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By Ashleigh Hallinan < Back to Issue 3 Space exploration in Antartica By Ashleigh Hallinan 10 September 2022 Edited by Tanya Kovacevic and Breana Galea Illustrated by Aisyah Mohammad Sulhanuddin Next The isolated southern expanse of the Earth is an alien realm, with vast expanses of white ice and blue sky that appear to stretch on infinitely. Despite its barren landscape, the Antarctic continent holds secrets to the origins of our Earth and the solar system in the form of meteorites. Meteorites are solid pieces of debris that originate in outer space, survive the journey through our atmosphere, and fall to the Earth’s surface.(1) Their unique components and pungent smells contain fascinating stories of cosmic clouds, condensing stardust and the fiery collisions of entire planets. These ‘space rocks’ can land anywhere on Earth, but the vast majority of meteorites are found in the cold deserts of Antarctica.(2) So, why Antarctica? Across the globe, meteorite abundance is dependent on two factors: the meteorites must be easy to spot, and their preservation must be guaranteed over long time periods.(3) It is the conditions of the Antarctic landscape that make all the difference when it comes to meteorite discovery. The cold, dry nature of Antarctica helps to preserve these extraterrestrial rocks, allowing for more pristine samples to be collected. In this way, we may think of Antarctica as a ‘natural freezer’. In fact, meteorites can be buried and preserved in the Antarctic ice for up to millions of years, allowing for a deep dive into the origins of the solar system upon analysis. Furthermore, meteorites are easier to find in Antarctica due to the stark contrast between the dark colours of meteorites and the white ice. And since so few rocks naturally form on ice sheets, you can be fairly certain the majority of rocks found in Antarctica are extraterrestrial. However, an expedition to Antarctica for meteorite hunting is no small feat. Thankfully, landscape processes occurring on the Antarctic continent create concentrated pockets of meteorites, making the hunt for meteorites less like trying to find a needle in a haystack. These meteorite hotspots are largely a result of the local geology and movement of ice across the Antarctic landscape.(4) As meteorites strike glaciers, they are buried and encased in the ice. These glaciers move across the landscape, acting as ‘conveyor belts’ that carry the meteorites until they reach a large barrier, such as the Transantarctic Mountains. The ice flow is blocked and builds up at the base of the mountain. Here, dry Antarctic winds slowly erode the ice, revealing a bounty of imprisoned meteorites. Traditionally, meteorites have been divided into three broad categories: stony, stony-iron, and iron.(5) While stony meteorites are made up of silicate minerals, iron meteorites are almost completely made of metal. Unsurprisingly, stony-iron meteorites are composed of nearly equal amounts of metal and silicate crystals. Alarmingly, warmer temperatures and melting ice associated with global warming may hinder our search for meteorites. This is particularly the case for iron meteorites, which conduct heat more efficiently than other meteorite types due to their higher metal content.(6) Consequently, meteorites can sink into the ice and out of sight. Despite Antarctica’s otherworldliness, it is not free of the impacts brought about by human activity occurring on landmasses separated by vast seas. However, with the help of artificial intelligence and machine-learning, the quest for meteorite discovery continues. Scientists recently estimated there are as many as 300,000 more meteorites to be discovered in Antarctica, their stories waiting to be uncovered in a never-ending game of hide-and-seek.(7) Using machine learning to combine satellite measurements of temperature, surface slope, speed of ice flow, and reflection of radar signals by ice, scientists have developed a ‘treasure map’ containing the predicted locations of concentrated meteorite zones.(7) The ’treasure map’ is accessible online,(8) so anyone can search the Antarctic continent for rocky remnants left over from the formation of the solar system. When we think of space exploration, we conjure up images of astronauts and spaceships. But Antarctica provides us with the opportunity to peer into the cosmos without ever leaving Earth, given we are brave enough to face the inhospitable conditions and pervasive alienness of the Earth’s southernmost continent. References 1. Sephton M, Bland P, Pillinger C, Gilmour I. The preservation state of organic matter in meteorites from Antarctica. Meteoritics & Planetary Science. 2004;39(5):747-54. 2. Corrigan C. Antarctica: The Best Place on Earth to Collect Meteorites. CosmoELEMENTS; 2011. p. 296. 3. Schlüter J, Schultz L, Thiedig F, Al‐Mahdi B, Aghreb AA. The Dar al Gani meteorite field (Libyan Sahara): Geological setting, pairing of meteorites, and recovery density. Meteoritics & Planetary Science. 2002;37(8):1079-93. 4. Steigerwald B. NASA Scientist Collects Bits of the Solar System from an Antarctic Glacier Greenbelt: NASA; 2018 [Available from: https://www.nasa.gov/feature/goddard/2018/antarctic-meteorites. 5. Lotzof K. Types of meteorites [Internet]. Natural History Museum; [Available from: https://www.nhm.ac.uk/discover/types-of-meteorites.html. 6. Evatt G, Coughlan M, Joy K, Smedley A, Connolly P, Abrahams I. A potential hidden layer of meteorites below the ice surface of Antarctica. Nature communications. 2016;7(1):1-8. 7. Tollenaar V, Zekollari H, Lhermitte S, Tax DM, Debaille V, Goderis S, et al. Unexplored Antarctic meteorite collection sites revealed through machine learning. Science Advances. 2022;8(4). 8. Tollenaar V, Zekollari H, Lhermitte S, Tax DM, Debaille V, S G. Antarctic Meteorite Stranding Zones [Internet]. [Available from: https://wheretocatchafallingstar.science/. Previous article Next article alien back to

< Back to Issue 9 The Life of Matcha by Kara Miwa-Dale 28 October 2025 Illustrated by Ingrid Sefton Edited by Isaac Tian I sway gently in the spring breeze, my vibrant green surface alive with chlorophyll. It’s a warm April day in Uji, Kyoto, and the conditions are perfect. If you haven’t already guessed, I am a matcha leaf. And this is my journey: from a shaded tea field to a powdered cultural icon. A farmer approaches, her movements calm and focused. She hums a soft tune as she reaches towards me. Then, everything goes dark. But this is not the end of my story – it is just the beginning… Cultivated in the shadows About four weeks before I was plucked, my world dimmed – intentionally. Farmers shaded me from direct sunlight using bamboo screens, an ancient practice known as tana cultivation (1). Among this shaded world, photosynthesis slowed and carbohydrates grew scarce. In response, I redirected my nitrogen reserves into free amino acids, favouring the formation of compounds like theanine (2). The shade also awakened genes involved in amino acid transport and theanine biosynthesis, enhancing the pathways responsible for L-theanine production - an amino acid known to induce a state of calm alertness in humans (2). At the same time, the production of catechins, the source of my bitterness, gradually declined (2). I don’t mean to brag, but the fact that I was chosen, among so many other leaves, meant that I was of exceptional quality. My glow-up from leaf to powder Shortly after harvest, I was gently steamed. This critical step deactivated polyphenol oxidase enzymes, stopping the process of oxidation before my leaves turned brown (3). From here, I was then air-dried, my veins and stems removed, and I was ground between granite millstones into an ultra-fine powder – matcha. My transformation into powder amplifies the capacity for the valuable L-theanine, catechins and chlorophyll to be ingested, enhancing my potential effects on the human body (4). A mindful celebration of my life I received the highest of honours: to be prepared in a traditional Japanese tea ceremony. In the 12 th century, Zen Buddhist monks first brought powdered green tea to Japan (5). They valued it as a tool for meditation, as much a spiritual discipline as a drink. The tea master – or chadoka – prepares me with graceful precision. Every movement is intentional; each sip a meditation. The ceremony follows the teaching of ‘ichigo ichie’, a philosophy that refers to the attitude of putting one’s whole spirit into a bowl of tea, since each tea ceremony is a once-in-a-lifetime gathering (6). My consumption increases alpha brain wave activity, a state associated with relaxed alertness, or focus without stress (7). My travels to the West I am one of the lucky ones. Elsewhere, leaves of a lower grade are processed with less care by hurried hands. They are shipped in bulk across continents, their bitterness masked with sugar and milk, where they are sold in Starbucks as ‘green tea lattes’ or in an array of matcha-flavoured sweets, far removed from my cultural roots. In the West, I’ve become something else entirely. A token of wellness, luxury, even a lifestyle aesthetic. I have become a cultural symbol of Japan, while also gaining status as a ‘health food’ and a marker of social prestige – representing the so-called ‘clean lifestyle’, or even the ideals of the ‘performative male’. Anthropologists describe this phenomenon as cultural food colonialism: the commodification of a food or drink by another society, often without a full appreciation of its historical and cultural roots. I am now enjoyed throughout the world, yet my true value and original purpose are sometimes forgotten, consumed more as a passing trend than with the intention of mindful presence. Sometimes I am added to products by companies eager to capitalise on a fad. My chemistry Science plays a big part in my newfound fame. Research has found that the L-theanine, e pigallocatechin gallate (EGCG) and rutin contained within my leaves elicit a variety of physiological benefits. L-theanine counteracts the stimulating effects of caffeine, giving drinkers a calmer ‘buzz’ and a more gradual release of energy compared to coffee. This unique combination of L-theanine and caffeine may enhance concentration and memory, while also alleviating stress (8). As a result, I am particularly appealing to those who embrace a ‘slow-living lifestyle’ or to individuals who become jittery from coffee due to overstimulation of the nervous system. Another prominent compound found in my powder, EGCG is renowned for its ability to protect cells from damage, reduce inflammation, and support heart health, while also exhibiting anti-tumour properties. By neutralising harmful free radicals, EGCG further helps to reduce oxidative stress, which is associated with ageing and a range of chronic diseases (9). I also contain a particularly high rutin content compared to other teas. This polyphenic compound is a potent antioxidant and, in combination with ascorbic acid (vitamin C), contributes to cardiovascular protection by strengthening blood vessels and improving circulation (10). In addition, rutin has demonstrated antidiabetic properties, helping to regulate blood sugar levels and improve metabolic function (10). A hot commodity and a growing concern As global demand for my vibrant green leaves continues to soar, tea plantations are expanding rapidly, sometimes at the expense of native ecosystems. My growth often comes with a cost: natural habitats are cleared to make way for me, leading to a loss of biodiversity. Farmers face increased pressure to cultivate larger harvests, striving to meet global demand while upholding sustainable practices. This so-called ‘matcha mania’ has even led to global shortages. Farmers can’t keep up, prices are climbing, and some companies have resorted to limiting purchases to stop people from stockpiling. My rise in popularity is exciting, but it raises an important question: how can we enjoy the benefits I bring while ensuring that my cultivation is ecologically responsible? My future I am torn - pulled in two different directions. On one hand, I swell with pride that my fellow matcha leaves and I are travelling across the globe, introducing more people to the calm, focused energy I can bring. I am pleased when coffee drinkers opt for me in search of a gentler buzz, or when someone slows down to whisk me into a beautiful frothy drink, savouring the ritual and satisfaction I was always meant to inspire. But my popularity is not without its complications. Can the old and the traditional truly coexist with the new? I watch, bewildered, as I am mixed with banana pudding, pistachio lattes, and other curious concoctions. Those consuming these drinks delight in their sweetness, but I wonder whether they can appreciate what makes me special under the layers of so many other products. I fear that my origins may be overshadowed by trends and novelty. I hope that my tradition is remembered, even as I am enjoyed in new ways around the world. Yet if you pause, every cup offers a quiet invitation. The next time you take a sip of my green goodness, take a deep breath. Let its warmth and aroma envelop you, and consider the long journey I’ve taken to reach your cup. From the shaded tea gardens where I was grown, to the careful whisking that releases my flavour, each sip embodies countless steps, immense human labour, and a story that spans cultures and continents. What seems like an everyday ritual holds so much more. In that stillness, remember how even small acts connect us to the world, to tradition, and to the delicate balance between old and new. References 1. Purvis L. Tencha: Why Shade-Growing is Essential to Matcha Green Tea. Mizuba Tea Co . September 26, 2017. https://mizubatea.com/blogs/news-1/it-can-only-be-tencha-why-shade-growing-is-essential-to-matcha 2. Chen X, Ye K, Xu Y, Zhao Y, Zhao D. Effect of Shading on the Morphological, Physiological, and Biochemical Characteristics as Well as the Transcriptome of Matcha Green Tea. International Journal of Molecular Sciences . 2022;23(22):14169. doi: 10.3390/ijms232214169 3. Wang J, Li Z. Effects of processing technology on tea quality analyzed using high-resolution mass spectrometry-based metabolomics. Food Chemistry . 2024;443:138548. doi: 10.1016/j.foodchem.2024.138548 4. Devkota HP, Gaire BP, Hori K, Subedi L, Adhikari-Devkota A, Belwal T, et al. The science of matcha: Bioactive compounds, analytical techniques and biological properties. T rends in Food Science & Technology . 2021;118:735-43. doi: 10.1016/j.tifs.2021.10.021 5. McNamee GL. Matcha . Encyclopaedia Britannica. September 10, 2025. https://www.britannica.com/topic/matcha 6. Phenimax Legends of Japan. Ichigo Ichie: The Deeper Meaning Behind a Once-in-a-Lifetime Tea Gathering. Phenimax Legends of Japan ; December 1, 2024. https://phenimax.com/sw/blogs/japanese-tea-article/onetime-onemeeting 7. Baba Y, Inagaki S, Nakagawa S, Kobayashi M, Kaneko T, Takihara T. Effects of Daily Matcha and Caffeine Intake on Mild Acute Psychological Stress-Related Cognitive Function in Middle-Aged and Older Adults: A Randomized Placebo-Controlled Study. Nutrients . 2021;13(5). doi: 10.3390/nu13051700 8. Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S. Green tea effects on cognition, mood and human brain function: A systematic review. Phytomedicine . 2017;34:26-37. doi: 10.3390/foods9040483 9. Capasso L, De Masi L, Sirignano C, Maresca V, Basile A, Nebbioso A, et al. Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential. Molecules . 2025;30(3):654. doi: 10.3390/molecules30030654 10. Kochman J, Jakubczyk K, Antoniewicz J, Mruk H, Janda K. Health Benefits and Chemical Composition of Matcha Green Tea: A Review. Molecules . 2021;26(1):85. doi: 10.3390/molecules26010085 Previous article Next article Entwined back to

Ever thought about whether we could build the Iron Man suit? We cannot replicate it exactly, but we can find some workarounds to build parts of it with currently available technology. With the exponential growth of technology, we are getting closer and closer to building the Iron Man suit. Cinema to Reality Can We Build the Iron Man Suit? By Manthila Ranatunga We see cool and fancy gadgets in movies every now and then. How can we bring them to reality? For this issue, we take a look at the Iron Man suit. Edited by Breana Galea, Ashleigh Hallinan & Tanya Kovacevic Issue 1: September 24, 2021 Illustration by Gemma Van der Hurk Warning: Iron Man (2008) spoilers When Marvel Studios released Iron Man in 2008, it was all the rage among comic book fans, film geeks and engineers alike. The Iron Man suit is one of the coolest and most iconic gadgets in film history. A generation of mechatronics engineers were inspired after watching Tony Stark build the suit, myself included. Now we wonder whether we could build it with today’s technology. So, the question remains: can we build the Iron Man suit? We are talking about the Mark III suit, the gold and hot-rod red one. Unfortunately, replicating the suit is impossible; the laws of physics would not allow it. However, we can make some compromises and find some workarounds to build the suit’s most defining systems. The Power Source We can all agree the most vital part of the suit is the power source. After all, it gave Mr Stark the idea for the suit. The suit is powered by an arc reactor, which is essentially a fusion reactor (1). These produce power using nuclear fusion, the same way the sun and stars burn as enormous balls of fire. We are talking about reactions between atoms which are the building blocks of everything. Atoms contain a cluster of even smaller particles inside. Collectively they form the nucleus, so you can see where nuclear fusion comes from. Now, where are we going with this? Well, when nuclear fusion occurs, heat energy is produced (2). Nuclear fusion was chosen as the suit’s power source due to the colossal amount of energy it produces. With the palm of your hand acting as a size guide, nuclear fusion is one of the highest energy density methods available. Sounds too good to be true, right? Correct. To replicate the conditions required, a reactor would need to be heated to 150 million degrees Celsius (3) - 10 times hotter than the sun’s core! Imagine that on your chest! Unsettling, to say the least. Mr Stark’s arc reactor is self-sustaining and can power the suit for hours, or even days. But with modern technology, fusion reactors consume more energy than they produce (4). Consequently, recreating an arc reactor of the same size and energy output is currently impossible. Nevertheless, there are workarounds to create a partially functioning arc reactor. Massachusetts Institute of Technology (MIT) has been working on a fusion reactor called the ‘Alcator C-Mod’ for the past 20 years (5). Their goal has been to reduce their size while maintaining power output. Typical fusion reactor size ranges from three to nine metres in diameter, but MIT has managed to reduce theirs to about one. Assuming fusion reactors are net-positive energy producing and well heat-insulated, we can assemble the Alcator C-Mod into our own arc reactor. There are many more factors that are too complicated for us and thus we will ignore them. Instead of being placed on the chest, it can be a giant backpack! The Flight System Now, why do we need so much power? Well, the flight system consumes the bulk of it, which leads to the next point. In the movie, Iron Man flies using the repulsors on his gloves and boots. They are not gas turbines like jet engines. The suit does not carry fuel – how could it? It does not have any storage compartments. The fuel must come from outside of the suit. Here is a hint: it is everywhere, yet invisible at the same time... Air! Helicopters fly by pushing air downwards with their rotors. This works according to Isaac Newton’s third law, which states that any force will have an equal and opposite reaction. By pushing air downwards, the helicopter goes upwards. Iron Man does not have a giant rotor, so how did he solve this? Get ready for another round of physics! Repulsors use muon beams to control flight as needed. Muons are particles smaller than atoms. They exist in the Earth’s upper atmosphere (6), but can also be created at large research facilities. For now, let us assume Mr Stark has a way to produce them on his own; remember, he is a billionaire! The muon beams are ignited using plasma made by the heating of air. To produce this on-demand, the suit draws power from the arc reactor for heating and the suction of air. The repulsor beams are then created, ready for flight! Muons have a short lifespan - about a millionth of a second. In real life, muon storage is not a viable option; they must be generated on the spot. Muon creation occurs in particle accelerators (7). These are long tubes for accelerating and making particles collide at high speeds. You may have heard of the Large Hadron Collider in Switzerland, a particle accelerator that is 27km long. Through efforts to miniaturise them, researchers at the SLAC National Accelerator Laboratory have designed one only 30 centimetres in size (8). Ignoring some laws of physics and with a few billion dollars, we can fabricate this into our own repulsors. Keep in mind - the suit’s hands and feet are smaller than 30 centimeters. Our gloves and boots will be longer and bulkier. The Future So there we have it - a semi-reasonable arc reactor and a flight system. Fun to explore the possibilities of current technology, right? But we must also consider the ethics of building such a deadly weapon. Yes - the Iron Man suit is a weapon. In the wrong hands, this technology would not be so exciting. Centuries or even decades from now, scientific breakthroughs may allow the replication of the suit. When that happens, as humans, it will be necessary to contemplate the moral consequences of such an advancement. Here we have only examined two principal systems of the suit. The rest is up to you! Traverse your mind and create your own semi-realistic Iron Man suit. As we saw here, the Iron Man suit is not far off from our time. Who knows what the future holds? References 1, 3, 4. Trevor English, “How Does Iron Man's Arc Reactor Work?” Interesting Engineering. Published June 26, 2020. https://interestingengineering.com/how-does-iron-mans-arc-reactor-work . 2. Matthew Lanctot, “DOE Explains...Nuclear Fusion Reactions.” U.S. Department of Energy. Accessed August 30, 2021. https://www.energy.gov/science/doe-explainsnuclear-fusion-reactions . 5. Earl Marmar, “Alcator C-Mod tokamak”. Plasma Science and Fusion Center - Massachusetts Institute of Technology. Accessed August 31, 2021. https://www.psfc.mit.edu/research/topics/alcator-c-mod-tokamak 6. Paul Kyberd, “How a ‘muon accelerator’ could unravel some of the universe’s greatest mysteries”. The Conversation. Published February 20, 2020. https://theconversation.com/how-a-muon-accelerator-could-unravel-some-of-the-universes-greatest-mysteries-131415 . 7. Seiichi Yamamoto, “First images of muon beams”. EurekAlert! Published February 3, 2021. https://www.eurekalert.org/news-releases/836969 . 8. Tibi Puiu, “Particle accelerator only 30cm in size is hundred times faster than LHC”. ZME Science. Published November 6, 2014. https://www.zmescience.com/science/physics/particle-accelerator-faster-lhc-5334/ .

By Lily McCann Svante Pääbo: Talking to the Past By Lily McCann 23 March 2022 Edited by Caitlin Kane Illustrated by Quynh Anh Nguyen For a collection of numbers on a screen, the World Population Clock stirs a lot of emotions (1). Watch it tick on, recording a life, another life, a death, then more lives. The number — well past 8 billion now — reflects the extent of Homo sapiens’ conquest over the world. Evidence of our culture, with its complex language, society and infrastructure, is everywhere. But we seem to be the only earthly species to live in such a way, the only species to track our own numbers on a digital clock. We swarm the planet, all its continents and yet we are, essentially, alone. To challenge this isolation, scientists reach out in all directions, hoping for some kind of reflection that might shed light on who we are. Astronomers look to space; they probe the depths of the universe in search of life like our own. Others, like Svante Pääbo, look to the past. 300,000 years ago, when Homo sapiens first evolved, there was no paper, no writing, no human-like language with which to record stories, cultures, or day to day recounts. Scant traces of our ancestors are all that are left to tease us: fossilised footprints, makeshift tools, bones, grave sites. These markers are indecipherable whispers, slipping through in a hazy, broken form from a past era to our own. With a time machine or resurrection tool perhaps we could converse with the dead, but while these remain foreign to our current reality, how can we talk to the past? For Pääbo, the language of genetics is the key. Using the information carried in Palaeolithic bones, Pääbo has discovered links between present-day humans and prehistoric hominids that tell the story of our evolution and current condition. These incredible findings have earnt Pääbo the Nobel Prize for Physiology or Medicine in 2022 (2). Some of his most important achievements establishing the field of Paleogenomics include the full sequencing of the Neanderthal genome and the discovery of a whole new hominin species: the Denisovan (3, 4). But what fascinates me is his discovery of genetic interrelations between these prehistoric species and Homo sapiens themselves. Pääbo compared Neanderthal and Denisovan genetics to those of modern humans across the world. He discovered similarities and patterns that suggest a flow of genes took place between our ancestors and these hominid species: in other words, our predecessors mingled sexually with Neanderthals and Denisovans at some point in history, passing their genetics onto us as encoded evidence of this fact (5). Human genomes from Europe and Asia were most closely related to Neanderthal genomes, and Pääbo has shown 1-2% of modern non-African Homo sapiens genes are Neanderthal in origin (3). Similar patterns were observed for Denisovans, with the closest relation with modern humans from Pacific islands (6). This data exposes an intimacy between prehistoric hominids that challenges our idea of humans as a species confined to solitude. This conversation between genomes is not without implications for modern human physiology. When Homo sapiens moved into Eurasia, Denisovan and Neanderthal locals had already adapted to places in which Homo sapiens were mere tourists (7). Transfer of certain genes from local populations into the Homo sapiens line may have assisted in their survival. One example is a gene found in Denisovans that is important for survival at high altitudes and has been inherited by modern day Tibetans (8). Researching the discrepancies between modern and prehistoric genetics can thereby allow us to show the function and significance of these shared genes. It is hard to visualise the world in which Neanderthals and Homo sapiens first met. Did the scene play out as a peaceful interaction between two groups of equals? Perhaps it was more akin to the pattern of colonisation with which we are familiar in modern history. As the last species of our evolutionary branch, the Homo genus, we cannot now recreate such a meeting. However these prehistoric meetings played out, we now have evidence that Homo sapiens and local species of hominids in Eurasia communicated on the most intimate of levels. An optimist might argue that these groups of pre-humans shared a harmonious understanding that could be reproduced if humans find an analogous life form elsewhere in the future. Communication is a powerful tool after all, traversing species and millennia. Perhaps genetic insights into the past can remind us that we are not really as isolated as we might think. References Current world population [Internet]. Worldometer. 2023 [cited 2023Mar7]. Available from: https://www.worldometers.info/world-population/ Hedestam GK, Wedell A. The Nobel Prize in Physiology or Medicine 2022 [Internet]. NobelPrize.org. The Nobel Foundation; 2022 [cited 2023Mar7]. Available from: https://www.nobelprize.org/prizes/medicine/2022/advanced-information/ Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. A draft sequence of the Neandertal genome. Science. 2010May7;328(5979):710–22. Krause J, Fu Q, Good JM, Viola B, Shunkov MV, Derevianko AP, et al. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature. 2010Mar24;464(7290):894–7. Villanea FA, Schraiber JG. Multiple episodes of interbreeding between Neanderthal and modern humans. Nature Ecology & Evolution. 2018May26;3(1):39–44. Reich D, Patterson N, Kircher M, Delfin F, Nandineni MR, Pugach I, et al. Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. The American Journal of Human Genetics. 2011Oct11;89(4):516–28. Rogers AR, Bohlender RJ, Huff CD. Early history of neanderthals and Denisovans. Proceedings of the National Academy of Sciences. 2017Jul7;114(37):9859–63. Huerta-Sánchez E, Jin X, Asan, Bianba Z, Peter BM, Vinckenbosch N, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014;512(7513):194–7. Previous article Next article

Issue 2: Disorder 10 December 2021 A few words on (Dis)Order! Sophia, Maya, Patrick and Felicity A few words on (Dis)Order! Columns Top Stories Maxing the Vax: why some countries are losing the COVID vaccination race Grace Law This piece discusses key challenges faced by some countries in increasing their rates of getting the jab. Chatter Tactile communication: how touch conveys the things we can’t say Lily McCann Our daily dose of touch has decreased through months of lockdowns. But why is touch so important to us, and why do we feel the lack of it so severely? The Body, Et Cetera Hiccups Rachel Ko Evolution might be a theory, but if it’s evidence you’re after, there’s no need to look further than your own body. From the column that brought you a deep-dive into ear wiggling in Issue 1, here’s an exploration of why we hiccup! Humans of UniMelb Postdoc Possibilities Renee Papaluca Thinking about postgraduate research? This column has some advice for you, courtesy of a recent PhD graduate. Cinema to Reality Building the Lightsaber Manthila Ranatunga Some of the most iconic movie gadgets are the oldest ones. For this issue we look at how the lightsaber was brought to life. Features Making sense of the senses: The 2021 Nobel Prize in Physiology or Medicine Dominika Pasztetnik What do spicy food, menthol lozenges and walking around blindfolded have in common? They all activate protein receptors, newly discovered by 2021 Nobel Prize winners. Law and Order: Medically Supervised Injecting Centres Caitlin Kane Keeping people safe from the harms of drug use is an important public health goal, but some question the value of medically supervised injecting centres in improving health and community outcomes. Spirituality and Science Hamish Payne Common thinking is that science is a rigid, cold and largely academic field which sneers at the domain of spirituality. I posit that one must move beyond this point of view in order to do good science, and to find the true aims and values of the discipline. Hidden Worlds: a peek into the nanoscale using helium ion microscopy Erin Grant How do scientists zoom further in than the typical optical microscope? Through the helium ion microscope – revealing beauty that at scales too small to imagine! Man-Made Science: On the Origins of the Gender Gap Mia Horsfall Scientific practice remains doused in centuries of unreasoned discrimination against women. But what is the best way to unravel the complexities of such an intricate web of injustice, intellectual theft and suffering? What’s the forecast for smallholder farmers of Arabica coffee? Hannah Savage Changing weather patterns are threatening the livelihoods of smallholder Arabica coffee bean farmers in rural East Timor and Ethiopia. How will dramatically reduced global coffee yields touch Melbourne’s privileged cafe culture? Discovery, Blue Skies... and Partisan Bickering? Andrew Lim Journeying from Cambridge, Massachusetts to Melbourne, Australia, this feature ponders over deadlocked bills, economic mandates and the era of the scientist-politician, considering science in the age of politics. The Evolution of Science Communication Monica Blasioli With social media users in now having far more power over content posted online than before, how does this impact the information which others receive about the COVID-19 pandemic? How to use a time machine Sabine Elias Whilst time travel is thought to be nothing more than science fiction, the very laws of physics point to its possibility. From rockets to wormholes, physicists have long sought the answer to such a phenomenon. Mastering Chaos with Pen and Paper Xen Papailiadis Drawing upon physics and meteorology, the mathematical laws which govern our chaotic and complex universe have found special use in describing the rapidly changing global climate.

< Back to Issue 9 The Cosmos in Our Palms: A Reflection of Our Cosmic Origins by Mishen De Silva 28 October 2025 Illustrated by Heather Sutherland Edited by Nirali Bhagat The Stars and I As I lay down, head held up high, I open my eyes to the Stars and I. In silent dominion, sits the adorned sky, Scattered patterns and celestine fortresses, Locked behind veils of gas, dust and time. Where do I stand, between the Stars and I? Separated by infinities, Yet entranced by familiarity, Perhaps the Stars and I are not as different as I thought. Iron cladded blood, calcium forged bones, carbon cells, Myself, an echo to a stellar memory. What lies between the Stars and I? Long before breath touched my lungs, Fire forged my heart, And light filled my eyes, I was written in the same primordial script, Of matter and light. Seven more lines to which I exist, As a witness and whisper to our shared cosmic thread. A child of the sky, A memory, dreaming of itself, Who am I, but both the Stars and I. The universe first learned to know itself, I second, Where could it have all begun, between the Stars and I? Origins of Cosmic Matter To understand this profound connection between us and the cosmos, we must trace back 13.8 billion years to the birth of matter itself. The complex matter which encapsulates our very existence stems from one crucial cosmic event, the Big Bang (1). In this moment, hydrogen and helium were formed and became the building blocks to the universe. In the early stages of our universe forming, seas of hydrogen and helium gas were pulled by gravity to create stars, in an event known as gravitational collapse (2). These stars became the furnaces for existence. As spheres of fire, they fused atoms together to create more complex ones. This is known as stellar nucleosynthesis, where stars form heavier elements, such as carbon, calcium, nitrogen, oxygen and iron, through the nuclear fusion of hydrogen and helium (3). As time goes on, the core of a star collapses in on itself, creating a supernova. A supernova is an explosion of unimaginable heat, which is crucial in forming all the elements heavier than iron (1). In its lifetime, a star transmutes what was once darkness and barren, into a seed of complex matter. In death, they scatter the elements of their creation across the cosmos, planting them in vast fields of space, from which new stars ignite, planets take form, and life may slowly emerge (3). Through this, we can begin to appreciate our existence as something far greater than ourselves, where the iron in our blood, calcium in our bones and carbon in our cells were all created long before Earth even existed. Life on Earth As the clouds of gas and dust from countless stellar generations drift through the galaxy, they soon clump together to form planetesimals, in a process known as accretion (4). Planetesimals are small, icy and rocky cosmic bodies, which collide together to form planets (4). The planetesimals which collided and merged to form a young Earth made an environment rich with the ingredients to create life. Over eons, elements such as carbon, hydrogen, nitrogen, oxygen, and phosphorus have worked together to create the complex chemistries we see on Earth (5). The same elements, once inside stars, became crucial hallmarks for organic life: carbon forms the backbone of DNA and protein, nitrogen is essential for amino acids, oxygen supports respiration, and phosphorus forms our energy molecules, ATP (6). In this way, every organism before us, from microscopic bacteria, to the fleeting fruit fly, across the vastness of a whale, to the depth of a human soul, were all forged in the fire of the stars. As we detangle the web of our cosmic origins, we can begin to view our existence not only as entwined with every being around us, but also a direct continuation of the cosmos and its evolution. Figure 1. Elements found in stars which make up our body (7) The Cycle of Return It is important to recognise that this cosmic history does not end with us. Matter and energy are never lost, only transformed to take on new forms. An example of this is the carbon cycle, where carbon atoms are continuously moving and taking on new forms in the atmosphere, land and oceans (8). Through death and decay, in between birth and being, our physical selves become part of the soil, water and air, being reused by plants and other organisms to create new biological cycles (9). Similar to the impermanence of our existence, the Earth too will not last forever. Just like any star, our Sun will eventually exhaust the hydrogen in its core, swelling into a giant inferno consuming our world with it (10). However, this is not the end we think it is. Over eons, through supernovae and stellar collisions, the elements to our origins of life will be scattered across different depths of space, perhaps forming new stars, planets or even life elsewhere (11). Figure 2. The Carbon Cycle (12) In the present, each organism, cell and breath of life, exists as an homage to the universe’s constant transformation and reorganisation into new forms. With each howl of a dog, cry of a baby and rustle of a tree, we all exist under a profound and truly out of this world connection. A part of a much bigger cycle, the matter which formed the stars, which created the elements giving rise to life on Earth, will one day become something new again. And so, the more we examine this complex cycle, the more we can dissolve the distance between the “Stars and I”. We were never separate from the stars, and the cosmos is no longer just ‘out there’; it is something within us, around us, and inextricably mixed with who we fundamentally are. References Muhammad, T. Why We’re All Made of Star Dust. Science News Today [Internet]. 2025 May [cited 2025 Oct 8]. Available from: https://www.sciencenewstoday.org/why-were-all-made-of-star-dust Lineweaver, C.H., Egan, C.A. Life, gravity and the second law of thermodynamics. Physics of Life Reviews. 2008;5(4): 225–242. doi: 10.1016/j.plrev.2008.08.002 Fox, R. F. Origin of Life and Energy. Encyclopedia of Energy . 2004:781–792. doi: 10.1016/b0-12-176480-x/00054-1 Halliday, A. N., Canup, R. M. The accretion of planet Earth. Nature Reviews Earth & Environment . 2022;4:1–17. doi: 10.1038/s43017-022-00370-0 The origin of life: The conditions that sparked life on Earth. Research Outreach [Internet]. 2019 Dec [cited 2025 Oct 8]. Available from: https://researchoutreach.org/articles/origin-life-conditions-sparked-life-earth/ Remick, K. A., Helmann, J. D. The elements of life: A biocentric tour of the periodic table. Advances in Microbial Physiology. 2023;82:1–127. doi: 10.1016/bs.ampbs.2022.11.001 Lotzof, K. Are we really made of stardust? Natural History Museum [Internet]. [cited 2025 Oct 8]. Available from: https://www.nhm.ac.uk/discover/are-we-really-made-of-stardust.html Pulselli, F. M. Global Warming Potential and the Net Carbon Balance. Encyclopedia of Ecology. 2008:1741–1746. doi: /10.1016/b978-008045405-4.00112-9 Huang, T., Hu, Q., Shen, Y., Anglés, A., Fernández-Remolar, D. C. Biogeochemical Cycles. Encyclopedia of Biodiversity. 2024;6:393–407. doi: 10.1016/b978-0-12-822562-2.00347-9 Staff, A. What will happen to the planets when the Sun becomes a red giant? Astronomy Magazine [Internet]. 2020 Sep [cited 2025 Oct 8]. Available from: https://www.astronomy.com/observing/what-will-happen-to-the-planets-when-the-sun-becomes-a-red-giant/ Betz, E. How will life on Earth end? Astronomy Magazine [Internet]. 2023 Aug [cited 2025 Oct 8]. Available from: https://www.astronomy.com/science/how-will-life-on-earth-end/ Sultan, H., Li, Y., Ahmed, W., Shah, A., Faizan, M., Ahmad, A., Nie, L., Yixue, M., & Khan, M. N. (2024). Biochar and nano biochar: Enhancing salt resilience in plants and soil while mitigating greenhouse gas emissions: A comprehensive review. Journal of Environmental Management. 2024; 355 :120448–120448. doi: 10.1016/j.jenvman.2024.120448 Previous article Next article Entwined back to

By Gaurika Loomba < Back to Issue 3 Mighty Microscopic Warriors! By Gaurika Loomba 10 September 2022 Edited by Niesha Baker and Khoa-Anh Tran Illustrated by Rachel Ko Next It’s a fine Saturday afternoon. You’re sitting in your backyard sipping on coffee and losing your mind over the daily Wordle. While you’re so engrossed, an unusual, blue-colored creature pulls another chair and solves the Wordle for you. Just as you look up and try to process the condescending smirk of this creature, your daily news notification pops up. It's true! The whole world has been invaded by aliens! Thankfully this is a figment of our imagination, but would you believe me if I told you that alien invasions are constantly happening unnoticed in the microscopic world of our bodies? Every day, our cells face new ‘alien invasions’, thanks to unhygienic eating, or even just from breathing! In the external world, such an invasion would unsettle the entire human population and adversely impact the lives of everyone. It’s amazing how such invasions inside our bodies are usually defeated daily. So who are these tiny ‘soldiers’ that fight them off, silently and efficiently? It’s time to introduce the two brothers of our story– the innate immune cells system and the adaptive immune cells system, the former being the more enthusiastic and energetic one, while the latter is calmer and wiser. Although different in nature, the two systems coordinate efficiently to eliminate our enemies and help us go on about our lives. The innate immune system acts first when a pathogen (a disease-causing microorganism) manages to enter our bodies by getting around our physical barriers like the skin, and the mucus in the respiratory, gastric, urinary, and sexual tracts, etc. The innate immune system consists of cells like macrophages and dendritic cells (DCs), which are constantly looking out for incoming invaders. These cells recognise pathogens through common foreign attributes that our native cells don’t possess. In order to defend us from the harmful effects of the pathogen, our innate cells engulf them. In fact, the word ‘macrophages’ literally means ‘big eaters.’ Inside our cells, the pathogens’ end is inevitable, smashed and broken into pieces, which are mounted on our soldier cells’ surfaces, informing other soldier cells that an invasion has occurred. Exposing broken parts of the pathogen on our innate cells’ surfaces also produces chemicals called cytokines that help recruit more of our soldier cells to the site of invasion. So, when we get flu, the secreted cytokines is why we run a fever, cough, sneeze, and influx of our soldier cells to the throat area is why we may have swelling around there. Similarly, if we bruise, our blood vessels dilate to allow entry of our soldier cells to the wounded area, which is then manifested as redness and swelling around it. Fortunately, this means of communication of our soldier cells is much faster than our internet connection and so the whole process occurs in a matter of hours. On most days, the keen innate immune system is enough to control an invasion. However, it needs big brotherly advice from the adaptive immune system in case things get out of hand. The main players of this part of the immune system are the calm B- and T-cells. These can be found resting in the lymph nodes, unaware of the invasion in the body. The B- and T-cells are wise soldiers, which is evident in the way they respond to an invasion. Each of these cells has molecules called ‘receptors’, which uniquely recognise pathogen parts presented to them. These receptors, on an adaptive cell, can be thought of as padlocks and the broken pathogen parts, mounted on an innate cell, as a key. In the lymph nodes, each resting B- and T-cell has a different type of padlock, unique for a different key. It is the job of a DC, with a broken pathogen part mounted on its surface, to enter the lymph nodes and search for the most accurate match for its key, from the variety of B- and T-cell padlocks. The key varies based on the different types of pathogens that invade our bodies. Once the perfect match is found, that specific B- and T-cell is activated and rapidly multiplied. This lock-and-key method of activation of adaptive cells confers the specificity of their action. These activated cells move from the lymph nodes to the site of infection and perform different functions that halt the pathogen from spreading the disease, by either killing the pathogen or stopping its reproduction. At the site of infection, innate cells, with the key (broken pathogen part) mounted on their surface wait for the brotherly advice, the incoming adaptive cells with the perfect match to the key. The activated T-cells uniquely interact with macrophages and signal them to start killing the pathogens that they have engulfed. This helps with clearance of the pathogen. Although B-cells are part of the adaptive immune system, they can also recognise the foreign pathogen products, break them down, and present these parts on their surface, just like the innate immune cells. So now B-cells also have a key to the activated T-cell padlocks. Their lock-and-key interaction facilitates the B-cells to release antibodies. Finally, the antibodies, together with the macrophages and DCs, as well as the B- and T-cells of the adaptive immune system, successfully win the war and die peacefully, having completed their purpose. But a small portion of B- and T-cells go on and develop into long-lived memory cells. Over the span of our lives, we are infected and reinfected with pathogens all the time, however not every encounter results in us falling sick. The credit goes to the B- and T-memory cells and their ability to remember the foreign attributes of the pathogen and kill it as soon as it re-invades. Adaptive cells’ memory is the principle of vaccination. An inactive pathogen or a part of the pathogen is introduced into the body. This trains our soldier cells for a real pathogen invasion by triggering the B-cells to form memory and specialised antibodies against the pseudo-pathogen. If the real pathogen infects us again, these pre-formed antibodies make fighting the war much easier and quicker. Correct training of immune cells is essential since a pathogen invasion is a life-or-death situation for us. Any mistakes by our soldier cells can have devastating effects. For example, an important part of the training process is to ensure the immune cells aptly distinguish between civilian cells and foreign cells. This education occurs in the bone marrow. Here, any B- or T-cells that attack civilian cells or cell parts are evicted from the training process so only the most eligible soldier cells continue to become eligible soldiers. (1) But even after a rigorous selection process, things can go wrong with our immune system. Instead of being our defending heroes, they turn their back against us and start identifying civilian cells as aliens and attacking them. Sadly, this is the reality for 5% of the Australian population, with a majority being women. This condition, when the immune cells stop distinguishing internal cells from alien cells, is called an auto-immune disorder. The cause for this disorder is mostly unknown, with some speculations of it being genetic or environmental. The repercussions can be mild, such as causing dry mouth and dry eyes - symptoms for Sjogren’s syndrome, or more severe such as joint pain and immobilisation, known as Rheumatoid Arthritis. These diseases are currently life-long and incurable because they involve our own cells fighting the healthy cells in our body. (2) Nevertheless, the immune system plays a very important role in helping us lead normal lives. It fights the battle against the invaders daily, without us realizing it. Thanks to the soldiers of the immune system, our daily activities, like solving a Wordle on a relaxing Saturday, are not hindered by an alien cell invasion in our bodies! References Kenneth Murphy, Casey Weaver. Basic concepts in Immunology. Janeway’s Immunobiology. 9th ed. United States: Garland Science Taylor and Francis; 2017. p. 4-11 Overview of autoimmune diseases [Internet]. Healthdirect. Available from: Overview of autoimmune diseases | healthdirect Previous article Next article alien back to

< Back to Issue 5 Black Holes: Defying Reality and Challenging Perception Mahsa Nabizada 24 October 2023 Edited by Arwen Nguyen-Ngo Illustrated by Louise Cen Black Holes: Portals to the Unknown Black holes are among the most mysterious and fascinating objects in the vast universe. Often portrayed as portals to the unknown, they distort space and time such that it challenges our understanding of reality (The Editors of Encyclopedia Britannica, 2018). In this article, I want to take you on a journey through the mysteries of black holes, exploring some philosophical questions, debunking myths, and shedding light on their profound significance in the universe. What is a Black Hole? A black hole is a place in space where gravity exerts an extraordinarily powerful force, to the extent that not even light can escape it. This intense gravitational pull results from the compression of matter into an incredibly compact region (NASA, 2018). When a massive star reaches the end of its life and exhausts its internal thermonuclear fuels, its core becomes unstable, gravitationally collapsing inward upon itself. The star's outer layers are blown away, giving rise to the formation of a black hole. Other methods of black hole formation may exist, but are yet to be understood. As a star nears the end of its life, it enters this pivotal phase that results in the formation of a black hole. For this transformation to occur, the star must possess sufficient mass, a condition that even our own Sun does not meet. When the gravitational collapse of the star’s core begins, what is known as a singularity is created—a point where the conventional laws of physics cease to apply. This singularity is characterized by an immense density, a consequence of the continuous collapse that occurs within. Black holes are invisible to the human eye. In order to detect and study them, astronomers rely on space telescopes equipped with specialized tools capable of discerning the distinctive behaviors of stars in close proximity to these gravitational phenomena. These observations provide invaluable insights into the presence and nature of black holes in the universe. Philosophy Meets Relativism: Challenging Reality and Perception Black holes challenge our understanding of reality and perception, particularly through the lens of relativism. As objects approach a black hole, space and time are distorted, creating a gravitational lensing effect. This phenomenon, predicted by Einstein's theory of relativity, is akin to looking through a cosmic funhouse mirror, where the very fabric of the universe appears twisted and surreal. Imagine standing at the event horizon of a black hole, the point of no return. To escape its gravitational pull, you would need to travel faster than the speed of light - an impossibility according to our current understanding of physics. However, a black hole isn't a vacuum. Rather, it warps space around it so profoundly that even light is trapped. This raises profound questions about the limits of our knowledge and the nature of reality itself. The Cosmic Duets: Black Hole Pairs and Gravitational Waves Beyond philosophy, black holes engage in cosmic duets, forming pairs of black holes that orbit each other in the dark expanse of space. As they draw nearer, they merge, releasing powerful gravitational waves that ripple through the universe. This phenomenon, observed by instruments like the Laser Interferometer Gravitational-wave Observatory (LIGO), provides an unprecedented chance to directly observe and study cosmic events (LIGO Caltech, 2019). By recording the motion of these gravitational waves, scientists can deduce the size and characteristics of the merging black holes, providing insight into their properties. These observations also challenge our perceptions of the universe, as they remind us that even the most elusive cosmic entities are within the reach of human exploration. Types of Black Holes: From Stellar to Supermassive Black holes come in various types, each with its own characteristics. Stellar black holes, relatively small in size, originate from the remnants of massive stars and may number in the hundreds of millions within our Milky Way galaxy alone. On the other end of the spectrum, we find supermassive black holes situated at the center of galaxies, including our own Milky Way (Volonteri, 2012). These giant astronomical objects, with masses millions or billions of times that of our Sun, play a crucial role in the formation and evolution of galaxies. The Cosmic Life Cycle: Birth, Existence, and Beyond A black hole's existence is not static. It evolves through various phases, influenced by variables like mass, rotation, and charge. Schwarzschild black holes are static, while Kerr black holes rotate, adding complexity to their behaviour. These defining characteristics, alongside their mass and spin, contribute to the diverse array of black holes in the cosmos. Inside a black hole, the laws of physics reach their limits, and we encounter the mysterious concept of the singularity, where space and time cease to exist as we know them. What occurs beyond this point remains a mystery, a subject of ongoing scientific inquiry and philosophical speculation. The Inscrutable Massiveness: Philosophical Reflections As we ponder the immense mass and gravity of black holes, we confront our own limitations as observers of the cosmos. These objects challenge us to question whether true understanding is attainable, considering the profound mysteries they represent. They beckon us to consider the nature of our universe and our place within it, inspiring philosophical contemplation about the boundaries of knowledge. Recent scientific discoveries have unveiled alternative pathways to black hole formation, expanding our understanding beyond the conventional route of star collapse and revealing novel mechanisms. This encourages ongoing research and theory that redefines our perception of these cosmic entities, demonstrating that they may not solely be life-takers. Instead, they may potentially play a role as essential components in the intricate fabric of the universe. Black holes, distorting space and time, challenge our understanding of reality and serve as profound philosophical enigmas, pushing the boundaries of human knowledge and imagination. As we continue to unravel their mysteries, black holes stand as a testament to the boundless curiosity and spirit of exploration that define the human quest to understand the universe. References The Editors of Encyclopedia Britannica. (2018). Black hole | Definition, Formation, & Facts . Encyclopædia Britannica. [Internet]. Available from: https://www.britannica.com/science/black-hole LIGO Caltech. (2019). What are Gravitational Waves? [Internet]. LIGO Lab | Caltech. Available from: https://www.ligo.caltech.edu/page/what-are-gw NASA. (2018). Black Holes | Science Mission Directorate . [Internet]. Nasa.gov . Available from: https://science.nasa.gov/astrophysics/focus-areas/black-holes/ Volonteri, M. (2012). The Formation and Evolution of Massive Black Holes. Science, 337(6094), 544–547. https://doi.org/10.48550/arXiv.1208.1106 Wicked back to

< Back to Issue 8 Friend or Foe?: The Mechanisms Behind Facial Recognition by Mishen De Silva 3 June 2025 Edited by Luci Ackland Illustrated by Aisyah Mohammad Sulhanuddin Among the many mysteries which encompass the world around us, lies a complex interaction right under our nose, or perhaps… right above it. In the labyrinth of human consciousness, we rely on the seemingly arbitrary judgements made from the combination of two eyes, a nose, and a mouth, to discern who might be a friend or foe. Facial recognition gives a snapshot into the intricate dance between our perception and cognition, which allows us to cultivate a more detailed understanding of those around us, and their thoughts, feelings and emotions. In those fleeting moments when you recognise your parents in a sea of unfamiliar faces, spot your friends ensconced among the rows of the lecture theatre, or simply bump into an old friend in a crowd of unacquainted strangers, your brain is able to identify faces in a fraction of a second, a remarkable feat of the human cognitive capacity. But what enables us to distinguish one face from another? How do the faces of those we know stand out from the countless other noses, eyes and mouths we see? To understand what makes these interactions so meaningful, we need to take a closer look at the mechanisms behind facial recognition and decoding within the brain. The Brain’s Blueprint To be human is to seek meaning, even when none may exist. The mind has transformed what is two eyes above a nose, and a nose above a mouth, into its own pattern for classifying the identities and expressions we see around us. Many studies have suggested facial processing to be holistic, where the featural patterns of the eyes, nose and mouth are perceived together and upright (1,2). This mechanism of holistic facial processing explains the interesting phenomena behind pareidolia, where the brain adapts the characteristics of human faces onto everyday objects. It’s the reason why when glancing at a bowling ball it may appear surprised (3), or why some have sworn to see a face on Mars (4)! Figure 1. Bowling balls with surprised facial expressions! (3) In pursuit of meaning for the patterns around us, the brain has developed specialised regions for processing the features of a face to help us recognise individual identities. Facial processing operates through a hierarchical mechanism where distinct aspects of the face are interpreted by different regions of the brain. The unchanging elements of the face such as gender, age, ethnicity and features related to someone’s identity are analysed by the Inferior Occipital Gyrus and Fusiform Face Area (FFA), while the changing aspects such as eye gaze, lip movements and facial expressions are analysed by the Superior Temporal Sulcus and Orbitofrontal Cortex (5,6). Of these face-selective regions, the FFA is particularly important for facial recognition as it helps us recognise who a person is (5). Through the activation of our FFA simple patterns shift from meaningless shapes into familiar visages representing our friends, family, or even our own reflection. Studies have uncovered the importance of the FFA for facial recognition by examining what may happen when this brain region malfunctions (7,8). A unique example of this is prosopagnosia, which results from damage to the FFA in the right hemisphere of the brain (9). Prosopagnosia is a relatively rare condition affecting about 1 in 50 people, impairing their ability to recognise faces (9). Imagine if every face you observed looked the same or unfamiliar… even your own reflection! It is through the brain and its specialised regions for facial recognition where we can appreciate the essence of human connection as a result of our neural hardware. These mechanisms responsible for transforming patterns into faces are the reason we can recognise our neighbour from a stranger, friend from a classmate, or our parents from a teacher. Often overlooked amidst the fleeting and impermanent nature of our social interactions, this complex system guides us along the fragile line of human relationships, between familiarity and estrangement, a friend or foe. It highlights how deeply-rooted our connection and sense of identity is to the faces we see. The Brain’s Threat Detection With each neuron, synapse and pathway, our brains are machines wired for connection, not just in how we think, but also in how we perceive and interact with our surroundings. From the brief exchange of smiles with a stranger, to the furtive glare from someone across the room, one of the hallmarks of our emotional understanding is the ability to decode the thoughts and intentions of others, even from the most subtle of expressions. In the vast and intricate web of neural connectivity, it can be difficult to isolate a singular brain region or connection to explain complex cognitive functions. Brain imaging studies have found a strong bidirectional link between the FFA and amygdala, making this a likely candidate for explaining our remarkable decoding ability (10,11). As the FFA picks up on who a person is or what facial expression is being made, it is the amygdala which then evaluates the emotional salience, or importance, of this face. The amygdala then signals back to the FFA to either increase or decrease the facial processing activity accordingly (10,12). Consider how the visibility of teeth in a barred expression can signal anger, the whiteness of someone’s eyes can hint fear or surprise, and the shape of a person’s eyebrows can indicate the intensity of their emotion, all which guide the brain to prioritise and interpret socially and emotionally relevant cues – almost like a survival filter! (13,14,15). From an evolutionary perspective, the FFA-amygdala feedback loop serves as an important tool for rapidly and accurately interpreting the intentions of others, a pinnacle function in the architecture of our physical and social survival (16). The ability to recognise whether someone poses a friend or foe has been a survival mechanism and evolutionary advantage for millennia. The role of our facial processing network, from the amygdala and FFA, to other brain regions discussed, provides a microcosm into our nature as social beings, and our evolutionary selective changes, which have enhanced our ability to sense, respond to, and connect with those around us (17). In this way, maybe the most profound mysteries lie not in distant galaxies or ancient ruins, but are hidden in plain sight, within the faces we walk past every day. Our brain’s ability to read them is not merely a mechanism for decoding emotion, but a mirror into the nature of what it means to be human, where connection, trust, and survival have long been written in the expressions of those around us. References 1. Farah M, Wilson K, Drain M, Tanaka J. What is “special” about face perception?. Psychological Review [Internet]. 1998 Aug [cited 2025 May 14]; 105(3):482–98. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5561817/ 2. Richler J, Gauthier I. A meta-analysis and review of holistic face processing. Psychological Bulletin [Internet]. 2014 Sep [cited 2025 May 14]; 140(5): 1281–302. Available from: https://pubmed.ncbi.nlm.nih.gov/24956123/ 3. What do you think these bowling balls saw to leave them so surprised & shocked?. Reddit [Internet]. 2022 [cited 2025 May 31]. Available from: https://www.reddit.com/r/Pareidolia/comments/zc12jo/what_do_you_think_these_bowling_balls_saw_to/#lightbox 4. Gilbert L. Why the brain is programmed to see faces in everyday objects. UNSW Sites [Internet]. 2020 Aug [cited 2025 May 14]. Available from: https://www.unsw.edu.au/newsroom/news/2020/08/why-brain-programmed-see-faces-everyday-objects 5. Kanwisher N, Yovel G. The fusiform face area: a cortical region specialized for the perception of faces. Philosophical Transactions of the Royal Society: Biological Sciences [Internet]. 2006 Dec 29 [cited 2025 May 14]; 361(1476):2109–28. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857737/ 6. Zhen Z, Fang H, Liu J. The Hierarchical Brain Network for Face Recognition. Ptito M, editor. PLoS ONE [Internet]. 2013 Mar [cited 2025 May 14]; 8(3):e59886. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059886 7. Hadjikhani N, de Gelder B. Neural basis of prosopagnosia: An fMRI study. Human Brain Mapping [Internet]. 2002 [cited 2025 May 14]; 16(3):176–82. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.10043 8. Sorger B, Goebel R, Schiltz C, Rossion B. Understanding the functional neuroanatomy of acquired prosopagnosia. NeuroImage [Internet]. 2007 Apr [cited 2025 May 14] ;35(2):836–52. Available from: https://www.sciencedirect.com/science/article/pii/S1053811906009906 9. Prosopagnosia | Psychology Today Australia [Internet]. www.psychologytoday.com . [cited 2025 May 14]. Available from: https://www.psychologytoday.com/au/basics/prosopagnosia 10. Herrington J, Taylor J, Grupe D, Curby K, Schultz R. Bidirectional communication between amygdala and fusiform gyrus during facial recognition. NeuroImage [Internet]. 2011 Jun [cited 2025 May 14]; 56(4):2348–55. Available from: https://pubmed.ncbi.nlm.nih.gov/21497657/ 11. Said C, Dotsch R, Todorov A. The amygdala and FFA track both social and non-social face dimensions. Neuropsychologia [Internet]. 2010 Oct [cited 2025 May 14]; 48(12): 3596–605. Available from: https://pubmed.ncbi.nlm.nih.gov/20727365/ 12. Šimić G, Tkalčić M, Vukić V, Mulc D, Španić E, Šagud M, et al. Understanding Emotions: Origins and Roles of the Amygdala. Biomolecules [Internet]. 2021 May [cited 2025 May 14]; 11(6):823. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8228195/ 13. Jacobs R, Renken R, Aleman A, Cornelissen F. The amygdala, top-down effects, and selective attention to features. Neuroscience & Biobehavioral Reviews [Internet]. 2012 Oct [cited 2025 May 14]; 36(9):2069–84. Available from: https://pubmed.ncbi.nlm.nih.gov/22728112/ 14. Horstmann G, Lipp O, Becker S. Of toothy grins and angry snarls – Open mouth displays contribute to efficiency gains in search for emotional faces. Journal of Vision [Internet]. 2012 May [cited 2025 May 14]; 12(5):7–7. Available from: https://jov.arvojournals.org/article.aspx?articleid=2192034#:~:text=We%20suspected%20that%20visible%20teeth,(see%20also%20Figure%205).&text=Mean%20target%20present%20slopes%20(in,while%20angry%20faces%20do%20not.&text=Mean%20target%20present%20slopes%20(in,while%20angry%20faces%20do%20not . 15. Hasegawa H, Unuma H. Facial Features in Perceived Intensity of Schematic Facial Expressions. Perceptual and Motor Skills [Internet]. 2010 Feb [cited 2025 May 14]; 110(1):129–49. Available from: https://pubmed.ncbi.nlm.nih.gov/20391879/ 16. Schmidt K, Cohn J. Human facial expressions as adaptations: Evolutionary questions in facial expression research. American Journal of Physical Anthropology [Internet]. 2001 [cited 2025 May 14]; 116(S33):3–24. Available from: https://pubmed.ncbi.nlm.nih.gov/11786989/ 17. Carter E, Pelphrey K. Friend or foe? Brain systems involved in the perception of dynamic signals of menacing and friendly social approaches. Social Neuroscience [Internet]. 2008 Jun [cited 2025 May 14]; 3(2):151–63. Available from: https://pubmed.ncbi.nlm.nih.gov/18633856/ Previous article Next article Enigma back to

< Back to Issue 4 The Mirage of Camouflage by Krisha Ajay Darji 1 July 2023 Edited by Megane Boucherat and Tanya Kovacevic Illustrated by Aisyah Mohammad Sulhanuddin Imagine driving on a highway and the road is shimmered by the scorching midday sun. Whilst you drive further on a day like this, you might envision a wet patch gleaming on the road. Does it make you wonder how a mirage passes by playing with your vision? While there is physics involved in this phenomenon, evolution through natural selection has rendered some of its own biological members the ability to play with visual perceptions in subtle but enchanting ways! What comes to your mind when you hear the word camouflage? Some might visualize a chameleon blending in almost any background possible. Others might envision a soldier wearing camouflage pants and shirts to match the earthy tones for their defence. Colourful frogs, butterflies, snakes and so on might cross your mind as you think deeper about this phenomenon. Nature is filled with some of the most fascinating examples of camouflage. Camouflage as a Prehistoric Phenomenon The coloration patterns found on the Sinosauropteryx, a tiny, feathered, carnivorous dinosaur that lived in what is now China during the Early Cretaceous period was studied by a group of scientists. They discovered evidence of coloration patterns corresponding to modern animal camouflage by tracing the distribution of the dark pigmented feathers over the body. This included stripes running around its eyes and across the tail, and countershading with a dark back and pale bottom. By contrasting and comparing the mask and striped tail with the colours of contemporary animals, we can learn more about the evolution of camouflage as a means of natural selection [1]. The presence of stripes on only tails rather than the whole body of certain animals is not well understood, but they are suspected to function as a type of disruptive camouflage. Disruptive camouflage means visually separating the outline of a portion of the body from the others and to make it less noticeable. It could also serve as a type of deception by attracting predators' attention to the tail and away from the more vital parts - the body and head. Birds are found to be the most evident illustration of this as they descend from the theropod dinosaur [1]. Early tyrannosauroids, the ancestors of the ferocious T-rex, coexisted with Sinosauropteryx and may have even hunted the little dinosaur. Sinosauropteryx hunted tiny lizards, as was demonstrated by direct evidence in the shape of a whole animal preserved in the stomach of one of the specimens found. Hence, it is clear that camouflage patterns were developing at that time; since vision was critically important to these dinosaurs while they were hunting and being hunted. This example demonstrates camouflage as a prehistoric phenomenon and its evolution in the animal kingdom. Camouflage in Modern Day Animals Animals use camouflage primarily for defence. Blending in with their background prevents them from being seen easily by predators. The use of warning coloration, mimicry, countershading, background matching and disruptive coloration are mechanisms through which animals employ camouflage. Sneaky Snakes! The harmless scarlet king snake has stripes that resemble those of the deadly coral snake, but it is not poisonous. The only significant distinction between the two is the arrangement of the colours in their patterns. While the pattern for coral snakes is red-yellow-black, for scarlet king snakes it is red-black-yellow [2]. The difference is simple for anyone to remember thanks to a rhyme! Red on yellow kills a fellow, Red on black won’t hurt Jack! This is a classic example of mimicry: a form of camouflage in which one organism imitates the appearance of another to avoid predators. The Walking Leaf! The leaf insect or the waking leaf belongs to the family Phylliidae and is quite like its name. The walking leaf's body has patterns on its outer edges that look like the bite marks that caterpillars leave behind in leaves. To resemble a leaf swinging more accurately in the breeze, the insect even sways while walking! This is an example of a type of camouflage known as background matching- one of the most prevalent forms of camouflage. It is a mechanism through which a particular organism hides itself by resembling its surroundings in terms of its hues, shapes, or movement [2]. Mottled Moth! It is challenging for predators to determine the form and direction of the tiger moth as it is mottled with intricate patterns of black, white, and orange on its wings. This is an example of disruptive camouflage: when an animal has a patterned coloration, such as spots or stripes, it can be difficult to detect the animal's contour [2]. Lurking Leopards! Black rosettes on a light tan backdrop serve as the hallmarks of the leopard’s well known coat patterns. Their coats also include a subtle countershading to help them amalgamate with their environment and evade detection by prey. A leopard's body has a significantly lighter underside than the rest of its coat, which consists mostly of its belly and the bottom of its legs. This produces a shading effect that helps conceal the leopard's body form and contour, making it more challenging to see in low light or when seen from below. This is a typical example of countershading, which is a type of camouflage wherein the animal’s body is darker in colour, but its underside is lighter. It works by manipulating the interactions between light and shadows; thus, making the animal difficult to detect [2]. But what allows these animals to change their colours? Animals can camouflage themselves through two primary mechanisms: Pigments - biochromes Physical structures - prisms While some species have natural and microscopic pigments known as biochromes, others possess physical structures like prisms for camouflage. Biochromes can reflect some wavelengths of light while absorbing others. Species with biochromes can actually seem to alter their colour. Prisms can reflect and scatter light to give rise to a colour that is different from the animal’s skin [2]. Camouflage is not quite restricted to the sense of vision. There are several other ways evolution has taught the living world to adapt and protect themselves in the wild. There is a whole exciting world of behavioural and olfactory camouflage employed by diverse species in the animal kingdom. Ultimately, the compelling association of camouflage with the phenomenon of mirage conveys to us how nature always evolves and expands to secure the continued existence of its inhabitants. From the glistening heat of mirages on arid vistas to the delicate patterns on the wings of a butterfly, this fascinating juxtaposition of mirage and camouflage delivers a peek into the incredible mechanisms that animals deploy to traverse their natural habitats and survive amidst the obstacles they encounter. References Smithwick F. We discovered this dinosaur had stripes – and that tells us a lot about how it lived [Internet]. 2017 [cited 2023 May 12]. Available from: https://theconversation.com/we-discovered-this-dinosaur-had-stripes-and-that-tells-us-a-lot-about-how-it-lived-86170 National Geographic. Camouflage [Internet]. [cited 2023 May 12]. Available from: https://education.nationalgeographic.org/resource/camouflage/ Previous article Next article back to MIRAGE

< Back to Issue 9 Eyeballs, a Knife, and No Fear of God by Jess Walton 28 October 2025 Illustrated by Anabelle Dewi Saraswati Edited by Chavindi Sinhara Mudalige Humans have wanted to understand our bodies the entire time we’ve had them, which is to say, the entire time. Late Classical Athens, around 300 BC, at a peak of intellectual prosperity: Herophilos cuts into a corpse. From this, he’s going to make the novel argument that the brain contains knowledge, and in doing so, he’s going to criticize Aristotle’s writing, which describes the brain as something akin to an air conditioner. Aristotle thought the brain was a cooling chamber, essentially, to prevent the heart from overheating, and that cognition happened in the heart. Much, much earlier, around 1000 BC in India, Sushruta, in his foundational surgical text, overestimated the bone count in humans by over 100. Many ancient societies had impressively detailed understanding of anatomy, considering they had no microscopes, no cameras, no X-rays; usually nothing more than their knives and eyeballs. It’s important to note as well that this article is a brief overview of a complex subject, with a major focus on Classical, meaning Ancient Greek and Roman, examples, and is in no way a complete story of early anatomical developments across the globe. Asia, Africa, the Americas and the Arab world each had their own rich and complex traditions, beyond the few examples cherry-picked here. Most societies had a few impressive hits and a few impressive misses; in a way, their approach to science isn’t all that different from ours today. What can we learn from them, and what can we learn about ourselves? In Ancient Athens, Aristotle believed the heart to be both the intellectual and emotional center of humans; the “seat of the soul” (1). Some remnants of this remain in our modern association between heart and emotion, though we know now it isn’t backed by science. His reasoning behind this was the convergence of blood vessels at the heart and its importance; from this, he also, perhaps reasonably, thought it to be the source of blood (2). Despite being deservedly considered a major anatomist, Aristotle likely made his observations from examining and dissecting the bodies of animals, particularly lower mammals, like dogs or livestock, instead of real humans (3). He unknowingly used homologous structures, long before evolution or even Charles Darwin himself was conceptualized, to essentially assume the anatomy of humans from other animals. Given this, his conclusions on the brain become a little more understandable. The brain is a strange-looking organ, critically important to life, though not obviously connected to the pulse or rich with blood; how were they to understand the structure of nerves and white matter? That it assists the heart in some way becomes a logical conclusion. So why not serve a cooling function? Blood is hot, so the heart must get hot. Overheating is usually bad; see fire. And the brain’s size makes it ideal for such a thing. The thing about anatomy and science, Aristotle’s assertion being one primordial example of many around the ancient world, is that it changes. Herophilos and Erasistratus were two more Greek anatomists who succeeded and often contested Aristotle. Unlike him, they dissected humans, having no qualms about a man’s dead—or, according to some sources, still alive—body (4). However, they offered several accurate, or at least more accurate, insights inside human bodies. Herophilus argued that the brain wasn’t a cooling chamber but contained knowledge (5). While he was at it, he argued that the heart has four chambers, unlike Aristotle, who claimed it only has three (5). Many of Herophilos and Erasistratus’ insights required Aristotle’s, or some other prior Mediterranean scholar’s, claims to give them something to criticise. Praxagoras was one such anatomist, from about 400 BC, about 100 years earlier. He correctly associated the pulse with natural movement within the body, but also asserted that arteries carry air (6). There is, possibly because of this claim, debate as to whether he had any practical anatomical experience or observed any dissections. If so, it’s quite impressive to miss the blood in arteries. He did, however, note that veins carry blood (2). Thus, he was later included in Herophilos’ critique. Before we criticise how long it took for them to realise seemingly obvious facts, we must remember that bloodletting as an acceptable treatment persisted into the 19 th Century. Modern and recent understandings are far from flawless. A couple of hundred years later, Galen, a Roman from the late 2 nd Century AD, would voice similar critiques (2). Galen would later become famous for his theory of the four humors: blood, yellow bile, black bile, and phlegm, each with associated personalities and elements (7). While these are all real liquids found somewhere in the human body, they do not really work as the four-way counterbalance he describes. Galen made some incredible leaps forward in Roman anatomy, including developing more elaborate tools for dissection and surgery processes, which would be instrumental in allowing future developments in the field. However, he also learned more anatomy from treating severe gladiator injuries—which is awesome—or like Aristotle, from dissections and studies on lower mammals (7). This led to some interesting conclusions; his description and diagrams of a human uterus match that of a dog’s uterus exactly, for example (7). He did well with the tools he had, but guesswork has its limits. Three hundred years before Aristotle, and over seven centuries before Galen, the ancient Indian physician Sushruta, a continent away, was revolutionizing, and if there was nothing to revolutionise, inventing surgeries and surgical techniques. He also valued an understanding of human anatomy, which likely contributed to his surgical skill, and dedicated a portion of his seminal Sanskrit work, Sushruta Samhita , to anatomy, calling it the Sharira Sthana . In his work, he describes in detail the head, which he correctly identified as the major center of essentially all function, particularly the cranial nerves (8). He also includes the first detailed guide to human dissection, alongside the anatomy of the embryo at various developmental stages; this is described as arising from seven skins, each with their own associated ailments, and while the skins are anomalous, many of the ailments correlate impressively with known diseases (8). There’s also, incredibly, a detailed description of cataract surgery procedure, where exceptionally specific incision locations in the cornea are interspersed with instructions to sedate the patient with wine mixed with cannabis, which makes sense in a world far predating modern anesthesia, then to spray the eye with breast milk (9). This part seems outlandish and harder to explain, but anyone who has studied immunology can tell you that breast milk contains antibodies and antibacterial proteins. Sushruta likely made some link between breast milk and reduced post-op infections, even if there were not yet microscopes to see bacteria with. Even if they couldn’t see why on the molecular scale, ancient anatomists were able to understand what worked and what didn’t and justify it to the best of their knowledge. When Sushruta describes the bones of the human body, he does so in great detail, and also counts more than 300 of them. Humans typically have 206 bones, give or take a rib: Sushruta mildly overestimated. This is thought to be from him, largely basing his skeletal insights off child cadavers, before many bones have fused together (9). Hindu religious law calls for the cremation of any body over two years old, in its natural and thus undissected state; though there are accounts of Sushruta performing dissections, presumably on adults, the bodies he likely had the most exposure to were infants. Sushruta was working within the confines of the society and world that he lived in, as was Herophilos. Medical insights which seem obvious to us today, like that the brain is for thinking and the heart is for beating blood, and that blood goes through the arteries and is most definitely a liquid, rely upon prior knowledge reached with tools that hadn’t even been invented yet. These firsts—surgeons, anatomists, scientists—would probably have to be physically pried away from microscopes and X-rays, if ever introduced to them. They often didn’t even have a human body to dissect, yet drew human anatomical conclusions regardless. And it’s easy to marvel at their mistakes, but it’s even easier to marvel at how much they got right; Herophilos correctly uncovered nerves and linked them to sensation and response, which is impressive in itself. Could you find a nerve in some meat, with just your naked eye? He also linked the heart and the pulse. The Huangdi Neijing , for example, is a Chinese medical text said, though disputed, to be from 2600 BC, which describes the relationships between organs in military terms: the heart as a king, the liver as a commandant, and the gallbladder as an attorney-general responsible for coordination (10). However, both like and before Herophilos, it also correctly identifies the cyclic nature of blood flow and links it to the heart (10). The Edwin Smith Papyrus, dating from 1700 BC in Ancient Egypt, is the oldest known surgical text, describing 48 different injuries with treatments; all shockingly accurate (11). Sushruta may have miscounted the bones, but he described their shapes accurately and suggested legitimate therapies for particular bone breakages and dislocations. Nowadays, little has changed: in just the 1950s, lobotomies became the standard cure for a headache; even long after we developed microscopes, we were recommending treatments, like scrambling our brains, that only 70 years later seem ridiculously stupid. We’re far from done charting our own bodies, either. In 2018, an entirely new type of tissue all throughout the body was found: the interstitium, which is critical in cell and organ communication across the body (12). It’s been there the whole time, but no one had noticed before. Humans are humans; it is only natural to want to understand ourselves, and as a part of that, our bodies. We now study our ancestors as they studied themselves; the same mix of awe, confusion and confidence. Their methods and conclusions may be fallible, but their curiosity was not, and as long as we remain, never will be, dead. These examples were only a fraction of those whose work has been preserved, who themselves were only a fraction of the ancient people across the globe who investigated human anatomy. A millennium from now, our descendants will laugh at our misconceptions, when they have mapped every neuron in the human brain with instruments we could not conceive of. But without us, they wouldn’t know what they know, and without our original anatomists, we wouldn’t know what we know. Our modern granular understanding of our own structure is built on the bodies we looked in before ours. So, we should perhaps extend some empathy to our predecessors. They had only eyeballs, a knife, and our own curiosity. Different tools, same bodies. References Aird WC. Discovery of the cardiovascular system: from Galen to William Harvey. J Thromb Haemost. 2011;9(Suppl 1):118–29. Johnston IH, Papavramidou N. Galen on the Pulses: Medico-historical Analysis, Textual Tradition, Translation [Internet]. De Gruyter; 2023 [cited 2025 Oct 10]. Available from: https://www.degruyterbrill.com/document/doi/10.1515/9783110612677/html Crivellato E, Ribatti D. A portrait of Aristotle as an anatomist. Clin Anat. 2007;20(5):447–85. Papa V, Varotto E, Vaccarezza M, Ballestriero R, Tafuri D, Galassi FM. The teaching of anatomy throughout the centuries: from Herophilus to plastination and beyond. Med Hist. 2019;3(2):69–77. Bay NSY, Bay BH. Greek anatomist Herophilus: the father of anatomy. Anat Cell Biol. 2010;43(4):280–3. Wright J. Review of: Praxagoras of Cos on Arteries, Pulse and Pneuma. Studies in Ancient Medicine, 48 . Bryn Mawr Class Rev [Internet]. [cited 2025 Oct 10]. Available from: https://bmcr.brynmawr.edu/2017/2017.07.34/ Ajita R. Galen and his contribution to anatomy: a review. J Evid Based Med Healthc. 2015;4(26):4509–16. Bhattacharya S. Sushruta—the very first anatomist of the world. Indian J Surg. 2022;84(5):901–4. Loukas M, Lanteri A, Ferrauiola J, Tubbs RS, Maharaja G, Shoja MM, et al. Anatomy in ancient India: a focus on the Sushruta Samhita . J Anat. 2010;217(6):646–50. O’Boyle C. TVN Persaud, Early history of human anatomy: from antiquity to the beginning of the modern era. Med Hist. 1987;31(4):478–9. van Middendorp JJ, Sanchez GM, Burridge AL. The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries. Eur Spine J. 2010 Nov;19(11):1815–23. Benias PC, Wells RG, Sackey-Aboagye B, Klavan H, Reidy J, Buonocore D, et al. Structure and distribution of an unrecognized interstitium in human tissues. Sci Rep. 2018;8(1):4947. Previous article Next article Entwined back to

About Us OmniSci Magazine is a science magazine at the University of Melbourne, run entirely by students, for students. Our team consists of talented feature writers, columnists, editors, graphics designers, social media and web development officers, all passionate about communicating science! Past Contributor Interviews Editors-in-Chief Ingrid Sefton President Aisyah M. Sulhanuddin President Current Committee Lauren Zhang Secretary Andrew Shin General Committee Ethan Bisogni Treasurer Luci Ackland General Committee Kara Miwa-Dale Events and Socials Hendrick Lin General Committee Elijah McEvoy Events and Socials Past Editors-in-Chief Rachel Ko 2022-2024 Sophia Lin 2021-2022 Patrick Grave 2021-2023 Maya Salinger 2021-2022 Caitlin Kane 2022-2023 Felicity Hu 2021-2022 Yvette Marris 2022-2023