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Thinking of joining the OmniSci committee? We spoke to Aisyah, who incorporates her love for design into illustrations, events and social media at OmniSci, and shares her advice for those interested in getting involved (just do it!). Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator. Meet OmniSci Designer & Committee Member Aisyah Mohammad Sulhanuddin Aisyah is a designer and Events Officer at OmniSci in her final year of a Bachelor of Science in geography. For Issue 4: Mirage, she is contributing to social media and as an illustrator interviewed by Caitlin Kane What are you studying? I am studying the Bachelor of Science in geography, now in my final year. Do you have any advice for younger students? It’s alright to not know what you’re doing. But on the flipside, if you do feel you know what you’re doing, be very aware that could change in the next few years. Always be open to new options. What first got you interested in science? When I was a kid, my parents encouraged me to ask questions about the world. I also had my own little book of inventions… if there was a problem somewhere, even if it was with the most outlandish invention, I would seek a way to solve that problem. That idea of being able to figure out how the world works is very fascinating to me. How did you get involved with OmniSci? During lockdown, I saw on the bulletin an expression of interest for a new magazine. I’d just entered uni, wanted to try everything and thought why not, it seems like such a great opportunity. And it is! What is your role at OmniSci? I’ve done a lot of graphic design and I’m going to return for this issue in that role. I’ve basically collaborated with writers to make art that looks good, goes with my style and can convey what they want to say in their article. I’m also in the committee for OmniSci, and have been since last year. Within that, I’ve put multiple hats on: I’ve enjoyed organising multiple events for the club, and helping out with social media. Social events have had a great turnout this year, which is awesome. A new year is always a new opportunity for more people to learn about the magazine. What is your favourite thing about contributing at OmniSci so far? I’ve really enjoyed the graphics side of things. I love creating and it’s really awesome to be able to put art to something text-based. It’s interpretation… You’re bound by what the article says and what the science says, but there is freedom within to express something. I definitely enjoy being able to put my creativity into promotion [as a committee member]. Doing it in a way that’s aesthetically pleasing—it matters to me when things look nice! Do you have any advice for people thinking of getting involved, especially more on the committee side? Yes—do it! Come and join… If you’re interested, feel free to come along because no role should be too daunting for you, and there is always opportunity to make the role fit how you want, it’s quite flexible. Can you give us a sneak peak of what you're working on this issue? If there’s a lot to come, maybe you can just tell us where you’re up to in the process. I’ll be working on the design and looking forward to collaborating with the writer as to how to convey their article properly. In the future, I’m looking forward to being able to create more content for OmniSci—really looking forward to that. What do you like doing in your spare time (when you're not contributing at OmniSci)? A range of things—I like to read, edit photos, do graphic design of random illustrations. I also crochet, do a bit of arts and crafts on the side, and take a whole lot of photos. Which chemical element would you name your firstborn child (or pet) after? Wait, let me pull up the periodic table! Let’s see… Neon. Feels like a great name for a child or an animal. Like calling your kid Jaz or Jet. It’s very snazzy! Do you have anything else you’d like to share with the OmniSci community? Stay looking on our Facebook page! Keep in touch and always keep on communicating, consuming and learning more about science, because that’s how the world progresses honestly. See Aisyah's designs Should We Protect Our Genetic Information? The Rise of The Planet of AI Maxing the Vax: why some countries are losing the COVID vaccination race What’s the forecast for smallholder farmers of Arabica coffee? The Ethics of Space Travel Space exploration in Antarctica The Mirage of Camouflage FINAL Big Bang to Black Holes: Illusionary Nature of Time

< Back to Issue 2 Hidden Worlds: a peek into the nanoscale using helium ion microscopy How do scientists know what happens at scales smaller than you can see using an optical microscope? One exciting method is the helium ion microscope which can be used to view cells, crystals and specially engineered materials with extreme detail, revealing the beauty that exists at scales too small to imagine! by Erin Grant 10 December 2021 Edited by Jessica Nguy and Hamish Payne Illustrated by Erin Grant The room is white, with three smooth walls and a fourth containing a small sample prep bench and high shelves. In the centre is a desk with three monitors. Next to it, occupying most of the space, is the microscope. Eight feet tall, a few feet wide, resting on an isolated floor surrounded by caution tape; “NO STEP” written in big block letters. Wires protrude from its tiered shape in orderly chaos. It is a clean, technological space; we are ready to explore science. A colleague and I are at the Materials Characterisation and Fabrication Platform of the University of Melbourne to finish off the last steps of a scientific paper I’ve been working on for many years. What I need, as the icing on the cake, is an image. What does my sample look like way down there, at the nanometre scale? Objects that are only nanometres in size are very hard to imagine when we’re used to thinking about metres, centimetres, or maybe even millimetres. We can see those length scales; they are part of our everyday. So, if you’re told that proteins have a diameter of a few nanometres, what does that mean? Well, to be precise, a nanometre is one-billionth of a metre. A human hair, the go-to yardstick for describing small things, has a width between 0.05-0.1 millimetres, which means that if you wanted to slice a hair into nanometre-wide strands you’d end up with nearly 100,000 pieces. Unfortunately, that’s still hard to visualise, but I’ve found that when working with and thinking about scales like this every day, you gain a sort of mental landscape that small things occupy, perhaps not entirely in context, but a space that contains an overall ‘vibe’ of smallness. I first noticed this when I worked in a laboratory that studies the tiny nematode worm C. elegans. These creatures are half a millimetre long, so although they are clearly visible to the naked eye, you need a microscope if you want to use them for science. After looking at these tiny creatures under magnification for many weeks, I came to recognise a feeling almost like being underwater. Upon putting my eyes to the lens, my focus would change from the macroscopic world around me, to one of minutiae. This change in perspective was quite immersive, I almost felt like I was inhabiting that small petri dish too. Working with samples even smaller than that now, I have carried some of that mental landscape with me. It now feels commonplace to imagine tiny systems, such as crystals or molecules which were once foreign. Much of this ability to visualise small things comes from the fact that in many cases, we can actually see them too. Physics has given us many tools with which we can peer into the smallest systems that exist. Helium ion microscopy, which I have come here to carry out, is one such technique. Dr Anders Barlow runs the helium ion microscope (HIM) at this facility. He warmly welcomes me and my colleague into the quiet room and jumps straight into an enthusiastic explanation of the machine – he can tell we’re not just here for some pictures, we want to know the inner workings of the microscope too. The HIM is a bit like the more mature surveyor of minuscule worlds: the electron microscope. While a regular optical microscope uses light to illuminate a sample, the electron microscope uses electrons. When they collide with the sample these electrons can bounce off or lose energy through several mechanisms. The lost energy can go into heat or light, but more usefully, the energy might be transferred to other electrons in the sample, called secondary electrons, ejecting them like a drill removing rocks from a quarry. The secondary electrons can be detected at each point across the sample as the beam is scanned over its surface. If more electrons are detected, then the pixel at that point is brighter compared to areas where there are fewer electrons. This tells you about the topography or composition of the sample at that point on its surface and provides a grayscale image. The HIM works in the same way, but it can generate sharper images because helium ions are heavier than electrons. This is important because the increased resolution of electron and helium ion microscopes is enabled by their quantum mechanical properties - namely the particle’s wavelength. You may have heard about the wave-like nature of light, which is a basic property of quantum mechanics. Particles also have a wavelength, called the de Broglie wavelength, which is inversely proportional to their mass - the heavier the particle, the shorter the wavelength. Having a shorter wavelength allows smaller details to be resolved because of a pesky phenomenon called diffraction. Diffraction occurs when a wave encounters a gap that is of the same or smaller width to its wavelength. When this happens, the wave that emerges on the other side will be spread out. You can think of the features that you want to image as being similar to gaps, so when light, or a particle, interacts with features that are very close together it will spread out, making those features blurry or even invisible. But if you can ensure that the wavelength is smaller than whatever feature you want to see, diffraction will not occur. Interestingly, physicists can actually take advantage of diffraction, and another phenomenon called interference, when they study periodic structures like crystals, but that’s a different article! So, because the de Broglie wavelength is very short for particles with mass, like electrons, an electron microscope can generate images of higher resolution than an optical microscope. Likewise, helium ions are even heavier than electrons because they are composed of one electron, two protons, and two neutrons. This makes them about 7,000 times heavier than a single electron (electrons are very light compared to protons and neutrons!) and consequently the images they can make are very sharp. With our samples ready, lab manager Anders loads my sample into the microscope and begins lowering the pressure in its internal chamber. Having a high vacuum – approximately a billion times lower than atmospheric pressure – is essential because it prevents air from interfering with the helium beam. Making the beam is perhaps the most miraculous part of this technological feat. At the very top of the microscope’s column, there’s a tiny filament shaped like a needle. Not like a needle, in fact, it is the sharpest needle we humans can make. To achieve this, the point is shaped by first extreme heat, and then some extreme voltages until the very tip is composed of only three atoms, reverently referred to as the trimer. Once the trimer has been formed, a high voltage is applied to the needle, resulting in an extreme electric field around the tip. Next, helium gas is introduced into the chamber and individual helium atoms are attracted towards the region of the high electric field. The field is so strong that it strips each helium atom of one electron, ionising it, and these now positively charged ions are repelled from each of the three atoms in the trimer as three corresponding beams. Using sophisticated focusing fields down the length of the column allows Anders to choose only one of the beams for imaging; we are creating a picture using a beam only one atom wide! Generating such a precise beam requires constant maintenance, but once Anders is satisfied with how it looks today, he begins scanning over a large area for what we’ve come to find: tiny proteins stuck to a diamond. In an experimental PhD, you often find yourself answering small incremental questions and today I want to know how well I’ve attached these proteins to my diamond and what the coverage looks like. Other measures have told me that I probably have a lot of them, but the best way to know is to have a look! That’s what Anders does for researchers at the university; he helps us find out whether we have done a good job putting things together or coming up with new techniques. This is something he loves about his job. “I love the exposure I get to many areas of science,” he says, “Imaging of all forms is ubiquitous in research, and the HIM is applicable to most fields, so we see samples from materials science, polymers, nanomaterials, and biomaterials, through to medical technologies and devices, to cell and tissue biology of human, plant and animal origin. I never get tired of seeing what new specimens may come through the lab door.” Unfortunately, the first images we see are very dark and washed out, like a photograph taken in low-light; not many secondary electrons are making it to the detector. To combat this, Anders uses a flood gun to stop charge build up on the surface of the diamond. When the helium ions create secondary electrons, they are ejected from the surface at low speeds. As electrons are negatively charged, the bombarded surface, which now lacks electrons, will become positive and the low energy secondary electrons will be attracted back to the surface instead of making it to the detector. In an electron microscope this is avoided by coating insulators, such as my diamond, with a conductive material like gold. If the surface is conductive, the positive charge that is left behind by the secondary electrons will be offset by electrons from the metallic coating that can flow towards the sudden appearance of positive charges. In this case, the ejected electrons can escape and be detected. However, a coating like this would reduce the resolution of the image; if you want to measure proteins that are twelve nanometres high, but you put a three-nanometre coating over them, you’ll lose a lot of the resolution! To get around this, the HIM uses the flood gun, which lightly sprays the surface with electrons of low energy as the helium beam passes over. This neutralises the surface and lets the secondary electrons escape in the same way as having a conductive layer. Once Anders turns on the flood gun, the contrast increases, allowing us to zoom in on a small region of the diamond, and there they are! Thousands of spherical proteins arranged neatly across the surface, only twelve nanometres in diameter. The sight is spectacular, only one try and we got what we came for. I am three years into a PhD and I’ve become very used to the feeling of disappointment that can accompany new experimental techniques. Things rarely work out the first time around, so to see those little spheres straight away was magical. Dotted across the diamond surface is another, extra, gem. To keep protein nice and happy, you must prepare it in a salty solution. So, when the protein was deposited, some regular table salt, NaCl, came too. We can see this salt in our images as crystals in two distinctive and very beautiful patterns which you can see in the images below. Protein on the surface of my diamond. Each small pale circle is one of these spherical proteins. The first image shows a large creeping pattern, reminiscent of snowflakes or tree roots, which spreads its soft fingers across several hundred nanometres. These crystals have taken on an amorphous pattern, where the crystal structure is broken up rather than being one continuous arrangement of the atoms. The second pattern however, shown in the right image, is what a continuous NaCl crystal looks like. When large enough crystals can form without becoming amorphous they look like precise cubes of various sizes all strewn about. One of my favourite aspects about looking at very small things, is how the patterns you see often mirror those at much larger scales. Look at a fingerprint and you’ll find mountains and valleys, or the roots of a tree and you’ll see a river system. Salt (NaCl) can take on a highly ordered structure shown by the cubic crystals (left) or an amorphous pattern similar in shape to tree roots (right). The astonishing images we get from this single session are all in a day’s work for Anders. He has imaged numerous kinds of cells on all manner of interesting substrates, patterned surfaces covered in needle-like protrusions, and many kinds of man-made materials. Today, there are vials on his prep-bench which, at first glance, look much like jars of hair. However, they are not hair, in fact they are strands of carbon fibre covered in various coatings, awaiting examination. ‘What are your favourite types of samples to look at?’ I want to know. “Cell biology is fascinating,” he says. “We’ve imaged red blood cells, pancreatic cells, stem cells, and various bacterial cells in this microscope. Most often researchers are interested in cell life and death, and the HIM assists by providing high resolution images of the structure and surface topography of the cell membrane.” Recently however, Anders has been helping researchers look at polymer materials for water filtration. “These are hierarchical porous structures, meaning they’re engineered to have pore sizes that vary through the membrane. It is stunning to see the materials at low magnification with large pores, and as we zoom in and in and in, to see new pore sizes become visible at each level, like a material engineered with a fractal quality.” One of the unique things about the HIM, Anders reminds me, is that it’s not just for imaging. Since helium ions are heavy, they carry a higher momentum than electrons. “We leverage the momentum of the ions to actually modify structures too. We can create new surface properties, new devices, new technologies, on a scale that is often too small for any other fabrication technique. This is some of the most exciting work.” If you know anyone who needs some nanoscale drilling done, then the HIM is your instrument! Today’s excursion across the university campus has been thrilling. I got what I came for and I’m excited to find other projects that could benefit from the insight and beautiful images the HIM can provide. Imaging instruments have always fascinated me and I’m looking forward to witnessing how far we will be able to delve into the nanoscale world in the years to come, thanks to the fast pace of engineering and physics research. Previous article back to DISORDER Next article

OmniSci Magazine is the University of Melbourne's science magazine, written by students. Read our recent issues and view the magnificent illustrations! Cover Art: Anabelle Dewi Saraswati READ NOW Welcome to OmniSci Magazine OmniSci Magazine is a student-led science magazine and social club at UniMelb. We are a group of students passionate about science communication and a platform for students to share their creativity. Read More More from OmniSci Magazine Previous Issues Illustration by Louise Cen READ ISSUE 6 National Science Week 'SCIENCE IS EVERYWHERE' PHOTO/ART COMPETITION VIEW SUBMISSIONS

< Back to Issue 7 Fossil Markets: Under the Gavel, Under Scrutiny by Jesse Allen 22 October 2024 edited by Zeinab Jishi illustrated by Jessica Walton At the crossroads between science and commerce, the trade in fossils has "developed into an organised enterprise" over the course of the twentieth century. With greater investment and heated competition between museums and private collectors, fossils increasingly took their place alongside “art, furniture, and fine wine” (Kjærgaard, 2012, pp.340-344). Fast forward to the twenty-first century, and this trend shows no signs of abating. On the contrary: as of 10 July 2024, a near-complete stegosaurus skeleton - nicknamed ‘Apex’ - was discovered by a commercial palaeontologist in Colorado, and was later purchased by “hedge-fund billionaire” Ken Griffin for US$44.6 million (Paul, 2024). This makes it the single most expensive dinosaur skeleton ever sold, eclipsing the previous record set in 2020 for a T-Rex named ‘Stan’, who was snapped up for US$31.8 million (Paul, 2024). These sales came with their fair share of criticism and controversy, reigniting the long-standing debate about how fossils should be handled, and where these ancient remains rightfully belong. Fossils (from the Latin fossilus , meaning ‘unearthed’) are the “preserved remains of plants and animals” which have been buried in sediments or preserved underneath ancient bodies of water, and offer unique insights into the history and adaptive evolution of life on Earth (British Geological Survey, n.d.). Their value is by no means limited to biology, however: they are useful for geologists in correlating the age of different rock layers (British Geological Survey, n.d.), and reveal the nature and consequences of changes in Earth’s climate (National Park Service, n.d.). Though new discoveries are being made all the time, fossils are inherently a finite resource, which cannot be replaced. This is part of what makes the fossil trade so lucrative, but the forces of limited supply and high demand have also led to the emergence of a dark underbelly. Cases of fossil forgery go back “as far as the dawn of palaeontology itself” in the late 18th and 19th centuries (Benton, 2024). The latest “boom in interest" is massively inflating prices and “fuelling the illicit trade” in fossils (Timmins, 2019). Whereas the US has a ‘finders-keepers’ policy, according to which private traders have carte blanche to dig up and sell any fossils they find, countries such as Brazil, China, and Mongolia do not allow the export of specimens overseas (Timmins, 2019). Sadly, this does little to prevent illegal smuggling; the laws are sometimes vague, and enforcement can be difficult when no single government agency is responsible for monitoring palaeontological activities (Winters, 2024). According to David Hone, a reader in zoology at Queen Mary University of London, “not every fossil is scientifically valuable”; but they are all “objects…worthy of protection,” and too many “scientifically important fossils appear briefly on the auction house website” before “vanish[ing] into a collector’s house, never to be seen again” (Hone, 2024). Museums, universities, and other scientific organisations are finding it more and more difficult to “financially compete with wealthy, private purchasers” as they are simply being priced out of the market (Paul, 2024). As sales become less open to expert scrutiny, the risk of forgery and price distortions become greater. It also has negative implications for future research. Private collectors might give access to one scientist, but not allow others to corroborate their findings. If the fossils aren’t open to all, many institutions simply won’t examine the items in private collections as a matter of principle. (Timmins, 2019). The general public also loses out in a world where dinosaur fossils are reduced to expensive conversation pieces. As Hone writes, “we might never dig up another Stegosaurus, or never find one nearly as complete as [Apex].” Having waited 150 million years to be unearthed, this latest fossil is one of many that may not see the light of day for a very long time. Bibliography Benton, M. (2024, September 5). Modern palaeontology keeps unmasking fossil forgeries – and a new study has uncovered the latest fake . The Conversation. https://theconversation.com/modern-palaeontology-keeps-unmasking-fossil-forgeries-and-a-new-study-has-uncovered-the-latest-fake-223501 British Geological Survey. (n.d.). Why do we study fossils? British Geological Survey. https://www.bgs.ac.uk/discovering-geology/fossils-and-geological-time/fossils/ Hone, D. (2024, June 10). The super-rich are snapping up dinosaur fossils – that’s bad for science . The Guardian. https://www.theguardian.com/commentisfree/article/2024/jun/10/super-rich-dinosaur-fossils-stegosaurus-illegal-trade-science Kjærgaard, P. C. (2012). The Fossil Trade: Paying a Price for Human Origins. Isis , 103 (2), 340–355. https://doi.org/10.1086/666365 National Park Service. (n.d.). The significance of fossils . U.S. Department of the Interior. https://www.nps.gov/subjects/fossils/significance.htm Paul, A. (2024, July 18). Stegosaurus 'Apex' sold for nearly $45 million to a billionaire . Popular Science. https://www.popsci.com/science/stegosaurus-skeleton-sale/ Timmins, B. (2019, August 8). What’s wrong with buying a dinosaur? BBC News. https://www.bbc.com/news/business-48472588 Winters, G.F. (2024). International Fossil Laws. The Journal of Paleontological Sciences , 19 . https://www.aaps-journal.org/Fossil-Laws.html Previous article Next article apex back to

Issue 6: Elemental 28 May 2024 This issue explores the building blocks that comprise the world we live in. Our talented writers braved the elements - have a read below! Editorial by Ingrid Sefton & Rachel Ko A word from our Editors-in-Chief. Fire and Brimstone by Jesse Allen The world has long been subject to the fury of fire and volcanic eruptions. Technology to predict seismic activity may allow us to tame this elemental force. Hidden in Plain Sight: The dangerous chemicals in our everyday products by Kara Miwa-Dale Drink bottles, tinned food, receipts: a recipe for disaster? Interviewing A/Prof Mark Green, Kara exposes the hidden dangers of endocrine disrupting chemicals. A Frozen Odyssey: Shackleton’s Trans-Antarctic Expedition by Ethan Bisogni A pursuit of knowledge and a testament to survival, Ethan navigates the enthralling legacy of Sir Ernest Shackleton's Trans-Antarctic Expedition. Everything, Everywhere, All at Once: The Art of Decomposition by Arwen Nguyen-Ngo Arwen breaks down the intricacies of decomposition, leading us to consider the fundamental power not only in creation, but destruction. Out of our element by Serenie Tsai Following the industrial revolution, humankind has exploited and degraded the Earth's natural resources. Serenie shows how nature resists, maintaining the capacity to restore what humans have destroyed. Cosmic Carbon Vs Artificial Intelligence by Gaurika Loomba Carbon constitutes life and death, shaping conscious human existence. What threat could AI hold to the power of this element? Proprioception: Our Invisible Sixth Sense by Ingrid Sefton Our mysterious, yet omnipresent sixth sense - proprioception is the reason we know where our body and limbs are, even in the dark. A Brief History of the Elements: Finding a Seat at the Periodic Table by Xenophon Papas There's hydrogen and helium, then lithium, beryllium - or is there? The periodic table we know today was not always so, as Xen recounts.

issue 3 : alien 10 September 2022 This issue is about exploring all things exotic, unfamiliar, unknown. Dive into the column and feature articles by our talented writers below! columns The Body, Et Cetera “Blink and you’ll miss it”: A Third Eyelid? By Rachel Ko This article unpacks the fascinating evidence for evolution reflected within our very own eyes, connecting us to our reptilian ancestors. Chatter Belly bugs: the aliens that live in our gut By Lily McCann In this issue we explore how microbes influence our health and emotions, and what this means for our concept of identity. Humans of UniMelb In conversation with Paul Beuchat By Renee Papaluca I caught up with Paul Beuchat to learn more about his research journey and his potentially ‘alien’ methods of teaching. Our Past, Present & Future Waving Hello to the Aliens By Reah Shetty Our interaction with the idea of aliens has evolved. The question is how far have we come and how far will we go? Science Books Believing in aliens... A science? By Juulke Castelijn I wasn’t expecting to be persuaded of the existence of life beyond the confines of Earth. Ethics in Science The Ethics of Space Travel By Monica Blasioli Being the beginning of research into the impacts of space travel, can turning space travel into monopoly truly be justified? Wonders of the Landscape Space exploration in Antartica By Ashleigh Hallinan What makes Antarctica special when it comes to meteorite discovery? Science in the Age of Politics Hope, Humanity and the Starry Night Sky By Andrew Lim This second feature in the ‘Science in the Age of Politics’ series considers the importance of the stars, and scientific diplomacy, amidst rising global tensions. features Death of the Scientific Hero By Clarisse Sawyer How do we teach scientific history without promoting historical bigots? Mighty Microscopic Warriors! By Gaurika Loomba Equipped with a plethora of signalling chemicals and cells with different features, our heroic immune system fights wars daily without us realising it. Love and Aliens By Gavin Choong The First Nations’ perspectives are profound, and must be recognised by the Australian legal system. Existing in an Alien World: Navigating Neurodiversity in a System Built for Someone Else By Hazel Theophania Autism isn’t some inscrutable mystery - we’re people, and learning how we operate will help dismantle the barriers built up around us. AI and a notion of 'artificial humanity' By Mia Horsfall We still consider AI as other (or 'alien') to us, but ideal utility would be gained from toeing the precarious line between humanity and machine.

< Back to Issue 8 Friend or Foe?: The Mechanisms Behind Facial Recognition by Mishen De Silva 3 June 2025 Edited by Luci Ackland Illustrated by Aisyah Mohammad Sulhanuddin Among the many mysteries which encompass the world around us, lies a complex interaction right under our nose, or perhaps… right above it. In the labyrinth of human consciousness, we rely on the seemingly arbitrary judgements made from the combination of two eyes, a nose, and a mouth, to discern who might be a friend or foe. Facial recognition gives a snapshot into the intricate dance between our perception and cognition, which allows us to cultivate a more detailed understanding of those around us, and their thoughts, feelings and emotions. In those fleeting moments when you recognise your parents in a sea of unfamiliar faces, spot your friends ensconced among the rows of the lecture theatre, or simply bump into an old friend in a crowd of unacquainted strangers, your brain is able to identify faces in a fraction of a second, a remarkable feat of the human cognitive capacity. But what enables us to distinguish one face from another? How do the faces of those we know stand out from the countless other noses, eyes and mouths we see? To understand what makes these interactions so meaningful, we need to take a closer look at the mechanisms behind facial recognition and decoding within the brain. The Brain’s Blueprint To be human is to seek meaning, even when none may exist. The mind has transformed what is two eyes above a nose, and a nose above a mouth, into its own pattern for classifying the identities and expressions we see around us. Many studies have suggested facial processing to be holistic, where the featural patterns of the eyes, nose and mouth are perceived together and upright (1,2). This mechanism of holistic facial processing explains the interesting phenomena behind pareidolia, where the brain adapts the characteristics of human faces onto everyday objects. It’s the reason why when glancing at a bowling ball it may appear surprised (3), or why some have sworn to see a face on Mars (4)! Figure 1. Bowling balls with surprised facial expressions! (3) In pursuit of meaning for the patterns around us, the brain has developed specialised regions for processing the features of a face to help us recognise individual identities. Facial processing operates through a hierarchical mechanism where distinct aspects of the face are interpreted by different regions of the brain. The unchanging elements of the face such as gender, age, ethnicity and features related to someone’s identity are analysed by the Inferior Occipital Gyrus and Fusiform Face Area (FFA), while the changing aspects such as eye gaze, lip movements and facial expressions are analysed by the Superior Temporal Sulcus and Orbitofrontal Cortex (5,6). Of these face-selective regions, the FFA is particularly important for facial recognition as it helps us recognise who a person is (5). Through the activation of our FFA simple patterns shift from meaningless shapes into familiar visages representing our friends, family, or even our own reflection. Studies have uncovered the importance of the FFA for facial recognition by examining what may happen when this brain region malfunctions (7,8). A unique example of this is prosopagnosia, which results from damage to the FFA in the right hemisphere of the brain (9). Prosopagnosia is a relatively rare condition affecting about 1 in 50 people, impairing their ability to recognise faces (9). Imagine if every face you observed looked the same or unfamiliar… even your own reflection! It is through the brain and its specialised regions for facial recognition where we can appreciate the essence of human connection as a result of our neural hardware. These mechanisms responsible for transforming patterns into faces are the reason we can recognise our neighbour from a stranger, friend from a classmate, or our parents from a teacher. Often overlooked amidst the fleeting and impermanent nature of our social interactions, this complex system guides us along the fragile line of human relationships, between familiarity and estrangement, a friend or foe. It highlights how deeply-rooted our connection and sense of identity is to the faces we see. The Brain’s Threat Detection With each neuron, synapse and pathway, our brains are machines wired for connection, not just in how we think, but also in how we perceive and interact with our surroundings. From the brief exchange of smiles with a stranger, to the furtive glare from someone across the room, one of the hallmarks of our emotional understanding is the ability to decode the thoughts and intentions of others, even from the most subtle of expressions. In the vast and intricate web of neural connectivity, it can be difficult to isolate a singular brain region or connection to explain complex cognitive functions. Brain imaging studies have found a strong bidirectional link between the FFA and amygdala, making this a likely candidate for explaining our remarkable decoding ability (10,11). As the FFA picks up on who a person is or what facial expression is being made, it is the amygdala which then evaluates the emotional salience, or importance, of this face. The amygdala then signals back to the FFA to either increase or decrease the facial processing activity accordingly (10,12). Consider how the visibility of teeth in a barred expression can signal anger, the whiteness of someone’s eyes can hint fear or surprise, and the shape of a person’s eyebrows can indicate the intensity of their emotion, all which guide the brain to prioritise and interpret socially and emotionally relevant cues – almost like a survival filter! (13,14,15). From an evolutionary perspective, the FFA-amygdala feedback loop serves as an important tool for rapidly and accurately interpreting the intentions of others, a pinnacle function in the architecture of our physical and social survival (16). The ability to recognise whether someone poses a friend or foe has been a survival mechanism and evolutionary advantage for millennia. The role of our facial processing network, from the amygdala and FFA, to other brain regions discussed, provides a microcosm into our nature as social beings, and our evolutionary selective changes, which have enhanced our ability to sense, respond to, and connect with those around us (17). In this way, maybe the most profound mysteries lie not in distant galaxies or ancient ruins, but are hidden in plain sight, within the faces we walk past every day. Our brain’s ability to read them is not merely a mechanism for decoding emotion, but a mirror into the nature of what it means to be human, where connection, trust, and survival have long been written in the expressions of those around us. References 1. Farah M, Wilson K, Drain M, Tanaka J. What is “special” about face perception?. Psychological Review [Internet]. 1998 Aug [cited 2025 May 14]; 105(3):482–98. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5561817/ 2. Richler J, Gauthier I. A meta-analysis and review of holistic face processing. Psychological Bulletin [Internet]. 2014 Sep [cited 2025 May 14]; 140(5): 1281–302. Available from: https://pubmed.ncbi.nlm.nih.gov/24956123/ 3. What do you think these bowling balls saw to leave them so surprised & shocked?. Reddit [Internet]. 2022 [cited 2025 May 31]. Available from: https://www.reddit.com/r/Pareidolia/comments/zc12jo/what_do_you_think_these_bowling_balls_saw_to/#lightbox 4. Gilbert L. Why the brain is programmed to see faces in everyday objects. UNSW Sites [Internet]. 2020 Aug [cited 2025 May 14]. Available from: https://www.unsw.edu.au/newsroom/news/2020/08/why-brain-programmed-see-faces-everyday-objects 5. Kanwisher N, Yovel G. The fusiform face area: a cortical region specialized for the perception of faces. Philosophical Transactions of the Royal Society: Biological Sciences [Internet]. 2006 Dec 29 [cited 2025 May 14]; 361(1476):2109–28. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857737/ 6. Zhen Z, Fang H, Liu J. The Hierarchical Brain Network for Face Recognition. Ptito M, editor. PLoS ONE [Internet]. 2013 Mar [cited 2025 May 14]; 8(3):e59886. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059886 7. Hadjikhani N, de Gelder B. Neural basis of prosopagnosia: An fMRI study. Human Brain Mapping [Internet]. 2002 [cited 2025 May 14]; 16(3):176–82. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.10043 8. Sorger B, Goebel R, Schiltz C, Rossion B. Understanding the functional neuroanatomy of acquired prosopagnosia. NeuroImage [Internet]. 2007 Apr [cited 2025 May 14] ;35(2):836–52. Available from: https://www.sciencedirect.com/science/article/pii/S1053811906009906 9. Prosopagnosia | Psychology Today Australia [Internet]. www.psychologytoday.com . [cited 2025 May 14]. Available from: https://www.psychologytoday.com/au/basics/prosopagnosia 10. Herrington J, Taylor J, Grupe D, Curby K, Schultz R. Bidirectional communication between amygdala and fusiform gyrus during facial recognition. NeuroImage [Internet]. 2011 Jun [cited 2025 May 14]; 56(4):2348–55. Available from: https://pubmed.ncbi.nlm.nih.gov/21497657/ 11. Said C, Dotsch R, Todorov A. The amygdala and FFA track both social and non-social face dimensions. Neuropsychologia [Internet]. 2010 Oct [cited 2025 May 14]; 48(12): 3596–605. Available from: https://pubmed.ncbi.nlm.nih.gov/20727365/ 12. Šimić G, Tkalčić M, Vukić V, Mulc D, Španić E, Šagud M, et al. Understanding Emotions: Origins and Roles of the Amygdala. Biomolecules [Internet]. 2021 May [cited 2025 May 14]; 11(6):823. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8228195/ 13. Jacobs R, Renken R, Aleman A, Cornelissen F. The amygdala, top-down effects, and selective attention to features. Neuroscience & Biobehavioral Reviews [Internet]. 2012 Oct [cited 2025 May 14]; 36(9):2069–84. Available from: https://pubmed.ncbi.nlm.nih.gov/22728112/ 14. Horstmann G, Lipp O, Becker S. Of toothy grins and angry snarls – Open mouth displays contribute to efficiency gains in search for emotional faces. Journal of Vision [Internet]. 2012 May [cited 2025 May 14]; 12(5):7–7. Available from: https://jov.arvojournals.org/article.aspx?articleid=2192034#:~:text=We%20suspected%20that%20visible%20teeth,(see%20also%20Figure%205).&text=Mean%20target%20present%20slopes%20(in,while%20angry%20faces%20do%20not.&text=Mean%20target%20present%20slopes%20(in,while%20angry%20faces%20do%20not . 15. Hasegawa H, Unuma H. Facial Features in Perceived Intensity of Schematic Facial Expressions. Perceptual and Motor Skills [Internet]. 2010 Feb [cited 2025 May 14]; 110(1):129–49. Available from: https://pubmed.ncbi.nlm.nih.gov/20391879/ 16. Schmidt K, Cohn J. Human facial expressions as adaptations: Evolutionary questions in facial expression research. American Journal of Physical Anthropology [Internet]. 2001 [cited 2025 May 14]; 116(S33):3–24. Available from: https://pubmed.ncbi.nlm.nih.gov/11786989/ 17. Carter E, Pelphrey K. Friend or foe? Brain systems involved in the perception of dynamic signals of menacing and friendly social approaches. Social Neuroscience [Internet]. 2008 Jun [cited 2025 May 14]; 3(2):151–63. Available from: https://pubmed.ncbi.nlm.nih.gov/18633856/ Previous article Next article Enigma back to

< Back to Issue 4 The Mirage of Camouflage by Krisha Ajay Darji 1 July 2023 Edited by Megane Boucherat and Tanya Kovacevic Illustrated by Aisyah Mohammad Sulhanuddin Imagine driving on a highway and the road is shimmered by the scorching midday sun. Whilst you drive further on a day like this, you might envision a wet patch gleaming on the road. Does it make you wonder how a mirage passes by playing with your vision? While there is physics involved in this phenomenon, evolution through natural selection has rendered some of its own biological members the ability to play with visual perceptions in subtle but enchanting ways! What comes to your mind when you hear the word camouflage? Some might visualize a chameleon blending in almost any background possible. Others might envision a soldier wearing camouflage pants and shirts to match the earthy tones for their defence. Colourful frogs, butterflies, snakes and so on might cross your mind as you think deeper about this phenomenon. Nature is filled with some of the most fascinating examples of camouflage. Camouflage as a Prehistoric Phenomenon The coloration patterns found on the Sinosauropteryx, a tiny, feathered, carnivorous dinosaur that lived in what is now China during the Early Cretaceous period was studied by a group of scientists. They discovered evidence of coloration patterns corresponding to modern animal camouflage by tracing the distribution of the dark pigmented feathers over the body. This included stripes running around its eyes and across the tail, and countershading with a dark back and pale bottom. By contrasting and comparing the mask and striped tail with the colours of contemporary animals, we can learn more about the evolution of camouflage as a means of natural selection [1]. The presence of stripes on only tails rather than the whole body of certain animals is not well understood, but they are suspected to function as a type of disruptive camouflage. Disruptive camouflage means visually separating the outline of a portion of the body from the others and to make it less noticeable. It could also serve as a type of deception by attracting predators' attention to the tail and away from the more vital parts - the body and head. Birds are found to be the most evident illustration of this as they descend from the theropod dinosaur [1]. Early tyrannosauroids, the ancestors of the ferocious T-rex, coexisted with Sinosauropteryx and may have even hunted the little dinosaur. Sinosauropteryx hunted tiny lizards, as was demonstrated by direct evidence in the shape of a whole animal preserved in the stomach of one of the specimens found. Hence, it is clear that camouflage patterns were developing at that time; since vision was critically important to these dinosaurs while they were hunting and being hunted. This example demonstrates camouflage as a prehistoric phenomenon and its evolution in the animal kingdom. Camouflage in Modern Day Animals Animals use camouflage primarily for defence. Blending in with their background prevents them from being seen easily by predators. The use of warning coloration, mimicry, countershading, background matching and disruptive coloration are mechanisms through which animals employ camouflage. Sneaky Snakes! The harmless scarlet king snake has stripes that resemble those of the deadly coral snake, but it is not poisonous. The only significant distinction between the two is the arrangement of the colours in their patterns. While the pattern for coral snakes is red-yellow-black, for scarlet king snakes it is red-black-yellow [2]. The difference is simple for anyone to remember thanks to a rhyme! Red on yellow kills a fellow, Red on black won’t hurt Jack! This is a classic example of mimicry: a form of camouflage in which one organism imitates the appearance of another to avoid predators. The Walking Leaf! The leaf insect or the waking leaf belongs to the family Phylliidae and is quite like its name. The walking leaf's body has patterns on its outer edges that look like the bite marks that caterpillars leave behind in leaves. To resemble a leaf swinging more accurately in the breeze, the insect even sways while walking! This is an example of a type of camouflage known as background matching- one of the most prevalent forms of camouflage. It is a mechanism through which a particular organism hides itself by resembling its surroundings in terms of its hues, shapes, or movement [2]. Mottled Moth! It is challenging for predators to determine the form and direction of the tiger moth as it is mottled with intricate patterns of black, white, and orange on its wings. This is an example of disruptive camouflage: when an animal has a patterned coloration, such as spots or stripes, it can be difficult to detect the animal's contour [2]. Lurking Leopards! Black rosettes on a light tan backdrop serve as the hallmarks of the leopard’s well known coat patterns. Their coats also include a subtle countershading to help them amalgamate with their environment and evade detection by prey. A leopard's body has a significantly lighter underside than the rest of its coat, which consists mostly of its belly and the bottom of its legs. This produces a shading effect that helps conceal the leopard's body form and contour, making it more challenging to see in low light or when seen from below. This is a typical example of countershading, which is a type of camouflage wherein the animal’s body is darker in colour, but its underside is lighter. It works by manipulating the interactions between light and shadows; thus, making the animal difficult to detect [2]. But what allows these animals to change their colours? Animals can camouflage themselves through two primary mechanisms: Pigments - biochromes Physical structures - prisms While some species have natural and microscopic pigments known as biochromes, others possess physical structures like prisms for camouflage. Biochromes can reflect some wavelengths of light while absorbing others. Species with biochromes can actually seem to alter their colour. Prisms can reflect and scatter light to give rise to a colour that is different from the animal’s skin [2]. Camouflage is not quite restricted to the sense of vision. There are several other ways evolution has taught the living world to adapt and protect themselves in the wild. There is a whole exciting world of behavioural and olfactory camouflage employed by diverse species in the animal kingdom. Ultimately, the compelling association of camouflage with the phenomenon of mirage conveys to us how nature always evolves and expands to secure the continued existence of its inhabitants. From the glistening heat of mirages on arid vistas to the delicate patterns on the wings of a butterfly, this fascinating juxtaposition of mirage and camouflage delivers a peek into the incredible mechanisms that animals deploy to traverse their natural habitats and survive amidst the obstacles they encounter. References Smithwick F. We discovered this dinosaur had stripes – and that tells us a lot about how it lived [Internet]. 2017 [cited 2023 May 12]. Available from: https://theconversation.com/we-discovered-this-dinosaur-had-stripes-and-that-tells-us-a-lot-about-how-it-lived-86170 National Geographic. Camouflage [Internet]. [cited 2023 May 12]. Available from: https://education.nationalgeographic.org/resource/camouflage/ Previous article Next article back to MIRAGE

< Back to Issue 9 Eyeballs, a Knife, and No Fear of God by Jess Walton 28 October 2025 Illustrated by Anabelle Dewi Saraswati Edited by Chavindi Sinhara Mudalige Humans have wanted to understand our bodies the entire time we’ve had them, which is to say, the entire time. Late Classical Athens, around 300 BC, at a peak of intellectual prosperity: Herophilos cuts into a corpse. From this, he’s going to make the novel argument that the brain contains knowledge, and in doing so, he’s going to criticize Aristotle’s writing, which describes the brain as something akin to an air conditioner. Aristotle thought the brain was a cooling chamber, essentially, to prevent the heart from overheating, and that cognition happened in the heart. Much, much earlier, around 1000 BC in India, Sushruta, in his foundational surgical text, overestimated the bone count in humans by over 100. Many ancient societies had impressively detailed understanding of anatomy, considering they had no microscopes, no cameras, no X-rays; usually nothing more than their knives and eyeballs. It’s important to note as well that this article is a brief overview of a complex subject, with a major focus on Classical, meaning Ancient Greek and Roman, examples, and is in no way a complete story of early anatomical developments across the globe. Asia, Africa, the Americas and the Arab world each had their own rich and complex traditions, beyond the few examples cherry-picked here. Most societies had a few impressive hits and a few impressive misses; in a way, their approach to science isn’t all that different from ours today. What can we learn from them, and what can we learn about ourselves? In Ancient Athens, Aristotle believed the heart to be both the intellectual and emotional center of humans; the “seat of the soul” (1). Some remnants of this remain in our modern association between heart and emotion, though we know now it isn’t backed by science. His reasoning behind this was the convergence of blood vessels at the heart and its importance; from this, he also, perhaps reasonably, thought it to be the source of blood (2). Despite being deservedly considered a major anatomist, Aristotle likely made his observations from examining and dissecting the bodies of animals, particularly lower mammals, like dogs or livestock, instead of real humans (3). He unknowingly used homologous structures, long before evolution or even Charles Darwin himself was conceptualized, to essentially assume the anatomy of humans from other animals. Given this, his conclusions on the brain become a little more understandable. The brain is a strange-looking organ, critically important to life, though not obviously connected to the pulse or rich with blood; how were they to understand the structure of nerves and white matter? That it assists the heart in some way becomes a logical conclusion. So why not serve a cooling function? Blood is hot, so the heart must get hot. Overheating is usually bad; see fire. And the brain’s size makes it ideal for such a thing. The thing about anatomy and science, Aristotle’s assertion being one primordial example of many around the ancient world, is that it changes. Herophilos and Erasistratus were two more Greek anatomists who succeeded and often contested Aristotle. Unlike him, they dissected humans, having no qualms about a man’s dead—or, according to some sources, still alive—body (4). However, they offered several accurate, or at least more accurate, insights inside human bodies. Herophilus argued that the brain wasn’t a cooling chamber but contained knowledge (5). While he was at it, he argued that the heart has four chambers, unlike Aristotle, who claimed it only has three (5). Many of Herophilos and Erasistratus’ insights required Aristotle’s, or some other prior Mediterranean scholar’s, claims to give them something to criticise. Praxagoras was one such anatomist, from about 400 BC, about 100 years earlier. He correctly associated the pulse with natural movement within the body, but also asserted that arteries carry air (6). There is, possibly because of this claim, debate as to whether he had any practical anatomical experience or observed any dissections. If so, it’s quite impressive to miss the blood in arteries. He did, however, note that veins carry blood (2). Thus, he was later included in Herophilos’ critique. Before we criticise how long it took for them to realise seemingly obvious facts, we must remember that bloodletting as an acceptable treatment persisted into the 19 th Century. Modern and recent understandings are far from flawless. A couple of hundred years later, Galen, a Roman from the late 2 nd Century AD, would voice similar critiques (2). Galen would later become famous for his theory of the four humors: blood, yellow bile, black bile, and phlegm, each with associated personalities and elements (7). While these are all real liquids found somewhere in the human body, they do not really work as the four-way counterbalance he describes. Galen made some incredible leaps forward in Roman anatomy, including developing more elaborate tools for dissection and surgery processes, which would be instrumental in allowing future developments in the field. However, he also learned more anatomy from treating severe gladiator injuries—which is awesome—or like Aristotle, from dissections and studies on lower mammals (7). This led to some interesting conclusions; his description and diagrams of a human uterus match that of a dog’s uterus exactly, for example (7). He did well with the tools he had, but guesswork has its limits. Three hundred years before Aristotle, and over seven centuries before Galen, the ancient Indian physician Sushruta, a continent away, was revolutionizing, and if there was nothing to revolutionise, inventing surgeries and surgical techniques. He also valued an understanding of human anatomy, which likely contributed to his surgical skill, and dedicated a portion of his seminal Sanskrit work, Sushruta Samhita , to anatomy, calling it the Sharira Sthana . In his work, he describes in detail the head, which he correctly identified as the major center of essentially all function, particularly the cranial nerves (8). He also includes the first detailed guide to human dissection, alongside the anatomy of the embryo at various developmental stages; this is described as arising from seven skins, each with their own associated ailments, and while the skins are anomalous, many of the ailments correlate impressively with known diseases (8). There’s also, incredibly, a detailed description of cataract surgery procedure, where exceptionally specific incision locations in the cornea are interspersed with instructions to sedate the patient with wine mixed with cannabis, which makes sense in a world far predating modern anesthesia, then to spray the eye with breast milk (9). This part seems outlandish and harder to explain, but anyone who has studied immunology can tell you that breast milk contains antibodies and antibacterial proteins. Sushruta likely made some link between breast milk and reduced post-op infections, even if there were not yet microscopes to see bacteria with. Even if they couldn’t see why on the molecular scale, ancient anatomists were able to understand what worked and what didn’t and justify it to the best of their knowledge. When Sushruta describes the bones of the human body, he does so in great detail, and also counts more than 300 of them. Humans typically have 206 bones, give or take a rib: Sushruta mildly overestimated. This is thought to be from him, largely basing his skeletal insights off child cadavers, before many bones have fused together (9). Hindu religious law calls for the cremation of any body over two years old, in its natural and thus undissected state; though there are accounts of Sushruta performing dissections, presumably on adults, the bodies he likely had the most exposure to were infants. Sushruta was working within the confines of the society and world that he lived in, as was Herophilos. Medical insights which seem obvious to us today, like that the brain is for thinking and the heart is for beating blood, and that blood goes through the arteries and is most definitely a liquid, rely upon prior knowledge reached with tools that hadn’t even been invented yet. These firsts—surgeons, anatomists, scientists—would probably have to be physically pried away from microscopes and X-rays, if ever introduced to them. They often didn’t even have a human body to dissect, yet drew human anatomical conclusions regardless. And it’s easy to marvel at their mistakes, but it’s even easier to marvel at how much they got right; Herophilos correctly uncovered nerves and linked them to sensation and response, which is impressive in itself. Could you find a nerve in some meat, with just your naked eye? He also linked the heart and the pulse. The Huangdi Neijing , for example, is a Chinese medical text said, though disputed, to be from 2600 BC, which describes the relationships between organs in military terms: the heart as a king, the liver as a commandant, and the gallbladder as an attorney-general responsible for coordination (10). However, both like and before Herophilos, it also correctly identifies the cyclic nature of blood flow and links it to the heart (10). The Edwin Smith Papyrus, dating from 1700 BC in Ancient Egypt, is the oldest known surgical text, describing 48 different injuries with treatments; all shockingly accurate (11). Sushruta may have miscounted the bones, but he described their shapes accurately and suggested legitimate therapies for particular bone breakages and dislocations. Nowadays, little has changed: in just the 1950s, lobotomies became the standard cure for a headache; even long after we developed microscopes, we were recommending treatments, like scrambling our brains, that only 70 years later seem ridiculously stupid. We’re far from done charting our own bodies, either. In 2018, an entirely new type of tissue all throughout the body was found: the interstitium, which is critical in cell and organ communication across the body (12). It’s been there the whole time, but no one had noticed before. Humans are humans; it is only natural to want to understand ourselves, and as a part of that, our bodies. We now study our ancestors as they studied themselves; the same mix of awe, confusion and confidence. Their methods and conclusions may be fallible, but their curiosity was not, and as long as we remain, never will be, dead. These examples were only a fraction of those whose work has been preserved, who themselves were only a fraction of the ancient people across the globe who investigated human anatomy. A millennium from now, our descendants will laugh at our misconceptions, when they have mapped every neuron in the human brain with instruments we could not conceive of. But without us, they wouldn’t know what they know, and without our original anatomists, we wouldn’t know what we know. Our modern granular understanding of our own structure is built on the bodies we looked in before ours. So, we should perhaps extend some empathy to our predecessors. They had only eyeballs, a knife, and our own curiosity. Different tools, same bodies. References Aird WC. Discovery of the cardiovascular system: from Galen to William Harvey. J Thromb Haemost. 2011;9(Suppl 1):118–29. Johnston IH, Papavramidou N. Galen on the Pulses: Medico-historical Analysis, Textual Tradition, Translation [Internet]. De Gruyter; 2023 [cited 2025 Oct 10]. Available from: https://www.degruyterbrill.com/document/doi/10.1515/9783110612677/html Crivellato E, Ribatti D. A portrait of Aristotle as an anatomist. Clin Anat. 2007;20(5):447–85. Papa V, Varotto E, Vaccarezza M, Ballestriero R, Tafuri D, Galassi FM. The teaching of anatomy throughout the centuries: from Herophilus to plastination and beyond. Med Hist. 2019;3(2):69–77. Bay NSY, Bay BH. Greek anatomist Herophilus: the father of anatomy. Anat Cell Biol. 2010;43(4):280–3. Wright J. Review of: Praxagoras of Cos on Arteries, Pulse and Pneuma. Studies in Ancient Medicine, 48 . Bryn Mawr Class Rev [Internet]. [cited 2025 Oct 10]. Available from: https://bmcr.brynmawr.edu/2017/2017.07.34/ Ajita R. Galen and his contribution to anatomy: a review. J Evid Based Med Healthc. 2015;4(26):4509–16. Bhattacharya S. Sushruta—the very first anatomist of the world. Indian J Surg. 2022;84(5):901–4. Loukas M, Lanteri A, Ferrauiola J, Tubbs RS, Maharaja G, Shoja MM, et al. Anatomy in ancient India: a focus on the Sushruta Samhita . J Anat. 2010;217(6):646–50. O’Boyle C. TVN Persaud, Early history of human anatomy: from antiquity to the beginning of the modern era. Med Hist. 1987;31(4):478–9. van Middendorp JJ, Sanchez GM, Burridge AL. The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries. Eur Spine J. 2010 Nov;19(11):1815–23. Benias PC, Wells RG, Sackey-Aboagye B, Klavan H, Reidy J, Buonocore D, et al. Structure and distribution of an unrecognized interstitium in human tissues. Sci Rep. 2018;8(1):4947. Previous article Next article Entwined back to

About Us OmniSci Magazine is a science magazine at the University of Melbourne, run entirely by students, for students. Our team consists of talented feature writers, columnists, editors, graphics designers, social media and web development officers, all passionate about communicating science! Past Contributor Interviews Editors-in-Chief Ingrid Sefton President Aisyah M. Sulhanuddin President Current Committee Lauren Zhang Secretary Andrew Shin General Committee Ethan Bisogni Treasurer Luci Ackland General Committee Kara Miwa-Dale Events and Socials Hendrick Lin General Committee Elijah McEvoy Events and Socials Past Editors-in-Chief Rachel Ko 2022-2024 Sophia Lin 2021-2022 Patrick Grave 2021-2023 Maya Salinger 2021-2022 Caitlin Kane 2022-2023 Felicity Hu 2021-2022 Yvette Marris 2022-2023

< Back to Issue 9 Ancient Asian Alchemy: Big Booms by Isaac Tian 28 October 2025 Illustrated by Aisyah Mohammad Sulhanuddin Edited by Luci Ackland One question has plagued the human condition since the beginning of time: how can we escape death? Well, we certainly know who didn’t find the answer – the alchemists of ancient China. It’s 210 BC, and you are an alchemist standing before Emperor Qin Shi Huang in his court. You hand him an elixir supposed to grant him immortality and eternal reign. Only the serum contains what we now call “mercury” and if anything, you granted him mortality, as he drops dead before you (1). Where does one begin in this journey to immortality? How do we combine chemicals to find the perfect serum? Keep in mind, we have not even come close to establishing the periodic table at this point (no, that will occur about 1000 years later) (2). Saltpetre – or potassium nitrate – had been used extensively to treat common illnesses and to maintain good health. There’s our starting point (3). The search for this magic elixir persists for the next eleven centuries. We never give up… do we? The ingenuity of the alchemists spoke to them: it told them to mix in a few other ingredients to the saltpetre. With the trio of saltpetre, sulfur and charcoal, gunpowder was henceforth born into this world (4). The alchemists must have been in for a surprise when their “potion of immortality” sparked and exploded before them. So how does gunpowder explode? Why don’t other flammable items like match tips and dry wood explode when we set them alight? It comes down to a few key things. First is our perception of explosions. Chemicals don’t simply “explode” – it’s not an inherent quality of reactions – however, they can combust. Combustion is the release of energy from a fuel. Wood and matches combust, but they do so in a way that is relatively slower than gunpowder. Gunpowder combusts rapidly – so there is a large amount of energy release within a short period of time. Secondly, it’s about the availability of oxygen. Items that combust slowly typically have to wait for the oxygen to trickle in from the surrounding air, since oxygen is a critical component of combustion. This does not apply to gunpowder. The oxygen for its combustion is right there in the nitrate compound (of potassium nitrate – or saltpetre). So unlike burning wood or matches, the combustion does not need to wait for oxygen to arrive from the surrounding environment – it’s already in there with the rest of the powder (5)! To go further on that point: the closer the atoms are, the faster the combustion reaction can progress, because chemical compounds don’t need to wait long for the heat to get to them. Since gunpowder is… well… a powder, it’s rather compact and all the molecules of potassium nitrate, sulfur, and carbon sit tightly next to one another. It is this physical arrangement that permits the fast transfer of heat between molecules, ensuring that a lot of energy can be released at once. Ultimately, when all these physical and chemical phenomena occur in perfect unison, the high temperatures rapidly increase the kinetic energy of surrounding air molecules, causing them to shoot outwards at great speeds to form a “barrier” of sorts. When this barrier, also known as a shockwave, hits your eardrums, the gunpowder delivers what it does best: BOOM! Now, let’s combust some gunpowder, build up some gaseous pressure, and launch ourselves into the modern day. It’s been about twelve centuries – what have we been doing with all the gunpowder? As it turns out, we humans are very inventive, but also violent (Wow – who knew?). We quickly realised that the physical properties of the resulting gases can be harnessed to quickly move very heavy objects (6). Said heavy objects could then be guided in the direction of, say, a human being or a structure. Weaponry derived from gunpowder has existed for a very long time, albeit rather inefficient at first. The introduction of gunpowder to warfare came in the early 10th century, when soldiers applied gunpowder to arrows that would ignite and create fire arrows. Of course, whilst it might have been effective in creating a hole in humans, it was significantly less so when it came to creating holes in walls and structures. Only after 300 years did we then invent cannons and guns. However, those guns were slow – really, really slow – to the point that bows and arrows were actually preferred during warfare of that era. It would be another 600 years before we realised that there were more effective ways of reloading a gun; brandishing a new trend of military technology that would set the stage for the First and Second World Wars (7). By that point, the most terrifying of weapons had begun to stray away from the use of gunpowder. Missiles and rockets began employing other chemicals as propellants, owing to the advantage it had over gunpowder (7). It would also be remiss of this article to omit the exploitation of atomic power – pervading the world with such destruction that gunpowder appeared like a child’s toy (8). The tragic irony of a supposed innovation in immortality leading to mortality by war and conflict will forever embed itself into our history. Even with the right intentions, the invention by the great minds of alchemy has sparked a chain reaction for widespread destruction and warfare. It only makes you wonder – what are we making now that will lead us further astray in the future? References 1. Glancey J. The army that conquered the world. BBC. Accessed August 24, 2025. https://www.bbc.com/culture/article/20170411-the-army-that-conquered-the-world 2. Guharay DM. A brief history of the periodic table. ASBMBTODAY. Accessed August 28, 2025. https://www.asbmb.org/asbmb-today/science/020721/a-brief-history-of-the-periodic-table 3. Butler A, Moffett J. Saltpetre in Early and Medieval Chinese Medicine. Asian Medicine . 2009;5(1):173-185. doi: 10.1163/157342109X568982 4. Paradowski, R.J. Invention of Gunpowder and Guns. EBSCO Research Starters. 2022. Accessed August 24, 2025. https://www.ebsco.com/research-starters/history/invention-gunpowder-and-guns 5. Stanford University. Detonation and Combustion. Stanford University. Accessed September 4, 2025. https://cs.stanford.edu/people/eroberts/courses/ww2/projects/firebombing/detonation-and-combustion.htm 6. Britannica. Ammunition | Bullets, Shells & Cartridges. Britannica. 2025. Accessed September 25, 2025. https://www.britannica.com/technology/ammunition 7. Beyer G. How Did Gunpowder Change Warfare? TheCollector. 2025. Accessed October 4, 2025. https://www.thecollector.com/how-did-gunpowder-change-warfare/ 8. ICAN. History of Nuclear Weapons. ICAN. Accessed October 4, 2025. https://www.icanw.org/nuclear_weapons_history Previous article Next article Entwined back to

< Back to Issue 2 The Evolution of Science Communication In the current age of social media, users hold far more autonomy over the posts and information which they share online. However, this was not always the case, with the media once being far more regulated, and restricted for only certain individuals. With users now having far more power over content posted online, how does this impact the information which others receive about the COVID-19 pandemic? by Monica Blasioli 10 December 2021 Edited by Khoa-Anh Tran & Yen Sim Illustrated by Rachel Ko Trigger warning: This article mentions illness, and death or dying. Since the beginning of the pandemic in March 2020, science communication has started to evolve in ways never before seen across the globe. There appears to be an endless amount of infographics, Facebook posts, and YouTube and TikTok videos… including some with dancing doctors. Information not only about the COVID-19 virus, but countless diseases and scientific concepts, is available in more casual, accessible language at only the touch of a button. Any questions which you might have about science or your body can be answered through a quick Google search. In this sense, science communication is now far more rapid, as well as more accessible than in research papers (which always seem like they are written in a foreign language at times). However, the downside of having vast amounts of information available is that it can create challenges in determining the validity of what is being presented. In previous years, science communication was typically limited to the more typical forms of media, such as in a newspaper or a magazine, or even through a television interview. These were typically completed by professionals in the field, such as a research scientist or a medical doctor. When looking at the 1920 Influenza outbreak, many citizens at that time would have received their information from printed newspapers and posters on bulletin boards, as seen below. Image 1, [1] Somewhat similar to today's age, there were signs displaying the importance of mask-wearing, and newspapers explaining the closures of schools and shops, the distribution of vaccines, and reports of death rates. These messages were, and still are, created and approved by larger institutions, governments and medical professionals, particularly doctors. As seen on the (left / right / below / above), doctors are urging people to not become complacent, despite a recent drop in influenza cases. This is rather similar to current newspaper or television news reports - only in reference to COVID-19, instead of influenza. Image 2, [2] There were, of course, still groups which were uncertain about the scientific evidence being provided by journalists, doctors and government officials at this time. In November of 1918, it was declared that “the epidemic of [influenza] disease is practically over,” with mask laws being relaxed. However, only a few days later, the previous mask laws were reintroduced with a spike in Influenza cases. As unpacked in Dr Dolan’s research [3], the “Anti-Mask League” formed and protested in response to this back track, claiming that masks were unsanitary, unnecessary, and stifling their freedom. As this was during the early 20th century, the league advertised their protests in local newspapers, with reports that hundreds of San Francisco residents were fined for not abiding by mask rules, often due to their alliance with the Anti-Mask League. The San Francisco Anti-Mask League is one of the most renowned and infamous groups of its time, with smaller-scale groups also questioning the science being communicated. This type of conflicting information surrounding mask issues, and the opinion that they restrict personal freedoms, have incited similar responses throughout history. However, resistance by anti-mask groups has not existed on such an influential and global scale, as it has during the current COVID-19 pandemic. With the rise of the age of “new media,” including platforms such as Instagram and Facebook, individuals now have far more autonomy over their role in the media, meaning that they yield a lot more power over the information others are receiving. Almost anybody can interpret scientific material online and upload it in a video of them dancing to some music on TikTok, spreading information to potentially hundreds of thousands of viewers across the globe. In many ways this new found autonomy and power can be quite beneficial. Australian Doctor Imogen Hines uses her platform on TikTok, alongside her medical education and current scientific research, to break down medical treatments and mistruths, particularly surrounding the COVID-19 pandemic. These videos use simple language and straight-forward analogies, “humanising” the often intimidating figures in the medical field, and allowing the general public to be well-informed about scientific concepts. For example, Dr Imogen breaks down the research surrounding long term side effects of vaccines using a milkshake analogy! https://www.tiktok.com/@imi_imogen1/video/7027448207823211777?is_copy_url=1&is_from_webapp=v1&lang=en On the other hand, this phenomenon can have pretty serious ramifications, with many individuals feeling rightfully confused about what the truth really is, when there appears to be so many versions of it posted across the internet. Following a rather controversial study on Ivermectin as a treatment for COVID-19, the internet was soon buzzing with excitement about the prospect of a drug that many believed could replace the need for a vaccine. Despite numerous gaps in the original study, and countless further studies refuting Invermectin’s ability to treat COVID-19, many social media users are continuing to spread this myth online. Both governments and hospitals alike have been accused of hiding a seemingly “good” cure from their citizens. In Texas, a group of doctors won a legal case which allowed Texas Huguley Hospital to refuse administering Ivermectin to a COVID-19 infected Deputy Sheriff. This sparked outrage on Facebook, with users and the Sheriff’s wife demanding greater freedoms over their medical treatments, instead of just relying on the judgement of doctors and hospital staff. In this instance, the misinformation surrounding Ivermectin is not only influencing individuals to seek out futile treatments, but it is also spreading mistrust with the science and medical communities, who work incredibly hard to protect the world, particularly over the past two years. Despite Ivermectin being used in a clinical setting to treat parasitic (not viral) infections in humans for a number of years now, it can be extremely dangerous for individuals to have complete power over their medical treatments. The dosage and timing of treatment is crucial in ensuring success. Just like with everyday medications such as paracetamol, taking Ivermectin in high doses is risky. A COVID-19 infected woman from Sydney who read about Ivermectin on social media took a very high dosage of the drug after purchasing it from an online seller, which resulted in severe diarrhea and vomiting. In order to combat some of this misinformation, a number of social media platforms are “fact checking” posts or providing warnings on posts with keywords, such as ‘COVID-19’ or ‘vaccination.’ On Instagram, each post with these keywords will contain a banner at the bottom inviting users to visit their “COVID-19 Information Centre,” which provides a list of information supported by WHO and UNICEF about how vaccines are of high-standard, well-researched, and generally resulting in mild side effects. In addition, on Facebook, posts identified to be spreading mistruths will provide users with websites explaining the truth, before they can access the original posts. However, these warnings and fact-checks can only go so far. Posts blindly supporting the use of Ivermectin, falsely reporting side effects of vaccines, and arguing that masks cannot block virus particles still circulate the internet. Often those most vulnerable in the community are at risk of being led astray with misinformation. In principle, evidence-based, concise, easy-to-understand science communication is essential to break down the barrier between research and the general public, ensuring that citizens are well-informed and more comfortable about the world around them. In the situation of a public health crisis such as the COVID-19 pandemic, this communication is crucial in ensuring that all citizens can remain well-informed, safe and healthy. Misinformation and dodgy studies can not only lead people astray, but also cost them their health and wellbeing. References: 1. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 2. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 3. Brian Dolan, Unmasking History: Who Was Behind the Anti-Mask League Protests During the 1918 Influenza Epidemic in San Francisco? Perspectives in Medical Humanities (San Francisco: UC Medical Humanities Consortium, 2020) Previous article back to DISORDER Next article