< Back to Issue 2 Spirituality and Science Science is limited by the philosophies which govern it. Common thinking is that science is a rigid, cold and largely academic field which sneers at the domain of spirituality. I posit that one must move beyond this point of view in order to do good science, and to find the true aims and values of the discipline. by Hamish Payne 10 December 2021 Edited by Irene Yonsuh Lee & Khoa-Anh Tran Illustrated by Quynh Anh Nguyen When I was fifteen, I thought that I could thwart my English teacher. He had given us homework that was simple enough; discuss with our families whether true altruism exists. I did not have this discussion with my household but instead hosted the debate in my head, coming to a measured conclusion. However, the privacy of my argumentation showed the next day when my teacher asked me to share. He immediately suggested that I had only been thinking by myself and had not welcomed others into my discussion. This is not my most interesting story, but it did teach me something important: every thought that I have had contains traces of me. Even when I am fiercely debating contrary viewpoints on a subject, even when I am having my most dissonant thoughts, it is my own voice against which I argue. Whenever I have drawn my pen across the page, I have been leaving my fingerprints in the ink. At the time, these traces of me made me very uncomfortable. I have always heard that the beauty in science is that it does not matter if it is considered in isolation or in consultation with others; its facts and its theorems are invariant. This vision of science as a haven for unchanging logic was popularised by Descartes. For the cartesian, the body is split from nature, allowing one to consider the latter more sterilely. But the mind is also split from the body, and our talents, ambitions and passions are split apart in our minds. This thinking for centuries has spurred enormous strides forward in physical technology and has made humanity feel in control of our environment largely because the cartesian divide heralds natural determinism wherein each phenomenon has a direct and exploitable cause[1]. However, there is no room for individual expression in the Cartesian framework – no place for perception, experience, or spirituality. Though my retelling is likely apocryphal, the story of Galileo serves in my mind as a symbol of this divide. From the instant Galileo sought to place the sun at the centre of our solar system, he toppled the heavens and was thus persecuted by the purveyors of spirituality. The persecution of both the scientist and his heliocentric principle barred faith and belief from the scientific process and hence placed reason and logic at its centre. Yet it should not be forgotten that the clergy of the Roman Inquisition paid Galileo in kind and forbad the scientist a spirit. But what are the consequences of taking such a divided view of nature? When I hear people talk about scientists today, they treat the scientist not as someone who lives but as someone who develops rules about life. Scientists must never strive for innate beauty, but for inert truth, guided by cold logic – even Oscar Wilde wrote that “the advantage of science is that it is emotionless”[2]. As a continuation of Galileo being branded apostate, the scientist has been stripped of the right to ambiguity in his explanations, and uncertainty in his world view. If science is not complete, it is deemed a failure. But this is ludicrous. Any scientist must know and accept that the cartesian split neglects certain aspects of the world – those properties of a system which emerge only when all its parts are combined. Moreover, nature still eludes science on a very deep level. For example, there is still no widely accepted philosophical explanation of quantum mechanics, no ability to predict the chaotic flow of a surging river, no profound understanding of the synchronisation of heart cells. Science is so woefully incomplete and incapable of dealing with the sheer scale of disorder in the world that most real-world systems must undergo several fundamental simplifications to be modelled, lest they take years to understand. And when things are cut apart, it becomes even more difficult to stitch them back into the complete picture. Then what remains of the aims of science if it is only an imitation of nature – a painting with no colours, shadows on the wall? When I ask myself this question, I find Feynman’s words echo back in my head: doing science is no more than thinking about “the inconceivable nature of nature”[3]. Science seeks to connect us with nature. It is not about disassembling it and organising it, splitting it into more and more isolated pieces, but about marvelling at the whole system, attempting to let it all sit in your mind - to look at the dancing shadows and understand what is casting them, enjoying the dance all the same. Likewise, in his book, Nonlinear Dynamics and Chaos, Steven Strogatz humorously lists life under the list of unexplored scientific domains[4]. He does not relegate, however, science to its usual, removed, and sterilised place in this. Instead, he suggests that nature is so complex, that one cannot help but marvel at it with no real hope of controlling or quantifying it. I argue that these two scientists are just as much talking about what it means to be spiritual as scientific. To be spiritual is to try relentlessly to understand our life and our world and their relationship, even as they mercurially shift and change. Simply put, spirituality arises from a profound connection with nature. For example, the unity of the mind and the natural world is the bedrock of Eastern mysticism. The discipline seeks to connect the two through considered meditation and direly avoids their division. Such is highlighted by the Buddhist philosopher Asvaghosha; “When the mind is disturbed, the multiplicity of things is produced, but when the mind is quieted, the multiplicity of things disappears.” Western religions similarly connect nature and the spirit. Polytheistic traditions like the ancient Greek and Roman ascribe to their gods an element of the world each to control. The communication of the individual with a god is thus the interaction of the individual with the natural world. Similarly, the God of Judaism, Christianity and Islam is often present in awesome acts of nature. Particularly in the oldest parts of the Bible, God is seen to communicate through natural disasters and great floods and great fish and plagues and pestilences. Whilst I must admit that this analysis is somewhat superficial, it certainly illustrates the place nature holds deep in our minds and mythology. In an overwhelming number of cases, nature begets spirituality. Science is likewise born of nature and, for me at least, is therefore spiritual. But the value in reclassifying science as something spiritual as well as logical is not argumentation for naught. The scientist who is spiritual and fully connected with nature is better equipped than any. Guarding the connection between the individual and nature as sacred allows us to question our world on a more fundamental, truer level. Take as an example a question I hear often in my studies of physics: “Why is this theorem true?” Whilst it sounds reasonable enough, this type of question leads its asker down a reductionistic rabbit hole, in pitting mathematics against nature. Instead of seeing mathematics as a tool to describe nature, nature is seen as a product of mathematics. The rich physical world is reduced into rigidly true or false statements when we know such dichotomies are severely inept in the real world. Perhaps the scientist who is more holistically, spiritually connected with nature would be prompted to ask instead: “How true is this theorem to the world?” One does not have to look far to see how this subtle shift in approach to science can be incredibly successful. A fundamental principle of quantum physics states that matter is simultaneously particle-like and wave-like. This ambiguity in physical explanation, which would not be allowed from a cartesian point of view, is acceptable because it matches completely what is observed rather than attempting to reduce nature into the language of mathematics. Werner Heisenberg even wrote that “we cannot speak about atoms in ordinary language”, demonstrating the need for scientific holism. Approaching scientific discovery from a spiritual perspective allows us to move beyond the constraints of a reductive language. Likewise, studying science increases our spiritual relationship with nature. Albert Camus, perhaps rather unknowingly, said much the same thing in his unpublished novel, La Mort Heureuse. The protagonist, Mersault, on the brink of his death, says of the red, sunset clouds: “When I was young, my mother told me that [the clouds] were the souls of the dead who were travelling to Heaven. I was amazed that my soul was red. Now I know that it’s more likely the promise of wind. But that’s just as marvelous.”[5] What is spiritual is natural. Intellectual curiosity is rooted in the physical world, even as it changes and develops, becomes completely chaotic and throws more and more unanswerable questions in our faces. Science persists not because it seeks to provide answers to all of life’s questions, but because it provokes the mind into deeper questioning and, in that, deeper connection with nature and its ineffable, uncapturable beauty. The most marvellous thing about taking this perspective is that the science I do becomes more personal and ignites a stronger passion. I no longer must worry about the traces of myself; they are a necessary part of my understanding of the world and have shown me that, although science is “emotionless” in its methodology, it should not be so in its execution. Science is not spiritual because it precludes knowledge that is born from blind faith, but because it pushes knowledge to somewhere that is deeply human and that is beyond faith. References: [1] Fritjof Capra. 2000. The Tao of Physics : An Exploration of the Parallels between Modern Physics and Eastern Mysticism. 35th Anniversary Edition. Boston: Shambhala. [2] Wilde, Oscar. (1890) 2018. The Picture of Dorian Gray. New York, Ny: Olive Editions. [3] Feynman, Richard. 1983. “Fun to Imagine with Richard Feynman.” Documentary. BBC. [4] Strogatz, Steven H. (2014) 2019. Nonlinear Dynamics and Chaos : With Applications to Physics, Biology, Chemistry, and Engineering. Second. Boca Raton: Crc Press. [5] Camus, Albert. (1971) 2010. La Mort Hereuse. Paris: Gallimard. Previous article back to DISORDER Next article

< Back to Issue 10 The Human Body: A Portrait Painted by a Thousand Minds by Isaac Tian 2 June 2026 Illustrated by Chris Cao Edited by Adrija Dutta The only nourishment humans hunger for more than food is truth. For millennia, we have been propelled by this inarticulable appetite for discovery, yet our understanding of the human body has remained limited–and at times, conflicting. Our fascination with ourselves began long before the modern day. Prior to the interconnectedness of the contemporary global platform, research into the human body was undertaken independently in various cultures. As a result of geographical separation, cultures have arrived at different interpretations of our bodies, diseases, and treatments (1). The Chinese developed Traditional Chinese Medicine; from the Indian subcontinent arose Ayurveda; the Greek laid the basis for Unani. More recently, the Europeans gave us naturopathy, homeopathy, and of course–Western medicine. The modern Australian medical system is predominantly founded on conventional Western medicine. Nevertheless, traces of foreign medical practices have embedded themselves into the system (2). In a world now riddled with cultural intersections, the frontiers of knowledge and established practices collide, leaving us – as patients – with a critical question: who is right, and who is wrong? More interestingly, could both sides of the argument be right? The vast backdrop of conventional Western medicine has certainly served us well. Western scientists have – for the most part – established a reliable theoretical basis upon which our understanding of bodily functions, diseases and treatments are founded (3). Through various experiments, they have visualised the microscopic and characterised the medically novel, revealing previously undiscovered cellular and molecular mechanisms, ultimately birthing the biomedical foundations of Western medicine (3). Discoveries such as William Harvey’s elaboration of the circulatory system in 1628, Edward Jenner’s founding principles of vaccination in the 1700s, and Louis Pasteur’s discovery of microbial origins in the 1800s are episodes in a lengthy collection that forms the foundation for Western medicine (3). Whilst there are still gaps in the Western understanding of bodies, studies such as these largely suggest that the foundations for Western medicine are tangibly sound - rendering them reliable to an extent. The strength of Western medicine lies in the tangibility of the proposed cellular mechanisms. Alternative approaches such as Traditional Chinese Medicine and Ayurveda places greater emphasis on spirituality in body systems, undertaking the belief that intangible forces are at play to influence the human condition (3). Due to their immaterial nature, scientific inquiry is largely unable to support or refute these spiritual ideas. Although, interestingly – treatments based on these foundations aren’t completely unfounded. For example, the concept of Qi (pronounced chee ) is central to Traditional Chinese Medicine. Qi is thought to be a fundamental life force that circulates around the body, and it is believed that acupuncture can stimulate this circulation to relieve pain (1, 4). Sounds insane right? How can we manipulate an immaterial force to alleviate physical symptoms? It turns out that it may not be the immaterial Qi the acupuncture needle targets – but rather the fascia of musculoskeletal systems that cause the nerve stimulation experienced in acupuncture (5). Remarkably, acupuncture has been shown to reduce multiple types of pain in patients (4). The fascination here lies neither in the tangibility of Western mechanisms nor the grandeur of Chinese spirituality alone, but in how the two systems converge. The treatment stems from ancient China, but its mechanisms are more clearly elucidated by Western medicine. This harmonious combination of varying cultural understanding is fascinating. Better yet, it achieves the ultimate goal of treatments – to deliver a beneficial outcome to the patient. The interplay of medical systems extends beyond just China and the West. For instance, yoga – widely prevalent in Ayurveda – is traditionally grounded in the Ayurvedic ideas of the three energies (called doshas) and the five elements in the human body, a foundation that may seem outdated. However, the practice of Yoga remains highly effective and complements many Western medical treatments (1). Additionally, it has been shown to improve outcomes of chronic conditions and pain (6). These positive outcomes for patients bode well with the Western understanding of pain sensation pathways (7). The human body seems endlessly complex and rightly so. Medicine has been and will likely always be a developing field of intersecting understanding. By virtue of their persistence throughout centuries and even millennia, the medical systems from various cultures merit exploration and investigation. Whilst it is imprudent to single out a medical system as the best, it is prudent to cherish how differing approaches can complement each other to deliver benefits to patients. Validity and truth should not be overly emphasised when the goal of medicine is to do the greatest good for the greatest number of people. Through cooperation and unity, each system contributes to a more complete understanding of health. References Baars EW, Hamre HJ. Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process. Evid Based Complement Alternat Med. 2017;2017:4904930. doi: 10.1155/2017/4904930 PubMed PMID: 28785290; PubMed Central PMCID: PMC5530407. Australian Health Practitioner Regulation Agency. AHPRA Annual Report 2023-24 [Internet]. Australian Health Practitioner Regulation Agency; [cited 2026 May 10]. Available from: https://www.ahpra.gov.au/Publications/Annual-reports/Annual-report-2024/Highlights.aspx Silvano G. A brief history of Western medicine. Journal of Traditional Chinese Medical Sciences. 2021 Nov 1;8:S10–6. doi: 10.1016/j.jtcms.2020.06.002 Vickers AJ, Linde K. Acupuncture for chronic pain. JAMA. 2014 Mar 5;311(9):955–6. doi: 10.1001/jama.2013.285478 PubMed PMID: 24595780; PubMed Central PMCID: PMC4036643. Finando S, Finando D. Qi, acupuncture, and the fascia: a reconsideration of the fundamental principles of acupuncture. J Altern Complement Med. 2012 Sep;18(9):880–6. doi: 10.1089/acm.2011.0599 PubMed PMID: 22874011. Holtzman S, Beggs RT. Yoga for chronic low back pain: A meta-analysis of randomized controlled trials. Pain Res Manag. 2013;18(5):267–72. doi: 10.1155/2013/105919 PubMed PMID: 23894731; PubMed Central PMCID: PMC3805350. Gupta S, Gautam S, Kumar U, Arora T, Dada R. Potential Role of Yoga Intervention in the Management of Chronic Non-malignant Pain. Evid Based Complement Alternat Med. 2022 May 28;2022:5448671. doi: 10.1155/2022/5448671 PubMed PMID: 35668780; PubMed Central PMCID: PMC9167073. Previous article back to Fact & Fiction Next article

By Reah Shetty < Back to Issue 3 Waving Hello to the Aliens By Reah Shetty 10 September 2022 Edited by Zhiyou Low and Ashleigh Hallinan Illustrated by Matt Duffy Next They arrived in a sea of indiscernible shapes, a massive looming body in the sky. We weren’t prepared. We never could have been. Our quest to uncover the unknown, our innate thirst for knowledge – this is humanity’s fatal flaw. We sent the invitation and they accepted it. In the serenity of Earth, with its blue skies and tranquillity, it was easy to convince ourselves we were invincible. If only we had known. *** Life beyond Earth is considered terrifying to some and exciting to others. It is a fascinating question that has plagued humanity for centuries - Do aliens exist? The idea of other – or extraterrestrial – life dates back to ancient times, with the 200AD fantasy novel Vera Historia describing alien lifeforms on the moon.1 Throughout the centuries, we see human imagination construct fantastical tales from humanoids being sent to Earth in the 10th century narrative The Tale of the Bamboo Cutter (1) to the first movie featuring aliens in 1902, A Trip to the Moon. (2) As we began pondering more about the possibility of aliens, we started connecting their existence with alien technology. During World War II, soldiers would see unknown airborne objects (3); these sightings kicked our curiosity into motion, laying the conceptual foundation of unidentified flying objects (UFOs). Belief in alien existence underwent rapid acceleration in 1947, marking a monumental turning point in the possibility of extraterrestrials. Kenneth Arnold, an American businessman and pilot, is largely credited with the first UFO sighting which newspapers described as “flying saucers”. (3) This catalysed a chain reaction of UFO appearances and the iconic images of UFOs as hovering disks. Later that same year, the first apparent tangible remnant of alien technology was discovered. Witnesses reported a large wreckage site at a New Mexico ranch, an event known as the ‘Roswell UFO Crash’. In the face of mass excitement and speculation, the army was quick to offer the explanation of a crashed weather balloon. However, in an interview years later, one of the officers who had attended the scene revealed they had been ordered to keep quiet. The US Air Force then released a statement saying the wreckage was actually from a classified project. (4) With all these mixed messages, it does lead us to wonder what really happened... Jumping forward to current times, the US government has officially recognised the existence of ‘Unidentified Aerial Phenomena’ (UAPs) (5) supplemented by recent puzzling aircraft footage of “pyramid-shaped objects” recorded by the Pentagon. (6) The government has approved the Unidentified Aerial Phenomena Task Force, a team whose mission is to “detect, analyse and catalog [unidentified aerial phenomena] that could potentially pose a threat to U.S. national security”. (3) With the government unable to provide an explanation and simultaneously confirming the veracity of UAPs, this reopens and supports the ever-intriguing notion that we are not alone. Our evolving comprehension of the solar system and universe corresponds with a growing fervour that we will indeed stumble upon extraterrestrial life. NASA believes Earth is only a small planet out of trillions in the Milky Way galaxy. (7) With so many unexplored and uncharted territories out there, many believe the odds of other living organisms existing are high. It is rather confounding to picture the centre of our lives as a mere tiny cog in the overarching mechanism that is the universe. But it is this grandeur and this vastness which should caution us against encroaching too far into space. Stephen Hawking, a renowned and respected physicist, publicly condemned this mission objective. He was very clear in his belief that aliens of some form do exist but that we should do absolutely everything we can to avoid contact with aliens. Hawking, articulate in his disapproval, paralleled that “if aliens visit us, the outcome would be much as when Columbus landed in America, which didn’t turn out well for the Native Americans”. (8) Yet in 1974, we began attempting to contact aliens by broadcasting the Arecibo message from Puerto Rico using radio waves. The project was decommissioned in 2020 following a partial collapse. There was no success in its goal of establishing communication. (9) Researchers are in the process of constructing a new updated message to make first contact. They are trying to send out Earth’s location to alien technology capable of receiving it in an attempt to establish a mutualistic relationship. Compared to the Arecibo attempt, not only has the message itself become more advanced but our understanding of the Milky Way Galaxy is more detailed enabling area-specific targeting. (9) The potential for success here demands our urgent attention. In recent years we have seen an influx of science fiction novels and films, many of which feature calamitous situations of hostile invading alien forces against mankind. We see The Avengers, The Matrix, Star Wars and countless others and we empathise with the characters. But the crucial point is that what is happening in those films could become our reality. If our signal is received, we are heading for a drastically different future – a time during which science fiction becomes science nonfiction. Considering this, should we be trying to communicate with aliens? We cannot begin to truly fathom what such a connection would lead to… be it beneficial or disastrous. References 1. Scharf C. The First Alien [Internet]. Scientific American Blog Network. 2019. Available from: https://blogs.scientificamerican.com/life-unbounded/the-first-alien/ 2. Monteil A. 50 best alien movies [Internet]. Stacker. 2020. Available from: https://stacker.com/stories/4458/50-best-alien-movies#:~:text=Aliens%20first%20appeared%20on%20screen,%E2%80%9Cufology%E2%80%9D%20emerged%2C%20leaving%20a 3. Wall M. UFOs and UAP: History, sightings and mysteries [Internet]. Space.com. 2021. Available from: https://www.space.com/ufos-uap-history-sightings-mysteries 4. Crookes D. Roswell UFO crash: What is the truth behind the 'flying saucer' incident? [Internet]. livescience.com. 2021. Available from: https://www.livescience.com/roswell-ufo-crash-what-really-happened.html 5. Bram C. UFOs exist, and might come from beyond Earth, the U.S. said. Will that encourage conspiracy theorists? [Internet]. The Washington Post. 2021. Available from: https://www.washingtonpost.com/politics/2021/07/30/ufos-exist-might-come-beyond-earth-us-said-will-that-encourage-conspiracy-theorists/ 6. Dockrill P. Pentagon Confirms 'Pyramid-Shaped' UFO Video Footage Is Authentic [Internet]. ScienceAlert. 2021. Available from: https://www.sciencealert.com/pentagon-confirms-pyramid-shaped-ufo-video-footage-is-authentic 7. Program P. Among Trillions of Planets, Are We 'Home Alone?' [Internet]. Exoplanet Exploration: Planets Beyond our Solar System. 2020. Available from: https://exoplanets.nasa.gov/news/1658/among-trillions-of-planets-are-we-home-alone/ 8. Jha A. Is Stephen Hawking right about aliens? [Internet]. The Guardian. 2010. Available from: https://www.theguardian.com/science/2010/apr/30/stephen-hawking-right-aliens 9. Pappas S. Is it time to send another message to intelligent aliens? Some scientists think so. [Internet]. livescience.com. 2022. Available from: https://www.livescience.com/new-seti-message Previous article Next article alien back to

Understanding the Mysterious Science of Sleep By Evelyn Kiantoro Sleeping is just something we do at the end of the day, but why? It’s a daily routine we rarely question! Check out this article for a brief review of the current research out there on sleep and dreams. Edited by Katherine Tweedie, Juulke Castelijn & Niesha Baker Issue 1: September 24, 2021 Illustration by Casey Boswell “Today I don’t feel like doing anything, I just wanna lay in my bed,” sings Bruno Mars in The Lazy Song. That is exactly what our inner narrative says every Monday morning, right? After the long weekend, having fun partying or catching up with some work, there is nothing worse than getting back into the weekday grind. All we want is an eternity of rest and sleep because – for the majority of us – sleep is a way to relax; it takes us away from the stressful reality of life. However, our physical condition when we sleep suggests that it is not actually very safe. When we sleep, we are in a mysterious state; we lie down and are vulnerable to predators without any defence. To minimise the dangers of sleeping, humans built houses that provide warmth and shelter from the weather and protection from predators. But sleeping is seen in various other lifeforms, not just us humans – and species that live in the wild experience conditions that are far more dangerous. Dreams are an even bigger mystery in the science of sleep; they do not seem to have any significant benefits, and their purpose is largely unknown. However, as with everything that is passed on from generation to generation, sleep and dreams must have a significant evolutionary advantage for our fitness and survival. Due to the different obstacles and routines faced by various species, different species sleep in different ways. Generally, predatory animals such as humans can sleep for long periods of time (1). Conversely, prey animals are constantly vigilant; instead of sleeping for a long time, they only rest for short periods (2). A particularly interesting example are dolphins and seals, who have evolved to keep half of their brain “asleep” while the other is “awake” during sleep (3). This shows us that sleep really is important for our survival, and that various organisms have even adopted mechanisms to combat obstacles to sleeping. So, the cost of sleeping must be worth it, right? The answer is “yes” – but scientists are unsure of exactly why. Why do we sleep? Various theories in literature on the purpose of sleep have been broadly categorised into two theories: the adaptive and restorative theories. One of the reasonings behind the adaptive theories proposes that creatures that are inactive at night have increased chances of survival due to a lower risk of injury (4). Another perspective suggests that humans sleep at night to conserve energy for the day, when it is more efficient to hunt for food (5). This theory has also been supported by the fact that humans have a 10 per cent decrease in metabolism during sleep (6). However, both theories were proposed in relation to our ancient lifestyle when we needed to physically hunt for food. Looking at our present lifestyle, this reasoning may not be as applicable – but it is still embedded in our system. There are other theories that explore the reasoning behind sleep from the perspective of restoration. The restorative theory speculates that sleep allows us to repair cellular components that were used throughout the day, as many important growth hormones are shown to be released during sleep (7). This theory is also supported by the most widely accepted reasoning for why we sleep, which is that sleep is necessary for the growth and maintenance of the brain’s structure and function, and that it is crucial for optimising memory consolidation (8, 9). Sleep also affects other physiological aspects, such as immune function, endocrine function, cardiovascular health and mood (10, 11, 12) . Sleep disorders are shown to be associated with cardiovascular disease, and sleep reportedly enhances immune defences against pathogens. The fact that there are various theories explaining why we sleep shows that there is no single perfect explanation. Regardless of why we sleep, we still get into bed at the end of the day. This is mainly because of our circadian rhythm, which controls our desire for sleep. Our circadian rhythm is controlled via the hypothalamus: an area at the centre of our brain that receives sensory inputs from various parts of the body. During sleep, the hypothalamus receives input from our eyes, which detect light levels (13). When we are exposed to high levels of light in the morning, the circadian rhythm promotes wakefulness (14). However, at night, when there is less exposure to light, the circadian rhythm promotes sleep due to the increase in the production of the sleep-regulating hormone, melatonin (15). Even though we have a central control system that regulates when we sleep, there is still a large variation in sleeping time among humans; some people sleep for only five hours, and others sleep for up to ten or more (16). Sleep duration is affected by factors such as physical and social environment, diet, activity, body mass index, comorbidities and mental health (17). Despite the contributions of lifestyle differences, some studies have shown that human sleep duration and timing is also influenced by genetic factors but is regulated by the circadian rhythm and brain activity (18). Currently, little is known about the specific genes and genetic mechanism involved in sleep duration, and more research is still being done in the area (19). These factors could explain why people often feel sleepy throughout the day, in addition to the variation in sleeping patterns in the population. However, as is so often the case in science, there is no one specific factor that may result in differences within the population – instead, a combination of these factors is likely to be responsible. The phases of sleep Did you know that there are different kinds of sleep? All humans go through two different sleep phases: non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep (20). NREM takes up approximately 75–80 per cent of our total sleep duration, whereas REM takes up 20–25 per cent (21). Sleeping normally progresses from NREM 1–4 through to REM, and this cycle occurs four to five times each night (22) - for more details on sleep phases, check out Table 1! Most of the restoration processes in the body are believed to take place during NREM 3, as well as during REM. However, one particular question often stands out when it comes to sleep stages: when do we dream? Dreams: what are they, anyway? While there are some exceptions, it is widely believed that dreaming most frequently occurs when a person is in the REM stage of sleeping (25). When some individuals sleep, they sometimes have difficulty distinguishing between reality and the dreaming state. This can be explained by the fact that we are consciously aware in dreams, and we often have perception and emotion (26). Dreams are in fact richer than our consciousness – they can create scenarios that may be impossible in our conscious reality (27). They are highly visual, contain sounds and are often an experience instead of a mere thought (28). Interestingly, the striking similarities between consciousness and dreams may indicate that dreams reflect the organisation and function of our brain (29)! Various evidence has shown that dreams are more likely to be a result of our imagination. One argument states that blended characters and the bizarre properties of our dreams are more likely to be produced by our imaginations, as these are not something an individual would experience in the conscious state (30). Furthermore, the fact that dreams rarely contain smells or pain may be a result of us having difficulties imagining those sensations while awake (31). Looking at dreams as a higher form of our imagination may explain our uncertainty, poor recall, disconnection from the environment and lack of control over the situation while dreaming (32). However, it is interesting to keep in mind that our imagination is a result of the knowledge we already have. This knowledge is based on what we learn from our conscious reality, explaining why our dreams sometimes feel so realistic. An unsolved mystery Did you realise that sleep is one of the few activities you were not taught to do? As newborns, we only know how to digest and excrete food, breathe, show emotions and sleep. We digest food as an energy source; we excrete food to prevent the build-up of toxic substances; we breathe to supply our organs with oxygen; and we show emotions to communicate how we feel. So why is sleep one of these essential activities? And why is dreaming such a universal human experience? Despite extensive research, the answer remains buried in us like a secret in a mystery novel. This answer is not so far away – but unfortunately for us, it is not the type of book you can finish in a day. Instead, it is one with an infinite number of chapters. References: 1, 2. Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, and Leonard E. White, Neuroscience (5th Edition). Sunderland, MA: Sinauer Associates, 2012, 627. 3. Siegel, Jerome M., “Do All Animals Sleep?”, Trends in Neurosciences 31, no. 4 (2008): 208-213. doi: 10.1016/j.tins.2008.02.001. 4. Siegel, Jerome M., “Sleep Viewed as a State of Adaptive Inactivity”, Nature Reviews 10, no. 10 (2009): 747-753. doi: 10.1038/nrn2697. 5. Freiberg, Andrew S., “Why We Sleep: A Hypothesis for an Ultimate or Evolutionary Origin for Sleep and Other Physiological Rhythms,” Journal of Circadian Rhythms 18, no. 1 (2020): 1-5. doi: 10.5334/jcr.189. 6, 7, 8, 13, 15, 22, 23, 25. Brinkman, Joshua E., Vamsi Reddy, and Sandeep Sharma, Physiology of Sleep (Treasure Island, FL: StatPearls, 2021). 9. Rasch, Bjorn, and Jan Born, “About Sleep’s Role in Memory”, Physiological Reviews 93, no. 2 (2013): 681-766. doi: 10.1152/physrev.00032.2012. 10. Leproult, Rachel, and Eve Van Cauter, “Role of Sleep and Sleep Loss in Hormonal Release and Metabolism”, Endocrine Development 17 (2009): 11-21. doi: 10.1159/000262524. 11, 14, 24. Jawabri, Khalid H., and Avais Raja, Physiology, Sleep Patterns. Treasure Island, FL: StatPearls, 2021. 12. Ahmad, Adeel and S. Claudia Didia, “Effects of Sleep Duration on Cardiovascular Events,” Current Cardiology Reports 22, no. 4 (2020): 18. doi: 10.1007/s11886-020-1271-0. 16, 19. Keene, Alex C., and Erik R. Duboue, “The Origins and Evolution of Sleep,” Journal of Experimental Biology 221, no. 11 (2018): 1-14. doi: 10.1242/jeb.159533. 17. Billings, Martha E., Lauren Hale, and Dayna A. Johnson, “Physical and Social Environment Relationship with Sleep Health and Disorders,” Chest 157, no. 5 (2020): 1305-1308. doi: 10.1016/j.chest.2019.12.002. 18. Porkka-Heiskanen, T., “Sleep regulatory factors,” Italiennes de Biologie 152, no. 2-3 (2014): 57-65. doi: 10.12871/000298292014231. 20. Miyazaki, Shinichi, Chih-Yao Liu, and Yu Hayashi, “Sleep in Vertebrate and Invertebrate Animals, and Insights Into the Function and Evolution of Sleep,” Neuroscience Research 118 (2017): 3-12. doi: 10.1016/j.neures.2017.04.017. 21. Troynikov, Olga, Christopher G. Watson, and Nazia Nawaz, “Sleep Environments and Sleep Physiology,” Journal of Thermal Biology 78, (2018): 192-203, doi: 10.1016/j.jtherbio.2018.09.012. 26, 27. Hobson, Allan J., “REM Sleep and Dreaming: Towards a Theory of Protoconsciousness,” Nature Reviews 10, (2009): 803-813. doi: 10.1038/nrn2716. 28, 31, 32. Nir, Yuval, and Giulio Tononi, “Dreaming and the Brain: From Phenomenology to Neurophysiology,” Trends in Cognitive Sciences 14, no. 2 (2011): 1-25. doi:10.1016/j.tics.2009.12.001. 30. Ichikawa, Jonathan, “Dreaming and Imagination,” Mind & Language 24, no.1 (2009): 103-121, doi: 10.1111/j.1468-0017.2008.01355.x.

How should scientific research and political legislation interact, and what role should they play in public discourse? Climate Change, Vaccines & Lockdowns: How and Why Science Has Become a Polarising Political Debate By Mia Horsfall In light of the compounding climate crisis and the COVID-19 pandemic, the discussion around how we implement scientific research into political realms is growing, and with it, the controversy. But perhaps the debate surrounding such contentious issues reveals more about how we communicate our science than the quality of the science itself. Edited by Yen Sim & Andrew Lim Issue 1: September 24, 2021 Illustration by Janna Dingle The degree to which public rhetoric morphs and formulates enactment of scientific research in topics such as climate change, energy politics and vaccinations has become increasingly evident in recent years, as evidenced by polarising public debates surrounding the COVID-19 pandemic and the ‘School Strike’ movements. The ‘apocalyptic narratives’ employed by climate protesters are often combated with condescension and intellectual elitism propagated by political figures, resulting in a remarkably detached exchange of dialogue and a good deal of reticence but an overwhelming lack of progress. Reluctance to accept COVID-19 vaccinations and lockdowns is indicative more of a dogmatic belief in exertion of liberty at all costs rather than a measured comprehension of the implications of such decisions. Likewise, discussions surrounding implementation of nuclear power showcase the disconnect between scientific research and economic policy making, resulting in conflict and frustration as the two struggle to reconcile. The role of science in political, legal and social spheres is contingent upon public discourses surrounding its relevance and remains largely subservient to public opinion. Scientific matters should increasingly, “be studied in relation to how they impact social structures,” (Holmberg & Alvinius, 2020) and it is in this way we can hope to understand the dimorphic nature of research and its intersection with political and social implications. To understand how scientific discourse shifts from a research-centric discussion to a tool to uphold political ideology, it is crucial to deconstruct the rhetoric utilised by opposing sides of the climate debate to advance support for their cause. Examination of the discourse on different sides of the ‘School Strike’ movement ironically reveals that both sides stem from the same source: an analysis of the authority of youth in political spheres. The succinct, punchy statements used to endorse student climate advocacy relish in the youth of the protesters – “you’ll die of old age, we’ll die of climate change”, “I’d be in school if the earth was cool”, “it’s getting hot in here so take off all your coals,'' (Kamarck, 2019). By focusing the targets of the movement on ‘abstract’ actors such as legal, political and economic ecosystems, the movement distances itself from the accepted scientific consensus and focuses on the issue of the mobilisation of policymakers in climate action. These ‘apocalyptic narratives’ do not question the authority of the science communicated, instead hinging their argument upon the challenge of inciting political change from a youth-driven movement. Their narrative relies on the distinct lack of political influence historically held by youth, and satirises the predicted response of politicians such as the then Federal Minister for Education Dan Tehan who asserted that the strikes were orchestrated by professional activists and children were missing valuable class time (Perinotto & Johnston, 2019). The difficulty then posed is that formulating the protester’s messages from a place of pathos drives the argument further away from the scientifically enforced urgency and enables politically interested individuals to divert the argument from one of scientific claim to one about challenging the authority of youth to speak with regards to politics. Prime Minister Scott Morrison’s suggestion to the school strikers to, “get a bit of context and perspective,” (Perinotto & Johnston, 2019), is saturated not only with elitism but an enforcement of the notion of political superiority, that some knowledge remains incomprehensible to the public sphere and is privy only to the select few. It remains, then, that the biggest obstacle in the school strikers’ position is the unification of scientific authorities, politicians and the emotionally driven and passionate youth. But perhaps the politicisation of climate change has more to do with political dichotomisation than the controversy of the science itself. Chinn, Hart and Soroka assert that, “beliefs about climate change have become a marker of partisan affiliation,” (Chinn, Hart, & Soroka 2020), and this is not the only realm of scientific contention to become politicised. Opposition to government-mandated lockdowns, vaccinations and regulations of genetic modification of food all stem from one crucial point of difference in belief; the degree to which the government should have the ability to regulate everyday happenings of our lives. This is not a new phenomenon. This key difference is at the heart of bipartisanship and is the central debate in almost every political issue. So perhaps the issue is not inherently the politicisation of scientific discourse, as implementation of policy in reference to new scientific findings will inevitably become politicised, but the monotonous rhetoric employed by the left and the right. As Kamarck upholds, “it is the lack of trust in government that may be one of the foundational barriers to effective environmental action,” (Kamarck, 2019). If we take the intent of science as being to seek a degree of objective insight about the nature of the world and its happenings, it will naturally lead to division in political climates saturated by individual motivation and greed. A 2020 American study utilised word frequency analysis software of articles from four major newspapers (New York Times, Chicago Tribune, Los Angeles Times and The Washington Post) to quantitatively determine the number of times scientists’ names were mentioned in regard to phrases such as ‘global warming’ or ‘fracking’, in comparison to politicians (see Figure 1 & 2). Whilst this understandably has to do with matters of climate policy making and does not in and of itself convey an image of the politicised nature of the debate, it does provide significant insight into the shifting obstacles faced in attaining climate action. What provides significantly greater insight is an analysis conducted of the language variance within the media of the parties across the years. From this data, we see that whilst the difference in rhetoric across the two major parties is significant, it is also largely unchanging. It is this divide in political narratives that fosters a sense of distrust and scepticism amongst individuals. Where more left-leaning parties emphasise the social inequalities that will be expounded upon as the consequences of climate change compound, conservatively leaning parties perpetuate the notion that climate action stipulates a greater control of the government on energy politics and enables less agency to the individual. In their narrative, the economic consequences outweigh the benefit of transition to renewable energy systems. From such polarised discourse, it becomes apparent that the way science operates within social spheres has more to do with pre-existing flaws in systemic structures than the quality of the science itself. Figure 1 (2) Figure 2 (2) Of course, a key consideration of how political and activist narratives impact the science that is upheld is through the medialisation of science. ‘Medialisation’ is the concept that science and media should engage in a reciprocal relationship, where scientists use media for broader impact and to advocate for more public funding while the media relies on interest to propagate scientific breakthroughs (Scheufele, 2014). The utility of science comes only from what is accepted and implemented in public opinion, hence scientific practice continues to grow into these frameworks, particularly in discussions around climate change or gene editing technologies. Ultimately, as Scheufele asserts, “the production of reliable knowledge about the natural world has always been a social and political endeavour,” (Scheufele, 2014), one that the media capitalises on to make as economical as possible. That is, it is in most media outlets’ interest to frame politics and science as being at odds with each other as, “coverage increases dramatically if and when issues become engulfed in political or societal controversy,” (Scheufele, 2014). Whilst science cannot and should never be removed from subjugation to moral scrutiny, discourse remains dominated by discussion surrounding the legitimacy of those advocating for one side or the other, rather than the quality of the science itself. Of course bias exists in media outlets , but is propagated by the bias of the consumers, as a consequence of ‘motivated reasoning’. That is, individuals subconsciously place more weight upon information that confirms pre-existing viewpoints and divert more energy into finding flawed reasoning for all that does not concur with preconceived perceptions. The result is a positive feedback loop that is hard to curtail. Individuals form opinions from information they are exposed to in the media, subconsciously seek further information to fortify their initial opinion, leading to opinion reinforcement. In this way, microcosmic ‘mediated realities’ form, each individual inhabiting a vastly different scientific landscape than those of the opposite opinion. In these realities, it is the implications of policy making rather than objective reasoning about the science itself that prevails, resulting in scientific breakthrough perpetually existing subserviently to the opinion of the people, irrespective of whether that opinion is informed. This consequently influences what scientific research is allocated what proportion of public funding, inadvertently providing a quantitative discriminator in what ‘sides’ are upheld in the media. So, what role should science play in political discourse? How do we ensure a mediation of scientific advice and democratic decision making? Darrin Durant of the University of Melbourne unpacks this question, deliberating on whether science should assume a ‘servant’ or ‘partner’ role when it exists within public discourse. Durant argues that if science were to assume the role of a servant (acting in an advisory position to politics), public perception would descend into a degree of populism, overrun by conspiracists and anti-pluralists. Rather, if it were to exist as a ‘partner’, legitimising the authority held by scientific figures, a degree of objectivity could be applied to an otherwise dynamic and transient political landscape. It is only by bridging the political dichotomy that prevails in media and social spheres that scientific discourse will cease to fall prey to political weaponization, existing as a level-ground for rational debate rather than morphing in accordance with ideology. References: Alvinius, A & Holmberg, A. (2020). Children’s protest in relation to the climate emergency: A qualitative study on a new form of resistance promoting political and social change. SAGE Journals. https://journals.sagepub.com/doi/full/10.1177/0907568219879970. Chinn, S., Hart, P., & Soroka, S. (2020). Politicization and Polarization in Climate Change News Content, 1985-2017. SAGE Journals. https://journals.sagepub.com/doi/full/10.1177/1075547019900290. Durant, D. (2018). Servant or partner? The role of expertise and knowledge in democracy. The Conversation.https://theconversation.com/servant-or-partner-the-role-of-expertise-and-knowledge-in-democracy-92026. Durant, D. (2021). Who are you calling 'anti-science'? How science serves social and political agendas. The Conversation. https://theconversation.com/who-are-you-calling-anti-science-how-science-serves-social-and-political-agendas-74755 . Feldman, H. (2020). A rhetorical perspective on youth environmental activism. Jcom.sissa.it. Retrieved 11 September 2021, from https://jcom.sissa.it/sites/default/files/documents/JCOM_1906_2020_C07.pdf . Kamarck, E. (2019). The challenging politics of climate change. Brookings. https://www.brookings.edu/research/the-challenging-politics-of-climate-change/ . Perinotto, T., & Johnston, P. (2019). What our leaders said about the school climate change strike. The Fifth Estate. https://thefifthestate.com.au/urbanism/climate-change-news/what-our-leaders-said-about-the-school-climate-change-strike/ . Scheufele, D. (2014). Science communication as political communication. Pnas.org. https://www.pnas.org/content/pnas/111/Supplement_4/13585.full.pdf. The best climate strike signs from around the globe – in pictures. The Guardian. (2021). https://www.theguardian.com/us-news/gallery/2019/sep/20/the-best-climate-strike-signs-from-around-the-globe-in-pictures . Image reference - https://journals.sagepub.com/doi/full/10.1177/1075547019900290

Have you ever wondered if trees talk to each other? Happily, many scientists across time have had the same thought. So much fascinating knowledge has arisen from their research about the intricacies of trees and the different ways they converse with one another. Chatter Silent Conversations: How Trees Talk to One Another By Lily McCann There are so many conversations that go on beyond our hearing. This column explores communication between trees and how it might change the way we perceive them. Edited by Ethan Newnham, Irene Lee & Niesha Baker Issue 1: September 24, 2021 Illustration by Rachel Ko It’s getting brighter. A long, long winter is receding and warm days are flooding in. I’m not one for sunbathing, but I love to lie in the backyard in the shade of the gums and gaze up into the branches. They seem to revel in the weather as much as I do, waving arms languidly in the light or holding still as if afraid to lose a single ray of sun. If there’s a breeze, you might just be able to hear them whispering to one another. There’s a whole family of these gums in my backyard and each one is different. I can picture them as distinctly as the faces of people I love. One wears a thick, red coat of shaggy bark; another has pale, smooth skin; a third sheds its outer layer in long, stringy filaments that droop like scarves from its limbs. These different forms express distinct personalities. Gum trees make you feel there is more to them than just wood and leaves. There’s a red gum in Central Victoria called the ‘Maternity Tree’. It’s incredible to look at. The huge trunk is hollowed out and forms a sort of alcove or belly, open to the sky. Generations of Dja Dja Wurrung women have sought shelter here when in labour. An arson attack recently blackened the trunk and lower branches, but the tree survived (1). Such trees have incredibly long, rich lives. Imagine all the things they would say, if they could only tell us their stories. Whilst the ‘whispering’ of foliage in the wind may not have significance beyond its symbolism, there are other kinds of communication trees can harness. All we see when a breeze blows are branches and leaves swaying before it, but all the time a plethora of tiny molecules are pouring out from trees into the air. These compounds act like tiny, encrypted messages riding the wind, to be decoded by neighbours. They can carry warnings about unwanted visitors, or even coordinate group projects like flowering, so that trees can bloom in synchrony. If we turn our gaze lower we can see that more dialogue spreads below ground. Trees have their own telephone cable system (7), linking up members of the same and even different species. This system takes the form of fungal networks, which transfer nutrients and signals between trees (3). Unfortunately, subscription to this network isn’t free: fungi demand a sugar supply for their services. Overall, though, the relationship is beneficial to both parties and allows for an effective form of underground communication in forests. These conversations are not restricted to deep-rooted, leaf-bearing beings: trees are multilingual. A whole web of inter-species dialogue murmurs amongst the branches beyond the grasp of our deaf ears. Through the language of scent, trees entice pollinators such as bees and birds to feed on their nectar and spread their pollen (4). They warn predators against attacking by releasing certain chemicals (5). They can even manipulate other species for their own defence: when attacked by wax scale insects, a Persimmon tree calls up its own personal army by alerting ladybugs, who feed on the scales, averting the threat to the tree (6). Such relationships demonstrate the crucial role trees play in local ecosystems and their essentially cooperative natures. Trees can be very altruistic, especially when it comes to family members. Mother trees foster the growth of young ones by providing nutrients, and descendants support their elderly relatives - even corpses of hewn-down trees - through their underground cable systems. These intimate, extensive connections between trees are not so different from our own societal networks. Do trees, too, have communities, family loyalties, friends? Can they express the qualities of love and trust required, in the human world, for such relationships? This thought begs the question: Can trees feel? They certainly have an emotional impact on us. I can sense it as I lie under the gums. Think about the last time you went hiking, sat in a tree’s shade, walked through a local park. There’s something about being amongst trees that calms and inspires. Science agrees: one study has shown that walking in forests is more beneficial to our health than walking through the city. How do trees manage to have such a strong effect on us? Peter Wohlleben, German forester and author of The Hidden Life of Trees, suggests that happy trees may impart their mood to us (9). He compares the atmosphere around ‘unhappy’ trees in plantations where threats abound and stress signals fill the air to old forests where ecosystem relations are more stabilised and trees healthier. We feel more relaxed and content in these latter environments. The emotive capacity of trees is yet to be proven scientifically, but is it a reasonable claim? If we define happiness as the circulation of ‘good’ molecules such as growth hormones and sugars, and the absence of ‘bad’ ones like distress signals, then we may suggest that for trees an abundance of good cues and a lack of warnings could be associated with a positive state. And this positive state - allowing trees to fulfill day-to-day functions, grow and proliferate, live in harmony with their environment - could be termed a kind of happiness in its own right. This may seem like a stretch - after all, how can you feel happiness without a brain? But Baluska et al. suggest that trees have those too, or something like them: command centres, integrative hubs in roots functioning somewhat like our own brains (10). Others compare a tree to an axon, a single nerve, conducting electrical signals along its length (11). Perhaps we could say that a forest, the aggregate of all these nerve connections, is a brain. Whilst we can draw endless analogies between the two, trees and animals parted ways 1.5 billion years ago in their evolutionary paths (12). Each developed their own ways of listening and responding to their environments. Who’s to say whether they haven’t both developed their own kinds of consciousness? If we take the time to contemplate trees, we can see that they are infinitely more complex and sensitive than we could have imagined. They have their own modes of communicating with and reacting to their environment. The fact is, trees are storytellers. They send out a constant flow of information into the air, the soil, and the root and fungal systems that join them to their community. Even if we can’t converse with trees in the same way that we converse with each other, it’s worth listening in on their chatter. They could tell us about changes in climate, threats to their environment, and how we can best help these graceful beings and the world around them. References: 1. Schubert, Shannon. “700yo Aboriginal Maternity Tree Set Alight in Victoria.” www.abc.net.au , August 8, 2021. https://www.abc.net.au/news/2021-08-08/dja-dja-wurrung-birthing-tree-set-on-fire/100359690. 2. Pichersky, Eran, and Jonathan Gershenzon. “The Formation and Function of Plant Volatiles: Perfumes for Pollinator Attraction and Defense.” Current Opinion in Plant Biology 5, no. 3 (June 2002): 237–43. https://doi.org/10.1016/s1369-5266(02)00251-0.; Falik, Omer, Ishay Hoffmann, and Ariel Novoplansky. “Say It with Flowers.” Plant Signaling & Behavior 9, no. 4 (March 5, 2014): e28258. https://doi.org/10.4161/psb.28258. 3. Simard, Suzanne W., David A. Perry, Melanie D. Jones, David D. Myrold, Daniel M. Durall, and Randy Molina. “Net Transfer of Carbon between Ectomycorrhizal Tree Species in the Field.” Nature 388, no. 6642 (August 1997): 579–82. https://doi.org/10.1038/41557. 4. Buchmann, Stephen L, and Gary Paul Nabhan. The Forgotten Pollinators. Editorial: Washington, D.C.: Island Press/Shearwater Books, 1997. 5. De Moraes, Consuelo M., Mark C. Mescher, and James H. Tumlinson. “Caterpillar-Induced Nocturnal Plant Volatiles Repel Conspecific Females.” Nature 410, no. 6828 (March 2001): 577–80. https://doi.org/10.1038/35069058. 6. Zhang, Yanfeng, Yingping Xie, Jiaoliang Xue, Guoliang Peng, and Xu Wang. “Effect of Volatile Emissions, Especially -Pinene, from Persimmon Trees Infested by Japanese Wax Scales or Treated with Methyl Jasmonate on Recruitment of Ladybeetle Predators.” Environmental Entomology 38, no. 5 (October 1, 2009): 1439–45. https://doi.org/10.1603/022.038.0512. 7, 9. Wohlleben, Peter, Jane Billinghurst, Tim F Flannery, Suzanne W Simard, and David Suzuki Institute. The Hidden Life of Trees : The Illustrated Edition. Vancouver ; Berkeley: David Suzuki Institute, 2018. 10. Baluška, František, Stefano Mancuso, Dieter Volkmann, and Peter Barlow. “The ‘Root-Brain’ Hypothesis of Charles and Francis Darwin.” Plant Signaling & Behavior 4, no. 12 (December 2009): 1121–27. https://doi.org/10.4161/psb.4.12.10574. 11. Hedrich, Rainer, Vicenta Salvador-Recatalà, and Ingo Dreyer. “Electrical Wiring and Long-Distance Plant Communication.” Trends in Plant Science 21, no. 5 (May 2016): 376–87. https://doi.org/10.1016/j.tplants.2016.01.016. 12. Wang, Daniel Y.-C., Sudhir Kumar, and S. Blair Hedges. “Divergence Time Estimates for the Early History of Animal Phyla and the Origin of Plants, Animals and Fungi.” Proceedings of the Royal Society of London. Series B: Biological Sciences 266, no. 1415 (January 22, 1999): 163–71. https://doi.org/10.1098/rspb.1999.0617.

< Back to Issue 2 Maxing the Vax: why some countries are losing the COVID vaccination race As Australia’s COVID vaccination rate reaches 90% for the adult population, are you aware of countries struggling with their vaccination program? This piece discusses three countries, Brazil, Papua New Guinea, and India, and the key challenges they face in increasing their vaccination rate. by Grace Law 10 December 2021 Edited by Neisha Baker Illustrated by Aisyah Mohammad Sulhanuddin Most Australians are now fully vaccinated against COVID-19, but are you aware of how other countries are handling their vaccination programs? Each country has its own set of challenges and setbacks it must overcome in getting its citizens vaccinated. The success and failure of vaccination programs depend on how well these are addressed, and how the people respond. Political, economic, geographical, and educational factors can have a huge impact on vaccination success. Below, I will discuss the key challenges affecting COVID-19 vaccination in three countries, Brazil, Papua New Guinea, and India, as well as its impact on the country’s vaccination rate. Brazil – the nation that changed their fate Brazil has suffered the highest overall death toll in Latin America which is also the second-highest in the world after the United States. Brazil’s President Jair Bolsonaro was strongly opposed to lockdowns, restrictions, and public-health measures such as masks, which some local areas sought to impose (1). He has also spread disinformation regarding the coronavirus and vaccines, such as posting a video falsely associating the coronavirus vaccines with the onset of AIDS, resulting in Facebook removing it after public outcry (2). As a leader, his words and actions have major roles in influencing opinion and informing the public. While the number of preventable deaths is shocking, the predicted wave of destruction by the Delta variant has not materialised. Over 60% of the population is fully vaccinated despite the mixed messages and deterrence from the central government (3). The city of Serrana became the testing site of the Chinese vaccine Sinovac with most adults being willing towards receiving the vaccine (4). Consequently, the symptomatic cases, hospitalisation and deaths in the area all fell dramatically, becoming a place of envy for the neighbouring communities (5). This initial success also offers hope for low and middle-income countries, which may rely on this cheaper vaccine (6). Despite governmental resistance throughout the pandemic, Brazilians have defied the odds and faced the virus as a united community. Local leaders have challenged the national government to ensure suitable public health orders are enforced, and citizens have actively sought vaccination, preventing further COVID-19 devastation. Papua New Guinea – our struggling neighbour One of Australia’s closest neighbours, Papua New Guinea (PNG), is among the countries with the lowest vaccination rate in the world. According to Our World in Data, only 2% of the population is fully vaccinated (7). One of the most difficult issues to address is mistrust in the vaccine, due to low health education, inadequate health and general resources, and a political and historical distrust in the government. PNG relies on Australia and New Zealand’s AstraZeneca donations to acquire COVID vaccines, as well as Australian embassy staff to help run pop-up clinics in shopping centres. A Chinese medical team has also been working outside the government to unofficially administer the Sinopharm vaccine at a hospital clinic, leading to speculations of politically-motivated manipulation and interference (8). PNG is caught between two great powers, and the already sceptical PNG people are neglected and uninformed about vaccine efficacy, safety, and choices (9). Low science literacy and mistrust in political institutions have made it extremely difficult to convince people to get vaccinated (10). This has furthered the development of conspiracy theories, which interplay with cultural beliefs around witchcraft and superstitions (11). Despite the recent introduction of the “no jab, no job” policy, people are turning to mass resignations or the acquisition of fraudulent certificates instead of receiving the COVID-19 vaccine (12). Australia recently offered aviation lift services to high priority provinces, delivering much-needed emergency supplies to geographically isolated areas in PNG (13). A lot of work is still needed in order to increase the vaccination uptake rate in PNG. Stronger and more impactful campaign messaging will be required to increase public demand for vaccines (14). Foreign aid and assistance should prioritise effective vaccination and long-term health improvement over political agenda (15). The priority must be to stop the pandemic devastation by getting people vaccinated, and addressing long-term infrastructure, funding, and governance issues. India – great challenges and great ambitions India has the second-largest population in the world and it has struggled to source an adequate number of vaccines for its people. The government was ambitious that local manufacturing of the Indian vaccine Covaxin would be sufficient for domestic consumption. Instead, Bharat Biotech’s newest facility in Bengaluru reports quality issues in its initial batches, leading to a delay and vaccine shortage (16). During the country’s destructive second wave from April to June of 2021, the vaccine shortage was exacerbated by the government hesitating to approve vaccines developed and manufactured overseas. Local supply was also hindered by raw material shortages at the beginning of 2021 (17). While the government has sought higher vaccine administrations, setbacks including delays in manufacture, lack of doses received from overseas, and difficulties in obtaining regulatory approval, have contributed to the delayed and restricted nature of the vaccination program. Initially, the people met the vaccination program with great enthusiasm, and the government aimed to vaccinate all adults against COVID-19 by 31 December 2021. But vaccine uptake has plateaued and declined since October, and there are fears this target will not be met. Many factors have contributed to the decreased vaccine uptake, including vaccine shortage, barriers to vaccination such as lockdowns, high infection rates causing fear of visiting vaccination centres, and misinformation particularly in under-resourced rural areas (18). Although an improved COVID-19 vaccination program could have reduced the severity of the second wave, attention now is on maintaining the vaccination uptake rate. As the Indian government started to offer free vaccinations to all adults, citizens living in poverty have had the chance to be vaccinated as well. While many countries wish to manufacture their own vaccines at a fraction of the cost of the pharmaceutical giants, quality control and quality assurance remain incredibly complex issues to tackle (19). Lower-income countries require sufficient guidance and support, and Shahid Jameel, a virologist from Ashoka University in New Delhi says, ‘We can’t fix vaccine inequalities until vaccine manufacturing is distributed.’ (20) Conclusion Numerous factors impact vaccine uptake, with each country facing its own set of challenges. Mismanagement, limited infrastructure, and rampant misinformation were highlighted here, but there are many problems impacting vaccination programs around the world. Urgently addressing these problems will be needed to reduce vaccination inequality around the world, and hopefully, reach the end of the pandemic very soon. For more information on COVID-19 and the vaccine, please visit the VaxFACTS website created by the University of Melbourne: https://www.vaxfacts.org.au/ References Jake Horton, “Covid Brazil: Why could Bolsonaro face charges?” BBC News, published 27 October, 2021, https://www.bbc.com/news/world-latin-america-56663217. “Facebook removes video in which Brazil’s Bolsonaro links coronavirus vaccines with AIDS,” Washington Post, published 25 October, 2021, https://www.washingtonpost.com/technology/2021/10/25/facebook-papers-live-updates/#link-UA7IQVP5E5D2VGUQX7OJQBCFIE. “Coronavirus (COVID-19) Vaccinations,” Our World in Data, published 26 November, 2021, https://ourworldindata.org/covid-vaccinations?country=OWID_WRL. Mauricio Savarese, “Sinovac vaccine restores a Brazilian city to near normal,” Associated Press News, published 2 June, 2021, https://apnews.com/article/caribbean-brazil-coronavirus-pandemic-business-health-20bd94d28ac7b373d7a8f3f9c557e5b6. “Sinovac vaccine restores a Brazilian city to near normal.” “Sinovac vaccine restores a Brazilian city to near normal.” “Coronavirus (COVID-19) Vaccinations.” Natalie Whiting, “PNG caught in China-Australia power play as COVID-19 Delta variant infiltrates Pacific nation,” ABC News, published 2 August, 2021, https://www.abc.net.au/news/2021-08-02/png-caught-between-australia-and-china-as-it-fights-delta/100329206. “PNG caught in China-Australia power play as COVID-19 Delta variant infiltrates Pacific nation.” Mihai Sora, “Overcoming community resistance to vaccination in Papua New Guinea,” The Interpreter, published 26 October, 2021, https://www.lowyinstitute.org/the-interpreter/overcoming-community-resistance-vaccination-papua-new-guinea. Liam Fox and Marian Faa, “Health workers face death threats as COVID-19 vaccine hesitancy takes hold in PNG,” ABC News, published 10 September, 2021, https://www.abc.net.au/news/2021-09-10/png-vaccine-hesitancy-papua-new-guinea-covid-19/100444380. Fraser Macdonald, “Just 1.7 per cent of PNG residents are vaccinated against COVID. Why are they so resistant?” SBS News, published 8 November, 2021, https://www.sbs.com.au/news/just-1-7-per-cent-of-png-residents-are-vaccinated-against-covid-why-are-they-so-resistant/72c40029-dec8-4202-b436-31562d983fbc. “COVID-19 partnership with Papua New Guinea strengthened” Minister for Foreign Affairs, published 27 October, 2021, https://www.foreignminister.gov.au/minister/marise-payne/media-release/covid-19-partnership-papua-new-guinea-strengthened. “Overcoming community resistance to vaccination in Papua New Guinea.” “Overcoming community resistance to vaccination in Papua New Guinea.” Sreenivasan Jain, “Quality Issues Behind Covaxin Shortage: Government vaccine panel chief,” New Delhi Television, published 2 August, 2021, https://www.ndtv.com/india-news/quality-issues-behind-covaxin-shortage-government-vaccine-panel-chief-2500998. Shruti Menon, “India vaccination: Does it have enough doses for all adults?” BBC News, published 3 August, 2021, https://www.bbc.com/news/world-asia-india-55571793. Liji Thomas, “Factors predicrting vaccine hesitancy in India,” News Medical, published 26 September, 2021, https://www.news-medical.net/news/20210926/Factors-predicting-vaccine-hesitancy-in-India.aspx. Amy Maxmen, “The fight to manufacture COVID vaccine in lower-income countries,” Nature, published 16 September, 2021, https://www.nature.com/articles/d41586-021-02383-z. “The fight to manufacture COVID vaccine in lower-income countries.” Previous article back to DISORDER Next article

< Back to Print Editions Print Edition 3: Issue 7, 8 and 9 2024/2025 ABOUT THIS EDITION OmniSci Magazine is driven by an ardent community of not solely scientists, but writers, artists, innovators and beyond; all who are united by their passion for science communication. Integrating interdisciplinary expertise, contributors seek to engage fellow students and the general public in scientific discussions. To spark such a discourse is to celebrate the beauty and dissonance embedded in science, holding space for disagreement and paving a path forward towards discovery. The creation of Issue 7: Apex , Issue 8: Enigma and Issue 9: Entwined over 2024 and 2025 has seen contributors create ever more thoughtful, informative and intriguing content, aiming to make the innovations of science readily accessible, yet duly nuanced to the public. With diverse written and visual formats, our contributors have formed a body of work that seeks to captivate and question. We are extremely proud to share this collection and hope that whether you leave with one more question answered or one more curiosity sparked, we have succeeded in our aims. FEATURED ISSUES Issue 7: Apex This issue surveys our world from above. So come along, and revel in the expansive view. Issue 8: Enigma This issue unspools the long-hidden threads in science. Come make sense of the puzzles and mysteries with us! Or perhaps, leave just as addled. Issue 9: Entwined This issue takes a moment to revel in the science that surrounds us. Come walk the tangled paths less followed, who knows what you may come across! PURCHASE A COPY Keen to purchase a copy of the magazine? Click here to do so, at an OmniSci Magazine exclusive price! Alternatively, visit the Science Gallery Melbourne to find our magazines stocked in person. back to print editions

< Back to Issue 10 Shining Light on the Grey by Ingrid Sefton, Kara Miwa-Dale and Anabelle Dewi Saraswati 2 June 2026 Illustrated by Anabelle Dewi Saraswati Edited by the Editor-in-Chiefs Truth: from that with a little t, to the just out of reach capital T “Truth”. We seek it, we declare it, we believe in it. An innate drive towards answers, embedded in the human process of scientific exploration. Our notions of fact and fiction often feel like black and white binaries with clear boundaries; easily distinguishable, one or the other. Consider an alternative. That science, as in life, is a chiaroscuro of fact and fiction. Shades of light and shadow, which contrast truths and contradictions in order to point us to a clearer, but never fully transparent view of reality. Our scientific methods help us whittle away outright lies, and approach a closer approximation to that of fact than one of fiction. Yet, undeniably, there remains frustratingly little we can say with utmost certainty. History is littered with reminders of how fragile “truth” can be. There was a time when illness was understood as a delicate imbalance of blood, phlegm, black bile and yellow bile. At one point, continents were assumed to be fixed and unmoving, until tectonic plates revealed a restless Earth in constant motion. It is precisely by interrogating these once-settled “facts” that science advanced — not in straight lines, but through disruption, revision, and occasional collapse. And still, there are questions we orbit but have not yet landed on. What exactly is dark matter, which seems to hold galaxies together while refusing to reveal itself? How does consciousness emerge from the quiet electrical choreography of neurons? In these spaces, science is not a catalogue of answers, but a map of known unknowns. A lack of absolutes does not negate the power of science – far from it. Indeed, this is a large part of what drives us to become ever more inquisitive, innovative and critically questioning of the scientific landscape. Ideas once accepted as unquestionable truths can be later overturned through science, just as concepts once dismissed as fantasy may eventually become reality. May this issue urge you to pause, to consider the myriad of grey space that exists in between as you traverse the boundaries of truth, certainty and fabrication. Where does one end, and another begin? A word from the Cover Illustrator Anabelle For this issue’s cover illustration, I was inspired by the history and strange patterns of crop circles. These vast, intricate formations pressed into fields that sit somewhere between scientific curiosity, mass hysteria, art, and folklore; the perfect visual encapsulation for this issue’s theme, Fact and Fiction. Cropping up throughout the late 70s to 80s, they became a cultural phenomenon tied to UFO sightings, conspiracy theories, extraterrestrial speculation, and pseudoscientific fascination. Conceptually, crop circles simultaneously exist as a hoax, artwork, scientific anomaly, and collective myth, depending on the observer. I approached the illustration through a lens of nostalgia, imagining it as the cover of a forgotten children’s mystery book you could stumble upon in an op-shop dating all the way back to the 80s or 90s; sun-faded, slightly eerie, but playful in its wonder. The Midwest-inspired rural scene allowed me to lean into that atmosphere of a quiet blue hour mystery that surrounded alien encounters and paranormal media in the late twentieth century, when crop circles occupied such a strange and persistent place in the pop culture zeitgeist. The beauty in crop formations lies in their underlying precision. Many are built off fractal geometry and repeating mathematical systems, and naturally occurring patterns found throughout science and nature. Even as objects associated with fiction and conspiracy, they are deeply rooted in structure, mathematics, and design. Crop circles are carefully designed spectacles intended to provoke interpretation. Whether read as evidence, artwork, prank, or myth, they reveal how deeply humans want to believe in stories larger than themselves. The cover became less about proving whether something is real or fabricated, and more about exploring the fragile, fascinating space in between. Previous article back to Fact & Fiction Next article

Issue 7: Apex 22 October 2024 This issue surveys our world from above. So come along, and revel in the expansive view - have a read below! Editorial Peaks and Perspectives: A Word from the Editors-in-Chief by the Editors-in-Chief A word from our Editors-in-Chief. Corals A Coral’s Story: From thriving reef to desolation by Nicola Zuzek-Mayer Nicola sheds light on the devastating future faced by our coral reefs, with the effects of anthropogenic climate change far from having reached its peak. Seeing Space Interstellar Overdrive: Secrets of our Distant Universe by Sarah Ibrahimi Embark on an epic journey as Sarah explores the cosmic mysterious being revealed by NASA's James Webb Space Teloscope. Fossil Markets Fossil Markets: Under the Gavel, Under Scrutiny by Jesse Allen Diving into the wild world of fossil auctions, Jesse prompts us to ask: who is the real apex predator, the T-rex or hedge-fund billionaires? Cancer Treatments Tip of the Iceberg: An Overview of Cancer Treatment Breakthroughs by Arwen Nguyen-Ngo Icebreakers. Follow Arwen as she recounts the countless stories of the giants before us, who carved a path for our cancer research today. Triangles Pointing the Way: A Triangular View of the World by Ingrid Sefton Guiding us through land, seas and screens, Ingrid explores this humble 3-sided shape as a vital tool of modern society and its many fascinating uses. Anti-ageing Science Timeless Titans: Billionaires defying death by Holly McNaughton From billionaire-backed pills to young blood transfusion, Holly traverses the futuristic world of anti-ageing and asks: what happens when death is no longer inevitable? Brain-computer Implants Neuralink: Mind Over Matter? by Kara Miwa-Dale Would the ability to control a computer with your mind bolster possibilities or bring harm? Kara visualises a possible future under the Neuralink implant. Fish Morphology Designing the perfect fish by Andy Shin With a splash of creativity, Andy concocts the ultimate 'Frankenfish' by investigating the traits that allow fish to flourish in their aquatic environments. Commercial Aviation Soaring Heights: An Ode to the Airliner by Aisyah Mohammad Sulhanuddin Settle in and take a round trip with Aisyah through the evolution of commercial aviation, from the secrets of aircraft cuisine to the mechanics of staying afloat.

< Back to Issue 8 In Your Dreams: Unpacking the Stories of Your Slumber by Ciara Dahl 3 June 2025 Edited by Ingrid Sefton Illustrated by Saraf Ishmam One minute you're flying through the sky, the next, you're naked in a room full of people. Except now, your teeth have started falling out? These surreal, and often illogical, experiences are what make dreams such a mystery. From ancient spiritual interpretations to modern neuroscience, people have long wondered not just what dreams mean , but why we have them at all. Are they cryptic messages from the unconscious? Perhaps a side effect of memory processing? Or maybe they are simply the brain’s way of entertaining itself while we sleep. Attempting to answer these questions is no easy feat. Despite being a universal human experience, dreams are inherently personal. Given no one but ourselves experiences our dreams, how can the fragmented recollections we have upon waking be objectively studied? Dream research was once steeped in spirituality and mysticism, often seen as divine messages from gods or whispered guidance from ancestors (1). Even Aristotle offered his own theory, suggesting dreams were the byproduct of internal bodily movements during sleep (1). It wasn’t until the early 20th century that dreams began to be studied through a psychological lens, most notably by Sigmund Freud, who proposed that dreams contained deeply personal and symbolic insights into the unconscious mind (2). Modern research, however, is beginning to uncover the connection between our dreams and complex cognitive processes such as memory consolidation. Techniques employed by oneirologists — that’s the fancy word for scientists specialising in the scientific study of dreams — includes fMRI, PET scans and EEG. Such methods are used to study brain activity during sleep and dreaming, particularly during REM and non-REM sleep (3). Using these technologies in tandem with qualitative descriptions gathered from individuals’ dream reports allows us to unpack the content and function of our dreams, whilst also considering questions such as why we seem to forget most of our dreams. What dreams are made of: influences on the content of our dreams There’s a growing body of evidence to suggest that our dream content is influenced by the consolidation of our memories as we sleep. Sleep provides an ideal neurological state for us to organise our recent memories into more long term memories (4). The reactivation and subsequent consolidation of memories in the sleeping brain appears to contribute to the content of dreams we recall upon awakening. In one study examining this phenomena, participants played extensive amounts of Tetris prior to sleeping. In the subsequent dream report collection, over 60% of participants cited seeing Tetris images in their dreams (5). This illustrates how the boundaries between waking and dreaming cognition are more porous than they appear, with dream content itself serving as a window into the neural mechanisms of memory consolidation. Not all dreaming can be directly tied to our most recent memories, but all dreams are built upon our prior experiences. For example, the appearance of recognisable friends or foes in our dreams in turn relies on our ability to recall their features and mannerisms (6). The bizarre patchwork of familiar situations we encounter in our dreams is also likely a reflection of the adaptive process of memory consolidation, as fragments of our memories are integrated during sleep. The Night Shift — what is the purpose of dreams We may be inching closer to understanding what influences the content of our dreams, but why do we dream in the first place? The Threat Simulation Theory (TST) argues that dreams act as an ancient biological defence mechanism, allowing us to simulate threatening events we may encounter in our waking life (7). TST suggests that on an evolutionary scale, being able to simulate threatening events in our sleep allows us to efficiently perceive and avoid threats whilst awake, leading to greater survival and reproductive success. It is a bit hard to imagine, however, that dreaming about being naked in public is going to be the key to our survival. This is why some scientists suggest that dreams are simply the brain’s attempt to make sense of random neural activity during REM sleep. This Activation-Synthesis Theory proposes that rather than rehearsing for real-life threats, our brains may just be firing off chaotic signals which it then tries to weave into bizarre and often disjointed stories (8). Whether dreams serve as a survival tool or are simply the byproduct of random brain activity, they offer a window into the complex workings of the sleeping mind. Vanishing Visions and the Concept of Dream Amnesia Have you ever woken up from such an absurd dream it seems impossible to forget, only to have forgotten the details by the end of breakfast? That’s what the experts call “dream amnesia”. It’s estimated that the average person dreams four to six times per night, yet you’d be lucky to remember even one of them by morning (6). At the molecular level, noradrenaline — a neurotransmitter associated with memory consolidation — is at its lowest concentrations while we sleep (9). This depletion could be a key factor contributing to dream amnesia, preventing the transfer of our dream experiences from short-term memory to long-term memory. Different sleep stages may also influence dream recall (6). It has been suggested that waking up during or just after REM sleep leads to more vivid dreams. In contrast, dream activity is low during non-REM sleep and hence, waking up during this sleep phase may also contribute to our poor dream recall. Although it can be disappointing to forget these wild dream experiences, dream amnesia may also serve an adaptive purpose. The “clean slate” hypothesis argues that forgetting dreams allows us to wake with a clear mind, free of the potentially disturbing content of our dreams (10). Alternatively, by maintaining a clear distinction between our dreaming and waking experiences, we are protected from confusing our dreams with reality, preventing anxiety that may otherwise ensue (11). Perhaps this forgetfulness may not be a flaw in our memory but a feature of it, helping us to preserve our mental clarity and emotional balance as we transition from the surreal world of our dreams to the demands of our waking life. In conclusion We may never fully unlock the secrets of our nightly adventures, but one thing is clear: dreams are a fascinating blend of memory, biology, and mystery. Whether they're ancient survival simulations, emotional clean-ups, or just the brain’s quirky way of entertaining itself while the lights are off, dreams remind us how wonderfully weird and complex the human mind truly is. Next time you find yourself tap dancing with Beyoncé or riding a roller coaster made of spaghetti, just enjoy the ride. Your brain is simply doing what it does best — keeping things entertaining, even in your sleep. References Palagini L, Rosenlicht N. Sleep, dreaming, and mental health: A review of historical and neurobiological perspectives. Sleep Medicine Reviews. 2011 Jun;15(3):179–86. Freud S. The Interpretation of Dreams [Internet]. 1900. Available from: https://psychclassics.yorku.ca/Freud/Dreams/dreams.pdf Ruby PM. Experimental Research on Dreaming: State of the Art and Neuropsychoanalytic Perspectives. Frontiers in Psychology [Internet]. 2011 Nov 18;2(286). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220269/#B107 Wamsley EJ. Dreaming and offline memory consolidation. Current Neurology and Neuroscience Reports [Internet]. 2014 Jan 30;14(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704085/ Stickgold R. Replaying the Game: Hypnagogic Images in Normals and Amnesics. Science. 2000 Oct 13;290(5490):350–3. Nir Y, Tononi G. Dreaming and the brain: from phenomenology to neurophysiology. Trends in Cognitive Sciences [Internet]. 2010 Jan 14;14(2):88–100. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814941/ Revonsuo A. The reinterpretation of dreams: An evolutionary hypothesis of the function of dreaming. Behavioral and Brain Sciences [Internet]. 2000 Dec;23(6):877–901. Available from: https://pubmed.ncbi.nlm.nih.gov/11515147/ Hobson JA, McCarley RW. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. The American journal of psychiatry [Internet]. 1977 [cited 2019 Nov 14];134(12):1335–48. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21570 Mitchell HA, Weinshenker D. Good night and good luck: Norepinephrine in sleep pharmacology. Biochemical Pharmacology. 2010 Mar;79(6):801–9. Eugene AR, Masiak J. The Neuroprotective Aspects of Sleep. MEDtube science [Internet]. 2015 Mar;3(1):35. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4651462/ Zhao J, Schoch SF, Valli K, Dresler M. Dream function and dream amnesia: dissolution of an apparent paradox. Neuroscience and Biobehavioral Reviews. 2024 Nov 20;167. Previous article Next article Enigma back to

< Back to Issue 2 Making sense of the senses: The 2021 Nobel Prize in Physiology or Medicine What do spicy food, menthol lozenges and walking around blindfolded have in common? They all activate protein receptors discovered by Professors David Julius and Ardem Patapoutian, the winners of the 2021 Nobel Prize in Physiology or Medicine. by Dominika Pasztetnik 10 December 2021 Edited by Breana Galea & Juulke Castelijn Illustrated by Casey Boswell Stimuli are changes to our environment, such as heat, cold and touch, that we recognise through our senses. We are all constantly bombarded with thousands of these stimuli from our surroundings. Despite this disorder, we are somehow able to perceive and make sense of the world. The protein receptors discovered by Professors Julius and Patapoutian make this possible. Located at the surface of the nerve cell, these receptors convert an external stimulus to an electrical signal. This signal then travels along nerve cells to the brain, allowing us to sense the stimulus. Based in California, Julius and Patapoutian are scientists in the fields of neuroscience and molecular biology. The main interest of their work has been identifying and understanding the protein receptors involved in detecting stimuli. For Julius, his major focus has been to identify the receptors involved in the sensation of pain (1). For Patapoutian, it has been to identify the protein receptors involved in detecting mechanical stimuli, such as touch (2). For their past 25 years of research, Julius and Patapoutian were awarded the Nobel Prize in Physiology or Medicine in October 2021. The Nobel Prize was founded by Alfred Nobel, a Swedish scientist also famous for inventing dynamite. Prior to his death in 1896, Nobel allocated most of his money to the first Nobel Prizes. Since 1901, the Nobel Prize has been annually bestowed on those who, in Nobel’s words, have “conferred the greatest benefit to mankind” in different fields (3). Notable past laureates of the Nobel Prize in Physiology or Medicine include Sir Alexander Fleming, Sir Ernst Chain and the Australian Howard Florey. They were awarded in 1945 for their discovery of the antibiotic penicillin (4). Sir Hans Krebs received the Nobel Prize in 1953 for his discovery of the citric acid cycle (5). Also known as the Krebs cycle, it is a series of reactions used to produce energy in our cells. TRPV1: spice it up It’s a rather chilly morning. You eye the packet of Shin Ramyun that’s been sitting in your pantry for weeks. Without a second thought, you prepare the noodles, adding all the soup powder. After a few mouthfuls, your eyes start streaming and your face matches the scarlet red of the now-empty packaging. The culprit is capsaicin, a substance in the chilli flakes added to the soup powder. It binds to a protein receptor embedded at the surface of the nerve cells in your mouth. Julius discovered this receptor in 1997, and called it TRPV1, which stands for transient receptor potential vanilloid type 1 (6). TRPV1 is a channel with a gate at either end that is usually closed (Figure 1, blue) (7). Capsaicin opens these gates, allowing ions, such as calcium, to move through TRPV1 and into the nerve cell (Figure 1, red). The nerve cell then signals to the brain, causing you to feel the searing heat in your mouth. TRPV1 is also found in your skin and can be activated by temperatures above 40°C, such as when you accidentally touch the kettle full of boiling water for your noodles (8). Figure 1. TRPV1 at the surface of a nerve cell. In the absence of capsaicin or at cool temperatures, TRPV1 is closed (blue). In the presence of capsaicin or at higher temperatures, TRPV1 opens, allowing ions to flow into the nerve cell (red). TRPM8: too cool for school On your way to uni, you notice your throat’s a bit sore from going overboard with karaoke the night before, so you pop a lozenge into your mouth. The soothing, cool sensation is thanks to menthol. It is a compound that binds to TRPM8, which stands for transient receptor potential melastatin 8. It is another receptor found on the nerve cells in your tongue, as well as on your skin (9). TRPM8 was separately discovered in 2002 by both Julius and Patapoutian (10). Like TRPV1, TRPM8 is a protein channel that is usually closed. In response to menthol or cool temperatures from 26 down to 8°C, TRPM8 opens and allows ions to enter the nerve cell, which then signals the cold sensation to your brain (11). PIEZO: peer pressure During your lunch break at uni, you and your mates decide to play blindfolded tag. Because, as we all know, that's what uni students do in their free time. In the first round, you have the misfortune of being chosen as ‘it’. Blindfolded, you walk around with your hands in front of you, trying to find your mates. Despite not being able to see anything, you can still walk and wave your arms and roughly know where your arms and legs are in space. This is due to a sense called proprioception. You lunge forward and nearly grab someone, only to feel their jacket brush your fingers. Both proprioception and the detection of light touch, such as of the jacket brushing your fingers, are made possible by another class of protein receptors called PIEZO2. Discovered by Patapoutian in 2010, its name comes from piesi, the Greek word for pressure (12). Like TRPV1 and TRPM8, PIEZO2 is an ion channel at the nerve cell surface. However, the structure of PIEZO2 is nothing like that of TRPV1 and TRPM8. PIEZO2 has three protruding blades, which form a dent, called a nano-bowl, in the outer surface of the cell (13). When the outside of the cell is prodded, the blades straighten and the nano-bowl flattens. This allows the channel in the centre of the PIEZO2 to open, so ions can flow into the nerve cell (Figure 2). The nerve cell then sends an electrical impulse to the brain, letting you know you’re failing at blindfolded tag. Figure 2. PIEZO at the surface of a nerve cell. When force is applied to the surface of the nerve cell, the PIEZO channel opens, allowing ions to move into the cell. Apart from being essential for playing blindfolded tag, PIEZO2 is also important in various other aspects of the human body’s functioning we often take for granted. For example, PIEZO2 prevents you from breathing in too much air (14). It is also present on the cells lining your digestive tract. PIEZO2 detects pressure exerted onto these cells by food, causing the cells to release hormones that help with digestion (15). Furthermore, PIEZO2 helps monitor the fullness of your bladder, saving you from embarrassment (16). If there is a PIEZO2, what about PIEZO1? Although it has a similar structure to PIEZO2, PIEZO1’s role is quite different. PIEZO1 handles the background maintenance required to keep your body healthy. This includes bone formation (17) and preventing your red blood cells from bursting (18). People with a particular mutated form of PIEZO1 have a reduced risk of getting malaria (19). Patapoutian found that this mutation causes red blood cells to shrivel, preventing the malaria parasite from infecting them. Many people living in malaria-affected areas, such as Africa, have this mutation. Therefore, knowledge regarding these receptors is improving our understanding of related diseases. Drug development Researchers are currently using information about the receptors discovered by Julius and Patapoutian to develop new drugs to treat various conditions. Knowing the identities and structures of these receptors is helping researchers design compounds that bind to them, either blocking or activating them. In this way, Julius and Patapoutian’s work is helping provide a “benefit to mankind”. For example, during a migraine, the TRPV1 channel opens more frequently in the nerve cells of the meninges, the envelope surrounding the brain (20). These nerve cells contain more TRPV1 at their surfaces. This causes the nerve cells to send more electrical signals to the brain and so increases the sensation of pain. Using a drug to block the TRPV1 receptor could reduce the number of these electrical impulses and lessen the pain associated with migraines. It’s been a busy day activating all these receptors, which, as it turns out, are part of your daily life as a uni student. So next time you eat chilli flakes, have a menthol lozenge or play blindfolded tag, you will know which tiny sensors to hold responsible for your pleasant — or unpleasant — experiences. Further reading Press release: The Nobel Prize in Physiology or Medicine 2021 The Nobel Prize in Physiology or Medicine 2021 - Advanced Information References: University of California San Francisco. “Biography of David Julius.” UCSF. Accessed November 10, 2021. https://www.ucsf.edu/news/2021/09/421486/biography-david-julius. Nobel Prize Outreach AB 2021. “Press release: The Nobel Prize in Physiology or Medicine 2021.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/press-release/. Nobel Prize Outreach AB 2021. "Alfred Nobel’s will." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/alfred-nobel/alfred-nobels-will/. Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1945.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1945/summary/ Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1953.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1953/summary/ Ernfors, Patrik, Abdel El Manira, and Per Svenningsson. "Advanced information." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/advanced-information/. Liao, M., E. Cao, D. Julius, and Y. Cheng. "Structure of the Trpv1 Ion Channel Determined by Electron Cryo-Microscopy." Nature 504, no. 7478 (Dec 5 2013): 107-12. doi: 10.1038/nature12822. Ernfors et al., “Advanced information.” McKemy, D. D. "Trpm8: The Cold and Menthol Receptor." In Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades, edited by W. B. Liedtke and S. Heller. Frontiers in Neuroscience. Boca Raton (FL), 2007. Ernfors et al., “Advanced information.” McKemy, Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Coste, B., J. Mathur, M. Schmidt, T. J. Earley, S. Ranade, M. J. Petrus, A. E. Dubin, and A. Patapoutian. "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels." Science 330, no. 6000 (Oct 1 2010): 55-60. doi: 10.1126/science.1193270. Jiang, Y., X. Yang, J. Jiang, and B. Xiao. "Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels." Trends in Biochemical Sciences 46, no. 6 (Jun 2021): 472-88. doi: 10.1016/j.tibs.2021.01.008. Nonomura, K., S. H. Woo, R. B. Chang, A. Gillich, Z. Qiu, A. G. Francisco, S. S. Ranade, S. D. Liberles, and A. Patapoutian. "Piezo2 Senses Airway Stretch and Mediates Lung Inflation-Induced Apnoea." Nature 541, no. 7636 (Jan 12 2017): 176-81. doi: 10.1038/nature20793. Alcaino, C., K. R. Knutson, A. J. Treichel, G. Yildiz, P. R. Strege, D. R. Linden, J. H. Li, et al. "A Population of Gut Epithelial Enterochromaffin Cells Is Mechanosensitive and Requires Piezo2 to Convert Force into Serotonin Release." Proceedings of the National Academy of Sciences of the United States of America 115, no. 32 (Aug 7 2018): E7632-E41. doi: 10.1073/pnas.1804938115. Marshall, K. L., D. Saade, N. Ghitani, A. M. Coombs, M. Szczot, J. Keller, T. Ogata, et al. "Piezo2 in Sensory Neurons and Urothelial Cells Coordinates Urination." Nature 588, no. 7837 (Dec 2020): 290-95. doi: 10.1038/s41586-020-2830-7. Li, X., L. Han, I. Nookaew, E. Mannen, M. J. Silva, M. Almeida, and J. Xiong. "Stimulation of Piezo1 by Mechanical Signals Promotes Bone Anabolism." Elife 8 (Oct 7 2019). doi: 10.7554/eLife.49631. Cahalan, S. M., V. Lukacs, S. S. Ranade, S. Chien, M. Bandell, and A. Patapoutian. "Piezo1 Links Mechanical Forces to Red Blood Cell Volume." Elife 4 (May 22 2015). doi: 10.7554/eLife.07370. Ma, S., S. Cahalan, G. LaMonte, N. D. Grubaugh, W. Zeng, S. E. Murthy, E. Paytas, et al. "Common Piezo1 Allele in African Populations Causes Rbc Dehydration and Attenuates Plasmodium Infection." Cell 173, no. 2 (Apr 5 2018): 443-55 e12. doi: 10.1016/j.cell.2018.02.047. Dux, M., J. Rosta, and K. Messlinger. "Trp Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches." International Journal of Molecular Sciences 21, no. 1 (Jan 4 2020). doi: 10.3390/ijms21010342. Previous article back to DISORDER Next article