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By Yvette Marris Behind the Mask By Yvette Marris 23 March 2022 Edited by Tanya Kovacevic Illustrated by Quynh Anh Nguyen It would be hard to write about A Year in Science without the obligatory COVID article. We hear constantly about the stresses of being a frontline healthcare worker, the signs and symptoms of long COVID, and the endless vaccine scepticism. I’d like to tell a slightly different story. During the COVID pandemic, other infections didn’t just take a holiday and cancers didn’t just stop growing. More ordinary illness and injury continued behind the headlines. As a consequence of the pandemic, healthcare workers are additionally dealing with an abundance of patients, delays with diagnosis and some very complex medical cases. Megan Gifford worked in a hospital that didn’t primarily treat COVID-19 patients, but still had to adapt to the constant changing of rules, regulations and policies put in place to protect staff and patients alike from the virus. Now at the Peter MacCallum Cancer Centre in Melbourne, Gifford spoke to me about her experiences working at Townsville University Hospital in the only bone marrow transplant ward servicing a large population across regional Queensland. Gifford experienced the stress and burden of trying, not only to assuage their own anxieties but to also provide current, up-to-date information to patients and deliver high quality care. There were the frustrations of unavoidable logistical problems like border closures, stay-at-home orders, preventing access to crucial materials and patient transport. There was heartbreak of watching transplant patients deteriorate mentally, as their will to persist with treatments began to fade. Pathologists and haematologists also found themselves facing an unprecedented logistical nightmare, including re-allocation of diagnostic equipment and protective equipment for mass COVID testing. Access to essential biomedical material like blood and plasma became increasingly difficult and many suffered as a result. While pandemic consequences like long COVID and the increased prevalence of affective disorders, like depression and anxiety, are well documented in media and academia, post-traumatic stress disorder (PTSD) hasn’t gotten the same amount of attention. Statistics and anecdotes alike are staggering, both for patients and healthcare workers. With stressors like an unprecedented number of critically ill patients, capricious disease progressions, high mortality, and ever-changing treatment guidelines the world was sympathetic to healthcare workers’ struggles (3). Yet with the lockdowns and restrictions over, it would be naïve to think everything would just return to normal. It was found that 29% of healthcare workers had clinical or sub-clinical symptoms of PTSD (1), and that this figure was significantly higher for healthcare workers directly treating COVID patients (2). Gifford recalled anecdotes of “patients suffering anxiety attacks when they smell the hospital alcohol rub and hear the familiar beeping of the various equipment”. Even beyond the mental health scope, logistical issues like delayed learning for medical students or the backlog of elective procedures is still placing an enormous burden on healthcare workers, despite the immediate threat seemingly behind us. But to say that everything remains in shambles would frankly be insulting to healthcare workers, who are working tirelessly to deliver good quality healthcare. The speed at which pathologists and scientists have adapted to limited resources and supply shortages, and the way in which doctors and frontline workers have shifted their style of care and developed new problem-solving skills, are exceptional and should not go unnoticed or unappreciated. Importantly, the COVID-19 pandemic and its ripple effects have brought centre stage the consequences of under-resourced healthcare centres in a way that affected all people, irrespective of geography, class or reputation. The reality is that the conditions in which many metropolitan hospitals found themselves in, with never enough staff or supplies, is a condition that some hospitals experienced long before COVID-19 ever appeared, particularly in rural settings. To say that every dark cloud has a silver lining would be horribly cliché, but in this case, there may be truth to it. This edition of A Year in Science is a chance for us to reflect on all that COVID-19 has called attention to and decide to do something about it. References Carmassi C, Foghi C, Dell’Oste V, Cordone A, Bertelloni CA, Bui E, et al. PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic. Psychiatry Research. 2020 Oct;113312. Janiri D, Carfì A, Kotzalidis GD, Bernabei R, Landi F, Sani G. Posttraumatic Stress Disorder in Patients After Severe COVID-19 Infection. JAMA Psychiatry. 2021 Feb; Johnson SU, Ebrahimi OV, Hoffart A. PTSD symptoms among health workers and public service providers during the COVID-19 outbreak. Vickers K, editor. PLOS ONE. 2020 Oct 21;15(10):e0241032. Previous article Next article

< Back to Issue 7 Fossil Markets: Under the Gavel, Under Scrutiny by Jesse Allen 22 October 2024 edited by Zeinab Jishi illustrated by Jessica Walton At the crossroads between science and commerce, the trade in fossils has "developed into an organised enterprise" over the course of the twentieth century. With greater investment and heated competition between museums and private collectors, fossils increasingly took their place alongside “art, furniture, and fine wine” (Kjærgaard, 2012, pp.340-344). Fast forward to the twenty-first century, and this trend shows no signs of abating. On the contrary: as of 10 July 2024, a near-complete stegosaurus skeleton - nicknamed ‘Apex’ - was discovered by a commercial palaeontologist in Colorado, and was later purchased by “hedge-fund billionaire” Ken Griffin for US$44.6 million (Paul, 2024). This makes it the single most expensive dinosaur skeleton ever sold, eclipsing the previous record set in 2020 for a T-Rex named ‘Stan’, who was snapped up for US$31.8 million (Paul, 2024). These sales came with their fair share of criticism and controversy, reigniting the long-standing debate about how fossils should be handled, and where these ancient remains rightfully belong. Fossils (from the Latin fossilus , meaning ‘unearthed’) are the “preserved remains of plants and animals” which have been buried in sediments or preserved underneath ancient bodies of water, and offer unique insights into the history and adaptive evolution of life on Earth (British Geological Survey, n.d.). Their value is by no means limited to biology, however: they are useful for geologists in correlating the age of different rock layers (British Geological Survey, n.d.), and reveal the nature and consequences of changes in Earth’s climate (National Park Service, n.d.). Though new discoveries are being made all the time, fossils are inherently a finite resource, which cannot be replaced. This is part of what makes the fossil trade so lucrative, but the forces of limited supply and high demand have also led to the emergence of a dark underbelly. Cases of fossil forgery go back “as far as the dawn of palaeontology itself” in the late 18th and 19th centuries (Benton, 2024). The latest “boom in interest" is massively inflating prices and “fuelling the illicit trade” in fossils (Timmins, 2019). Whereas the US has a ‘finders-keepers’ policy, according to which private traders have carte blanche to dig up and sell any fossils they find, countries such as Brazil, China, and Mongolia do not allow the export of specimens overseas (Timmins, 2019). Sadly, this does little to prevent illegal smuggling; the laws are sometimes vague, and enforcement can be difficult when no single government agency is responsible for monitoring palaeontological activities (Winters, 2024). According to David Hone, a reader in zoology at Queen Mary University of London, “not every fossil is scientifically valuable”; but they are all “objects…worthy of protection,” and too many “scientifically important fossils appear briefly on the auction house website” before “vanish[ing] into a collector’s house, never to be seen again” (Hone, 2024). Museums, universities, and other scientific organisations are finding it more and more difficult to “financially compete with wealthy, private purchasers” as they are simply being priced out of the market (Paul, 2024). As sales become less open to expert scrutiny, the risk of forgery and price distortions become greater. It also has negative implications for future research. Private collectors might give access to one scientist, but not allow others to corroborate their findings. If the fossils aren’t open to all, many institutions simply won’t examine the items in private collections as a matter of principle. (Timmins, 2019). The general public also loses out in a world where dinosaur fossils are reduced to expensive conversation pieces. As Hone writes, “we might never dig up another Stegosaurus, or never find one nearly as complete as [Apex].” Having waited 150 million years to be unearthed, this latest fossil is one of many that may not see the light of day for a very long time. Bibliography Benton, M. (2024, September 5). Modern palaeontology keeps unmasking fossil forgeries – and a new study has uncovered the latest fake . The Conversation. https://theconversation.com/modern-palaeontology-keeps-unmasking-fossil-forgeries-and-a-new-study-has-uncovered-the-latest-fake-223501 British Geological Survey. (n.d.). Why do we study fossils? British Geological Survey. https://www.bgs.ac.uk/discovering-geology/fossils-and-geological-time/fossils/ Hone, D. (2024, June 10). The super-rich are snapping up dinosaur fossils – that’s bad for science . The Guardian. https://www.theguardian.com/commentisfree/article/2024/jun/10/super-rich-dinosaur-fossils-stegosaurus-illegal-trade-science Kjærgaard, P. C. (2012). The Fossil Trade: Paying a Price for Human Origins. Isis , 103 (2), 340–355. https://doi.org/10.1086/666365 National Park Service. (n.d.). The significance of fossils . U.S. Department of the Interior. https://www.nps.gov/subjects/fossils/significance.htm Paul, A. (2024, July 18). Stegosaurus 'Apex' sold for nearly $45 million to a billionaire . Popular Science. https://www.popsci.com/science/stegosaurus-skeleton-sale/ Timmins, B. (2019, August 8). What’s wrong with buying a dinosaur? BBC News. https://www.bbc.com/news/business-48472588 Winters, G.F. (2024). International Fossil Laws. The Journal of Paleontological Sciences , 19 . https://www.aaps-journal.org/Fossil-Laws.html Previous article Next article apex back to

< Back to Issue 6 A Brief History of the Elements: Finding a Seat at the Periodic Table by Xenophon Papas 28 May 2024 Edited by Arwen Nguyen-Ngo Illustrated by Rachel Ko What are we made of and where did it all come from? Such questions have pervaded the minds of scientific thinkers since ancient times and have entered all fields of enquiry, from the physical to the philosophical. Our best scientific theory today asserts that we’re made of atoms, and these atoms come in different shapes and sizes. Fundamentally, they can be described by the number of subatomic particles (protons, neutrons, and electrons) they contain (Jefferson Lab, 2012). Neatly arranged in a grid, these different elements form the periodic table we know and love today; but it was not always this way. The story of how the periodic table of elements came to be harks back to Ancient Greece and winds its way through the enlightenment into the 20th century. It is an unfinished story of which we are at the frontier of today: in search of dark matter and the ultimate answer to what the universe is made of. We may never know for sure exactly what everything in existence consists of, but it’s a pursuit our earliest ancestors would be proud to see us follow. Thales was first in the ancient Greek-speaking world to postulate about the origins of all material things. He theorised that all matter in the universe was made up of just one type of substance – water – and any other forms of solids, liquids and gases were just derivatives thereof. This idea was not initially opposed, given Thales was one of the earliest of the Ancient Greeks to pursue such questions of a scientific nature. Afterall, he’s remembered today as the “Father of Science” in the Western world. As Thales was from Miletus, a city on the coast of the Ionian Sea in modern day Türkiye and part of Magna Graecia in the 6th cent BC, it is not hard to imagine that water was a crucial aspect in trade, agriculture, and daily life at the time. However, this seemed to oversimplify the matter to some of his contemporaries. Empedocles, who was considered more a magician than a philosopher, revised this mono-elemental theorisation in the 5th Century BC. He proposed four basic substances from which all others were made (Mee, 2020). We know them today famously as the four classical elements: Earth, Air, Water and Fire. This asserted a fundamental principle of “fourness”, encompassing the cardinal directions in the Western world during this time. Interestingly, concurrent to this other traditions such as those in China acknowledged five elements and compass points instead. A generation later to Empedocles’ work, Plato embraced his “fourish” formulation. Being heavily influenced by mathematics as the medium through which we make reason of the natural world, Plato related each of these elements to a mathematical object: a convex, regular polyhedron in three-dimensional Euclidean space, otherwise known as a Platonic solid. Earth was associated with the cube, air with the octahedron, water with the icosahedron, and fire with the tetrahedron. Lastly, the most complicated solid, the dodecahedron – itself made up of composite regular polygons – was associated with the makeup of the constellations and the Heavens themselves, their workings said to be unfathomable by human minds (Ball, 2004). His student, Aristotle, ran with this idea and devised a clever way to break up the elements based on their "qualities”, akin to a first periodic table. These binary roles were hot and cold, wet and dry, with an element containing just two of these qualities each. According to Aristotle, each of these elements could be converted to the other by inverting one of their qualities, seemingly bringing about an early form of alchemy. To these four elements, he also appended a fifth - aether or “pure air” - to fill the expanses of the heavens, which also became associated with the fifth Platonic solid. In the Western World, Aristotle’s word was taken as doctrine for a very long time owing greatly to the fall of Rome and the cultural instability thereafter. Where Europe plummeted into the Dark Ages with a reverence for the scholars of antiquity, scientific and literary endeavour flourished in the Middle East – the word alchemy itself having etymologically Arabic roots. It was not until the late 17th century that the likes of Galileo, Newton, and Descartes revived Western scientific pursuit, and sought to understand how the natural world arranged itself. In the 18th century, new discoveries were being made on the frontiers of science in major cities throughout Europe. In 1772, in Paris, Antoine Lavoisier began work on combustion of materials like phosphorus and sulphur. Lavoisier concluded that if something decomposes into simpler substances, then it is not an element. For example, while water can be turned into a gas when passed over hot iron and is therefore not an element, oxygen and hydrogen are indeed elemental. English chemist John Dalton took after Lavoisier and in 1808 began to arrange elements spatially into a chart, accounting for their various properties. In Strasbourg 1827, Wolfgang Döbereiner recognised that groups of threes arose from the list of elements which behaved similarly, known as “Döbereiner's triads" (Free Animated Education, 2023). John Newlands in 1866 put forward the “Law of Octaves”. Elements with similar properties ended up at regular intervals, dividing the elements into seven groups of eight – hence octaves. However, this method of dividing up the elements broke down in some special cases. Now turning to St. Petersburg, Russia, in February of 1869. Dmitri Mendeleev sits at his desk, with a mess of cards covering the surface of his working space. The professor of chemistry rearranges these elemental cards like a jigsaw puzzle, arranging and rearranging them to align them in accordance with their properties. Supposedly after coming to him in a dream, a pattern emerged. Mendeleev saw the ability for the simple tabulation of the elements based on their atomic number and hence their common properties. This newfound tool, based on Lavoisier’s work a century prior, allowed for the prediction of properties of elements which had not even been discovered yet. Elements which Mendeleev believed to exist, even though they presented as empty gaps in the grid structure of the periodic table. Within just twenty years, Mendeleev’s prediction of the existence of such elements like gallium, scandium, and germanium had been validated with experimental fact. All of this was predicted without knowledge of the true reason for similarities of elemental properties – the electron shell arrangement at a subatomic level. Mendeleev had totally changed the way chemists viewed their discipline and has been immortalised for perhaps the greatest breakthrough work in the history of chemistry (Rouvray, 2019). Today we recognise that all the elements in the universe have origins in the high-pressure hearts of stars. Like a hot furnace, they churn out heavier and heavier elements under their immense internal pressures. Once this life cycle comes to an end, the star erupts into a fiery supernova, releasing even more of the heavier elements we see further down the periodic table. In the last 75 years, scientists have added an additional 24 elements to the periodic table, some of which are so difficult to produce that their half-lives last only a few fractions of a millisecond before decaying away to nothing (Charley, 2012). This begs the question; how do we find new elements? Elements can be created via either fission, splitting apart a heavier atom, or fusion, binding two bodies of atoms together. The heavier an element, that is, the more protons and neutrons in its nucleus, the more unstable it is. Hence it is with great difficulty that scientists attempt to churn out new elements from large particle accelerators, by colliding and combining elements into new ones (Chheda, 2023). The story of physical matter is just one aspect in the search for what “everything” is made of. Dark matter and dark energy – so named because they do not interact with light – have been found to drive the expansion of the universe and the rotation speeds of galaxies. We know remarkably little about these substances, given that they make up around 95% of the total mass of the universe! Without a doubt, we have only just begun the journey to find out what makes up the universe around us. References Chheda, R. (2023, March 31). Can we add new elements to the periodic table? Science ABC. https://www.scienceabc.com/pure-sciences/can-we-add-new-elements-to-the-periodic-table.html Charley, S. (2012). How to make an element. PBS. https://www.pbs.org/wgbh/nova/insidenova/2012/01/how-to-make-an-element.html Free Animated Education. (2023, February 10). Perfecting the periodic table [Video]. YouTube. https://www.youtube.com/watch?v=7tbMGKGgCRA&ab_channel=FreeAnimatedEducation Jefferson Lab. (2012, November 20). The origin of the elements [Video]. YouTube. Ball, P. (2004). The elements: A very short introduction . Oxford University Press. Mee, N. (2020). Earth, air, fire, and water. In Oxford University Press eBooks (pp. 16–23). https://doi.org/10.1093/oso/9780198851950.003.0003 Rouvray, D. (2019). Dmitri Mendeleev. New Scientist. https://www.newscientist.com/people/dmitri-mendeleev Previous article Next article Elemental back to

< Back to Issue 4 PT by Saachin Simpson 1 July 2023 Edited by Caitlin Kane, Rachel Ko and Patrick Grave Illustrated by Jolin See 'Pt' (medical abbreviation for ‘patient’) recounts a patient visit on an early-morning ward round at Footscray Hospital in my first placement as a second-year medical student. The line “I came to hospital with my innocence” was actually said by the patient and stuck with me, eventually inspiring this poem, which I wrote in a Narrative Medicine class run by Dr Fiona Reilly and Dr Mariam Tokhi. The poem depicts a dramatic rise and fall in tension during the patient visit. It is bookended by soulless technical medical abbreviations that exemplify patient notes on electronic medical records. Pt Pt alert and oriented, sitting upright in chair. Breathing comfortably, responsive to questions. Bilat basal creps, bilat pitting oedema to knee. Pt gazes out window at the opposite concrete wall Pt’s cataracts suddenly shimmer, a sorcerer’s crystal ball. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt’s power becomes apparent in his mighty ocular grip Pt’s lungs echo black tattered sails of a ramshackle timber ship. “I came to hospital with my innocence” Professional, qualified eyes dart from computer To patient And back. “and now I muse on dark and violent tricks” Med student looks at intern looks at reg looks at consultant. Feet shuffle, lips purse Pretending not to hear. “Your poisons gift no remedy, your words fat and hollow” Like a serpentine hiss, his derision rings through sterile air 5-step Therapeutic Guidelines for Reassurance (vol 23.4, updated 2023) does little for his despair. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt to await GEM. Frusemide 40mmHg. Cease abx. Refer physio. Refer OT. Call family. For d/c Monday. Previous article Next article back to MIRAGE

By Mia Horsfall < Back to Issue 3 AI and a notion of 'artificial humanity' By Mia Horsfall 10 September 2022 Edited by Breana Galea and Andrew Lim Illustrated by Matthew Duffy Next In the cradle of the day, a girl blinks to life. The sun is cool, still crouched beyond the trees, waiting for its cue to take centre-stage. Knees and knobs and spokes and all, she struggles to stand in the grass, furrowing her toes into the Earth for traction. Clean, unmarked and without memories, she looks to the sky with contentment, unaware of the work ahead. The notion of “Artificial” Intelligence is an interesting way to describe the vast and variegated mechanisms it encompasses. Not only does it pre-suppose the existence of “intelligence” within these machines, but it implies the existence of some antithetical “natural” intelligence. The term itself is a dichotomy, simultaneously alienating and connecting AI to humans. This poses some significant moral and ethical dilemmas that are becoming increasingly difficult to ignore. As the advent of AI becomes more intricately interwoven with mundane happenings, we are forced to grapple with the seemingly unanswerable question: At what point does “Artificial” Intelligence become indistinguishable from “Authentic” Intelligence? With the advent of Artificial Intelligence, public opinion surrounding the role AI should and does occupy has undergone dramatic alterations. Films and books such as “Her” (2013) and “Klara and the Sun” (2021) have explored the implications of assimilation of AI with humanity. In both pieces, AI transcends the purely utilitarian role originally defined and progresses into emotional connections with human counter-parts. It stands to reason that if these AI can enter and engage in emotionally significant relationships in the same capacity as humans, what exactly does the distinction between human and machine become? In order to define what AI is, we should first come to a conclusion of what it means to be human. So why is it so important to arrive at a definition of humanity in considering the ethics of AI inclusion in society? Well, as Hauskeller points out ‘the term ‘human’ is not primarily used to refer to a particular kind of entity...it implies a particular moral status’ (Hauskeller, 2009). That is, a subject is assigned a higher moral value in its assignment as ‘human’ and a purely physical application of the word would result in little distinction between us and other species. ‘A meaning of the word is a kind of employment of it’ (Wittgenstein, 1953), suggesting meanings and the terms to describe them are co-dependent and self-referential. Hence what it means to be ‘human’ is directly aligned with what subjects are assigned such a title. But arriving at a definition for “human” is no easy task. Philosophers and scientists have debated what constitutes the term human with little success, the definition changing across historical periods. In order to demonstrate the transient nature of the term ‘human’, a comparative analysis of definitions across historical periods provides a comprehensive overview of the dynamism that defines humankind. Hauskeller contends that any given definition of ‘human’ is ‘persuasive’. That is, each attempt ‘implicitly or explicitly claims to be of prime significance for the way we ought to lead our lives’ (Haukeller, 2009). By nature of the fact there exists multiple definitions of what characterises humanity, it can be inferred ideals of human society are themselves transient. For instance, Plato contends intelligence prevails above every aspect of human nature (White, 2013) as it is ‘the only part of himself which he does not share with the animal kingdom’ (Plato, referenced in White 2013). Whilst this definition may appear simplistic or constrictive, it is also not intrinsically wrong, merely indicative of the era in which it was formulated. Kant expounds upon the need to define ‘humanity’ asserting that any definition of an individual in isolation from a collective is futile and insufficient. Rather, it is only the ability ‘to treat himself and others according to the principle of freedom under the laws’ (Kant, referenced in Cohen, 2008) that defines humanity. In essence, it is only in relation to others that individuals may exist as human, congruent with Cohen’s assertion that ‘the study of the other is the yardstick by which men measure their own common humanity’ (Cohen, 2008). Heidegger adopts a markedly different approach in his ‘Being and time’, recognising the fluidity of human nature and creating Dasein who Oleson asserts is ‘the being of a human being, understood as the being that is concerned with being itself’ (Oleson, 2013), embodying the definition of humanity through a representation of the history of being (Oleson, 2013). Dasein exists as ‘the connection between historicality and temporality’ (Heidegger, 1927), and in this way, Heidegger seeks to define humanity by means of its instability. From these hugely variegated definitions of what constitutes the state of being human, it becomes clear we are unlikely to determine one singular, immutable definition of what it is to be human. Hence, it is difficult to have a constant point of comparison to see whether AI has “surpassed” its limits and transcended into some form of humanity. But with the increasing capabilities of AI, it stands to reason there be provisions in place in both law and politics to account not only for the implications of AI upon humanity, but for the representation of AI and its potential forms. Even if this representation or legislation is aspirational, it stands to reason there be policies in place, as various machine learning figures become more and more prominent in society and culture. At the end of the day, the girl stands cemented in her place. The line between her arms and the cogs she operates is indistinguishable amongst the black haze of smoke. In a town not too far from here, children kiss their mothers good night and fall asleep. But here, in this place, with this grime, she stands cold and unfeeling, the sky obscured by the machinery above. Previous article Next article alien back to

By Renee Papaluca < Back to Issue 3 In conversation with Paul Beuchat By Renee Papaluca 10 September 2022 Edited by Zhiyou Low and Andrew Lim Illustrated by Ravon Chew Next Paul is currently a postdoctoral teaching fellow in the Faculty of Engineering and Information Technology. In his spare time, he enjoys overnight hikes, fixing bikes, and rock climbing. Note: The following exchange has been edited and condensed. What was the ‘lightbulb moment’ that prompted you to study science? I often say that I chose engineering a little bit by not wanting to choose anything else. I think it also played into my strengths back in high school. I wasn't particularly into English, history or languages but I really enjoyed physics, chemistry and maths. So, that already drew me to science broadly. What ended up directing me towards engineering, and particularly mechanical engineering, was just always tinkering at home. My dad was always tinkering and building things. We had a garage with all of the tools necessary, and I had free rein to pull things apart and put them back together. Mechanical engineering was a way of taking a more formal route of enjoyment into the hobby. Why did you choose to pursue a research pathway? After I finished my double degrees in Science and Engineering, I got a job, which I enjoyed. It was fun working with a bigger team. In this case, it was an oil and gas company with some pretty big equipment involved. This wasn’t just tinkering with something little in the garage, but something on an industrial scale. At some stage, though, I felt like there was a bit missing. There was a research arm as part of the company, but that wasn't somewhere that I could get to. I was excited by the kind of work being done in that area, and I saw a PhD as a way of pursuing that love so that I could then work on those sorts of exciting things. What advice would you give to students considering a research pathway? Certainly, while I was a PhD, all the postdocs would say that the PhD was the best time of their life. Then the PhDs would say that the Masters was the best. So, be prepared for it to be hard. The advice is to be passionate about the topic and not be fearful about uncertainty or knowing the exact topic straightaway. Also, you likely will need a lot of support to get through the hard parts. It’s nice to have tangential input in the form of seminars, visiting academics from other institutions or even from PhDs in the same group or department. This input gives you new knowledge, new exciting fields and new industry connections. What sparked your love of teaching? My original intention was to complete my PhD, gain the relevant skills and return to the industry. My passion for teaching was sparked during my PhD experience; I got to supervise Masters students that are working on a larger project with me. It was a close collaboration with someone, where you start the process of teaching them whatever the topic is. You work on it together, and eventually, the student becomes the master. They can now guide you along, as well as having vibrant discussions together. That's what I find exciting about tertiary education more broadly - we all are pushing the limits of engineering to achieve better outcomes together. What does your day-to-day life as a teaching fellow look like? One of the focuses of my position was to include more project-based teaching, i.e. to include more hands-on education and work in the classroom, which was not included previously. I got the opportunity to create a new subject. I initially spent a lot of time developing what it was going to be. My day-to-day work included choosing new topics to add to the subject and linking them to a hands-on project, like a ground robot. There's a whole bunch of work that goes into designing a robot and the relevant software on top of preparing lecture slides and delivery—all these bits and pieces that make up a subject. Scattered throughout all this is teaching research; the teaching team assesses the students, and I need to assess the teaching itself. For instance, I need to understand what is being attempted in a particular class, what we are intending to achieve and how this aligns with the current best practices in education research publications. What advice would you give to students considering academic teaching as a career? One of the very nice things here at the University of Melbourne is the support teaching staff can receive through the Graduate Certificate of University Teaching. This gives you insight into and guidance on how to tackle the whole field. For instance, one of the lecturers mentioned that you have to be passionate about teaching because it has its ups and downs. Certainly, while developing a new subject, I found it to be quite stressful. It’s a different way of thinking, and all-new terminology, which is exciting and scary, and that took me a little bit by surprise. Where I shot myself in the foot the most was trying to do too much. I was in a very lucky position where I had free rein to make a subject as hands-on as possible, which opened the floodgates to possibilities. Prioritising was extremely important. It's not that you don’t try everything, but trying too many new exciting ideas at the same time means they probably are all going to fail or take an exorbitant amount of time to implement properly. Being realistic in my instruction was important. Also, having a mentor or someone you can talk very openly with was helpful. What are your future plans? For now, my intention is to stay in teaching. I’d like to push this position to the limits of what I can achieve and see where it takes me. I can also imagine the level of curriculum redesign in shifting whole courses to project-based learning. Current reports, like from the Council of Engineering Deans, are pushing for all engineering education to shift over to project-based learning within the next five to ten years. I’d like to continue teaching, with a view to contributing to higher-level curriculum development. Previous article Next article alien back to

New to science? New to Melbourne? New to OmniSci? Yes, yes and yes! We spoke to Jolin about joining OmniSci with an art background, growing through challenges, and her best local exhibit recommendations. Jolin is a designer at OmniSci and an exchange student from Singapore studying Psychology and Arts & Culture Management. For Issue 4: Mirage, she is contributing to our website, and to two articles as an illustrator. Meet OmniSci Designer Jolin See Jolin is a designer at OmniSci and an exchange student from Singapore studying Psychology and Arts & Culture Management. For Issue 4: Mirage, she is contributing to our website, and to two articles as an illustrator. interviewed by Caitlin Kane What are you studying? I am an exchange student doing psychology and arts management. Do you have any highlights of your uni career so far? Recently my friend showed me around campus. Parkville in particular is really pretty so I guess it would be a nice thing to romanticise your student life. I think that was one of the highlights. She showed me the secret garden at the Bioscience Building, which was really nice. It’s fun to just explore and stuff. What is your role at OmniSci and how would you explain it to someone? I am an illustrator. I guess using visual cues and using design processes to communicate text, communicate ideas. That’s how I would describe my role, or describe what I want to do when I illustrate. What first got you interested in science? I don’t know, I think this is my attempt to reconcile both arts and science. I feel like a lot of artists try to stay in their own little circles. Like if you’re doing art you just do art. If you’re doing theatre you only know how to do theatre and you never branch out to visual art or music or even psychology… But I think it is good to have many disciplines under your belt. You don’t have to be super good at every single thing, but I guess it helps in every single thing that you do if you have knowledge about everything else. Like you can transfer skills or knowledge from one discipline to another. I think that's very valuable. That’s what got me interested in science, because I'm not doing science in school, except psychology. Back at the management university where I’m from we do more managerial psychology, like HR and marketing, we don’t really do clinical psychology. It has been interesting, because here in UniMelb I am doing a clinical psych mod, which is very very different from what I do back home. Like the topics they choose to uncover are very different. It is expanding my knowledge, my horizons. And what stage are you up to in the process now? Just reading the first drafts, so familiarising myself with them. Trying to grasp the ideas, because I think a lot of them are beyond what I’ve ever known, so trying to grasp that first. How did you get involved with OmniSci? I heard about it first at O-Week. I met you [Editor-in-Chief Caitlin] at Southbank campus, so then we talked. I was planning on joining clubs but I didn’t know what club I wanted to join. This is one of the two clubs that I joined—I also joined the Bubble Tea Society. I just wanted to do something meaningful and nice while I’m here, rather than just travelling and having fun and everything. I thought it would be nice to get to know people and talk about our ideas and see how our perspectives are different, especially because I’m so far away. And also reconciling art and science. We always highlight the differences between science and art, but I thought that OmniSci would be an amazing place to create a bridge between that. I’ve also had ideas of starting my own communications channel about psychology facts, because a lot of things that I’ve learnt at school have been very useful in my own personal life. Perhaps this way of making science accessible through art would be helpful for the general public. There are people out there who want to share and impart the knowledge that they have. I thought OmniSci might be a nice place to start doing that. What is your favourite thing about contributing at OmniSci so far? I think having the opportunity itself is the best part. It takes a lot to start a magazine on your own, so to have that platform is a big thing. The accessibility, the opportunity given to put your work out there, or have your ideas made concrete and shared with everyone. I think that’s the best thing. Low barriers of entry! Can you share something you're excited about working on this issue? Collaborating with the writers! It’s one thing to work alone and develop your ideas, and it’s another to develop them with someone else. I’m really looking forward to exploring how my style can adapt to newer themes. What do you like doing in your spare time when you're not contributing at OmniSci? I like to go to book stores, art galleries, theatre…just a bunch of arts stuff. Do you have any recommendations for theatre, anything that you’ve seen recently? I was at Malthouse Theatre a few months back, and it was really good. I really recommend Malthouse. There’s a State Library Exhibition on fringe festivals in Australia . I really believe in fringe stuff, so I think that’s a really thought-provoking exhibition to reflect on what we define as “good” and “bad” art. I also went to watch Patroclus and Achilles at the UniMelb Shakespeare company. It’s important to support student theatre because that’s where future artists start out! Which chemical element would you name your firstborn child (or pet) after? Oh my god, it’s so painful…I’m going to go with Potassium, so I can nickname them K. I’ll call them K all the time, except when I’m mad—then I’ll call them Potassium. See Jolin's designs PT PT Real Life Replicants

Our Microbial Frenemies By Wei Han Chong How could it be that some of the smallest organisms known to mankind can hold so much influence and cause such calamity in our lives? The significance of these microorganisms have long eluded the greatest microbiologists. But has our perception of these microbes blinded us to their advantages, if any? Edited by Khoa Anh Tran & Tanya Kovacevic Issue 1: September 24, 2021 Illustration by Rachel Ko Throughout human history, diseases and plagues have amassed death tolls reaching hundreds of millions, if not billions. From the Black Death in the 14th century, which killed about 200 million people, or about 30–50% of Europe’s population, to outbreaks of tuberculosis and typhoid fever, resulting in 1.4 million and 200,000 deaths every year, respectively (1, 2, 3). It should come as no surprise then that we have long perceived these microorganisms as a threat to public health and have consequently sought to eradicate these microbes from our environment. But have we been looking at them the wrong way? First and foremost, we know very little about the microorganisms living around us. In bacterial species alone, some scientists have estimated around a billion species worldwide, though even this value is believed to be a gross underestimation (4). Before the germ theory, the most widely accepted theories were the spontaneous generation and miasma theories. Spontaneous generation was a simple theory, believing that living organisms could develop from nonliving matter, such as maggots developing from rotting flesh. The miasma theory, on the other hand, was more prevalent throughout both ancient and modern history. From this perspective, “toxic” vapours from rotting organisms or unsanitary locations were believed to have caused disease (5). This all changed with the germ theory of disease: an idea that would revolutionise our understanding of microorganisms for centuries to come. First theorised as “invisible seeds” by Italian scholar Girolamo Fracastoro in 1546, Fracastoro believed that these seeds could cause disease when spread from infected to healthy individuals (6). For the most part, the basis of the germ theory would continue to follow this logic of a specific microorganism, a “germ”, that could cause a specific disease when invading its host (7). Yet, it was not until nearly 200 years later that the field of microbiology would see huge developments. In 1861, French scientist Louis Pasteur had disproved the spontaneous generation theory by means of sterilisation and proper sealing of food items, which would prevent microbial growth (8). However, Louis Pasteur would not be the only one contributing to developments in microbiology. In 1884, German scientist Robert Koch would be the first to develop a classification system for establishing a causative relationship between a microorganism and its respective disease, effectively confirming the germ theory of disease (9). Even to this day, Koch’s system is still very much influential in microbial pathogenesis, albeit refined to a higher standard. Now known as Koch’s Molecular Postulates — as opposed to Koch’s Original Postulates — which is a model that places a greater emphasis on the virulence genes causing disease, rather than the microorganism itself (10). Today, while we have much to thank Pasteur and Koch for in laying the foundation of modern microbiology, undoubtedly one of the biggest discoveries in microbiology was the discovery of the human microbiota. When we think of microbial life, we usually think of diseases and plagues, cleanliness and dirtiness. Rarely do we ever consider the idea of microbes living inside and around us. Yet, even less so can we begin to comprehend the sheer number of microorganisms that live and proliferate all around ourselves. In our gastrointestinal tract, estimates suggest that there are some 100 trillion microorganisms encoding three million genes altogether, which is 130 times more than what we encode ourselves (11). Figure 1. Microbes in Food (25) So, what do we know about the microbiota; specifically, our microbiota? Firstly, we know that the microorganisms occupying our gut do not cause disease, under normal circumstances. Secondly, we know that they can provide us with a multitude of benefits, such as helping us digest complex organic molecules, and preventing invasion of foreign microbes by directly competing for resources and keeping the immune system stimulated. These are just a few of the advantages our microbial allies provide us. However, that is not to say that they pose no danger to ourselves either. Typically, these microorganisms are categorised into being in a beneficial, pathogenic or commensal relationship with its host. Beneficial microbes, or probiotics, are as the name suggests: these microbes typically provide some form of health benefit to the host and are usually non-pathogenic. Many of the bacterial species found in our gut lumen, for example, have the capability to digest cellulose. As such, without these microbes, digesting vegetables would be a much harder and less rewarding task. Most of the probiotics found in our microflora are of lactic acid bacteria origin and are most common in diets that incorporate fermented dairy products (12). Pathogenic microbes, on the other hand, mostly describe microbes of foreign origin. These microorganisms will infect and exploit the host’s cells, ultimately causing disease. Commensal microorganisms walk an interesting line, in comparison to beneficial and pathogenic microbes. This group of microbes encompasses all of the characteristics described above, depending on circumstance. This ranges from benefiting both the host and microbe, the microbe itself, or even causing disease within its host when given the opportunity. An example of a commensal microorganism is Escherichia coli, or E. coli. It is a bacterium that colonises our gastrointestinal tract as soon as we are born, where it fends off more than 500 competing bacteria species, thanks to its versatility and adaptations to our gut environment (13). Furthermore, the presence of E. coli along our gut epithelium helps to stimulate mucin production, inhibiting any foreign microbes from invading the epithelium (14). However, as is typical of a commensal organism, when given the chance, E. coli is capable of causing intestinal or extraintestinal disease in our bodies. Urinary tract infections due to E. coli are among the most common causes of a microflora-associated infection and often occur when the bacterium is allowed to enter the urinary tract via cross contamination with the anus, where E. coli is typically shed as part of the faeces (15). Typically, these beneficial and commensal bacteria are found all over our body. They can be found in our hair, on our skin, and as we have discussed, in our gut. Malassezia, for example, is a fungus that colonises our scalp, and is what causes dandruff in most people. While dandruff may be a nuisance to those who experience it, do the disadvantages necessarily outweigh the benefits? The presence of Malassezia on our scalps means that other, possibly dangerous, microorganisms will have to compete with Malassezia in order to invade. Additionally, the stimulation of our body’s defenses due to Malassezia aids in repelling foreign invaders (16). Staphylococcus aureus is another example of a commensal microbe, and an even better example of an opportunistic pathogen that can be found living harmoniously on our skin and nasal passages, helping us fend off other competing microbes just as Malassezia does on our scalp. However, when the skin is pierced, whether by means of injury or even medically through surgeries or treatments, the Staphylococcus bacteria will opportunistically attempt to invade and infect its host (17). As such, Staph infections and outbreaks are among some of the most common forms of hospital-related infections (18). Source: Thomas L Dawson, “What causes dandruff, and how do you get rid of it?” February 10, 2021, Ted-Ed video (19). Looking to the future, we have begun to see a spike in non-communicable diseases as opposed to microorganism-based diseases. These include most forms of heart diseases, cancers, diabetes, and others. Still, while the rise of non-communicable diseases is arguably a cause for concern, the return of long extinct diseases and antibiotic resistant pathogens may prove costly. Staph infections, as previously mentioned, are extremely common in hospital environments where continued usage of antibiotics such as penicillin or methicillin has produced a “super strain” of Staphylococcus that is resistant to most commercially available drugs (20). Currently, superbugs such as multidrug-resistant mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus are most common in healthcare settings, but community transmissions have become a concern (21). As such, with our current practices of antibiotic overprescriptions and continued reliance on sterilisation, future outbreaks of mutated and resistant pathogens may be inevitable. That being said, should we redefine what “clean and sterile” means to us? Should “sterile” necessarily be a microbe-free environment? Our perception of microbial life has consistently been “antibacterial” and believed to have been a threat to public health ever since the inception of the germ theory. However, the fact of the matter is that these microorganisms are unavoidable. There are microorganisms living all over us. Our fingers, our phones, even the soles on our shoes carry certain microorganisms. In hospital rooms, the composition of microbes is constantly changing as patients and visitors enter and leave (22). Besides, the composition of microbes in the environment is not determined solely by its occupants. Other factors, such as ventilation and even architecture, can determine what microbes we find in our environment. In fact, hospital rooms with more airflow and humidity were found to have suppressed the growth of potential pathogens and had fewer human-associated bacteria in its microbial composition (23). Just as the microbe composition in the environment can be determined by architectural and building factors, the microbe composition in our microflora can hold incredible influence over our physiology. Dysbiosis, an imbalance in our microflora, can occur as a result of repeated consumption of antibiotics, and it is a serious illness resulting in a significant loss of beneficial and commensal microbes (24). Consequently, invasion and colonisation capabilities of foreign pathogens is increased; as has been shown in antibiotic-treated mice exposed to M. tuberculosis, where pathogenic colonisation was promoted when in a dysbiotic state (25). Other factors, such as diet and lifestyle, also contribute as “disturbance” factors that influence dysbiosis, as can be seen in typical Western-style diets that mostly consist of high fatty and sugary foods (26). In the future, while the crises of pandemics originating from drug-resistant superbugs loom over us, our understanding of microbial life has come far; from its humble beginnings as a rejected theory amongst scholars, to the discovery of an extensive microbial ecosystem inside of our guts. Despite that, our comprehension of this “hidden world” remains lacking, and we have yet to fully realise the potential of microbial life. Throughout history we have constantly taken an antimicrobial stance to preserve public health, but in recent times it has become increasingly clear that these microorganisms play a much greater role in health. References: 1. LePan, Nicholas. “Visualizing the History of Pandemics.” Visual Capitalist. Last modified September 2021. https://www.visualcapitalist.com/history-of-pandemics-deadliest/ . 2. World Health Organization. “Tuberculosis.” Published October 2020. https://www.who.int/news-room/fact-sheets/detail/tuberculosis . 3. Centers for Disease Control and Prevention. “Typhoid Fever and Paratyphoid Fever.” Last modified March 2021. https://www.cdc.gov/typhoid-fever/health-professional.html . 4. Dykhuizen, Daniel. “Species Numbers in Bacteria.” Supplement, Proceedings. California Academy of Science 56, no. S6 (2005): 62-71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160642/ . 5. Kannadan, Ajesh. “History of the Miasma Theory of Disease.” ESSAI 16, no. 1 (2018): 41-43. https://dc.cod.edu/essai/vol16/iss1/18/ . 6, 8. Greenwood, Michael. “History of Microbiology – Germ Theory and Immunity.” News-Medical. Last modified May 2020. https://www.news-medical.net/life-sciences/History-of-Microbiology-e28093-Germ-Theory-and-Immunity.aspx . 7. Britannica. “Germ theory.” Last modified April 2020. https://www.britannica.com/science/germ-theory . 9, 10. Gradmann, Christoph. “A spirit of scientific rigour: Koch’s postulates in twentieth-century medicine.” Microbes and Infection 16, no. 11 (2014): 885-892. https://doi.org/10.1016/j.micinf.2014.08.012 . 11. Valdes, Ana M, Jens Walter, Eran Segal, and Tim D Spector. “Role of the gut microbiota in nutrition and health.” BMJ 361, no. k2179 (2018): 36-44. https://doi.org/10.1136/bmj.k2179 . 12, 24. Martín, Rebeca, Sylvie Miquel, Jonathan Ulmer, Noura Kechaou, Philippe Langella, and Luis G Bermúdez-Humarán. “Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease.” Microbial Cell Factories 12, no. 71 (2013): 1-11. https://doi.org/10.1186/1475-2859-12-71 . 13, 15. Leimbach, Andreas, Jörg Hacker, and Ulrich Dobrindt. “E. coli as an All-rounder: The Thin Line Between Commensalism and Pathogenicity.” In Between Pathogenicity and Commensalism, edited by Ulrich Dobrindt, Jörg Hacker and Catharina Svanborg, 3-32. Springer: Berlin, 2013. 14. Libertucci, Josie, and Vincent B Young. “The role of the microbiota in infectious diseases.” Nat Microbial 4, no. 1 (2019): 35-45. https://doi.org/10.1038/s41564-018-0278-4 . 15. Harvard Medical School. “When urinary tract infections keep coming back.” Published September 2019. https://www.health.harvard.edu/bladder-and-bowel/when-urinary-tract-infections-keep-coming-back . 16. Saunders, Charles W, Annika Scheynius, Joseph Heitman. “Malassezia Fungi Are Specialized to Live on Skin and Associated with Dandruff, Eczema and Other Skin Diseases.” PLoS pathogens 8, no. 6 (2012): 1-4. https://doi.org/10.1371/journal.ppat.1002701 . 17. Cogen, A. L., V. Nizet, and R. L. Gallo. “Skin microbiota: a source of disease or defence?” British journal of dermatology 158, no. 3 (2008), https://doi.org/10.1111/j.1365-2133.2008.08437.x . 18, 20. Klein, Eili, David L Smith, and Ramanan Laxminarayan. “Hospitalizations and Deaths Caused by Methicillin-Resistant Staphylococcus aureus, United States, 1999–2005.” Emerging infectious diseases 13, no. 12 (2007): 1840-1846. https://doi.org/10.3201/eid1312.070629 . 19. Dawson, Thomas L. “What causes dandruff, and how do you get rid of it?” February 10, 2021. Ted-Ed video, 5:04. https://youtu.be/x6DUOokXZAo . 21. Better Health. “Antibiotic resistant bacteria.” Last modified March 2017. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/antibiotic-resistant-bacteria#bhc-content . 22, 23. Arnold, Carrie. “Rethinking Sterile: The Hospital Microbiome.” Environmental health perspective 122, no. 7 (2014): A182-A187. https://doi.org/10.1289/ehp.122-A182 . 25. Khan, Rabia, Fernanda C Petersen, and Sudhanshu Shekhar. “Commensal Bacteria: An Emerging Player in Defense Against Respiratory Pathogens.” Frontiers in Immunology 10, no. 1 (2019): 1203-1211. https://doi.org/10.3389/fimmu.2019.01203 . 26. Schippa, Serena, and Maria P Conte. “Dysbiotic Events in Gut Microbiota: Impact on Human Health.” Nutrients 6, no. 12 (2014): 5786-5805. https://doi.org/10.3390/nu6125786 . 27. Sottek, Frank. Microbes in Food. c. 1904. The Tacoma Times, Tacoma. https://commons.wikimedia.org/wiki/File:Sottek_cartoon_about_microbes_in_food.jpg .

< Back to Issue 5 Black Holes: Defying Reality and Challenging Perception Mahsa Nabizada 24 October 2023 Edited by Arwen Nguyen-Ngo Illustrated by Louise Cen Black Holes: Portals to the Unknown Black holes are among the most mysterious and fascinating objects in the vast universe. Often portrayed as portals to the unknown, they distort space and time such that it challenges our understanding of reality (The Editors of Encyclopedia Britannica, 2018). In this article, I want to take you on a journey through the mysteries of black holes, exploring some philosophical questions, debunking myths, and shedding light on their profound significance in the universe. What is a Black Hole? A black hole is a place in space where gravity exerts an extraordinarily powerful force, to the extent that not even light can escape it. This intense gravitational pull results from the compression of matter into an incredibly compact region (NASA, 2018). When a massive star reaches the end of its life and exhausts its internal thermonuclear fuels, its core becomes unstable, gravitationally collapsing inward upon itself. The star's outer layers are blown away, giving rise to the formation of a black hole. Other methods of black hole formation may exist, but are yet to be understood. As a star nears the end of its life, it enters this pivotal phase that results in the formation of a black hole. For this transformation to occur, the star must possess sufficient mass, a condition that even our own Sun does not meet. When the gravitational collapse of the star’s core begins, what is known as a singularity is created—a point where the conventional laws of physics cease to apply. This singularity is characterized by an immense density, a consequence of the continuous collapse that occurs within. Black holes are invisible to the human eye. In order to detect and study them, astronomers rely on space telescopes equipped with specialized tools capable of discerning the distinctive behaviors of stars in close proximity to these gravitational phenomena. These observations provide invaluable insights into the presence and nature of black holes in the universe. Philosophy Meets Relativism: Challenging Reality and Perception Black holes challenge our understanding of reality and perception, particularly through the lens of relativism. As objects approach a black hole, space and time are distorted, creating a gravitational lensing effect. This phenomenon, predicted by Einstein's theory of relativity, is akin to looking through a cosmic funhouse mirror, where the very fabric of the universe appears twisted and surreal. Imagine standing at the event horizon of a black hole, the point of no return. To escape its gravitational pull, you would need to travel faster than the speed of light - an impossibility according to our current understanding of physics. However, a black hole isn't a vacuum. Rather, it warps space around it so profoundly that even light is trapped. This raises profound questions about the limits of our knowledge and the nature of reality itself. The Cosmic Duets: Black Hole Pairs and Gravitational Waves Beyond philosophy, black holes engage in cosmic duets, forming pairs of black holes that orbit each other in the dark expanse of space. As they draw nearer, they merge, releasing powerful gravitational waves that ripple through the universe. This phenomenon, observed by instruments like the Laser Interferometer Gravitational-wave Observatory (LIGO), provides an unprecedented chance to directly observe and study cosmic events (LIGO Caltech, 2019). By recording the motion of these gravitational waves, scientists can deduce the size and characteristics of the merging black holes, providing insight into their properties. These observations also challenge our perceptions of the universe, as they remind us that even the most elusive cosmic entities are within the reach of human exploration. Types of Black Holes: From Stellar to Supermassive Black holes come in various types, each with its own characteristics. Stellar black holes, relatively small in size, originate from the remnants of massive stars and may number in the hundreds of millions within our Milky Way galaxy alone. On the other end of the spectrum, we find supermassive black holes situated at the center of galaxies, including our own Milky Way (Volonteri, 2012). These giant astronomical objects, with masses millions or billions of times that of our Sun, play a crucial role in the formation and evolution of galaxies. The Cosmic Life Cycle: Birth, Existence, and Beyond A black hole's existence is not static. It evolves through various phases, influenced by variables like mass, rotation, and charge. Schwarzschild black holes are static, while Kerr black holes rotate, adding complexity to their behaviour. These defining characteristics, alongside their mass and spin, contribute to the diverse array of black holes in the cosmos. Inside a black hole, the laws of physics reach their limits, and we encounter the mysterious concept of the singularity, where space and time cease to exist as we know them. What occurs beyond this point remains a mystery, a subject of ongoing scientific inquiry and philosophical speculation. The Inscrutable Massiveness: Philosophical Reflections As we ponder the immense mass and gravity of black holes, we confront our own limitations as observers of the cosmos. These objects challenge us to question whether true understanding is attainable, considering the profound mysteries they represent. They beckon us to consider the nature of our universe and our place within it, inspiring philosophical contemplation about the boundaries of knowledge. Recent scientific discoveries have unveiled alternative pathways to black hole formation, expanding our understanding beyond the conventional route of star collapse and revealing novel mechanisms. This encourages ongoing research and theory that redefines our perception of these cosmic entities, demonstrating that they may not solely be life-takers. Instead, they may potentially play a role as essential components in the intricate fabric of the universe. Black holes, distorting space and time, challenge our understanding of reality and serve as profound philosophical enigmas, pushing the boundaries of human knowledge and imagination. As we continue to unravel their mysteries, black holes stand as a testament to the boundless curiosity and spirit of exploration that define the human quest to understand the universe. References The Editors of Encyclopedia Britannica. (2018). Black hole | Definition, Formation, & Facts . Encyclopædia Britannica. [Internet]. Available from: https://www.britannica.com/science/black-hole LIGO Caltech. (2019). What are Gravitational Waves? [Internet]. LIGO Lab | Caltech. Available from: https://www.ligo.caltech.edu/page/what-are-gw NASA. (2018). Black Holes | Science Mission Directorate . [Internet]. Nasa.gov . Available from: https://science.nasa.gov/astrophysics/focus-areas/black-holes/ Volonteri, M. (2012). The Formation and Evolution of Massive Black Holes. Science, 337(6094), 544–547. https://doi.org/10.48550/arXiv.1208.1106 Wicked back to

< Back to Issue 2 Postdoc Possibilities Thinking about postgraduate research? This column has some advice for you, courtesy of a recent PhD graduate. by Renee Papaluca 10 December 2021 Edited by Ruby Dempsey and Breana Galea Illustrated by Casey Boswell The idea of (dis)order is apparent in many scientific fields. One example of this is artificial light at night, which can disrupt our ecosystems. I caught up with Marty Lockett, a recent PhD graduate in this field, to learn more about the research pathway and their experience studying science at the University of Melbourne. Marty Lockett. Image included with permission. Marty recently completed his PhD in the Urban Light Lab, School of Biosciences. In his spare time, Marty enjoys birdwatching, Lego and science fiction. What was the ‘light-bulb moment’ that prompted you to study science? “I have always enjoyed the outdoors. For example, bushwalking, snorkelling, birdwatching — all that sort of stuff. I am more of a latecomer to science. About 10 years ago, I took long-service leave from my job. I used to be a lawyer. I ended up spending a lot of time doing volunteer work for conservation and restoration organisations… and I was exposed for the first time to the world of science and ecology. The work involved things like cleaning up rubbish, tree planting, weed removal, and banding and recapturing birds with researchers. It was really eye-opening! I realised I could do this for a job… I had never studied science, apart from chemistry at school. I had never been exposed to ecology or really considered it as a potential career option. Having that opportunity to immerse myself in nature in a more constructive and helpful way, rather than being a passive observer, really got me thinking.” Why did you choose to complete a research pathway? “So, I came into this not having an undergraduate degree in science. I completed a Masters of Environment to begin with. My thinking there was to try and get into environmental management, conservation or restoration management. As part of that masters, I completed a couple of third-year animal behaviour subjects. I found this really interesting as I hadn’t studied much about the behaviour of wildlife. Off the back of that, I decided to focus on this area for my research capstone subject. I met Dr Therésa Jones [current supervisor] and … did a mini research project on artificial light at night which is her area of specialization. From there, I got hooked on research… I wanted to find out more and, from there, decided to complete a PhD… There’s so much to learn about the world. Being in the position where the world now knows something that it once didn’t because of your work is really powerful.” What was the focus of your PhD research? Why did you choose this area? “My main project was looking at the effects of artificial light at night on an important food chain in Eucalyptus woodlands.” “There's a lot of research on the effects of artificial light at night on individual organisms… There's less but increasing research on interactions between species. As you spread out wider, there's [even] less research on more complex communities and on the wider cascading ecological effects of artificial light at night. I wanted to look into the effects of artificial light on a system that was underexplored and really important here in Australia.” “I chose a specific Eucalyptus woodland food chain consisting of river red gum trees, lerp psyllids, and birds that eat them. Lerps are the white bumps you sometimes see on Eucalyptus leaves. These are made by the nymphs [juveniles] of insects called lerp psyllids. Psyllids feed on leaf sap. Since eucalyptus sap is very rich in carbohydrates, they secrete the excess carbohydrates and use it to build little white domes over themselves. This takes a resource which is completely indigestible by most animals [Eucalyptus sap] and it turns it into something that is highly digestible by a whole range of animals… like birds, other insects, possums [and] bats. So lerps are a really key food resource in Eucalyptus woodlands. At the next level of the food chain, I chose a bird that was particularly dependent on lerps known as bell miners. I wanted to see the effect of artificial light at night at each level of this food chain. This is because all three organisms were vulnerable to… [the] effects of artificial light at night in different ways, and impacts at one level of the food chain might have cascading effects on other levels.” What did your day-to-day life as a PhD researcher look like? “It's really varied. In my case, I broke it down into three main work categories. So first up, you've got reading and writing. In the early days, before you start doing any experiments, you've got to learn a lot about your area, find out what's known, what's unknown, form hypotheses and figure out ways of testing them…” “In the middle, there is much more time spent on fieldwork and lab work. The extent of this will vary depending on the project… In my case, it was probably 50/50… An amazing amount of research involves what we refer to as ‘art and crafts’ where, after you design an experiment, you've got to then figure out a way to test that experiment on a tight budget. For example, building insect traps; you have to think about how you will make it work logistically. You need something that can be easily broken down and transported, but is rigid enough to stand up in a street, doesn't blow over in the wind and all those kinds of things. Fieldwork involved rigging up electric lights in a paddock, finding ways to stop parrots eating sound recorders; all kinds of weird stuff I never thought I'd be doing. Then there’s the actual fieldwork itself — catching bugs, measuring trees — whatever it is you need to do to gather data.” “The third main activity is statistical analysis and coding, which often go hand in hand. Most of [my] analysis was done in R [programming language], which was another thing that I hadn't done before… I hadn't really appreciated, as an outsider, just how much time scientists spend on statistics and coding. Coding governs a whole lot of things [in research], not just statistics. So you'll use coding to measure the number and diversity of vocalisations in birdsong recordings. You also may use it for physical mapping of study sites. In stats, there is obviously coding involved in statistical analysis, but also for creating the plots for your papers. It's all coding!” “At the end, you come back to reading and writing. You've gathered all your data, you've written up your results and then you've got to put them in context for your reader.” What advice would you give to students considering this research pathway? “There's two aspects to a PhD. On one hand, you are researching something that is of interest to you. This might be a particular organism, process or scientific question… That's a really important element of the PhD. But the other element is about you upskilling. Basically, a PhD is like a research apprenticeship and it's mostly self-driven… Your supervisor is there to guide you but you've got to come up with all the questions yourself, and figure out how to test them. I feel like it's really important to make the most of both these aspects; you want to do a great research project and find out something interesting that the world didn't know before. But you also want to make sure you're making the most of this time to meet people, take on skills, try things out and get outside your comfort zone. This is really important in making yourself as attractive as possible to future employers and a well-rounded researcher.” What are your future plans following your PhD? “I would like to take these skills and apply them in an in-house ecologist or research position. I’d like to do work where there's a chance to both conduct research and apply what we know to achieve better outcomes for wildlife. So, for example, working on the practical application of artificial light, working with people who make decisions about installing artificial light fixtures and helping them to find better ways to balance the needs of humans and the needs of wildlife.” Previous article back to DISORDER Next article

< Back to Issue 2 The Evolution of Science Communication In the current age of social media, users hold far more autonomy over the posts and information which they share online. However, this was not always the case, with the media once being far more regulated, and restricted for only certain individuals. With users now having far more power over content posted online, how does this impact the information which others receive about the COVID-19 pandemic? by Monica Blasioli 10 December 2021 Edited by Khoa-Anh Tran & Yen Sim Illustrated by Rachel Ko Trigger warning: This article mentions illness, and death or dying. Since the beginning of the pandemic in March 2020, science communication has started to evolve in ways never before seen across the globe. There appears to be an endless amount of infographics, Facebook posts, and YouTube and TikTok videos… including some with dancing doctors. Information not only about the COVID-19 virus, but countless diseases and scientific concepts, is available in more casual, accessible language at only the touch of a button. Any questions which you might have about science or your body can be answered through a quick Google search. In this sense, science communication is now far more rapid, as well as more accessible than in research papers (which always seem like they are written in a foreign language at times). However, the downside of having vast amounts of information available is that it can create challenges in determining the validity of what is being presented. In previous years, science communication was typically limited to the more typical forms of media, such as in a newspaper or a magazine, or even through a television interview. These were typically completed by professionals in the field, such as a research scientist or a medical doctor. When looking at the 1920 Influenza outbreak, many citizens at that time would have received their information from printed newspapers and posters on bulletin boards, as seen below. Image 1, [1] Somewhat similar to today's age, there were signs displaying the importance of mask-wearing, and newspapers explaining the closures of schools and shops, the distribution of vaccines, and reports of death rates. These messages were, and still are, created and approved by larger institutions, governments and medical professionals, particularly doctors. As seen on the (left / right / below / above), doctors are urging people to not become complacent, despite a recent drop in influenza cases. This is rather similar to current newspaper or television news reports - only in reference to COVID-19, instead of influenza. Image 2, [2] There were, of course, still groups which were uncertain about the scientific evidence being provided by journalists, doctors and government officials at this time. In November of 1918, it was declared that “the epidemic of [influenza] disease is practically over,” with mask laws being relaxed. However, only a few days later, the previous mask laws were reintroduced with a spike in Influenza cases. As unpacked in Dr Dolan’s research [3], the “Anti-Mask League” formed and protested in response to this back track, claiming that masks were unsanitary, unnecessary, and stifling their freedom. As this was during the early 20th century, the league advertised their protests in local newspapers, with reports that hundreds of San Francisco residents were fined for not abiding by mask rules, often due to their alliance with the Anti-Mask League. The San Francisco Anti-Mask League is one of the most renowned and infamous groups of its time, with smaller-scale groups also questioning the science being communicated. This type of conflicting information surrounding mask issues, and the opinion that they restrict personal freedoms, have incited similar responses throughout history. However, resistance by anti-mask groups has not existed on such an influential and global scale, as it has during the current COVID-19 pandemic. With the rise of the age of “new media,” including platforms such as Instagram and Facebook, individuals now have far more autonomy over their role in the media, meaning that they yield a lot more power over the information others are receiving. Almost anybody can interpret scientific material online and upload it in a video of them dancing to some music on TikTok, spreading information to potentially hundreds of thousands of viewers across the globe. In many ways this new found autonomy and power can be quite beneficial. Australian Doctor Imogen Hines uses her platform on TikTok, alongside her medical education and current scientific research, to break down medical treatments and mistruths, particularly surrounding the COVID-19 pandemic. These videos use simple language and straight-forward analogies, “humanising” the often intimidating figures in the medical field, and allowing the general public to be well-informed about scientific concepts. For example, Dr Imogen breaks down the research surrounding long term side effects of vaccines using a milkshake analogy! https://www.tiktok.com/@imi_imogen1/video/7027448207823211777?is_copy_url=1&is_from_webapp=v1&lang=en On the other hand, this phenomenon can have pretty serious ramifications, with many individuals feeling rightfully confused about what the truth really is, when there appears to be so many versions of it posted across the internet. Following a rather controversial study on Ivermectin as a treatment for COVID-19, the internet was soon buzzing with excitement about the prospect of a drug that many believed could replace the need for a vaccine. Despite numerous gaps in the original study, and countless further studies refuting Invermectin’s ability to treat COVID-19, many social media users are continuing to spread this myth online. Both governments and hospitals alike have been accused of hiding a seemingly “good” cure from their citizens. In Texas, a group of doctors won a legal case which allowed Texas Huguley Hospital to refuse administering Ivermectin to a COVID-19 infected Deputy Sheriff. This sparked outrage on Facebook, with users and the Sheriff’s wife demanding greater freedoms over their medical treatments, instead of just relying on the judgement of doctors and hospital staff. In this instance, the misinformation surrounding Ivermectin is not only influencing individuals to seek out futile treatments, but it is also spreading mistrust with the science and medical communities, who work incredibly hard to protect the world, particularly over the past two years. Despite Ivermectin being used in a clinical setting to treat parasitic (not viral) infections in humans for a number of years now, it can be extremely dangerous for individuals to have complete power over their medical treatments. The dosage and timing of treatment is crucial in ensuring success. Just like with everyday medications such as paracetamol, taking Ivermectin in high doses is risky. A COVID-19 infected woman from Sydney who read about Ivermectin on social media took a very high dosage of the drug after purchasing it from an online seller, which resulted in severe diarrhea and vomiting. In order to combat some of this misinformation, a number of social media platforms are “fact checking” posts or providing warnings on posts with keywords, such as ‘COVID-19’ or ‘vaccination.’ On Instagram, each post with these keywords will contain a banner at the bottom inviting users to visit their “COVID-19 Information Centre,” which provides a list of information supported by WHO and UNICEF about how vaccines are of high-standard, well-researched, and generally resulting in mild side effects. In addition, on Facebook, posts identified to be spreading mistruths will provide users with websites explaining the truth, before they can access the original posts. However, these warnings and fact-checks can only go so far. Posts blindly supporting the use of Ivermectin, falsely reporting side effects of vaccines, and arguing that masks cannot block virus particles still circulate the internet. Often those most vulnerable in the community are at risk of being led astray with misinformation. In principle, evidence-based, concise, easy-to-understand science communication is essential to break down the barrier between research and the general public, ensuring that citizens are well-informed and more comfortable about the world around them. In the situation of a public health crisis such as the COVID-19 pandemic, this communication is crucial in ensuring that all citizens can remain well-informed, safe and healthy. Misinformation and dodgy studies can not only lead people astray, but also cost them their health and wellbeing. References: 1. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 2. Kathleen McGarvey, “Historian John Barry compares COVID-19 to the 1918 flu pandemic,” University of Rochester, October 6, 2020. https://www.rochester.edu/newscenter/historian-john-barry-compares-covid-19-to-1918-flu-pandemic-454732/ 3. Brian Dolan, Unmasking History: Who Was Behind the Anti-Mask League Protests During the 1918 Influenza Epidemic in San Francisco? Perspectives in Medical Humanities (San Francisco: UC Medical Humanities Consortium, 2020) Previous article back to DISORDER Next article

< Back to Issue 2 Maxing the Vax: why some countries are losing the COVID vaccination race As Australia’s COVID vaccination rate reaches 90% for the adult population, are you aware of countries struggling with their vaccination program? This piece discusses three countries, Brazil, Papua New Guinea, and India, and the key challenges they face in increasing their vaccination rate. by Grace Law 10 December 2021 Edited by Neisha Baker Illustrated by Aisyah Mohammad Sulhanuddin Most Australians are now fully vaccinated against COVID-19, but are you aware of how other countries are handling their vaccination programs? Each country has its own set of challenges and setbacks it must overcome in getting its citizens vaccinated. The success and failure of vaccination programs depend on how well these are addressed, and how the people respond. Political, economic, geographical, and educational factors can have a huge impact on vaccination success. Below, I will discuss the key challenges affecting COVID-19 vaccination in three countries, Brazil, Papua New Guinea, and India, as well as its impact on the country’s vaccination rate. Brazil – the nation that changed their fate Brazil has suffered the highest overall death toll in Latin America which is also the second-highest in the world after the United States. Brazil’s President Jair Bolsonaro was strongly opposed to lockdowns, restrictions, and public-health measures such as masks, which some local areas sought to impose (1). He has also spread disinformation regarding the coronavirus and vaccines, such as posting a video falsely associating the coronavirus vaccines with the onset of AIDS, resulting in Facebook removing it after public outcry (2). As a leader, his words and actions have major roles in influencing opinion and informing the public. While the number of preventable deaths is shocking, the predicted wave of destruction by the Delta variant has not materialised. Over 60% of the population is fully vaccinated despite the mixed messages and deterrence from the central government (3). The city of Serrana became the testing site of the Chinese vaccine Sinovac with most adults being willing towards receiving the vaccine (4). Consequently, the symptomatic cases, hospitalisation and deaths in the area all fell dramatically, becoming a place of envy for the neighbouring communities (5). This initial success also offers hope for low and middle-income countries, which may rely on this cheaper vaccine (6). Despite governmental resistance throughout the pandemic, Brazilians have defied the odds and faced the virus as a united community. Local leaders have challenged the national government to ensure suitable public health orders are enforced, and citizens have actively sought vaccination, preventing further COVID-19 devastation. Papua New Guinea – our struggling neighbour One of Australia’s closest neighbours, Papua New Guinea (PNG), is among the countries with the lowest vaccination rate in the world. According to Our World in Data, only 2% of the population is fully vaccinated (7). One of the most difficult issues to address is mistrust in the vaccine, due to low health education, inadequate health and general resources, and a political and historical distrust in the government. PNG relies on Australia and New Zealand’s AstraZeneca donations to acquire COVID vaccines, as well as Australian embassy staff to help run pop-up clinics in shopping centres. A Chinese medical team has also been working outside the government to unofficially administer the Sinopharm vaccine at a hospital clinic, leading to speculations of politically-motivated manipulation and interference (8). PNG is caught between two great powers, and the already sceptical PNG people are neglected and uninformed about vaccine efficacy, safety, and choices (9). Low science literacy and mistrust in political institutions have made it extremely difficult to convince people to get vaccinated (10). This has furthered the development of conspiracy theories, which interplay with cultural beliefs around witchcraft and superstitions (11). Despite the recent introduction of the “no jab, no job” policy, people are turning to mass resignations or the acquisition of fraudulent certificates instead of receiving the COVID-19 vaccine (12). Australia recently offered aviation lift services to high priority provinces, delivering much-needed emergency supplies to geographically isolated areas in PNG (13). A lot of work is still needed in order to increase the vaccination uptake rate in PNG. Stronger and more impactful campaign messaging will be required to increase public demand for vaccines (14). Foreign aid and assistance should prioritise effective vaccination and long-term health improvement over political agenda (15). The priority must be to stop the pandemic devastation by getting people vaccinated, and addressing long-term infrastructure, funding, and governance issues. India – great challenges and great ambitions India has the second-largest population in the world and it has struggled to source an adequate number of vaccines for its people. The government was ambitious that local manufacturing of the Indian vaccine Covaxin would be sufficient for domestic consumption. Instead, Bharat Biotech’s newest facility in Bengaluru reports quality issues in its initial batches, leading to a delay and vaccine shortage (16). During the country’s destructive second wave from April to June of 2021, the vaccine shortage was exacerbated by the government hesitating to approve vaccines developed and manufactured overseas. Local supply was also hindered by raw material shortages at the beginning of 2021 (17). While the government has sought higher vaccine administrations, setbacks including delays in manufacture, lack of doses received from overseas, and difficulties in obtaining regulatory approval, have contributed to the delayed and restricted nature of the vaccination program. Initially, the people met the vaccination program with great enthusiasm, and the government aimed to vaccinate all adults against COVID-19 by 31 December 2021. But vaccine uptake has plateaued and declined since October, and there are fears this target will not be met. Many factors have contributed to the decreased vaccine uptake, including vaccine shortage, barriers to vaccination such as lockdowns, high infection rates causing fear of visiting vaccination centres, and misinformation particularly in under-resourced rural areas (18). Although an improved COVID-19 vaccination program could have reduced the severity of the second wave, attention now is on maintaining the vaccination uptake rate. As the Indian government started to offer free vaccinations to all adults, citizens living in poverty have had the chance to be vaccinated as well. While many countries wish to manufacture their own vaccines at a fraction of the cost of the pharmaceutical giants, quality control and quality assurance remain incredibly complex issues to tackle (19). Lower-income countries require sufficient guidance and support, and Shahid Jameel, a virologist from Ashoka University in New Delhi says, ‘We can’t fix vaccine inequalities until vaccine manufacturing is distributed.’ (20) Conclusion Numerous factors impact vaccine uptake, with each country facing its own set of challenges. Mismanagement, limited infrastructure, and rampant misinformation were highlighted here, but there are many problems impacting vaccination programs around the world. Urgently addressing these problems will be needed to reduce vaccination inequality around the world, and hopefully, reach the end of the pandemic very soon. For more information on COVID-19 and the vaccine, please visit the VaxFACTS website created by the University of Melbourne: https://www.vaxfacts.org.au/ References Jake Horton, “Covid Brazil: Why could Bolsonaro face charges?” BBC News, published 27 October, 2021, https://www.bbc.com/news/world-latin-america-56663217. “Facebook removes video in which Brazil’s Bolsonaro links coronavirus vaccines with AIDS,” Washington Post, published 25 October, 2021, https://www.washingtonpost.com/technology/2021/10/25/facebook-papers-live-updates/#link-UA7IQVP5E5D2VGUQX7OJQBCFIE. “Coronavirus (COVID-19) Vaccinations,” Our World in Data, published 26 November, 2021, https://ourworldindata.org/covid-vaccinations?country=OWID_WRL. Mauricio Savarese, “Sinovac vaccine restores a Brazilian city to near normal,” Associated Press News, published 2 June, 2021, https://apnews.com/article/caribbean-brazil-coronavirus-pandemic-business-health-20bd94d28ac7b373d7a8f3f9c557e5b6. “Sinovac vaccine restores a Brazilian city to near normal.” “Sinovac vaccine restores a Brazilian city to near normal.” “Coronavirus (COVID-19) Vaccinations.” Natalie Whiting, “PNG caught in China-Australia power play as COVID-19 Delta variant infiltrates Pacific nation,” ABC News, published 2 August, 2021, https://www.abc.net.au/news/2021-08-02/png-caught-between-australia-and-china-as-it-fights-delta/100329206. “PNG caught in China-Australia power play as COVID-19 Delta variant infiltrates Pacific nation.” Mihai Sora, “Overcoming community resistance to vaccination in Papua New Guinea,” The Interpreter, published 26 October, 2021, https://www.lowyinstitute.org/the-interpreter/overcoming-community-resistance-vaccination-papua-new-guinea. Liam Fox and Marian Faa, “Health workers face death threats as COVID-19 vaccine hesitancy takes hold in PNG,” ABC News, published 10 September, 2021, https://www.abc.net.au/news/2021-09-10/png-vaccine-hesitancy-papua-new-guinea-covid-19/100444380. Fraser Macdonald, “Just 1.7 per cent of PNG residents are vaccinated against COVID. Why are they so resistant?” SBS News, published 8 November, 2021, https://www.sbs.com.au/news/just-1-7-per-cent-of-png-residents-are-vaccinated-against-covid-why-are-they-so-resistant/72c40029-dec8-4202-b436-31562d983fbc. “COVID-19 partnership with Papua New Guinea strengthened” Minister for Foreign Affairs, published 27 October, 2021, https://www.foreignminister.gov.au/minister/marise-payne/media-release/covid-19-partnership-papua-new-guinea-strengthened. “Overcoming community resistance to vaccination in Papua New Guinea.” “Overcoming community resistance to vaccination in Papua New Guinea.” Sreenivasan Jain, “Quality Issues Behind Covaxin Shortage: Government vaccine panel chief,” New Delhi Television, published 2 August, 2021, https://www.ndtv.com/india-news/quality-issues-behind-covaxin-shortage-government-vaccine-panel-chief-2500998. Shruti Menon, “India vaccination: Does it have enough doses for all adults?” BBC News, published 3 August, 2021, https://www.bbc.com/news/world-asia-india-55571793. Liji Thomas, “Factors predicrting vaccine hesitancy in India,” News Medical, published 26 September, 2021, https://www.news-medical.net/news/20210926/Factors-predicting-vaccine-hesitancy-in-India.aspx. Amy Maxmen, “The fight to manufacture COVID vaccine in lower-income countries,” Nature, published 16 September, 2021, https://www.nature.com/articles/d41586-021-02383-z. “The fight to manufacture COVID vaccine in lower-income countries.” Previous article back to DISORDER Next article