re used to thinking about metres, centimetres, or maybe even millimetres. We can see those length scales; they are part of our everyday. So, if you’re told that proteins have a diameter of a few nanometres, what does that mean? Well, to be precise, a nanometre is one-billionth of a metre. A human hair, the go-to yardstick for describing small things, has a width between 0.05-0.1 millimetres, which means that if you wanted to slice a hair into nanometre-wide strands you’d end up with nearly 100,000 pieces. Unfortunately, that’s still hard to visualise, but I’ve found that when working with and thinking about scales like this every day, you gain a sort of mental landscape that small things occupy, perhaps not entirely in context, but a space that contains an overall ‘vibe’ of smallness. I first noticed this when I worked in a laboratory that studies the tiny nematode worm C. elegans. These creatures are half a millimetre long, so although they are clearly visible to the naked eye, you need a microscope if you want to use them for science. After looking at these tiny creatures under magnification for many weeks, I came to recognise a feeling almost like being underwater. Upon putting my eyes to the lens, my focus would change from the macroscopic world around me, to one of minutiae. This change in perspective was quite immersive, I almost felt like I was inhabiting that small petri dish too. Working with samples even smaller than that now, I have carried some of that mental landscape with me. It now feels commonplace to imagine tiny systems, such as crystals or molecules which were once foreign. Much of this ability to visualise small things comes from the fact that in many cases, we can actually see them too. Physics has given us many tools with which we can peer into the smallest systems that exist. Helium ion microscopy, which I have come here to carry out, is one such technique. Dr Anders Barlow runs the helium ion microscope (HIM) at this facility. He warmly welcomes me and my colleague into the quiet room and jumps straight into an enthusiastic explanation of the machine – he can tell we’re not just here for some pictures, we want to know the inner workings of the microscope too. The HIM is a bit like the more mature surveyor of minuscule worlds: the electron microscope. While a regular optical microscope uses light to illuminate a sample, the electron microscope uses electrons. When they collide with the sample these electrons can bounce off or lose energy through several mechanisms. The lost energy can go into heat or light, but more usefully, the energy might be transferred to other electrons in the sample, called secondary electrons, ejecting them like a drill removing rocks from a quarry. The secondary electrons can be detected at each point across the sample as the beam is scanned over its surface. If more electrons are detected, then the pixel at that point is brighter compared to areas where there are fewer electrons. This tells you about the topography or composition of the sample at that point on its surface and provides a grayscale image. The HIM works in the same way, but it can generate sharper images because helium ions are heavier than electrons. This is important because the increased resolution of electron and helium ion microscopes is enabled by their quantum mechanical properties - namely the particle’s wavelength. You may have heard about the wave-like nature of light, which is a basic property of quantum mechanics. Particles also have a wavelength, called the de Broglie wavelength, which is inversely proportional to their mass - the heavier the particle, the shorter the wavelength. Having a shorter wavelength allows smaller details to be resolved because of a pesky phenomenon called diffraction. Diffraction occurs when a wave encounters a gap that is of the same or smaller width to its wavelength. When this happens, the wave that emerges on the other side will be spread out. You can think of the features that you want to image as being similar to gaps, so when light, or a particle, interacts with features that are very close together it will spread out, making those features blurry or even invisible. But if you can ensure that the wavelength is smaller than whatever feature you want to see, diffraction will not occur. Interestingly, physicists can actually take advantage of diffraction, and another phenomenon called interference, when they study periodic structures like crystals, but that’s a different article! So, because the de Broglie wavelength is very short for particles with mass, like electrons, an electron microscope can generate images of higher resolution than an optical microscope. Likewise, helium ions are even heavier than electrons because they are composed of one electron, two protons, and two neutrons. This makes them about 7,000 times heavier than a single electron (electrons are very light compared to protons and neutrons!) and consequently the images they can make are very sharp. With our samples ready, lab manager Anders loads my sample into the microscope and begins lowering the pressure in its internal chamber. Having a high vacuum – approximately a billion times lower than atmospheric pressure – is essential because it prevents air from interfering with the helium beam. Making the beam is perhaps the most miraculous part of this technological feat. At the very top of the microscope’s column, there’s a tiny filament shaped like a needle. Not like a needle, in fact, it is the sharpest needle we humans can make. To achieve this, the point is shaped by first extreme heat, and then some extreme voltages until the very tip is composed of only three atoms, reverently referred to as the trimer. Once the trimer has been formed, a high voltage is applied to the needle, resulting in an extreme electric field around the tip. Next, helium gas is introduced into the chamber and individual helium atoms are attracted towards the region of the high electric field. The field is so strong that it strips each helium atom of one electron, ionising it, and these now positively charged ions are repelled from each of the three atoms in the trimer as three corresponding beams. Using sophisticated focusing fields down the length of the column allows Anders to choose only one of the beams for imaging; we are creating a picture using a beam only one atom wide! Generating such a precise beam requires constant maintenance, but once Anders is satisfied with how it looks today, he begins scanning over a large area for what we’ve come to find: tiny proteins stuck to a diamond. In an experimental PhD, you often find yourself answering small incremental questions and today I want to know how well I’ve attached these proteins to my diamond and what the coverage looks like. Other measures have told me that I probably have a lot of them, but the best way to know is to have a look! That’s what Anders does for researchers at the university; he helps us find out whether we have done a good job putting things together or coming up with new techniques. This is something he loves about his job. “I love the exposure I get to many areas of science,” he says, “Imaging of all forms is ubiquitous in research, and the HIM is applicable to most fields, so we see samples from materials science, polymers, nanomaterials, and biomaterials, through to medical technologies and devices, to cell and tissue biology of human, plant and animal origin. I never get tired of seeing what new specimens may come through the lab door.” Unfortunately, the first images we see are very dark and washed out, like a photograph taken in low-light; not many secondary electrons are making it to the detector. To combat this, Anders uses a flood gun to stop charge build up on the surface of the diamond. When the helium ions create secondary electrons, they are ejected from the surface at low speeds. As electrons are negatively charged, the bombarded surface, which now lacks electrons, will become positive and the low energy secondary electrons will be attracted back to the surface instead of making it to the detector. In an electron microscope this is avoided by coating insulators, such as my diamond, with a conductive material like gold. If the surface is conductive, the positive charge that is left behind by the secondary electrons will be offset by electrons from the metallic coating that can flow towards the sudden appearance of positive charges. In this case, the ejected electrons can escape and be detected. However, a coating like this would reduce the resolution of the image; if you want to measure proteins that are twelve nanometres high, but you put a three-nanometre coating over them, you’ll lose a lot of the resolution! To get around this, the HIM uses the flood gun, which lightly sprays the surface with electrons of low energy as the helium beam passes over. This neutralises the surface and lets the secondary electrons escape in the same way as having a conductive layer. Once Anders turns on the flood gun, the contrast increases, allowing us to zoom in on a small region of the diamond, and there they are! Thousands of spherical proteins arranged neatly across the surface, only twelve nanometres in diameter. The sight is spectacular, only one try and we got what we came for. I am three years into a PhD and I’ve become very used to the feeling of disappointment that can accompany new experimental techniques. Things rarely work out the first time around, so to see those little spheres straight away was magical. Dotted across the diamond surface is another, extra, gem. To keep protein nice and happy, you must prepare it in a salty solution. So, when the protein was deposited, some regular table salt, NaCl, came too. We can see this salt in our images as crystals in two distinctive and very beautiful patterns which you can see in the images below. Protein on the surface of my diamond. Each small pale circle is one of these spherical proteins. The first image shows a large creeping pattern, reminiscent of snowflakes or tree roots, which spreads its soft fingers across several hundred nanometres. These crystals have taken on an amorphous pattern, where the crystal structure is broken up rather than being one continuous arrangement of the atoms. The second pattern however, shown in the right image, is what a continuous NaCl crystal looks like. When large enough crystals can form without becoming amorphous they look like precise cubes of various sizes all strewn about. One of my favourite aspects about looking at very small things, is how the patterns you see often mirror those at much larger scales. Look at a fingerprint and you’ll find mountains and valleys, or the roots of a tree and you’ll see a river system. Salt (NaCl) can take on a highly ordered structure shown by the cubic crystals (left) or an amorphous pattern similar in shape to tree roots (right). The astonishing images we get from this single session are all in a day’s work for Anders. He has imaged numerous kinds of cells on all manner of interesting substrates, patterned surfaces covered in needle-like protrusions, and many kinds of man-made materials. Today, there are vials on his prep-bench which, at first glance, look much like jars of hair. However, they are not hair, in fact they are strands of carbon fibre covered in various coatings, awaiting examination. ‘What are your favourite types of samples to look at?’ I want to know. “Cell biology is fascinating,” he says. “We’ve imaged red blood cells, pancreatic cells, stem cells, and various bacterial cells in this microscope. Most often researchers are interested in cell life and death, and the HIM assists by providing high resolution images of the structure and surface topography of the cell membrane.” Recently however, Anders has been helping researchers look at polymer materials for water filtration. “These are hierarchical porous structures, meaning they’re engineered to have pore sizes that vary through the membrane. It is stunning to see the materials at low magnification with large pores, and as we zoom in and in and in, to see new pore sizes become visible at each level, like a material engineered with a fractal quality.” One of the unique things about the HIM, Anders reminds me, is that it’s not just for imaging. Since helium ions are heavy, they carry a higher momentum than electrons. “We leverage the momentum of the ions to actually modify structures too. We can create new surface properties, new devices, new technologies, on a scale that is often too small for any other fabrication technique. This is some of the most exciting work.” If you know anyone who needs some nanoscale drilling done, then the HIM is your instrument! Today’s excursion across the university campus has been thrilling. I got what I came for and I’m excited to find other projects that could benefit from the insight and beautiful images the HIM can provide. Imaging instruments have always fascinated me and I’m looking forward to witnessing how far we will be able to delve into the nanoscale world in the years to come, thanks to the fast pace of engineering and physics research. Previous article back to DISORDER Next article

< Back to Issue 4 From the Editors-in-Chief by Caitlin Kane, Rachel Ko, Patrick Grave, Yvette Marris 1 July 2023 Edited by the Committee Illustrated by Gemma van der Hurk Scirocco, summer sun, shimmering on the horizon. Salt-caked channels spiderweb your lips, scored by rivulets of sweat. Shifting, hissing sands sting your legs. You are the explorer, the adventurer, the scientist. A rusted spring, you heave forward, straining for each step, hauling empty waterskins. ----- The lonely deserts of science provide fertile ground for mirages. An optical phenomenon that appears to show lakes in the distance, the mirage has long been a metaphor for foolhardy hopes and desperate quests. The allure of a sparkling oasis just over the horizon, however, is undeniable. The practice of science involves both kinds of stories. Some scientists set a distant goal and reach it — perhaps they are lucky, perhaps they have exactly the right skills. Other scientists yearn to crack a certain problem but never quite get there. In this issue of OmniSci Magazine, we chose to explore this quest for the unknown that may be bold, unlucky, or even foolhardy: chasing the ‘Mirage’. Each article was written entirely by a student, edited by students, and is accompanied by an illustration that was created by a student. We, as a magazine, exist to provide university students a place to develop their science communication skills and share their work. If there’s a piece you enjoy, feel free to leave a comment or send us some feedback – we love to know that our work means something to the wider world. We’d like to thank all our contributors — our writers, designers, editors, and committee — who have each invested countless hours into crafting an issue that we are all incredibly proud of. We’d also like to thank you, our readers; we are incredibly grateful that people want to read student pieces and learn little bits from the work. That’s enough talking from us until next issue. Go and read some fantastic student writing! Previous article Next article back to MIRAGE

< Back to Issue 2 Tactile communication: how touch conveys the things we can’t say Our daily dose of touch has decreased through months of lockdowns. But why is touch so important to us, and why do we feel the lack of it so severely? by Lily McCann 10 December 2021 Edited by Juulke Castelijn and Ethan Newnham Illustrated by Janna Dingle In a confusing world, thrust in and out of lockdowns, estranged from family and friends, you may have felt somewhat lost and out of touch in recent years. What helps to bring you back to a sense of self and belonging? For me it's a hug from my partner, a pat on the back from a sibling or a cuddle with my dog. Positive physical contact helps ground us and reassure us of our place in the world. It's an instinct cultivated from our first moments of life and one crucial to development. As the first sense to form, touch is the start of our gradual awakening into the world and informs our developmental progress. Even touching a mother’s stomach in pregnancy can alter the behaviour of the foetus within[1]. In the mid-late 20th century, researchers began to study the impact of sensory deprivation on children and infants, examining those placed in institutions who suffered from neglect[2]. This was a poignant problem following World War II, when millions of children were orphaned or displaced. The limited number of carers in overcrowded orphanages that attempted to harbour them meant that infants and young children were often left to lie day after day without a hug, stroke or any other form of caring contact. Upon studying these children, it became clear that the impact of deprivation was devastating, resulting in a number of cognitive, behavioural and physical deficits. Studies have since established that increasing tactile contact with developing children is protective against such problems[3]. For instance, simply stroking isolated premature babies improves mental development and physical growth[4]. It seems that touch provides a message to the infant’s body, communicating that it is safe and guarded and in an environment where it can grow and flourish. As you might expect, this process is closely related to stress responses. Studies have shown that in stressful situations of food deprivation, mice populations prioritise survival, neglecting breeding and exploration. When food is plentiful, this is reversed. A mother’s touch has a similar effect on human infants, decreasing stress levels and facilitating development and exploration[5]. We see another good example of this in dogs. Along with other domesticated animals, dog display something called ‘Domestication Syndrome’, which describes a set of features animals shaped by human breeding efforts share[6]. The ‘cute’ physique of such animals (floppy ears, snubby nose, curly tails) are correlated with increased stress tolerance and more tame behaviours. Interestingly, in dogs this decrease in stress is also paired with increased desire for and pleasure in touch. This is clear even between dog breeds: the working Australian Kelpie with its active herding instincts is more likely to chase down a bicycle than snuggle into you and ignore it like the floppy-eared Cavalier. Correlation studies abound, but what about the mechanism behind all these associations? How does touch affect our body? How is its message conveyed? The key mediators of tactile communication are nerve cells, otherwise known as neurons. These cells conduct signals to, from and within our brain. They’re particularly important for sensation, transferring information about our external environment to our inner mind. For touch, there are neurons in our skin with specialised endings that can sense pressure, vibration, temperature and stretch. They respond to these stimuli by firing little signals that tell our brain we’re touching something. There are actually two distinct types of touch that we use. Typing, turning book pages or handling tools are all mediated by the first type, discriminative touch, which is mainly limited to the palmar surface of our hands and fingers. Have a look at your palm now, then flip it over and examine the back of your hand. Notice anything different? The main difference is that the inner surface of your hand is smooth. Check out the back of it – it’s hairy. Hairy skin is differentiated by – you guessed it – hair, but also by the method of touch sensation. The type of touch experienced by hairy skin is affective touch. Affective touch holds the key to explaining our emotional dependence on tactile communication because it describes touch that has emotional and social relevance. It relies on a type of sensory nerve called CT fibres, which are specialised for positive social touch: they respond best to the temperature of human skin and a gentle, stroking pressure. Parents automatically use this sort of touch when interacting with their children[7]. This caring touch is incredibly powerful. It can cause the release of oxytocin (the “bonding hormone”)[8], decrease stress levels[9], and trigger the facial muscles that form a smile[10]. It can stimulate unique emotional responses, such as excitement, affection or calm. It even has the power to speak to DNA itself: research has shown that changing touch exposure in mice affects how DNA is structured and expressed[11]. Social touch is an essential component of how we define ourselves as humans. Without it, touch would mean nothing more than that a person is present, that their skin is warm or cold, dry or wet. The warmth of our partner’s hand wouldn’t create a sense of belonging, hugging a friend wouldn’t trigger memories of time spent together, stroking your child wouldn’t give rise to feelings of love. Affective touch colours our world and gives it meaning. Whilst some suggest that social touch encompasses all intentional, consensual interpersonal touch, I would argue that even accidental touch has a social impact[12]. In recent times we have all felt the change of walking down empty streets. Where bumping or brushing against another person was taken for granted as simply unavoidable on the morning train a couple of years ago, COVID19 has introduced new connotations to such accidental touch, all but prohibiting it. Whilst you may have been frustrated by clustered train carriages, you can’t help but notice that it feels a little lonely when the train is quiet, and the nearest passenger is more than 1.5m away. Even accidental touch signals to the body that you are part of a community, part of a herd, and for a social animal that must be comforting. Look at sheep, for instance: under stress, harassed by sheepdogs or farmers, they automatically cluster together in a group. Whilst an individual bump between two sheep in the herd may be fortuitous, the fact that crowding together maximises interpersonal contact is no accident. The comfort of touch is a fact of human life, but one not often actively acknowledged. Lockdowns and isolation have reminded us all how necessary social contact can be for our wellbeing. Touch is a part of the chatter that defines our place amongst others and our identities as part of a community. So if your pet, friend or partner are in need of comfort, administer a bit of affective touch and see the miraculous calming effects of the actions of those CT nerve cells. Stay safe and sanitise, but remember, hugs are helpful too! References [1]Marx, Viola, and Emese Nagy. 2017. "Fetal Behavioral Responses To The Touch Of The Mother’S Abdomen: A Frame-By-Frame Analysis". Infant Behavior And Development 47: 83-91. doi:10.1016/j.infbeh.2017.03.005. [2] van der Horst, Frank C. P., and René van der Veer. 2008. "Loneliness In Infancy: Harry Harlow, John Bowlby And Issues Of Separation". Integrative Psychological And Behavioral Science 42 (4): 325-335. doi:10.1007/s12124-008-9071-x. [3] Ardiel, Evan L, and Catharine H Rankin. 2010. "The Importance Of Touch In Development". Paediatrics & Child Health 15 (3): 153-156. doi:10.1093/pch/15.3.153. [4] Rice, Ruth D. 1977. "Neurophysiological Development In Premature Infants Following Stimulation.". Developmental Psychology 13 (1): 69-76. doi:10.1037/0012-1649.13.1.69. [5] Caldji, Christian, Josie Diorio, and Michael J Meaney. 2000. "Variations In Maternal Care In Infancy Regulate The Development Of Stress Reactivity". Biological Psychiatry 48 (12): 1164-1174. doi:10.1016/s0006-3223(00)01084-2. [6] Trut, Lyudmila. 1999. "Early Canid Domestication: The Farm-Fox Experiment". American Scientist 87 (2): 160. doi:10.1511/1999.2.160. [7]Croy, Ilona, Edda Drechsler, Paul Hamilton, Thomas Hummel, and Håkan Olausson. 2016. "Olfactory Modulation Of Affective Touch Processing — A Neurophysiological Investigation". Neuroimage 135: 135-141. doi:10.1016/j.neuroimage.2016.04.046.v [8]Walker, Susannah C., Paula D. Trotter, William T. Swaney, Andrew Marshall, and Francis P. Mcglone. 2017. "C-Tactile Afferents: Cutaneous Mediators Of Oxytocin Release During Affiliative Tactile Interactions?". Neuropeptides 64: 27-38. doi:10.1016/j.npep.2017.01.001. [9]Field, Tiffany. 2010. "Touch For Socioemotional And Physical Well-Being: A Review". Developmental Review 30 (4): 367-383. doi:10.1016/j.dr.2011.01.001. [10]Pawling, Ralph, Peter R. Cannon, Francis P. McGlone, and Susannah C. Walker. 2017. "C-Tactile Afferent Stimulating Touch Carries A Positive Affective Value". PLOS ONE 12 (3): e0173457. doi:10.1371/journal.pone.0173457. [11]Bagot, R. C., T.-Y. Zhang, X. Wen, T. T. T. Nguyen, H.-B. Nguyen, J. Diorio, T. P. Wong, and M. J. Meaney. 2012. "Variations In Postnatal Maternal Care And The Epigenetic Regulation Of Metabotropic Glutamate Receptor 1 Expression And Hippocampal Function In The Rat". Proceedings Of The National Academy Of Sciences 109 (Supplement_2): 17200-17207. doi:10.1073/pnas.1204599109. [12] Cascio, Carissa J., David Moore, and Francis McGlone. 2019. "Social Touch And Human Development". Developmental Cognitive Neuroscience 35: 5-11. doi:10.1016/j.dcn.2018.04.009. Previous article back to DISORDER Next article

< Back to Issue 2 Hiccups Evolution might be a theory, but if it’s evidence you’re after, there’s no need to look further than your own body. The human form is full of fascinating parts and functions that hold hidden histories - from the column that brought you a deep-dive into ear wiggling in Issue 1, here’s an exploration of why we hiccup! by Rachel Ko 10 December 2021 Edited by Katherine Tweedie and Ashleigh Hallinan Illustrated by Gemma Van der Hurk Hiccups bring a special brand of chaos to a day. It’s one that lingers, rendering us helpless and in suspense; a subtle, internal chaos of quiet frustration that forces us to drop what we’re doing to monitor each breath – in and out, in and out – until the moment they abruptly decide to stop. It’s an experience we’ve all had – one that can hit anyone at any time – and for most of us, hiccups are a concentrated episode of inconvenience; best ignored, and overcome. Yet, despite our haste to get rid of them when they interrupt our day, hiccups seem to have mystified humans for generations. Historically, the phenomenon has been the source of many superstitions, both good and bad. A range of cultures associate them with the concept of remembrance: in Russia, hiccups mean someone is missing you (1), while an Indian myth suggests that someone is remembering you negatively for the evils you have committed (2). Likewise, in Ancient Greece, hiccups were a sign that you were being complained about (3), while in Hungary, they mean you are currently the subject of gossip. On a darker note, a Japanese superstition prophesises death to one who hiccups 100 times. (4) Clearly, the need to justify everything, even things as trivial as hiccups, has always been an inherent human characteristic, transcending culture and time. As such, science has more recently made its attempt at objectively identifying a reason behind the strange phenomenon of hiccups. After all, if you take a step back and think about it, hiccups are indeed quite strange. Anatomically, hiccups (known scientifically as singultus) are involuntary spasms of the diaphragm (5): the dome-like sheet of muscle separating the chest and abdominal cavities. (6) The inspiratory muscles, including the intercostal and neck muscles, also spasm, while the expiratory muscles are inhibited. (7) These sudden contractions cause a rapid intake of air (“hic”), followed by the immediate closure of the glottis or vocal cords (“up”). (8) As many of us have probably experienced, a range of stimuli can cause these involuntary contractions. The physical stimuli include anything that stretches and bloats the stomach, (9) such as overeating, rapid food consumption and gulping, especially of carbonated drinks. (10) Emotionally, intense feelings and our responses to them, such as laughing, sobbing, anxiety and excitement, can also be triggers. (11) This list is not at all exhaustive; in fact, the range of stimuli is so large that hiccups might be considered the common thread between a drunk man, a Parkinson’s disease patient and anyone who watches The Notebook. The one thing that alcohol, (12) some neurological drugs (13) and intense sobbing (14) do have in common is that they exogenously stimulate the hiccup reflex arc. (15) This arc involves the vagal and phrenic nerves that stretch from the brainstem to the abdomen which cause the diaphragm to contract involuntarily. (16) According to Professor Georg Petroianu from the Herbert Wertheim College of Medicine, (17) many familiar home remedies for hiccupping – being scared, swallowing ice, drinking water upside down – interrupt this reflex arc, actually giving these solutions a somewhat scientific rationale. While modern research has successfully mapped out the process of hiccups, their purpose is still unclear. As of now, the hiccup reflex arc and the resulting diaphragmatic spasms seem to be effectively useless. Of the existing theories for the function of hiccups, the most prominent seems to be that they are a remnant of our evolutionary development, (18) essentially ‘vestigial’; in this case, a feature that once served our amphibian ancestors millions of years ago, but now retain little of their original function. (19) In particular, hiccups are believed to be a relic of the ancient transition of organisms from water to land. (20) When early fish lived in stagnant waters with little oxygen, they developed lungs to take advantage of the air overhead, in addition to using gills while underwater. (21) In this system, inhalation would allow water to move over the gills, during which a rapid closure of the glottis – which we see now in hiccupping – would prevent water from entering the lungs. It is theorised that when descendants of these fish moved onto land, gills were lost, but the neural circuit for this glottis closing mechanism was retained. (22) This neural circuit is indeed observable in human beings today, in the form of the hiccup central pattern generator (CPG). (23) CPGs exist for other oscillating actions like breathing and walking, (24) but a particular cross-species CPG stands out as a link to human hiccupping: the neural CPG that is also used by tadpoles for gill ventilation. Tadpoles “breathe” in a recurring, rhythmic pattern that shares a fundamental characteristic feature with hiccups: both involve inspiration with closing of the glottis. (25) This phenomenon strengthens the idea that the hiccup CPG may be left over from a previous stage in evolution and has been retained in both humans and frogs. However, the CPG in frogs is still used for ventilation, while in humans, the evolution of lungs to replace gills has rendered it useless. (26) Based on this information, it seems hiccupping lost its function with time and the development of the human lungs, remaining as nothing more than an evolutionary remnant. However, we cannot discredit hiccupping as having become entirely useless as soon as gills were lost. Interestingly, hiccupping has only been observed in mammals – not in birds, lizards or other air-breathing animals. (27) This suggests that there must have been some evolutionary advantage to hiccupping at some point, at least in mammals. A popular theory for this function stems from the uniquely mammalian trait of nursing. (28) Considering the fact that human babies hiccup in the womb even before birth, this theory considers hiccupping to be almost a glorified burp, intended to remove air from the stomach. This becomes particularly advantageous when closing the glottis prevents milk from entering the lungs, aiding the act of nursing. (29) Today, we reduce hiccups to the disorder and disarray they bring to our day. But, next time you are hit with a bout of hiccups, take a second to find some calm amidst the chaos and appreciate yet another fascinating evolutionary fossil, before you hurry to dismiss them. After that, feel free to eat those lemons or gargle that salty water to your diaphragm’s content. References Sonya Vatomsky, "7 Cures For Hiccups From World Folklore," Mentalfloss.Com, 2017, https://www.mentalfloss.com/article/500937/7-cures-hiccups-world-folklore. Derek Lue, "Indian Superstition: Hiccups | Dartmouth Folklore Archive," Journeys.Dartmouth.Edu, 2018, https://journeys.dartmouth.edu/folklorearchive/2018/11/14/indian-superstition-hiccups/. Vatomsky, "7 Cures For Hiccups From World Folklore". James Mundy, "10 Most Interesting Superstitions In Japanese Culture | Insidejapan Tours," Insidejapan Blog, 2013, https://www.insidejapantours.com/blog/2013/07/08/10-most-interesting-superstitions-in-japanese-culture/. Paul Rousseau, "Hiccups," Southern Medical Journal, no. 88, 2 (1995): 175-181, doi:10.1097/00007611-199502000-00002. Bruno Bordoni and Emiliano Zanier, "Anatomic Connections Of The Diaphragm Influence Of Respiration On The Body System," Journal Of Multidisciplinary Healthcare, no. 6 (2013): 281, doi:10.2147/jmdh.s45443. Christian Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," Bioessays no. 25, 2 (2003): 182-188, doi:10.1002/bies.10224. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. John Cameron, “Why Do We Hiccup?,” filmed for TedEd, 2016, TED Video, https://ed.ted.com/lessons/why-do-we-hiccup-john-cameron#watch. Monika Steger, Markus Schneemann, and Mark Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," Alimentary Pharmacology & Therapeutics 42, no. 9 (. 2015): 1037-1050, doi:10.1111/apt.13374. Lien-Fu Lin, and Pi-Teh Huang, "An Uncommon Cause Of Hiccups: Sarcoidosis Presenting Solely As Hiccups," Journal Of The Chinese Medical Association 73, no. 12 (2010): 647-650, doi:10.1016/s1726-4901(10)70141-6. Steger, Schneemann and Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," 1037-1050. Unax Lertxundi et al., "Hiccups In Parkinson’s Disease: An Analysis Of Cases Reported In The European Pharmacovigilance Database And A Review Of The Literature," European Journal Of Clinical Pharmacology 73, no. 9 (2017): 1159-1164, doi:10.1007/s00228-017-2275-6. Lin and Huang, "An Uncommon Cause Of Hiccups: Sarcoidosis Presenting Solely As Hiccups," 647-650. Peter J. Kahrilas and Guoxiang Shi, "Why Do We Hiccup?" Gut 41, no. 5 (1997): 712-713, doi:10.1136/gut.41.5.712. Steger, Schneemann and Fox, "Systemic Review: The Pathogenesis And Pharmacological Treatment Of Hiccups," 1037-1050. Georg A. Petroianu, "Treatment Of Hiccup By Vagal Maneuvers," Journal Of The History Of The Neurosciences 24, no. 2 (2014): 123-136, doi:10.1080/0964704x.2014.897133. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Cameron, “Why Do We Hiccup?” Michael Mosley, "Anatomical Clues To Human Evolution From Fish," BBC News, published 2011, https://www.bbc.com/news/health-13278255. Michael Hedrick and Stephen Katz, "Control Of Breathing In Primitive Fishes," Phylogeny, Anatomy And Physiology Of Ancient Fishes (2015): 179-200, doi:10.1201/b18798-9. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Pierre A. Guertin, "Central Pattern Generator For Locomotion: Anatomical, Physiological, And Pathophysiological Considerations," Frontiers In Neurology 3 (2013), doi:10.3389/fneur.2012.00183. Hedrick and Katz, "Control Of Breathing In Primitive Fishes," 179-200. Straus et al., "A Phylogenetic Hypothesis For The Origin Of Hiccough," 182-188. Daniel Howes, "Hiccups: A New Explanation For The Mysterious Reflex," Bioessays 34, no. 6 (2012): 451-453, doi:10.1002/bies.201100194. Howes, "Hiccups: A New Explanation For The Mysterious Reflex," 451-453. [1] Howes, "Hiccups: A New Explanation For The Mysterious Reflex," 451-453. Previous article back to DISORDER Next article

< Back to Issue 8 Microbic Mirror of The Self by Sarah Ibrahimi 3 June 2025 Edited by Jax Soon-Legaspi Illustrated by Noah Chen For decades, we did not fully understand the functional purposes of many parts of the human body. The spleen was once thought of as dispensable, earwax merely as dirty waste and the appendix as a useless leftover from the course of human evolution. But science has a habit of humbling us and we now know that all of these components serve essential purposes in the human body. Our understanding of the gut microbiome is following a similar pattern. However, beyond knowing that it plays a role, we still lack a full understanding of the true nature and mechanisms of this mysterious system. Given the average person's current understanding of microbes, it is unsurprising that they are often associated with disease, capable of causing some of the most deadly disorders. They are thought of as a foreign figure entirely and that should remain separate from us. Nevertheless, just like their occupation all over our skin, our gut is home to them too. When we think of our own identities, we tend to boil ourselves down to a singular body, a singular self. Typically, we define ourselves by our jobs, the activities we enjoy and the values we admire - elements all tied to a single individual. Yet, within us lives an entire biosphere that hosts a whole community of microbes. These minute beings govern our guts in symbiosis with other systems of the human body and outnumber human cells ten to one (1). It is a wonder how we are home to trillions of bacteria and are barely conscious of their existence. How do these seemingly fatal organisms operate cooperatively with the body? Can we construe the self as a singular individual when our body is a complex community with seemingly precarious organisms living within us? “What lies behind us and what lies before us are tiny matters compared to what lies within us” - Ralph Waldo Emerson The community that is composed of bacteria, fungi, viruses and archaea plays a significant role in many aspects of our lives, affecting the way we digest food down to the regulation of our mental health. We understand the digestive system to be composed of the mouth, stomach, intestines and other vital organs as the main drivers of digestion. Similarly, the immune system depends on the bone marrow, spleen, white blood cells and antibodies to suppress an infection. Yet, the microbes sequestered within our gut assist extensively in driving the actions associated with these systems. In digestion, the range of their skill extends from the ability to synthesise vitamin K to using cross-feeding mechanisms - a phenomena where one bacterium breaks down parts of plant compounds and passes the byproducts to others, resulting in boosted health (2,3). They have also been shown to promote gut barrier integrity to prevent the entry of harmful pathogens, while also aiding in regulating immune system homeostasis, assisting the body in blocking harmful pathogens and enabling a strengthened immune response in the face of infection (3). Although there has been extensive research conducted to investigate the role of gut microbes in our physical health, their effects on our mental health have often been overlooked. Yet, they play a fundamental role in its regulation and the promotion of positive wellbeing. This contribution is most evident in the context of the gut-brain axis, which consists of two-way signalling between the central nervous system and enteric nervous system, serving the emotional and cognitive domains of the brain. Working hand-in-hand, the mental state of an individual can cause harmful alterations to the composition of healthy gut microbes and in a reciprocal manner, a dysregulated gut flora can adversely affect the brain through pathways such as immune activation and the production of neuroactive substances (4). Such imbalances in the gut microbiota have been linked to the emergence of depressive-like behaviours (5), though there is an increased prevalence of other psychiatric disorders like bipolar disorder, schizophrenia and anxiety that occur as a result too (6). The last decade of science has demonstrated a dramatic increase in the understanding of the gut microbiome as we know it today. Like in any field however, there is still more to be discovered. Similar to the infamous genome-wide association studies that assist in the recognition of certain genetic markers to particular diseases or traits through a statistical basis, metagenome-wide association studies are being conducted to identify associations with microbiome structures and several major diseases (7). Research in this field has already allowed for the detection of shifts in gut compositions and how these changes functionally contribute to many metabolic diseases. However, small sample sizes for such research highlight the requirement for greater development within the field. “The self is not something ready-made, but something in continuous formation through choice of action” - John Dewey The human body has a mutual relationship with the gut microbiome, like that of the gut-brain axis. So when one of these systems is not functioning at its peak, the performance of the other is also derailed. Dysbiosis of the gut's natural flora contributes to clinical conditions such as Irritable Bowel Syndrome (IBS), Autism Spectrum Disorder (ASD) and anxiety (4). However, microbial imbalance is mediated through the actions and behaviours of the individual at hand. Both chronic and acute stressors can increase gut barrier permeability, resulting in a “leaky” gut, allowing bacteria to seep into the cracks and trigger an array of physiological responses like inflammation. It is safe to say that there is no single, definitive state that our individual guts exist in. In a world driven by antimicrobial usage, fluctuating diets and the invisible weight of daily stress, the gut microbiome remains in a state of constant transformation. Ever-changing, they mirror the conscious and unconscious choices we make, ultimately shaping our health in ways we are only beginning to imagine. References National Institutes of Health (NIH) [Internet]. 2015 [cited 2025 Jun 1]. NIH Human Microbiome Project defines normal bacterial makeup of the body. Available from: https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body Mueller C, Macpherson AJ. Layers of mutualism with commensal bacteria protect us from intestinal inflammation. 2006 Feb 1 [cited 2025 Jun 1]; Available from: https://gut.bmj.com/content/55/2/276 Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences. 2015 Apr;16(4):7493–519. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203–9. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I – autointoxication revisited. Gut Pathogens. 2013 Mar 18;5(1):5. Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH. Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis. JAMA Psychiatry. 2021 Dec 1;78(12):1343–54. Wang J, Jia H. Metagenome-wide association studies: fine-mining the microbiome. Nat Rev Microbiol. 2016 Aug;14(8):508–22. Previous article Next article Enigma back to

< Back to Issue 4 Big Bang To Black Holes: Probing the Illusionary Nature of Time by Mahsa Nabizada 1 July 2023 Edited by Elijah McEvoy and Caitlin Kane Illustrated by Aisyah Mohammad Sulhanuddin Time is ubiquitous: it governs our daily lives, marking our existence from birth to death. We measure time in seconds, minutes, hours, days or years, using man-made tools like clocks and calendars which reinforce the perception that it is tangible and objective. In fact, the most used noun in English is time (1). However, delving into the realms of science and philosophy, the true nature of time becomes illusionary. We can acknowledge our personal perception of time is inherently subjective. Our experiences of time vary depending on our surroundings, emotional state and physical state. For example, while time may seem to drag on when we're bored or anxious, it can pass quickly when we're having a good time. Although we imagine time to be objective, it could be merely an illusion resulting from the limitations of our perceptions and the conditions of our observation. Exploring these questions requires scientific perspectives, so let's delve into the enigmatic physics of time. In three-dimensional space, physical spaces are fixed, meaning that we can revisit the same location repeatedly. For example, we may visit our favourite restaurant as many times as we wish. However, this is not the case with time. Time only moves forward, and we cannot go back to a previous moment; it belongs to the past and cannot be retrieved (2). This unidirectional nature of time is referred to as the arrow of time. Time is believed to originate from the Big Bang, the event that marked the beginning of the universe (3). From that point, time has progressed towards the present, where you are currently reading this article, and it continues to move into the future. The second law of thermodynamics, known as entropy, plays a crucial role in representing the forward movement of this arrow of time (4). Entropy refers to the state of disorder, uncertainty, or randomness in a system like a measure of the disorder present in the universe. At the moment of the Big Bang, the universe had low entropy, with matter and energy concentrated and organised. However, since that initial state, matter in the universe has been expanding and moving away from each other, leading to an increase in entropy and transforming the universe into a high entropy system. The concepts of the arrow of time and entropy, guided by the second law of thermodynamics, allow for a distinction between the past and the future and play a pivotal role in the existence of life. Without entropy and the resulting change there would be no discernible difference between events that occurred 1000 years ago and events happening in the present. Furthermore, the progression of life from birth to death can be explained through the phenomenon of entropy, as governed by the second law. However, on the quantum level, the behaviour of particles becomes more complex. Just as there is no inherent forward or backward direction in vast space, at the molecular level, the concept of entropy is not as apparent. While time appears to have a clear direction on the macroscopic level, when observing the particles that make up the universe, time can flow and operate in multiple directions. The laws of physics that govern these particles do not distinguish between the past and the future. They describe the behaviours of physical systems without differentiating between temporal directions. The theory of general relativity, proposed by Albert Einstein, provides a fundamental framework for understanding the workings of spacetime (5). According to the theory of general relativity, the presence of mass or energy causes a distortion in the fabric of spacetime, which in turn affects the motion of other objects. For example, it describes gravity as the curvature of spacetime caused by the presence of mass and energy. Essentially, spacetime can be thought of as a fluid that is influenced by both gravity and velocity. This theory has illuminated not just the behaviour of celestial bodies and the vast structure of the universe, but also enhanced our understanding of the intricate interplay between space, time, and matter. Within Einstein’s theories, time dilation is a scientific phenomenon that can be explored through a thought experiment known as the twin paradox (6). It demonstrates how the perception of time can vary between two individuals who experience different levels of motion or gravitational forces. Time dilation is not limited to the twin paradox or space travel; it is a fundamental concept in understanding the relationship between time, motion, and gravity. It has been experimentally confirmed and plays a significant role in our understanding of the universe. Imagine you, Twin A, are stationary on Earth while your sister, Twin B, is traveling in a rocket at a constant speed. Due to the sideways motion of the rocket, Twin B’s clock will appear slower to Twin A since her path through spacetime is longer due to the effects of special relativity and time dilation. Therefore, from Twin A’s perspective on Earth, time seems to pass slower on the moving rocket. However, from Twin B’s perspective, Twin A is the one in motion and therefore Twin A’s clock appears slower to her. Both frames of reference seem to indicate that the other's clock is slower, which seems contradictory. In reality, both observations are correct because the laws of physics remain the same in both frames of reference. Now, the question arises: who is actually younger? According to each twin's viewpoint, the other twin is younger. However, in reality, only one twin can have aged less than the other. Fortunately, there is a resolution to this paradox. When Twin B turns around to return to Earth, she undergoes acceleration which means the usual laws no longer apply. As a result, Twin B will be younger than her Earth-bound sister, Twin A, upon returning to Earth due to the effects of acceleration. To explain this effect during the period of acceleration, we need to consider that general relativity causes time dilation in the presence of gravitational fields. Gravitational time dilation means that clocks run slower in stronger gravitational fields compared to clocks in weaker gravitational fields. During the acceleration phase, when Twin B’s rocket is returning to Earth, her time now appears to go slower, while the clock on Earth appears to run faster. This phenomenon is similar to the extreme time dilation experienced near the edge of a black hole, known as an event horizon (7). From the observer’s frame of reference outside the black hole, time slows as an object approaches the event horizon, until it appears time has stopped. Hence an object falling into the black hole would appear to have stopped, completely frozen. Even though it governs our daily lives and despite our ability to measure it with great accuracy, there is no definitive answer to what time truly is. From the subjective experiences of our daily lives to the enigmatic physics of the Big Bang and black holes, the illusionary nature of time unveils an array of complexities, reminding us that this fundamental concept remains one of the most captivating mysteries of our existence. As famously stated by Einstein: "For us believing physicists, the distinction between past, present, and future is only a stubbornly persistent illusion” (8). References Study: “Time” Is Most Often Used Noun [Internet]. www.cbsnews.com . 2006. Available from: https://www.cbsnews.com/news/study-time-is-most-often-used-noun/ Davies P. The arrow of time. Royal Astronomical Society [Internet]. 2005 Feb 1 [cited 2023 Jun 4];46(1):1.26–9. Available from: https://academic.oup.com/astrogeo/article/46/1/1.26/253257 University of Western Australia. Evidence for the Big Bang [Internet]. Evidence for the Big Bang. 2014 p. 1–4. Available from: https://www.uwa.edu.au/study/-/media/Faculties/Science/Docs/Evidence-for-the-Big-Bang.pdf Hall N. Second Law - Entropy [Internet]. Glenn Research Center | NASA. 2023. Available from: https://www1.grc.nasa.gov/beginners-guide-to-aeronautics/second-law-entropy/ Norton JD. General Relativity [Internet]. sites.pitt.edu . 2001 [cited 2022 Feb]. Available from: https://sites.pitt.edu/~jdnorton/teaching/HPS_0410/chapters/general_relativity/ Perkowitz S. Twin paradox | physics | Britannica. In: Encyclopædia Britannica [Internet]. 2020 [cited 2013 Jun 14]. Available from: https://www.britannica.com/science/twin-paradox Hadi H, Atazadeh K, Darabi F. Quantum time dilation in the near-horizon region of a black hole. Physics Letters B [Internet]. 2022 Nov 10 [cited 2023 Jun 11];834:137471. Available from: https://www.sciencedirect.com/science/article/pii/S0370269322006050 A Debate Over the Physics of Time | Quanta Magazine [Internet]. Quanta Magazine. 2016. Available from: https://www.quantamagazine.org/a-debate-over-the-physics-of-time-20160719/ Previous article Next article back to MIRAGE

Thinking of joining the OmniSci committee? We spoke to Aisyah, who incorporates her love for design into illustrations, events and social media at OmniSci, and shares her advice for those interested in getting involved (just do it!). Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator. Meet OmniSci Designer & Committee Member Aisyah Mohammad Sulhanuddin Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator interviewed by Caitlin Kane What are you studying? I am studying the Bachelor of Science in geography, now in my final year. Do you have any advice for younger students? It’s alright to not know what you’re doing. But on the flipside, if you do feel you know what you’re doing, be very aware that could change in the next few years. Always be open to new options. What first got you interested in science? When I was a kid, my parents encouraged me to ask questions about the world. I also had my own little book of inventions… if there was a problem somewhere, even if it was with the most outlandish invention, I would seek a way to solve that problem. That idea of being able to figure out how the world works is very fascinating to me. How did you get involved with OmniSci? During lockdown, I saw on the bulletin an expression of interest for a new magazine. I’d just entered uni, wanted to try everything and thought why not, it seems like such a great opportunity. And it is! What is your role at OmniSci? I’ve done a lot of graphic design and I’m going to return for this issue in that role. I’ve basically collaborated with writers to make art that looks good, goes with my style and can convey what they want to say in their article. I’m also in the committee for OmniSci, and have been since last year. Within that, I’ve put multiple hats on: I’ve enjoyed organising multiple events for the club, and helping out with social media. Social events have had a great turnout this year, which is awesome. A new year is always a new opportunity for more people to learn about the magazine. What is your favourite thing about contributing at OmniSci so far? I’ve really enjoyed the graphics side of things. I love creating and it’s really awesome to be able to put art to something text-based. It’s interpretation… You’re bound by what the article says and what the science says, but there is freedom within to express something. I definitely enjoy being able to put my creativity into promotion [as a committee member]. Doing it in a way that’s aesthetically pleasing—it matters to me when things look nice! Do you have any advice for people thinking of getting involved, especially more on the committee side? Yes—do it! Come and join… If you’re interested, feel free to come along because no role should be too daunting for you, and there is always opportunity to make the role fit how you want, it’s quite flexible. Can you give us a sneak peak of what you're working on this issue? If there’s a lot to come, maybe you can just tell us where you’re up to in the process. I’ll be working on the design and looking forward to collaborating with the writer as to how to convey their article properly. In the future, I’m looking forward to being able to create more content for OmniSci—really looking forward to that. What do you like doing in your spare time (when you're not contributing at OmniSci)? A range of things—I like to read, edit photos, do graphic design of random illustrations. I also crochet, do a bit of arts and crafts on the side, and take a whole lot of photos. Which chemical element would you name your firstborn child (or pet) after? Wait, let me pull up the periodic table! Let’s see… Neon. Feels like a great name for a child or an animal. Like calling your kid Jaz or Jet. It’s very snazzy! Do you have anything else you’d like to share with the OmniSci community? Stay looking on our Facebook page! Keep in touch and always keep on communicating, consuming and learning more about science, because that’s how the world progresses honestly. See Aisyah's designs Should We Protect Our Genetic Information? The Rise of The Planet of AI Maxing the Vax: why some countries are losing the COVID vaccination race What’s the forecast for smallholder farmers of Arabica coffee? The Ethics of Space Travel Space exploration in Antarctica The Mirage of Camouflage FINAL Big Bang to Black Holes: Illusionary Nature of Time

By Mia Horsfall < Back to Issue 3 AI and a notion of 'artificial humanity' By Mia Horsfall 10 September 2022 Edited by Breana Galea and Andrew Lim Illustrated by Matthew Duffy Next In the cradle of the day, a girl blinks to life. The sun is cool, still crouched beyond the trees, waiting for its cue to take centre-stage. Knees and knobs and spokes and all, she struggles to stand in the grass, furrowing her toes into the Earth for traction. Clean, unmarked and without memories, she looks to the sky with contentment, unaware of the work ahead. The notion of “Artificial” Intelligence is an interesting way to describe the vast and variegated mechanisms it encompasses. Not only does it pre-suppose the existence of “intelligence” within these machines, but it implies the existence of some antithetical “natural” intelligence. The term itself is a dichotomy, simultaneously alienating and connecting AI to humans. This poses some significant moral and ethical dilemmas that are becoming increasingly difficult to ignore. As the advent of AI becomes more intricately interwoven with mundane happenings, we are forced to grapple with the seemingly unanswerable question: At what point does “Artificial” Intelligence become indistinguishable from “Authentic” Intelligence? With the advent of Artificial Intelligence, public opinion surrounding the role AI should and does occupy has undergone dramatic alterations. Films and books such as “Her” (2013) and “Klara and the Sun” (2021) have explored the implications of assimilation of AI with humanity. In both pieces, AI transcends the purely utilitarian role originally defined and progresses into emotional connections with human counter-parts. It stands to reason that if these AI can enter and engage in emotionally significant relationships in the same capacity as humans, what exactly does the distinction between human and machine become? In order to define what AI is, we should first come to a conclusion of what it means to be human. So why is it so important to arrive at a definition of humanity in considering the ethics of AI inclusion in society? Well, as Hauskeller points out ‘the term ‘human’ is not primarily used to refer to a particular kind of entity...it implies a particular moral status’ (Hauskeller, 2009). That is, a subject is assigned a higher moral value in its assignment as ‘human’ and a purely physical application of the word would result in little distinction between us and other species. ‘A meaning of the word is a kind of employment of it’ (Wittgenstein, 1953), suggesting meanings and the terms to describe them are co-dependent and self-referential. Hence what it means to be ‘human’ is directly aligned with what subjects are assigned such a title. But arriving at a definition for “human” is no easy task. Philosophers and scientists have debated what constitutes the term human with little success, the definition changing across historical periods. In order to demonstrate the transient nature of the term ‘human’, a comparative analysis of definitions across historical periods provides a comprehensive overview of the dynamism that defines humankind. Hauskeller contends that any given definition of ‘human’ is ‘persuasive’. That is, each attempt ‘implicitly or explicitly claims to be of prime significance for the way we ought to lead our lives’ (Haukeller, 2009). By nature of the fact there exists multiple definitions of what characterises humanity, it can be inferred ideals of human society are themselves transient. For instance, Plato contends intelligence prevails above every aspect of human nature (White, 2013) as it is ‘the only part of himself which he does not share with the animal kingdom’ (Plato, referenced in White 2013). Whilst this definition may appear simplistic or constrictive, it is also not intrinsically wrong, merely indicative of the era in which it was formulated. Kant expounds upon the need to define ‘humanity’ asserting that any definition of an individual in isolation from a collective is futile and insufficient. Rather, it is only the ability ‘to treat himself and others according to the principle of freedom under the laws’ (Kant, referenced in Cohen, 2008) that defines humanity. In essence, it is only in relation to others that individuals may exist as human, congruent with Cohen’s assertion that ‘the study of the other is the yardstick by which men measure their own common humanity’ (Cohen, 2008). Heidegger adopts a markedly different approach in his ‘Being and time’, recognising the fluidity of human nature and creating Dasein who Oleson asserts is ‘the being of a human being, understood as the being that is concerned with being itself’ (Oleson, 2013), embodying the definition of humanity through a representation of the history of being (Oleson, 2013). Dasein exists as ‘the connection between historicality and temporality’ (Heidegger, 1927), and in this way, Heidegger seeks to define humanity by means of its instability. From these hugely variegated definitions of what constitutes the state of being human, it becomes clear we are unlikely to determine one singular, immutable definition of what it is to be human. Hence, it is difficult to have a constant point of comparison to see whether AI has “surpassed” its limits and transcended into some form of humanity. But with the increasing capabilities of AI, it stands to reason there be provisions in place in both law and politics to account not only for the implications of AI upon humanity, but for the representation of AI and its potential forms. Even if this representation or legislation is aspirational, it stands to reason there be policies in place, as various machine learning figures become more and more prominent in society and culture. At the end of the day, the girl stands cemented in her place. The line between her arms and the cogs she operates is indistinguishable amongst the black haze of smoke. In a town not too far from here, children kiss their mothers good night and fall asleep. But here, in this place, with this grime, she stands cold and unfeeling, the sky obscured by the machinery above. Previous article Next article alien back to

< Back to Issue 7 Timeless Titans: Billionaires defying death by Holly McNaughton 22 October 2024 edited by Arwen Nguyen-Ngo illustrated by Esme MacGillivray Humans are destined to face an unavoidable end, but what if we weren't? What if humans could push the boundaries of death and become "un-ageable"? What would be the consequences if the world's top apex predators became immortal? The concept of anti-ageing and the quest for eternal life is not new. Cleopatra supposedly bathed in donkeys’ milk to reduce wrinkles. The first emperor of the Qin dynasty (221-206 B.C.), tried to achieve immortality by taking pills. Unfortunately for him, the key ingredient was the highly toxic substance—mercury. In 16th century France, members of the nobility would drink gold to preserve youthful looks. Much like in the past, today’s leading figures in the anti-ageing field are those with power and wealth. Today, the same obsessive quest for youth persists, but now it is backed by cutting-edge science and more importantly, staggering wealth. This article delves into the latest anti-ageing trends—pills, specialised diets, and more—championed by modern-day billionaires. We’ll explore the innovations they fund, and more provocatively, what it means for humanity when death is no longer inevitable. Anti-ageing pills The first “key” to anti-ageing is metformin, which dates to the1920s and was first discovered in the medicinal herb Galega officinalis . It lowers blood sugar levels and is taken as a popular treatment for type 2 diabetes (Bailey, 2017). Metformin works by tricking your body into thinking there is not enough energy, lowering blood glucose levels, and helping the insulin your body makes to work better. In a 2014 clinical study, patients with type 2 diabetes initiated with metformin had longer survivals than non-diabetics who did not receive the drug (Bannister et al. 2014). Although this is a correlation, not causation, some studies state Metformin has increased lifespan in mice (Martin-Montalvo et al., 2013). While we are anticipating the results of a trial on the effects on humans, and particularly the effects on non-diabetic lifespan, some are already convinced by the results from preliminary studies, such as Byran Johnson. Johnson is a self-proclaimed Professional Rejuvenation Athlete and founder of Project Blueprint. The Blueprint protocol is an extensive regimen of exercise, health tests, supplements, and a strict diet, to reverse biological age. Bryan has been following the protocol since 2021 and has successfully slowed down his rate of ageing to 0.76, meaning that for every year, Bryan is only ageing 277 days. Luckily, it only costs him 2 million a year. As part of the protocol, Bryan takes several prescription drugs daily, including metformin twice a day and rapamycin. Rapamycin is another promising “key” anti-ageing drug that works as a mTOR inhibitor. mTOR is a key component in cell growth, proliferation and survival. By inhibiting mTOR, cell growth and protein synthesis processes are slowed, thus reducing the chance of pathology (disease and/or injury) of cells and tissues. It has been shown to extend the lifespan of mice, yeast, worms and fruit flies (Harrison et al., 2009) and in 2018, elderly humans given rapamycin showed promising results with improvement in immune function and decreased infection rates (Mannick et al., 2018), which could ultimately lead to longer lifespans. Young blood transfusion Throughout history, blood has been a popular anti-ageing remedy. In the 15th century, Pope Innocent VIII drank the blood of three young boys, to heal his ailments (Scott & DeFrancesco, 2015). It did not work. The term “Young Blood transfusion” is now used to refer to the practice of transfusing blood from a young person into an older one to tackle age-related diseases. The rationale comes from parabiosis experiments. Parabiosis is the anatomical and physiological union of two organisms, and in the 1950s it was performed on two mice, surgically stitched together. A month after the procedure, the older mice showed rejuvenation (Conboy et al., 2005). In 2017, a new startup called Ambrosia emerged offering transfusion from young people at $8,000 a session. According to the U.S Food and Drug Administration, there were no clinical benefits of this treatment, and it was shortly shut down. PayPal founder Peter Thiel believes he will live to be 120 years old; a fan of young blood transfusions, he also credits his future success to taking human growth hormones daily and following a strict paleo diet. The science of which diet is best for anti-ageing is constantly changing. The paleo diet cuts out sugar, carbohydrates and highly processed food and is praised by celebs, but is not currently supported by science for having anti-aging benefits. Other diets such as intermittent fasting, keto and veganism are all praised for their anti-aging properties, but again the claims are under-researched. However, there is a growing body of evidence that a whole-food, plant-based diet can aid in the prevention, and in some cases reversal, of chronic diseases (Solway et al., 2020). For example, in Loma Linda, California, one of the world's five original blue zones (areas of the world with the healthiest, longest-living populations), the life expectancy is 10 years longer than the average American, which has been linked to the high number of Adventist vegetarians in the community. The key link between all five blue zones is a mostly whole-food, plant-based diet. Ethical and social implications – consequences of immortal humans The cure to ageing is still a while away but there is already a growing body of evidence of how we can extend our lifespans, but is that a good idea? The first argument against extending human lifespans is the risk of furthering the gaps in inequality. There is already a 30–40-year life expectancy gap between first-world and third-world countries. As highlighted in this article, it is primarily the wealthy benefiting from advancements in anti-ageing. Although, it is the responsibility of politicians and governments to remove the disparities worldwide. Thus, the question arises – should our focus and resources be directed towards addressing the health crises in developing countries instead? The second argument is overpopulation. An interesting study that looked at a 100-year projection of population size if no one aged after 60 showed that total population size only increased by 22% or 9 million to 11 million (Gavrilov & Gavrilova, 2010). They also pointed out that many members of society may choose to reject new anti-ageing technologies due to religious reasons, fear of side effects and/or costs. I would also like to point out that the world’s declining birth rates due to increased fertility issues may also mean overpopulation won’t be a near-future issue. An increasing population size does however mean increased demand for finite resources like water. Increases in water demand could cause an increase in civil and international conflicts over existing water supplies. In Australia, water scarcity is already a persistent issue, given the relatively dry and variable climate and an increased population size will see demand rise above our limits. To conclude, science has not found a cure for mortality, but with the development in age reversal or anti-ageing science, we may see the longevity of life increasing as well as quality of life. There are several ethical and social implications of an “un-ageable” race, but most importantly, developments in the anti-ageing community may allow loved ones to be healthier for longer. References AIHW, Australian Institute of Health and Welfare. (2024). Deaths in Australia. Retrieved from https://www.aihw.gov.au/reports/life-expectancy-deaths/deaths-in-australia Bannister, C. A., Holden, S. E., Jenkins-Jones, S., Morgan, C. L., Halcox, J. P., Schernthaner, G.,Mukherjee, J., & Currie, C. J. (2014). Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes Metab , 16 (11), 1165-1173. https://doi.org/10.1111/dom.12354 Bailey, C. J. (2017). Metformin: historical overview. Diabetologia , 60 (9), 1566-1576. Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature , 433 (7027), 760-764. https://doi.org/10.1038/nature03260 Gavrilov, L. A., & Gavrilova, N. S. (2010). Demographic consequences of defeating aging. Rejuvenation Res , 13 (2-3), 329-334. https://doi.org/10.1089/rej.2009.0977 doi.org Metformin: historical overview - Diabetologia Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat’s rue), a traditional herbal medicine in Europe, found to be rich in guanidine, which, in 1918, was shown to lower blood glucose. Guanidine derivatives, including metformin, were synthesised and some (not metformin) were used to treat diabetes in the 1920s and 1930s but were discontinued due to toxicity and the increased availability of insulin. Metformin was rediscovered in the search for antimalarial agents in the 1940s and, during clinical tests, proved useful to treat influenza when it sometimes lowered blood glucose. This property was pursued by the French physician Jean Sterne, who first reported the use of metformin to treat diabetes in 1957. However, metformin received limited attention as it was less potent than other glucose-lowering biguanides (phenformin and buformin), which were generally discontinued in the late 1970s due to high risk of lactic acidosis. Metformin’s future was precarious, its reputation tarnished by association with other biguanides despite evident differences. The ability of metformin to counter insulin resistance and address adult-onset hyperglycaemia without weight gain or increased risk of hypoglycaemia gradually gathered credence in Europe, and after intensive scrutiny metformin was introduced into the USA in 1995. Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, providing a new rationale to adopt metformin as initial therapy to manage hyperglycaemia in type 2 diabetes. Sixty years after its introduction in diabetes treatment, metformin has become the most prescribed glucose-lowering medicine worldwide with the potential for further therapeutic applications. Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E., & Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature , 460 (7253), 392-395. https://doi.org/10.1038/nature08221 Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M. J., Schwab, M., Pollak, M., Zhang, Y., Yu, Y., Becker, K. G., Bohr, V. A., Ingram, D. K., Sinclair, D. A., Wolf, N. S., . . . de Cabo, R. (2013). Metformin improves healthspan and lifespan in mice. Nat Commun , 4 , 2192. https://doi.org/10.1038/ncomms3192 Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., Glass, D. J., & Klickstein, L. B. (2018). TORC1 inhibition enhances immune function and reduces infections in the elderly. Science Translational Medicine , 10 (449), eaaq1564. https://doi.org/doi:10.1126/scitranslmed.aaq1564 Scott, C., & DeFrancesco, L. (2015). Selling Long Life. Nature Biotechnology , 33 , 28-37. Solway, J., McBride, M., Haq, F., Abdul, W., & Miller, R. (2020). Diet and Dermatology: The Role of a Whole-food, doi.org Selling long life - Nature Biotechnology A new generation of commercial entities is beginning to explore opportunities for new types of interventions and services in a graying world. Plant-based Diet in Preventing and Reversing Skin Aging-A Review. J Clin Aesthet Dermatol , 13 (5), 38-43. Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T.,Haghani, A., Gong, T., Hedman, A. M., Andolf, E., Pershagen, G., Almqvist, C., Clish, C. B., Horvath, S., White, J. P., & Gladyshev, V. N. (2023). Biological age is increased by stress and restored upon recovery. Cell Metab , 35 (5), 807-820.e805. https://doi.org/10.1016/j.cmet.2023.03.015 Previous article Next article apex back to

< Back to Issue 10 Unpacking Myths: Distortions of Sex Differences in Popular Culture by Vicenta Wheatley 2 June 2026 Illustrated by Jessica Walton Edited by Han Chong Open TikTok, scroll through Reddit, or fall down a Youtube rabbit hole about dating and relationships, and you will almost certainly encounter a familiar set of claims: men are biologically wired to seek young, fertile women, while women are evolutionarily programmed to prefer high-status providers. These preferences are presented as universal, ancient, and essentially fixed. The studies cited are real, and the researchers exist, yet something crucial gets lost between the data that differentiates a statistical pattern from a universal truth. This is not simply a story about misunderstanding science. In some cases, simplified narratives about attraction may be actively reinforced because they are commercially effective (1). Dating platforms, for example, operate within engagement driven systems where presenting certain patterns such as “younger is more desirable” can increase competition, user activity, and in some cases subscription behaviour. Whether intentional or not, the result is the same: complex research is translated into persuasive but incomplete stories about how men and women are supposed to be. To understand how distortion happens, it helps to first understand what the science actually says, because the research is more careful and more interesting than its popular reputation suggests. Evolutionary psychology does not claim that all men and women behave identically, but instead it identifies probabilistic patterns shaped by millions of years of reproductive pressures. The key thing to note here is that these are tendencies, not rules, and they come with enormous individual variation. The question, then, is not whether differences exist, but how they are interpreted, and why that interpretation so often becomes simplified the moment it enters public discourse. What the Science Actually Says Evolutionary psychology attempts to explain certain human behaviours through the lens of reproductive adaptation. At its core is the idea that psychological tendencies, much like physical traits, may have evolved because they increased reproductive success in ancestral environments. One of the field’s most influential frameworks is the sexual selection theory first proposed by Charles Darwin, suggesting that traits linked to mate competition and mate choice become more common over generations. From this perspective, evolutionary psychologists argue that men and women may, on average, display somewhat different mating preferences due to asymmetries in parental investment (2). Figure 1 . Average importance ratings of partner characteristics across male and female participants in romantic and sexual attraction contexts. While average sex differences appear in some traits, substantial overlap remains between groups. Adapted from (3). Since women have historically faced greater biological costs associated with reproduction through pregnancy, childbirth and, for most of human history, primary infant care, the parental investment theory predicts that women may place greater emphasis on stability, commitment, and resources when selecting long-term partners. Men, in contrast, may be somewhat more likely to prioritise cues associated with fertility and reproductive health, such as youth and physical attractiveness (Fig. 1). Research in this area is not purely speculative, nor was it invented by a podcast host holding a microphone the size of a small telescope. In a widely cited 1989 cross-cultural study spanning 37 societies, evolutionary psychologist David Buss found that women consistently rated financial prospects and ambition as more important in long-term partners, while men placed greater emphasis on youth and attractiveness (4). Subsequent studies have identified similar broad patterns across cultures, lending support to the idea that some mating preferences may have evolutionary roots (5). Yet the popular interpretation of these findings is usually far more rigid than the research itself. Let’s be clear, evolutionary psychologists do not argue that all men pursue casual relationships, nor that all women seek wealthy providers. The differences observed are statistical averages across populations, not fixed scripts handed out at birth. In reality, the overlap between men and women is substantial, and human attraction is shaped by a dense interaction of biology, personality, culture, upbringing, social norms, economic conditions, and individual experience. Let’s also remember that humans exhibit mutual mate choice, meaning both sexes tend to value qualities such as kindness, intelligence, emotional stability and loyalty among others, particularly in long term relationships. The science, in other words, is far more nuanced and probabilistic than its online afterlife often suggests. When Research Becomes Content Once these findings leave academic journals, however, they often undergo a dramatic simplification. On social media platforms, dating podcasts, YouTube commentary channels, and algorithm-driven feeds, probabilistic patterns are frequently reframed as fixed biological truths. For instance, a statistical tendency for men, on average, to prioritise youth in certain contexts becomes the sweeping claim that women inevitably “lose value” with age, which is usually accompanied by a graph created from non-peer-reviewed data, a ring light, and enough confidence to make one briefly forget what a sample bias is. Findings about short-term mating strategies are transformed into declarations that men are biologically incapable of monogamy. The context and variation embedded within the original research are gradually stripped away and replaced with narratives that are far easier to package into viral content. Part of the appeal of these narratives lies in their simplicity. We all know human relationships are emotionally messy and socially complicated, but biological explanations can sometimes offer the illusion of certainty. Algorithms further intensify this process by rewarding emotionally charged claims that provoke engagement. Nuance rarely performs as well online as confidence does. A creator who states that attraction is shaped by a complex interaction of evolutionary, social, and cultural influences is unlikely to generate the same reaction as someone confidently declaring that “men are just wired this way” while speaking in a podcast. In this sense, the distortion of scientific findings is not always accidental. Simplified biological narratives are highly marketable because they are easily understood and capable of reinforcing existing insecurities. Within digital dating ecosystems, where apps and influencers often profit from continued dissatisfaction and competition, there may even be incentives to amplify narratives that encourage users to constantly optimise themselves in the pursuit of desirability. Dating app data provides a particularly striking example of how this process unfolds. OkCupid user data is frequently circulated online to support the claim that men of all ages overwhelmingly prefer women in their early twenties, with stronger aggregate attention toward younger women (Fig. 2b); while female preference patterns appear to remain relatively age-aligned. These visualisations are often interpreted in a highly deterministic way, stripped of their behavioural and contextual limitations. In particular, messaging and preference data from dating platforms reflect engagement patterns within an insular digital environment rather than stable or universal mate preferences. Despite this, such findings are repeatedly circulated as evidence of fixed biological tendencies. Figure 3. Distribution of age differences in unmarried/cohabitant straight couples within the U.S. Age disparity between male-to-female is displayed in years on the x-axis, while frequency of couple age gap is shown as a percentage on the y-axis. Data compiled from U.S. Census Bureau estimates. Adapted from (7). Messaging behaviour on dating apps does not necessarily reflect long-term compatibility or actual partner selection. When broader relationship outcomes are considered, this interpretation becomes less stable. Age differences in real-world couples are generally modest, with most partnerships clustering around relatively small age gaps (Fig. 3). Marriage and cohabitation data, for instance, show far smaller age gaps than viral internet discourse might imply. Nor do these datasets capture the influence of culture, social expectations, or the fact that attraction itself is highly multidimensional. The issue, then, is not that the original research is fabricated, but that selective interpretations become amplified to the point that statistical tendencies are reframed as fixed biological determinism. The Social Cost of Simplified Science The distortion of these findings matters because biological explanations rarely stay confined to academic discussion. Once ideas about attraction and sex differences enter popular culture, they begin shaping real expectations about relationships and personal value. Claims that men are biologically programmed to prioritise youth, for example, are often interpreted less as statistical observations and more as warnings directed at women. Entire online industries have emerged around this premise, from female value discourse to anti-ageing products marketed with thinly veiled evolutionary language. Exposure to enough of this content can encourage the perception that desirability functions like a countdown, reinforced by highly persuasive and aggressive marketing frameworks. What makes these narratives particularly persuasive is their association with science . Most people are not reading evolutionary psychology papers directly, nor are they spending their evenings analysing sample sizes and methodological limitations for fun. Instead, findings are filtered down through influencers, dating coaches, podcasts, and viral clips that present contested or nuanced ideas with remarkable certainty. Once a claim is framed as biological, it can become harder to critique because it appears rooted in nature itself rather than social interpretation. Statements such as “men are naturally non monogamous” or “women are wired to seek providers” can gradually shift from descriptive claims about averages into prescriptive assumptions about how people should behave. In this way, scientific language can end up reinforcing existing gender norms while giving them the appearance of inevitability. These narratives affect all genders, albeit in different ways. Men are increasingly told that their value depends on wealth, height, status, confidence, and sexual success, while emotional vulnerability is framed as weakness. Women, meanwhile, are frequently confronted with narratives suggesting that desirability peaks in their early twenties before declining with age; encouraging constant self-monitoring through beauty routines, cosmetic procedures, anti-ageing products, and pressure to remain attractive within increasingly narrow standards. However, while rising engagement with cosmetic procedures is often linked to these cultural narratives, this relationship is likely multifactorial rather than singular in origin. An increased access to minimally invasive treatments, changing medical norms around cosmetic enhancement, and broader social media exposure all plausibly contribute to these trends, alongside the influence of appearance-focused cultural messaging. For instance, reports indicate a substantial rise in cosmetic procedures among younger age groups in recent years (8,9), and while these figures cannot be attributed to a single causal driver, they are nonetheless consistent with environments in which aesthetic pressure and visibility have increased. Taken together, this suggests a complex interaction between cultural narratives, medical technology, and evolving aesthetic norms, where expectations about attractiveness may play a meaningful reinforcing role. Research into human attraction and sex differences can offer valuable insight into broad behavioural patterns, but those findings are frequently distorted once they enter popular culture. Probabilistic trends in mating preferences and behaviour are often repackaged into rigid truths about how men and women supposedly are. In an online environment that rewards certainty over nuance, scientific literacy matters more than ever for not only understanding the research itself, but for recognising when complex findings are being simplified into something far more prescriptive than they were ever intended to be. References Brady WJ, Wills JA, Jost JT, Tucker JA, Van Bavel JJ. Emotions shapes the diffusion of moralized content in social networks. Proc Natl Acad Sci U S A. 2017;114(28):73138. doi:10.1073/pnas.1618923114 Trivers, R. Parental investment and sexual selection. In: Campbell B, editor. Sexual Selection and the Descent of Man . Chicago: Aldine Publishing Company; 1972. P.136-79 Scheller M, de Sousa AA, Brotto LA, Little AC. The role of sexual and romantic attraction in human mate preferences. J Sex Res. 2023. doi:10.1080/00224499.2023.2176811 Buss, D. Sex differences in human mate preferences: evolutionary hypotheses tested in 37 cultures. Behav Brain Sci . 1989;12(1):1-14. doi:10.1017/S0140525X00023992 Thomas AH, Jonason PK, Blackburn JD, Kennair LEO, Lowe R, Malouff JM, et al. Mate preference priorities in the East and West: a cross cultural test of the mate preference priority model. J Pers. 2020;88(3):606-20. doi:10.1111/jopy.12514 Rudder C. Dataclysm: Who we are (when we think no one’s looking). New York: Crown; 2014. Kamenov A. Age disparities in relationships: statistics. City-Data Blog; 2020. https://www.city-data.com/blog/2620-age-disparity/ CNN Health. Surge in cosmetic procedures among young people. 2024 Jan 16. https://edition.cnn.com/2024/01/16/health/young-cosmetic-procedures Australian Broadcasting Corporation. Gen Z driving increase in cosmetic injectables. 2026 Feb 28. https://www.abc.net.au/news/2026-02-28/gen-z-driving-boost-cosmetic-injectables/106258646 Previous article back to Fact & Fiction Next article