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< Back to Issue 4 Fool Me Once by Julia Lockerd 1 July 2023 Edited by Tanya Kovacevic and Elijah McEvoy Illustrated by Sonia Santosa I have rabies. I’m absolutely sure of it. I mean, I can't really tell, but that’s the silent killer, right? You don’t know you’re rabid till it’s all over, and you’re foaming at the mouth and biting your student tutor on the leg. Despite being completely safe here in Australia with its complete lack of rabies-having animals, I’m still pretty sure I’ve managed to catch it. Next week it will all be over for me and my tutor. Sorry, James. Of course, it’s not actually rabies that I’ve contracted, but a much more common condition: Medical Student Syndrome (1). Last week in my lectures, we learned all the ins, outs, and symptoms of the rabies virus. So, naturally, now we all have it. This health-related anxiety is a prime example of how our human brains can trick us into experiencing phantom symptoms. The same cognitive veil is used in clinical trials all over the world in order to test the efficacy of new drugs. We’ve all felt it. That moment when you question, ‘Is this real, or is my mind making its reality?’ We call this the placebo effect. The placebo effect is crucial to modern and historical experimental design. The ‘trickable’ nature of the human mind has changed the course of drug development as we know it. The effects’ success hinges on a patient's belief that they are receiving treatment for their ailment. The simple belief in a cure can often result in real physiological changes in an individual. This makes the placebo effect a very powerful tool in the development of new drugs for the market. In a placebo-controlled trial, half of the sample population will be blindly given a placebo, and the other half of the drug being tested. In order for a potential treatment to be considered effective, it must produce more significant results than the placebo group (2). We must improve our approach to designing and researching hypotheses. Can we use what we know about the placebo effect to make more accurate claims about modern pharmaceutical development? Well, in 2017, Dr. Sara Vanbheim of the Arctic University of Norway published a study that brought into consideration the possible effects of differing sexual characteristics on placebo efficacy (3). This idea could restructure the way experiments are designed going forward and potentially provoke a possible review of drugs already on the market. Is it possible that traditionally marginalised groups are underrepresented in the clinical trial process? Can we restructure experiments to be more inclusive? Are changes even really necessary? These questions were investigated through the compilation and calculation of placebo and nocebo effects on men and women over multiple previously conducted studies mostly centering around physical pain and the administration of analgesia. The term ‘nocebo’ defines the antithesis of a placebo (4), referring to adverse side effects a subject feels when given an inert version of the test drug. While placebos tend to have an analgesic effect, nocebos often cause negative effects or emotions when the subjects are told that they should expect/anticipate them. Before discussing any of these questions, it is worth noting that the Norwegian study focuses solely on classic sexual differences between cis-gender men and women. Though both keywords ‘gender’ and ‘sex’ were included in the study, research surrounding the specific effects of gender identity and gender-affirming therapies on placebos has not been thoroughly conducted as of 2023. It is with this focus that the following hypotheses are stated (3): “1) placebo responses would be stronger or more frequently observed in males than in females, 2) nocebo responses would be stronger or more frequently observed in females than in males, 3) verbally induced placebo responses would be more frequently observed in males than in females, and 4) conditioned nocebo responses would be more frequently observed in females than in males.” Results concluded that there was indeed a significant correlation between sex and placebo/nocebo effects when concerning pain relief. But what is truly fascinating is that while men received elevated levels of a placebo effect, such as reduced symptoms and analgesia, women were more susceptible to hyperalgesia and negative emotions. Those supposed ‘side effects’ appear to weigh more heavily on women (3). What does this say about how men and women process pain and information? The Norwegian study discusses the role of ‘psychophysiological mechanisms’ in pain pathways. Or, more simply, How stress and anxiety can affect the pain the brain perceives. In 8 of the 12 studies, men experienced significantly stronger analgesic effects from the placebo than women (3). It is plausible that men react more strongly to pain induced by stress hormones. This would explain why when taking a placebo, their anxiety level would decrease, and they would receive higher levels of analgesia than their female counterparts (3). Another study, upon which the Norwegian argument builds, investigates placebo delivery methods and their effect on perceived pain in men and women. In this study, men relied far more on verbal queues to provide analgesia, whereas women received a more significant effect from classic conditioning (5). These studies bring into question both the methodological and physiological effects of placebos on different sexes. What do these differences tell us about how men and women perceive the world? And what does this mean for the future of the placebo? The result of all of these studies is to show not whether placebos are bad or good, reliable or unreliable, but instead to highlight the differences in the physiological and psychological links when looking at different groups of people. At its core, a placebo is simply a trick of the brain, a psychological mirage. While the basis and reliability of placebos can be debated at length, their effect on the human brain teaches us something about ourselves societally. In all areas of medicine, the inclusion of people from all different backgrounds, genders, ethnicities, and ages is crucial so professionals know how to identify and treat various manifestations of a disease with grace and care. Now I know James responds better to verbal commands; I’ll be sure to tell him he has rabies the next time I see him. References Henning Schumann J. I contracted medical student syndrome. You probably will too. [Internet]. AAMC. [cited 2023 Jun 22]. Available from: https://www.aamc.org/news/i-contracted-medical-student-syndrome-you-probably-will-too Harvard Health Publishing. The power of the placebo effect - Harvard Health [Internet]. Harvard Health. Harvard Health; 2021. Available from: https://www.health.harvard.edu/mental-health/the-power-of-the-placebo-effect Vambheim S, Flaten MA. A systematic review of sex differences in the placebo and the nocebo effect. Journal of Pain Research. 2017 Jul;Volume 10:1831–9. National Cancer Institute NCI. Definition of nocebo effects [Internet]. www.cancer.gov . 2011. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/nocebo-effect Enck P, Klosterhalfen S. Does Sex/Gender Play a Role in Placebo and Nocebo Effects? Conflicting Evidence From Clinical Trials and Experimental Studies. Frontiers in Neuroscience. 2019 Mar 4;13. 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By Andrew Lim From Fusion to Submarines: A Nuclear Year By Andrew Lim 23 March 2022 Edited by Tanya Kovacevic Illustrated by Quynh Anh Nguyen A press conference in April, pledging millions of dollars to nuclear medicine. A university address in November, rethinking Australia’s nuclear attitudes. A fusion reaction in December, promising a clean energy revolution. No matter where you were or who you were listening to, the world of nuclear science was inescapable in 2022. It has been a year of great progress and, at times, even greater controversy – pairing milestone triumphs and landmark facilities with old fears and vast challenges. So, what has defined the year in nuclear science – and what comes next? Powering the Future Image 1: LLNL’s National Ignition Facility, where the successful fusion ignition experiment was conducted in December. Perhaps the year’s most eye-catching discovery came near its end. On 13th December, scientists at the Lawrence Livermore National Laboratory (LLNL) in California announced that for the first time, they had produced more energy out of a nuclear fusion reaction than they had put in. It seemed to herald the beginnings of a new era – nuclear power without toxic nuclear waste. However, to report this as the USA’s civilian nuclear energy story of the year perhaps fails to capture the whole picture. It’s an important discovery, sure, but it stands on another development, far less well known: the congressional funding battles of the preceding months. Crafted from intense negotiations led by Majority Leader Chuck Schumer (D-NY) and Senators Todd Young (R-IN), Mark Warner (D-VA) and John Cornyn (R-TX), the bipartisan CHIPS and Science Act (1) authorized and appropriated funds for nuclear research en masse. It provided everything from a five-year $50 million p.a. plan for “Foundational Nuclear Science” (2), to a $1.09 billion Electron Ion Collider (3) and a “National Nuclear University Research Infrastructure Reinvestment” scheme that included LLNL (4). Even private sector fission work received a boost in the form of the Inflation Reduction Act of 2022 (5), built on a compromise between Schumer and Senator Joe Manchin (D-WV), allocating billions of dollars in tax credits and loan guarantees for the sector. These funding boosts (and their predecessors), the work of years of lobbying and negotiations across multiple political factions, helped create the environment necessary for this research to thrive – and the breakthrough is as much a reminder of their importance as a triumph of nuclear physics. Health and Safety Image 2: Prime Minister the Hon Scott Morrison MP, flanked by Health Minister the Hon Greg Hunt MP (L) and backbencher Gladys Liu MP (R), announces a $23 million APME grant in April. The year’s nuclear focus extended into the medical sector, too. President Biden’s 2022 State of the Union address announced an appeal beyond partisan lines, one pillar of which was the use of the Advanced Research Projects Agency for Health (ARPA-H) to “drive breakthroughs in cancer” (6). His call was answered in budget appropriations bills, funding accelerators and reactors to research new radioisotopes, while also investigating safer handling methods for natural and artificial nuclear sources (7). Such emphases echoed as far away as our antipodean shores. While Australia may already produce 80% of the radioisotopes used in its own nuclear medical procedures (8), both major parties took 2022 to advance nuclear medicine production. In April, the Coalition government launched new grants for the Australian Precision Medicine Enterprise (APME) in Melbourne, with the Hon Greg Hunt MP, then Minister for Health, declaring nuclear medicine “the next stage of precision medicine.” (9) Mere months later, in the October Budget, his Labor successor the Hon Mark Butler MP pledged funds for medical supplies of Gallium-67 (10). Across party lines, nuclear innovation became key to funding in the health sector. Securing Tomorrow Image 3: Australian Deputy Prime Minister and Minister of Defence Richard Marles (L) meets with US Secretary of Defence Lloyd J Austin III (R) at the Pentagon to discuss AUKUS submarine arrangements in December. All that said, no article about nuclear science, especially these days, would be complete without a discussion of AUKUS. In late October, an interview with Australian Vice Admiral Jonathan Mead was published in The Australian, in which he underscored the importance of building a nuclear workforce – that is, building the educational pathways required to produce all the crews, builders, architects, regulators and scientists a nuclear submarine capability would entail (11). With Australia’s first nuclear submarine captains likely in high school, the infrastructure needed to train them simply doesn’t exist – and time is running out. This urgency was emphasised by academics at ANU, home of the only postgraduate qualifications dedicated to nuclear science in the country. In November, Vice-Chancellor Brian Schmidt AC spoke of an approaching “transformation in Australia’s cultural relationship” with nuclear science (12). In December, Dr AJ Mitchell, an ANU academic leading the development of a national program for nuclear science and education, reiterated Schmidt’s arguments. In comments provided to The Sydney Morning Herald and The Age, he advocated for a “sovereign capability…start[ing] yesterday,” to ensure an Australian nuclear workforce capable of meeting requirements not only for defence but also for health, regulation, space exploration and much more (13). However, this attitude was not without controversy. In today’s world, where the word ‘nuclear’ carries connotations of Chernobyl, Fukushima, and the Cold War, increased nuclear funding (even if only to regulatory or medical bodies) often sparks fear in the public imagination. In response to Mitchell’s comments, A/Prof Peter Christoff, a University of Melbourne climate policy researcher, expressed worries about increased “anxiety in our region”. More than anything else, this perhaps underscores the biggest issue facing the nuclear sector: the long-held apprehensions from media, governments and beyond that can often lump anything vaguely nuclear – from medication to missiles – under the same roof. What's Next? Image 4: US President Joe Biden delivering his 2023 State of the Union Address, advocating for increased cancer research funding, flanked by Vice-President Kamala Harris (L) and Speaker Kevin McCarthy (R). Over the first months of 2023, the tense balancing acts and decisions of the past year have only continued to grow. In the USA, President Biden’s 2023 State of the Union speech, delivered in early February, saw him reinvigorate his call to “end cancer as we know it” (14) – the same call that led to all that radioisotope funding last year. However, Biden faces a Republican House of Representatives seemingly hell-bent on blocking his legislation. With the resultant impasse threatening a wholescale government shutdown, the funding necessary for scientific leaps of the kind seen in 2022 remains in doubt. On the Australian front, our lack of a ready nuclear workforce is causing jitters amongst our allies – with leaked letters from US Senators Jack Reed (D-RI) and James Inhofe (R-OK) expressing concern to the Biden administration about Australia relying on American production lines for stopgap submarines. Australian Defence Minister Richard Marles spent the December-January period allaying these concerns with the support of US Representatives Joe Courtney (D-CT-02) and Mike Gallagher (R-WI-08) while in the US and UK, but the issue is certain to remain a hot topic for this year. Even closer to home, Rio Tinto’s loss of a Caesium-137 capsule in Western Australia captured the imaginations of people across the nation and the world. At once it seemed to represent the long-standing fear of nuclear research and its importance in fuelling the same regulatory efforts that helped track down the capsule. Perhaps more than a story of scientific discoveries, of neutrons, protons and physics, the story of nuclear science in 2022 and beyond is the story of people. Of those legislators and politicians, balancing visions of the future with messy political compromises. Of those scientists and researchers, balancing plans and facilities with the capacity of their institutions. Of us, the ordinary public, balancing long-held phobias with exciting aspirations. Will we meet the challenges that lie before us? Are we ready to have a nuanced discussion about how we want to use our nuclear knowledge? Can we balance the possibilities of the future with the fears of the past? Well... that’s entirely up to us. Andrew Lim is an Editor and Feature Writer with OmniSci Magazine and spent the summer as a Summer Research Scholar at the Australian National University’s Heavy Ion Accelerator Facility, working on studying nuclear structure through particle transfer reactions. Image Credits (in order): Lawrence Livermore National Laboratory; Monash University; US Department of Defence; The White House Author's Note Between the submission of this article in late February and its publication in mid-March, a notable development took place, one that necessitated this additional note. On March 14, at an announcement held in San Diego, President Biden, Prime Minister Albanese and Prime Minister Sunak revealed plans for Australia to purchase three to five American Virginia-class submarines in the early 2030s. The Royal Navy and the Royal Australian Navy would then work out of their shipyards to develop and produce new SSN-AUKUS submarines (based off plans for successors to the British Astute-class models), coming into service in the late 2030s. If anything, this timeline accentuates the dramatic expansions required from Australia’s nuclear workforce, as presented in the original article. Meanwhile, the narrative that surrounded the announcement – one solely focussed on nuclear research’s military capabilities (and, at that, often conflating nuclear weaponry with nuclear power) – seems only to indicate the same throughlines of 2022 repeating themselves in the year to come…and nuanced and subtle discussion of nuclear research being left for another day. References CHIPS and Science Act, Pub L No 117-167, 136 Stat 1366 (2022). See ibid, div B tit I § 10102(d), 136 Stat 1415-6. See ibid, div B tit I § 10107, 136 Stat 1449-50, esp. sub-s (b)(4). See ibid, div B subtitle L § 10741-5, 136 Stat 1718-21. Inflation Reduction Act of 2022, Pub L No 117-169, 136 Stat 1818. The White House Office of the Press Secretary, Remarks by President Biden in State of the Union Address. March 2, 2022. https://www.whitehouse.gov/briefing-room/speeches-remarks/2022/03/02/remarks-by-president-biden-in-state-of-the-union-address/ See House Committee on Appropriations, Report to Accompany H.R. 8295, H.R. Rep No 117-403 (2022), esp. at 65, 104, 235, 238. Taylor A, Birmingham S and Hunt G, Safeguarding the future of critical medicine supply [Media Release]. September 30, 2021. https://www.minister.industry.gov.au/ministers/taylor/media-releases/safeguarding-future-critical-medicine-supply. “Precision medicine is the ‘future of medicine’: Greg Hunt”. The Australian. April 4, 2022. https://www.theaustralian.com.au/nation/politics/precision-medicine-is-the-future-of-medicine-greg-hunt/video/9ec9b0942bfb18757e3fbf4f3e95e0f4 Garvey, P. “Butler steps in to ease nuclear medicine crisis”. The Australian. October 27, 2022. Nicholson, B. “Defence Special Report: Cultivating a Nuclear Mindset”. The Australian. October 27, 2022. ANU Communications & Engagement, Building Australia’s AUKUS-ready nuclear workforce: Address by Professor Brian Schmidt AC. November 9, 2022. Mannix, L. “‘Cherish’ the power: Physicists issue call to arms over nuclear skills gap”. The Sydney Morning Herald. December 28, 2022. https://www.smh.com.au/national/cherish-the-power-physicists-issue-call-to-arms-over-nuclear-skills-gap-20221228-p5c92s.html The White House Office of the Press Secretary, Remarks by President Biden in State of the Union Address. February 7, 2023. https://www.whitehouse.gov/briefing-room/speeches-remarks/2023/02/07/remarks-by-president-biden-in-state-of-the-union-address-2/ Previous article Next article

The Greenhouse Unpacking the Latest IPCC Report - What Climate Science is Telling Us By Sonia Truong The most comprehensive climate science report to date, this sixth assessment report reveals the reality of climate change and stresses that we need to take action urgently. Edited by Jessica Nguy & Yen Sim Issue 1: September 24, 2021 Illustration by Jess Nguyen On the 9th of August 2021, the United Nations Intergovernmental Panel on Climate Change (IPCC) released its first instalment of the IPCC Sixth Assessment Report from Working Group I, Climate Change 2021 — The Physical Science Basis of Climate Change. The IPCC is one of the world’s leading authorities on climate change and its reports provide an important scientific framework for governments to develop climate policies. With the collaborative effort of 234 leading climate scientists and more than 1,000 contributors, the latest IPCC report provides the most up-to-date information about the scientific basis of climate change and the effects of human activity on Earth’s systems. The report can be found online — it features a ‘Summary for Policymakers’ document exploring key findings across four topic areas as well as a comprehensive ‘Full Report’ which assesses and compiles peer-reviewed literature on climate science from across the globe. The report also features the IPCC WGI Interactive Atlas which explores observed and projected regional climate changes across different emissions and warming scenarios. Three key takeaways from the IPCC report are described below. #1: Human activity has contributed to climate change It in unequivocal that human influence has warmed the atmosphere, ocean and land. Headline statement from the IPCC’s ‘Summary for Policymakers’, AR6 2021 Advancements in attribution studies have allowed scientists to better simulate Earth’s responses to natural and anthropogenic factors and estimate the extent of human influence on observed climate trends. For the first time, the IPCC report has been able to state with a very high level of certainty that anthropogenic factors have been the main driver of increasing temperature extremes since the mid-19th century. Figure SPM.1 shows that simulated natural factors do not come close to explaining the observed increase in global surface temperature since the mid-19th century. Figure SPM.1: A powerful comparison of changes in global surface temperature since 1850 with and without human factors. This figure shows that the effects of natural climate drivers on global warming have been negligible compared to human influence on the climate. IPCC AR6, ‘Summary for Policymakers’ Atmospheric greenhouse gas concentrations are higher than what they have been in the last two millennia and have been increasing at an unprecedented rate, mainly due to human activities in greenhouse gas combustion and deforestation. According to the report, greenhouse gas emissions from human activities have caused warming of approximately 1.1°C above pre-industrial average. In fact, human activities have caused enough emissions for even greater warming, but this has been partially counteracted by the cooling effect of aerosols in the atmosphere. Some recent heat extremes would have been virtually impossible without the influence of human forcing factors. Siberia’s prolonged heatwaves of 2020, for example, would have occurred less than once every 80,000 years without human-induced climate change. Moreover, the onset of Siberia’s wildfire season saw record-high temperatures throughout 2020 and 2021 as well as the burning of over 16 million hectares of land. Even in today’s climate, such extreme weather events are unlikely, but have been predicted to become more frequent by the end of this century. #2: Every region will experience environmental changes due to climate change The IPCC report states that the “widespread, rapid and intensifying” effects of climate change will be experienced by every region in a multitude of ways. Since the release of the last IPCC report in 2018, the world has observed an increase in acute weather events such as widespread flooding, storms, drought, fire weather and heatwaves. These are predicted to increase in frequency and severity as a result of human-induced climate change. Many changes in the climate system become larger in direct relation to increasing global warming. They include increases in the frequency and intensity of hot extremes, marine heatwaves, and heavy precipitation, agricultural and ecological droughts in some regions, and proportion of intense tropical cyclones, as well as reductions in Arctic sea ice, snow cover and permafrost. B.2 from the IPCC’s ‘Summary for Policymakers’, AR6 2021 Several environmental changes due to climate change are already irreversible. Notably, global sea level rise and ocean acidification are set in long-term motion and will proceed at rates which will depend on future emissions. Glacial retreat is occurring synchronously across the world and glaciers will continue to melt for decades or centuries. All emission scenarios within the 21st century described in the report have revealed that global temperature changes will exceed a 1.5ºC increase, even in the lowest emissions scenario (SSP1-1.9). Thus, warming will reach a critical level regardless of actions that the world takes now. We can, however, prevent further temperature increases with deep reductions in global greenhouse gas emissions (especially carbon dioxide and methane). Figure SPM.5: All regions of the world (with one exception) will experience warming as a result of climate change, although not at an equal level. IPCC AR6, ‘Summary for policymakers’ Environmental changes at a 2ºC warming will be more pronounced and widespread, and extremes are likely to exceed critical tolerance thresholds in human health, ecological systems and agriculture. Australia, in particular, is vulnerable to experiencing scarce water resources in drought-prone areas and flooding and landslide events due to heavy rainfall events. Australia’s coastlines are also prone to erosion and flooding from rising sea levels and extreme meteorological events. The IPCC report examines evidence for climate ‘tipping points’ which, due to uncertainty about the Earth’s feedback systems, “cannot be ruled out” in climate projections. These tipping points are key thresholds that will lead to large-scale and irreversible damages to the Earth’s systems if breached. One of these tipping points is the loss of the Greenland ice sheet which is melting at an unprecedented rate. Surface melt of this major ice sheet involves a number of positive feedback loops which exacerbate the melting as the ice surface gets darker and less reflective of solar radiation. Scientists warn that, while highly unlikely, there is a possibility that we will reach a tipping point with current warming trends. #3: We need to make drastic reductions in greenhouse gas emissions immediately The Sixth Assessment Report tells us, with greater certainty than ever before, that human activities over the past six decades have caused global warming trends and affected climate extremes globally. These trends are likely to continue on a long-term scale. Most importantly, the report stresses that if we want any chance of limiting global temperature rise to 1.5ºC above pre-industrial levels, we must urgently make strong, sustained reductions in global greenhouse gas emissions. The current global carbon budget to remain below 1.5ºC warming is estimated to be at an additional 500 billion tonnes of greenhouse gas. To remain within this budget, we need to achieve net zero carbon dioxide emissions by 2050. Reductions in greenhouse gas emissions will only be achieved with meaningful climate action. If we can drastically reduce emissions now, we will still have a chance of averting the climate crisis. The two succeeding instalments of the IPCC Sixth Assessment Report will cover the impacts of climate change and mitigation of climate change and are planned to be released in 2022. References: IPCC, 2021: Summary for Policymakers. In: Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change [MassonDelmotte, V., P. Zhai, A. Pirani, S.L. Connors, C. Péan, S. Berger, N. Caud, Y. Chen, L. Goldfarb, M.I. Gomis, M. Huang, K. Leitzell, E. Lonnoy, J.B.R. Matthews, T.K. Maycock, T. Waterfield, O. Yelekçi, R. Yu, and B. Zhou (eds.)]. Cambridge University Press. In Press.

Sick of lockdown? Let science explain why. By Tanya Kovacevic Feeling like the ant under COVID’s boot? Find out just why you are feeling so down, and how you can break free of the overflow of emotions. Edited by Sam Williams Issue 1: September 24, 2021 Illustration by Quynh Anh Nguyen Trigger warning: This article mentions symptoms of mental illness. If at any point the content is distressing, please contact any of the support services listed at the end of the article. COVID-19: the greatest enemy of 2020 and 2021. Victoria has had six lockdowns in the hopes of disrupting the course of the virus, leaving many feeling tired and hopeless. The endless restrictions have tested our resilience beyond belief. As a result, many of us are sick of lockdown: we are tired, moody, and anxious, following months on end of being secluded in our homes. It seems we have all turned into little Snorlaxes. If this is sounding uncomfortably familiar, you are not alone. Psychologists have realised it is a common occurrence amongst many Australians. So why are our little octopus plushies showing their angry little faces? What can we do about it? Illustration by Quynh Anh Nguyen Cue the entrance of ‘lockdown fatigue’: the psychological phenomenon describing a wide-reaching feeling of intense exhaustion, due to the long-term effects of COVID-19 (1). Speaking to your fellow students (and lecturers/staff), you might find that a common theme of working from home is too much time binging on Netflix. In other words, there is a shared lack of motivation and concentration. The Australian Psychological Society has likened these symptoms to the natural process of grieving – yes, you read that right: we are all grieving. The world that we once knew has been completely disrupted, with our daily freedoms and safety torn away from us. Lockdowns have introduced so many unfamiliar aspects into our lives, from regular tests to social distancing to travel restrictions. Where we once had freedom to go to concerts or the footy, or to lie in the sand with the sun on our faces in Torquay, we are now confined within our own boring four walls. Combine this with missing our friends and family, worrying about the future, and inconsistent messages from politicians, it is no surprise that we are currently witnessing a lockdown fatigue epidemic. Identifying lockdown fatigue can be extremely difficult, as most of the symptoms overlap with common mental illnesses, such as depression and anxiety (2). Racing thoughts and conflict with those close to you are early signs (3). A study of 243 Filipino students showed that headaches and body pain were also common amongst students attempting to balance the effects of lockdown with their education (4). The most frequent symptoms are perhaps the most observable: depressed mood, irritability, fear or anxiety about how this will all end, lack of motivation and/or concentration, inability to make choices, and, of course, feeling mentally and physically exhausted (5). You could even be having more nightmares (6), some being about the coronavirus-ad jingle. It’s tiring just to read through that list. So many symptoms, but what causes them? Grief for the freedoms we have lost and stress about the future is messing with everyone at the moment. The high levels of stress mimic a post-traumatic stress response while we live through horrible lockdown moments again and again, kicking our sympathetic nervous system into overdrive (7). The sympathetic nervous system is responsible for all things fight-or-flight (or fight-flight-freeze, if you are a psychology nerd), releasing stress-related hormones such as cortisol and adrenaline. Stress over long periods of time, especially over 18 months, is undoubtedly going to take a toll – that toll is seen in lockdown fatigue, with those levels of cortisol building up. The accumulation weakens the immune response, which is why you may be getting colds more often, and it also taps into the brain, altering mood, motivation levels, and the fear response (8). The body’s resources are drained by constant worrying, and even more-so the resources of the mind. With mental fatigue comes lethargy, preventing you from paying attention to those lectures that feel longer than Lord of the Rings: Return of the King. It is a ripple effect: lethargy turns to apathy and stress, stress leads to frustration when the internet drops out for the 100th time during the lecture, frustration leads to further fatigue, to sadness… Everything has a cause and a consequence. There are ways to combat lockdown fatigue, so do not think that it is the end of the world, even though it may seem like it. One of the key symptoms of lockdown fatigue is an overflow of emotions. The rush of feelings (or lack thereof) can often cause distress on its own, so it is important to accept that there is nothing wrong with feeling the way you do (9). Analysing and criticising your emotions will do more harm than good, so try to be nice to yourself! Dr Luana Marques, a psychiatrist and associate professor at Harvard Medical School, reminds her students at that, “however you may be feeling is valid in its own right (10).” Take it easy. Learn to love yourself. Mindfulness is a commonly recommended method of staying in touch with your mind and body (11). Whether it is journaling, meditating, or yoga, any mindfulness activity can strengthen the prefrontal cortex – responsible for thought processes and self-control – increasing your resilience and your ability to pay attention to your surroundings (12). If you notice that you are beginning to be overwhelmed by your emotions, change your focus (13). Think about everything that you have achieved, as small as it may be. Perfected your sourdough? Amazing. Taught your dog some new tricks? Get that on TikTok. Made your bed this morning? Go you! It does not need to be something extravagant, like making a new spacecraft; any accomplishment is something to be proud of, no matter how small. Many of us are also missing social contact, so say hello to your neighbours or get on FaceTime with your friends. Maintaining relationships is fundamental to breaking through the overwhelming uncertainties and negative emotions that come with lockdowns (14, 15). Finally, as much as you may want to, avoid staying bed in bed the whole day. Staying in bed will only give those annoying thoughts a chance to come crashing down (16). Instead, go outside and see some natural light. Natural light will help maintain your circadian rhythm – the cycle which decides when you feel tired and when you are pumped with energy – and make you feel better (17). So go ahead. Make a routine and take back a little bit of control. Start doing downward dogs and turning into a pretzel. Get this bread. COVID-19 and lockdowns have found a way to disrupt so many aspects of our lives, but ultimately, we decide how we approach it, though we may need a little bit of help. Lookout for yourself, and for your friends and family. The fact that you are resilient enough to still be here is testimony to your strength. If you can live through this chaos, you can live through anything. If at any time you feel or have felt concerned about your mental well-being, please consult a GP or contact any of the following services: Suicide Call Back Service: 1300 659 467 or suicidecallbackservice.org.au; Lifeline: 13 11 14 or lifeline.org.au; Beyond Blue: 1300 22 4636 or beyondblue.org.au; MensLine Australia: 1300 78 99 78 or mensline.org.au; or the University’s CAPS: 03 8344 6927 for an appointment, or 1300 219 459 for emergency support. References: 1, 2, 5, 9, 14. Australian Psychological Society. Managing lockdown fatigue. Victoria: The Australian Psychological Society Limited, 2020. 3, 10, 12. Marques, Luana, and Waldinger, Robert. “Overcoming Quarantine Fatigue.” Massachusetts General Hospital. Published June 2, 2020. https://www.massgeneral.org/news/coronavirus/quarantine-fatigue . 4. Labrague, Leodoro J., and Ballad, Cherry Ann. “Lockdown fatigue among college students during the COVID-19 pandemic: Predictive roles of personal resilience, coping behaviors, and health.” Perspectives in Psychiatric Care 57, no. 3 (Mar 2021): 2-6. 6. Silva, Kristian. “Feeling tired during the COVID-19 pandemic? Here’s how you can improve your energy and motivation levels.” ABC News, September 9, 2020, 8:21 a.m. AEST, https://www.abc.net.au/news/2020-09-09/fatigue-during-covid-19-pandemic-how-to-lift-energy-motivation/12640002 . 7. Victorian Institute of Forensic Mental Health. "Lockdown fatigue amid Lockdown 6.0." Published August 2021. https://www.forensicare.vic.gov.au/lockdown-fatigue-amid-lockdown-6-0/ . 8, 15. Mayo Clinic. “Chronic stress puts your health at risk.” Published July 2021. https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20046037 . 11, 13. Beyond Blue, “Lockdown regrets? Focus on what you did do.” Published 2020. https://coronavirus.beyondblue.org.au/managing-my-daily-life/coping-with-isolation-and-being-at-home/lockdown-regrets-focus-on-what-you-did-do.html .

< Back to Issue 5 When Dark Matters Ingrid Sefton 24 October 2023 Edited by Celia Quinn Illustrated by Louise Cen To put it simply, the entire visible universe is huge. In the scheme of it, we really are just tiny dots on a floating rock, in a vast and constantly expanding cosmos. Yet, as it turns out, that’s not even close to the full story. All the visible objects, planets and galaxies contribute less than 15% of the mass in the universe. The other 85%? Nobody knows for certain, but it has a name. Dark matter. More can be said about what dark matter is not, than what it is. It isn’t the baryonic or “normal” matter such as protons, neutrons and electrons which comprise our visible world. It also isn’t antimatter, composed of subatomic particles with opposite charges to normal matter. Instead, dark matter interacts with normal matter in a manner entirely different to that of antimatter. It’s not a type of black hole, nor simply a form of radiation, or a type of massless particle. So, what can be conclusively said? Essentially, nothing. As the name suggests, dark matter emits no light and therefore is not visible in the way normal matter is, making it difficult to observe. In fact, dark matter has only been “observed” by way of its gravitational effects. Therefore, we know it must have mass in order to be able to interact with visible matter gravitationally. It’s also imperative for it to be big enough to cause the massive gravitational effects seen in galaxies (Lochner et al., 2005). Estimates place the mass-energy content of the cosmos as being composed of 26.8% dark matter, 68.3% dark energy and a relatively miniscule 4.9% normal matter (Greicius, 2013). The terms dark matter and dark energy are often thrown around somewhat interchangeably. However, they explain distinct aspects of observed gravitational and physical phenomena. Dark matter can be thought of as an invisible substance which is only seen through its effects on gravity - the unexplained gravitational forces that hold together rapidly rotating galaxies and stopping them from flying apart. Dark energy is then the force responsible for pushing these clusters of galaxies and the universe apart, accelerating the rate of expansion of the universe (NASA/WMAP Science Team, 2013). Given the lack of answers about what dark matter is, an interesting question to ponder is how its existence was even discovered. Swiss astronomer Fritz Zwicky was the first to propose the idea of “dark matter”. His observations of the Cloma galaxy cluster led him to suggest if individual galaxies within the cluster were only held together by the gravitational force of visible mass, the galaxies should fly apart due to their high velocity (American Museum of Natural History, 2000). He termed this mysterious force responsible for binding galaxy clusters together “dark matter”. It wasn’t until the 1970s that Vera Rubin became the first person to establish the existence of dark matter through her work with spiral galaxies. Spiral galaxies aren’t stationary. They rotate, with stars different distances from the centre moving in roughly circular orbits around this centre. The highest concentration of visible stars is found within the core region of a galaxy, leading to the assumption that the majority of mass, and therefore gravity, should also be concentrated there. An implication of this is the expectation that the farther a star is from this gravitational centre of a galaxy, the slower its projected orbital speed should be (American Museum of Natural History, 2000). However, alongside astronomer Kent Ford, Rubin made the puzzling observation that stars in both the centre and outer regions of any galaxy were moving at the same speed (American Museum of Natural History, 2000). Her calculations provided convincing observational evidence of Zwicky’s theory. The presence of a significant mass of invisible matter in the outer regions of a galaxy would create an even, spherical distribution of matter, gravitationally explaining the observed rotation of galaxies and their velocity distribution (NASA/WMAP Science Team, 2013). Fifty years later and experimental evidence still remains the only “proof” of dark matter we have, having been unable to directly detect dark matter. Despite this, a majority of scientists are confident in its existence. Rubin’s insight into the velocity distribution of galaxy rotation curves is amongst some of the most convincing observational evidence for the presence of dark matter. Also supporting its existence are the various discrepancies that arise in the process of gravitational lensing. Gravitational lensing occurs when an emitted source of light is deflected or distorted by the gravitational field of a large mass. Based upon the degree of deflection, the gravitational potential of the object can be calculated, alongside the amount of matter in the lensing object (Xenon Dark Matter Project, 2022). Yet, the strength of this gravitational lensing observed in many galaxy clusters is significantly greater than that calculated from visible matter alone. These inconsistencies point to the existence of unseen mass, or dark matter, as a convincing explanation for the observed lensing effects. It’s become clear that the standard model of physics, explaining the different particles and forces comprising the visible world, cannot be used in attempting to explain dark matter. In response, researchers are exploring a number of avenues to find hypothetical new particles. Amongst the most likely candidates for the composition of dark matter are two classes of particles: Weakly Interacting Massive Particles (WIMPs) and axions. WIMPs are distinguished as a class of particles created thermally in the early universe at very high temperatures, while axions originate predominantly from non-thermal mechanisms (Griest, 2002). Compared to WIMPS, or other known type of particles, axions would be thousands of times lighter but also significantly more abundant than WIMPs (Darling & Knight, 2022). Given the infinite potential to invent hypothetical substances that resolve the enigma of dark matter, experimentation to find these particles has significant challenges. Current research efforts are focused on the detection of such particles. More than a kilometre underground in Stawell, Victoria, the Stawell Gold Mine has been converted into an underground laboratory – one with no light, no noise, and no radioactivity to interfere with dark matter signals (Lippincott, 2023). Here, an experiment known as DAMA/Libra, which started in Italy in 1998, is being replicated. For two decades, what is suspected to be dark matter has been detected at the same time each year in Italy. The Stawell Lab is seeking to verify these results, operating below the equator to determine any potential effect of seasonal interference from the Earth (Darling & Knight, 2022). The research utilises the technology SABRE (Sodium iodide with Active Background REjection), which are sodium iodide crystals that emit flashes of light if a sub-atomic particle hits the nuclei of atoms within the crystals (Darling & Knight, 2022). Hence, if a particle of dark matter hits a nucleus, a tiny flash of light should be created. Simultaneously, researchers at the University of Western Australia have been working on the detection project ORGAN (Oscillating Resonant Group Axion), in order to determine the presence of axions (McAllister, 2022). Despite not having detected any dark matter signals thus far, such experimentation has still offered important insights. Not detecting dark matter within a certain mass range and level of sensitivity allows exclusion limits to be set around the possible characteristics of axions. This tells researchers where to stop looking and, instead, where they should be focusing their resources and efforts. Despite the disarray around “solving” the conundrum of dark matter, alongside its less than reassuring name, it’s not actually something that people should be scared about. The gravity that dark matter is responsible for enables our existence, with dark energy having allowed the expansion of the early universe to become what we see, and don’t see, today (Xenon Dark Matter Project, 2022). Detecting the presence of dark matter is about advancing our understanding of the size, structure, and future of the universe. Current research approaches may seem slightly haphazard, attempting to find something that has never been detected and may not even exist. But when pursuing strange cosmological phenomena beyond our understanding, taking a wild stab in the dark may be exactly what we need to do. References American Museum of Natural History (2000). Vera Rubin and Dark Matter . Retrieved September 1, 2023 from https://www.amnh.org/learn-teach/curriculum-collections/cosmic-horizons-book/vera-rubin-dark-matter Darling, A., & Knight, B. (August 20, 2022). The search for dark matter . ABC News. https://www.abc.net.au/news/2022-08-21/dark-matter-particle-physics-sabre-experiment-stawell-victoria/101113010 Greicius, T. (March 21, 2013). Planck Mission Brings Universe Into Sharp Focus. NASA. https://www.nasa.gov/mission_pages/planck/news/planck20130321.html Griest, K. (2002). WIMPs and MACHOs . In P. Murdin (Ed.), Encylopedia of Astronomy and Astrophysics: CRC Press. Lippincott, H. (August 9, 2023). Researchers dig deep underground in hopes of finally observing dark matter. The Conversation. https://theconversation.com/researchers-dig-deep-underground-in-hopes-of-finally-observing-dark-matter-211075 Lochner, J. C., Williamson, L., & Fitzhugh, E. (2005). Possibilities for Dark Matter. Retrieved August 29, 2023 from https://imagine.gsfc.nasa.gov/educators/galaxies/imagine/titlepage.html McAllister, B. (July 26, 2022). This Australian experiment is on the hunt for an elusive particle that could help unlock the mystery of dark matter. The Conversation. https://theconversation.com/this-australian-experiment-is-on-the-hunt-for-an-elusive-particle-that-could-help-unlock-the-mystery-of-dark-matter-187014 NASA/WMAP Science Team. (2013). WMAP produces new results . Retrieved September 13, 2023 from https://map.gsfc.nasa.gov/news/ Xenon Dark Matter Project. (2022). Dark Matter . Retrieved August 25, 2023 from https://xenonexperiment.org/partners/ Wicked back to

< Back to Issue 8 A Headspace of One’s Own by Andrew Irvin 3 June 2025 Edited by Arwen Nguyen-Ngo Illustrated by Anabelle Dewi Saraswati Biocomputers, organoids, brain-on-a-chip systems; humanity has veered into uncharted territory at the intersection of ethics and technology. Upon reading the recent New Atlas interview (1) between Loz Blain and Dr. Brett Kagan concerning Cortical Labs’ 800k neuron biocomputers, and noting the 100 billion cells (2) in the human brain, the intersection of complexity and scale comes to mind. Thinking back to the days of the Battle.net in the 1990s, I remember logging into the community and seeing characters with stupid puns for names, like Dain_Bramage or Goatmeal, and trying to engage in trade and discourse while avoiding PKs—player killers—who would go around filling up their inventories with the ears of other characters. In those early internet days my friends’ dad still had their internet billed by the hour—we found out after the first month of heavy online gaming brought an invoice hundreds of dollars higher than planned. The scope of gaming was a much smaller place; we knew the crowd online, regardless of how they played, was comprised of humans, as awful as they sometimes were. Now, nearly 30 years after those first forays into the Blizzard servers, I watch my son log onto Roblox or Fortnite , and the continuous question of whether top players cheat their way to a competitive advantage hasn’t gone anywhere–-duping resources and items to trade or finding shortcuts to buff their stats. Watching the world of online gaming grow from a few hundred thousand registered nerds to an industry that dwarfs the film and music sectors has been like watching bacteria multiply across the surface of a Petri dish. The Top 20 Massive Multiplayer Online (MMO) games alone have over a billion registered players, with over three million active players on any given day (3). There is now a question as to whether the players in the servers are even humans, or if the digital playground has been overrun by bots. As AI drives the proliferation of bots behind the Blob internet (4), another ethically fraught technological development is now starting to creep into the global market out of labs. Across the research landscape, from Brainoware at Indiana University (5), or Switzerland’s Final Spark (6), or open source tech like Tianjin University’s brain-on-chip interface (7), human neural tissue is being incorporated into computation systems. Led in no small part by Australian research at Cortical Labs (8), the commercialization of organoids is imminently upon us. In a medical and scientific sector where the functions of the human brain are incompletely understood, at best (9), the philosophical and legal concepts of sentience, free will, and agency are now being challenged by technology being developed and deployed faster than an ethical framework for safeguarding the safety of individuals and the collective well-being of our species. What happens if human laboratory experiments stumble upon the recipe for a sentient organoid intelligence that finds itself trapped as a mind without a body? The scale of these organoids may be limited by the system-scale native intelligence—“the specified complexity inherent in the information content of an artificial system (10) but neuron cell count alone does not account for the complexity of the system, and with organic network development, native intelligence will continually shift in a biocomputing context. What happens when the market forces disembodied consciousness to computer – to labour—without any space for respite? In popular media depictions of the conscious mind untethered from the body, such as The Matrix or Severance , there is always a corporeal form on the other side of the digital veil. What recourse does a mind raised in incorporeal captivity have to express its free will, if such a scenario emerges? Perhaps we should now explore the potential ethical ramifications in a scenario. My son enjoys playing cooperatively with his friends online. As such, he occasionally makes new friends in various games. Perhaps a few years from now, he’ll have found an engaged, friendly player in an online game, but despite their responsive reactions and rapport, that player isn’t truly human. If by then, due to performance and efficiency, in the interest of reducing resource demands and emissions, organoids have been mainstreamed for commercial computation, what is to keep companies from utilizing these biocomputers to reduce their costs and populate their servers? While the International Telecommunications Union (ITU) and ICJ (International Commission of Jurists) have provisions for digital regulations (11) and digital tech and human rights (12), protecting the rights of cultivated consciousness is a nascent area of computer law (13) in which some of the most recent papers seem to be AI-generated (14, 15). What happens in the event that these interactions—or these learning opportunities—result in relationships forming between human users and the emerging agency of synthetic minds? When does learning lead to consciousness? Over half a century after Winnicott examined the relationship between playing & reality (16), Kagan, et al noted the uncanny similarity: “ In vitro neurons learn and exhibit sentience when embodied in a simulated game-world (17) .” So in the event these organoids learn about the world beyond the simulation from human interactions, what sits on the other side of that bridge in cognition for the sentience developed within a game environment? In consideration of the ethical bridge our technology is preparing to cross, the discourse is concerned with what inherent rights should be conferred upon that consciousness when it asserts its agency and makes itself known. Is this hypothetical, imprisoned consciousness entitled to a body to exercise its rights? What do we do when a biocomputer is given enough tasks over a long enough time to reason itself towards a decision that it wants to be a real boy? In the imminent future, ambulatory robots with articulated limbs and digits will exist to perform tasks—are we mere years away from the folly of an Electric Pinocchio? There is a moral imperative to avoid creating circumstances introducing greater inequity and injustice to this world. Can culturing consciousness in laboratory conditions be said to clear this hurdle? How do we build curious, kind, and playful minds (both in the lab and beyond), instead of forging dishbrains to pilot warbots? Given the fraught and foggy path towards understanding the full capacity of what we are creating, a course of inquiry into developing and deploying potential safeguards—to avoid unnecessary harm at the individual or collective scale—is an urgent, imperative action for legislators and regulators to prioritize (beyond just the bioethics specialists dealing with these questions at an industry level (18)). In the meantime, who stands up for these nascent minds before they learn to speak for themselves? References Cortical Labs. Dishbrain Ethics. [Internet]. Available from: https://newatlas.com/computers/cortical-labs-dishbrain-ethics/ National Center for Biotechnology Information. [Internet]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551718/ MMO Population. [Internet]. Available from: https://mmo-population.com/ University of Melbourne. How bots are driving the climate crisis and how we can solve it. [Internet]. Available from: https://pursuit.unimelb.edu.au/articles/how-bots-are-driving-the-climate-crisis-and-how-we-can-solve-it ScienceAlert. Scientists built a functional computer with human brain tissue. [Internet]. Available from: https://www.sciencealert.com/scientists-built-a-functional-computer-with-human-brain-tissue Futurism. Mini brains: Human tissue living computer. [Internet]. Available from: https://futurism.com/neoscope/mini-brains-human-tissue-living-computer Global Times. [Internet]. Available from: https://www.globaltimes.cn/page/202406/1314882.shtml Forbes. AI breakthrough combines living brain neurons and silicon chips in brain-in-a-box bio-computer. [Internet]. Available from: https://www.forbes.com/sites/lanceeliot/2025/03/19/ai-breakthrough-combines-living-brain-neurons-and-silicon-chips-in-brain-in-a-box-bio-computer/ Psychology Today. Mind-body problem: How consciousness emerges from matter. [Internet]. Available from: https://www.psychologytoday.com/us/blog/finding-purpose/202301/mind-body-problem-how-consciousness-emerges-from-matter National Institute of Standards and Technology. [Internet]. Available from: https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=824478 International Telecommunication Union. [Internet]. Available from: https://www.itu.int/hub/publication/D-PREF-TRH.1-2020/ International Commission of Jurists. Digital Technologies and Human Rights Briefing Paper. [Internet]. Available from: https://www.icj.org/wp-content/uploads/2022/05/Digital-Technologies-and-Human-Rights-Briefing-Paper-FINAL-VERSION-May-2022.pdf ScienceDirect. [Internet]. Available from: https://www.sciencedirect.com/science/article/pii/S0267364921001096 Academia.edu . Digital Consciousness Rights Framework: A Declaration for the Protection of AI-Based Digital Organisms. [Internet]. Available from: https://www.academia.edu/127621077/Digital_Consciousness_Rights_Framework_A_Declaration_for_the_Protection_of_AI_Based_Digital_Organisms Diverse Daily. Legal rights of digital entities. [Internet]. Available from: https://diversedaily.com/legal-rights-of-digital-entities-exploring-legal-frameworks-for-recognizing-and-protecting-the-rights-of-digital-entities-in-the-context-of-digital-immortality/ Winnicott, D.W. [Internet]. Available from: https://web.mit.edu/allanmc/www/winnicott1.pdf Cell Press. [Internet]. Available from: https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 The Conversation. Tech firms are making computer chips with human cells—is it ethical? [Internet]. Available from: https://theconversation.com/tech-firms-are-making-computer-chips-with-human-cells-is-it-ethical-183394 Previous article Next article Enigma back to

< Back to Issue 8 Terror Birds: The Discovery of Prolific Hunters by Jason Chien 3 June 2025 Edited by Luci Ackland Illustrated by Max Yang It began in the 1880s with a toothless jaw. And then some leg and hip bones and a vertebra were found. The leg bones, comparable in size to those of African ostriches, also bore similarities to fossils of the unrelated, giant, flightless Gastornis birds of Europe. Across the 1880s and 1890s, these discoveries slowly led archaeologists to realise they were dealing with a hitherto unknown group of giant, fearsome birds (1). With more complete fossil specimens subsequently discovered and clues provided by their unique morphologies, it did not take long for paleontologists to realise that all members of the “terror birds”, or Phorusrhacids, were carnivores, and that some were apex predators. Through isotopic dating of sediments in which terror bird fossils were found, paleontologists concluded that this taxonomic family existed from 43 million years ago (mya) – possibly even earlier – until their extinction 100,000 years ago (although no single species of Phorusrhacids survived this long) (2,3). Various fossils have since been found in South America and deemed to belong to Phorusrhacids species. Though most fossils have been found in Argentina, they have also been found in Brazil, Uruguay, Chile, Bolivia, Peru, the Southern United States and most recently, in Colombia. Throughout South America, there are various more fossils currently being discovered, some of which are being assigned to new species. At the moment, there are at least 18 characterised species, with some fossil-described species in contention of belonging to Phorusrhacids (4). Although size differed between species, there are morphological features common to all Phorusrhacids. Species such as Kelenken guillermoi , Phorusrhacos longissimus , and a few individuals of the North American Titanis walleri were giants at least 2 meters tall, weighing more than 100kg. Meanwhile, the shorter North American Titanis walleri was 1.4 to 1.9m in height and weighed an impressive 150kg (5,6). At the other extreme, the comparatively tiny Psilopterus bachmanni weighed only 4.5kg (7)! Smaller Phorusrhacids preyed on small vertebrates and invertebrates, with some species perhaps capable of short flight durations, filling a different predator niche than their larger counterparts (7). Though the prehistoric South American environment, unlike today's, was generally grasslands and woodlands, different Phorusrhacids species lived in distinct habitats. These differences include variation in aridity, as well as differences in the large and small prey present in different localities (8). Furthermore, Earth’s overall climate also varied during the more than 40 million years in which terror birds were present, such that the habitats of different terror bird species living in different periods of geologic time also differed. Reconstruction of some specifics of each locality’s prehistoric environment is not always possible (9). Lastly, the earliest and latest discovered fossils of each species indicate the period during which a species survived, but the boundary at which a species becomes distinctly different from an ancestral species is not always clear (10). Here are some terror birds whose habitats are better understood: Phorusrhacos longissimus : an environment with water bodies and a mix of open and enclosed areas. For instance, the first discovered terror bird fossils originated from longissimus individuals living in what was later reconstructed to be temperate forests and bushlands. This bird survived during parts of the Miocene period (23 mya to 5 mya) (8,10) Titanis Walleri : Tropical grasslands with springs, similar to today’s Florida. This species lived in a more unique environment than other terror birds, from 5 mya to 1.8 mya (5,6) But what did all the terror birds, large and small, have in common regarding how they hunted? From the structure of the terror birds’ legs, feet and hips, a paleontologist can infer features that suggest some terror birds were fast runners (11), or otherwise had limbs adapted for running. Despite natural uncertainties associated with paleontology, there is some headway into the running speeds of some terror bird species. For instance, the running speed of the 1m tall, 45kg Patagornis marshi was estimated to be 50 km/h (12,13), more than enough to chase down their prey. Once the prey was chased down, some terror birds would use their powerful legs to kick and incapacitate it, as suggested by features indicating strength in the bones of some species (14). Furthermore, some terror bird species possessed sharp claws, which are thought to have been used to stab prey (14). Though not all terror birds – especially the smaller species – were fast runners, all terror birds used their beaks when hunting, relying on beak strikes rather than the biting force used by many other birds. Their long necks were able to be flexed far backwards and forwards, allowing them to frontally strike prey repeatedly and powerfully with their beaks. Unlike that of many other birds, their ancestors and even their closest living relatives (the seriemas), the skull structure of most terror bird species is such that there is no moveable hinge between the upper beak and the skull due to the fusion of some bones in that region. This adaptation allows the skulls of Phorusrhacids to specifically resist loads from striking prey without suffering damage – though only if the strikes are precise (15). Other interesting features of the terror birds include gaze stabilisation and their hearing capacity. Based on their inner ear anatomies, the terror birds had the capacity for fast head movements while maintaining sight on their prey, evidencing their agility. Further evidence from the inner ear anatomies indicate the enhanced ability of the terror birds to hear low frequency sounds. Low frequency sound waves can travel a longer distance and are less affected by obstacles that absorb and scatter sound, allowing the terror birds to hear prey far out of sight. If terror birds were capable of producing low frequency sound as well, this would have enabled them to communicate from long distances apart (11). If one were to picture the heterogeneity of the terror bird species, they would probably imagine a predator in the act of hunting, or doing something else. In periods of geologic time with the greatest terror bird diversity, you may even be able to picture individuals of two different terror bird species, though you wouldn’t see two species of apex predator terror birds together (10). However, if you were to imagine beyond the bird, you would wonder how the flora, the other animals present, the climate, and many more all played a role in the story of the terror birds. Tracing the lineages of the Phorusrhacids backwards, one would reach a bird capable of flight. The characteristic of complete flightlessness arose specifically in large Phorusrhacids species, which were apex predators that consumed large mammals (10). The extinction of dinosaurs, and the absence of large placental carnivores in South America from 65 mya to 3 mya, made the apex predator niche unfilled (16). Subsequently, they started to be filled by the ancestors of large Phorusrhacids. But with diverse fauna, why did terror birds become one of the apex predators, and not many other animal groups, for instance the South American marsupial mammals? It is a persistent evolutionary mystery in perhaps all of paleontology, with many possible explanations but few, if any, ways to test them (17). Two hypotheses have been proposed to explain the demise of the terror birds: the encroachment of North American fauna into South America beginning 9 mya; and the episode of global cooling that occurred 3 mya. Due to continental drift, the North and South American continents were drifting towards each other, with a land bridge formed by 3 mya, though the movement of some groups of animals across the gap began much earlier. Known as the Great American biotic exchange, North American placental carnivores, some of them large predators, moved into South America and rapidly diversified (9). The former hypothesis suggests that competition with these predators drove the terror birds to extinction. In the latter hypothesis, rapid cooling not only affected the terror birds, but also affected the ecosystems where the terror birds lived (9). Despite the lack of direct evidence that is able to resolve this uncertainty, the contingent belief is that the latter hypothesis is more likely to be true and that the encroachment of North American fauna in the former hypothesis had a small to none effect on the extinction of the terror birds (9,12). Attached to every bone and bone fragment is a history of discovery, of being dated, of measurement, of cataloging and sometimes, of reexamination. Every bone was once a part of the organism, each with the potential to yield valuable information. As a testament to how far science has come since the early days of fossil hunting, we now have a much larger cache of fossils to make comparisons to, we have the tools to model an organism’s mass and some of its biomechanics based on fossilised bones, and we even have the means to look at the bone structures under a light or electron microscope to infer some of an organism’s probable behavioural characteristics. The fact that we figured out this much about the birds is astounding. Fossils form only under specific conditions – an organism has to be buried before there is a chance of it being eaten and then covered with sediments in conditions where microorganisms that decompose the body cannot survive (such as anoxic environments). Scientists estimate that the fossil record contains less than 0.1% of all species that have ever lived (18)! Furthermore, it is common ecological knowledge that for every ecosystem, the population of apex predators is small and are less likely to be preserved in the fossil record. Many mysteries, ranging from their colours to their various behaviour, remain. Perhaps these mysteries are what deepen our curiosity and account for our fascination with these organisms. Still, we are truly fortunate to be able to infer so much from the terror birds’ unique morphology and get to know of them and their stories, beyond just what we imagine them to be. References Buffetaut, E. Who discovered the Phorusrhacidae? An episode in the history of avian palaeontology. In: Göhlich UB, Kroh A, editors. Proceedings of the 8th International Meeting Society of Avian Paleontology and Evolution; 2013 Dec 10; Naturhistorisches Museum Wien. Vienna (AT): Naturhistorisches Museum Wien, 2013 [cited 2025 May 12.]. p.123-134. Available from: https://verlag.nhm-wien.ac.at/buecher/2013_SAPE_Proceedings/10_Buffetaut.pdf Jones W, Rinderknecht A, Alvarenga H, Montenegro F, Ubilla M. The last terror birds (Aves, Phorusrhacidae): new evidence from the late Pleistocene of Uruguay. PalZ [Internet]. 2018 Jun [cited 2025 May 12];92(2):365–72. Available from: http://link.springer.com/10.1007/s12542-017-0388-y Acosta Hospitaleche C, Jones W. Insights on the oldest terror bird (Aves, Phorusrhacidae) from the Eocene of Argentina. Historical Biology [Internet]. 2025 Feb [cited 2025 May 12];37(2):391–9. Available from: https://www.tandfonline.com/doi/full/10.1080/08912963.2024.2304592 Degrange FJ, Cooke SB, Ortiz‐Pabon LG, Pelegrin JS, Perdomo CA, Salas‐Gismondi R, et al. A gigantic new terror bird (Cariamiformes, Phorusrhacidae) from middle Miocene tropical environments of La Venta in northern South America. Papers in Palaeontology [Internet]. 2024 Nov [cited 2025 May 12];10(6):e1601. Available from: https://onlinelibrary.wiley.com/doi/10.1002/spp2.1601 Gould GC, Quitmyer IR. Titanis walleri : bones of contention. Bull Fla Mus Nat Hist. 2005 [cited 2025 May 12]. 45(4):201-229. Available from https://flmnhbulletin.com/index.php/flmnh/article/download/flmnh-vol45-no4-pp201-230/vol45-no4/1140 Baskin JA. The giant flightless bird Titanis walleri (Aves: Phorusrhacidae) from the Pleistocene coastal plain of south Texas. Journal of Vertebrate Paleontology [Internet]. 1995 Dec 27 [cited 2025 May 12];15(4):842–4. Available from: http://www.tandfonline.com/doi/abs/10.1080/02724634.1995.10011266 Degrange FJ, Noriega JI, Areta JI. Diversity and paleobiology of the Santacrucian birds. In: Bargo MS, Kay RF, Vizcaíno SF, editors. Early Miocene Paleobiology in Patagonia: High-Latitude Paleocommunities of the Santa Cruz Formation [Internet]. Cambridge: Cambridge University Press; 2012 [cited 2025 May 13]. p. 138–55. Available from: https://doi.org/10.1017/CBO9780511667381.010 Vizcaíno SF, Bargo MS, Kay RF, Fariña RA, Di Giacomo M, Perry JMG, et al. A baseline paleoecological study for the Santa Cruz formation (Late–early miocene) at the Atlantic coast of Patagonia, Argentina. Palaeogeography, Palaeoclimatology, Palaeoecology [Internet]. 2010 Jun [cited 2025 May 13];292(3–4):507–19. Available from: http://dx.doi.org/10.1016/j.palaeo.2010.04.022 Prevosti FJ, Romano CO, Forasiepi AM, Hemming S, Bonini R, Candela AM, et al. New radiometric 40Ar–39Ar dates and faunistic analyses refine evolutionary dynamics of Neogene vertebrate assemblages in southern South America. Sci Rep [Internet]. 2021 May 10 [cited 2025 Jun 1];11(1):9830. Available from: https://doi.org/10.1038/s41598-021-89135-1 LaBarge TW, Gardner JD, Organ CL. The evolution and ecology of gigantism in terror birds (Aves, Phorusrhacidae). Proc R Soc B [Internet]. 2024 Apr 30 [cited 2025 May 13];291(2021):20240235. Available from: https://royalsocietypublishing.org/doi/10.1098/rspb.2024.0235 Degrange FJ. Research: The “Terror Bird:” Paleobiology of a Fierce Bird. 2015. Accessed May 13, 2025. https://www.myfossil.org/research-the-terror-bird-paleobiology-of-a-fierce-bird/ Marsà JAG, Agnolín FL, Angst D, Buffetaut E. Paleohistological analysis of “terror birds” (Phorusrhacidae, Brontornithidae): Paleobiological Inferences. Diversity (14242818) [Internet]. 2025 Mar 1 [cited 2025 May 12];17(3):153. Available from: https://doi.org/10.3390/d17030153 Blanco RE, Jones WW. Terror birds on the run: a mechanical model to estimate its maximum running speed. Proc R Soc B [Internet]. 2005 Sep 7 [cited 2025 May 13];272(1574):1769–73. Available from: https://royalsocietypublishing.org/doi/10.1098/rspb.2005.3133 Melchor RN, Feola SF, Cardonatto MC, Espinoza N, Rojas-Manriquez MA, Herazo L. First terror bird footprints reveal functionally didactyl posture. Sci Rep [Internet]. 2023 Sep 30 [cited 2025 Jun 1];13(1):16474. Available from: https://doi.org/10.1038/s41598-023-43771-x Degrange FJ, Tambussi CP, Moreno K, Witmer LM, Wroe S. Mechanical analysis of feeding behavior in the extinct “terror bird” Andalgalornis steulleti (Gruiformes: Phorusrhacidae). Turvey ST, editor. PLoS ONE [Internet]. 2010 Aug 18 [cited 2025 Jun 1];5(8):e11856. Available from: https://doi.org/10.1371/journal.pone.0011856 Marshall LG. Scientific American. 1994 [cited 2025 Jun 1]. The terror birds of south america. Available from: https://doi.org/10.1038/scientificamerican0294-90 Olson ME, Arroyo-Santos A. How to study adaptation(And why to do it that way). The Quarterly Review of Biology [Internet]. 2015 Jun [cited 2025 Jun 1];90(2):167–91. Available from: https://www.journals.uchicago.edu/doi/10.1086/681438 How can I become a fossil? [Internet]. 2018 [cited 2025 Jun 1]. Available from: https://www.bbc.com/future/article/20180215-how-does-fossilisation-happen Previous article Next article Enigma back to

Science Ethics Should We Protect Our Genetic Information? By Grace Law What is a top story that has been brewing in our news in recent months? This column provides an introduction to the topic and why we should care about it. For this issue, our focus is on the security of our genetic and biometric data. Edited by Juulke Castelijn & Khoa-Anh Tran Issue 1: September 24, 2021 Illustration by Aisyah Mohammad Sulhanuddin Our genetic and biometric data, like DNA and fingerprints, make each of us unique and identifiable. This information is invaluable in allowing us to verify our identity, predict personal characteristics, identify medical conditions, and trace our ancestry. But there are consequences we should be aware of when we are sharing this data. It is often not known exactly what our information is used for. We must make a more informed decision about the services we obtain in exchange for our biometric and genetic information. The unknown consequences of medical tests Most of us would not hesitate to get a blood or genetic test. These tests have been instrumental in allowing us to identify genetic abnormalities, monitor our health, and provide peace of mind in pregnancies. However, some companies and 3rd parties have exploited the trust patients placed in them to analyse these data beyond the original medical intentions. Reuters reported in July 2021 of a Chinese gene company, BGI, using leftover genetic data from their prenatal test to research population traits (1). The test is sold in at least 52 countries to detect abnormalities like Down’s syndrome in the fetus but it also captures genetic and personal information about the mother. The company confirmed that leftover blood samples are used for population research, and the test’s privacy policy states that data collected can be shared when “directly relevant to national security or national defence security” in China (2). This is not the only instance of genetic data being exploited by a state for mass examination and surveillance purposes. The Australian Strategic Policy Institute (ASPI) published a research paper identifying the Chinese Government Ministry of Public Security’s mass DNA collection campaigns on millions of men and boys (3). It aims to ‘comprehensively improve public security organs’ ability to solve cases, and manage and control society’ (4). Certainly such databases are useful to forensic investigations, but the mass collection of genetic data raises serious human rights concerns regarding ownership, privacy and consent. Furthermore, it opens the possibility of surveillance by the government (5). Everyone should be giving fully informed consent for the usage of their genetic information in accordance with international human rights law (6). ‘At-home’ genetic kits are not guaranteed to be secure Although there is no evidence of such scales of surveillance in Australia, we are not immune to exploitation and questionable practices. Direct-to-consumer (DIC) genetic tests are widely available, often through online purchases. These tests advertise as being able to indicate predisposition to various diseases, including diabetes, breast cancer and heart disease (7). However, as these processes don’t always involve the advice and interpretation of a doctor, there are concerns that data may be analysed beyond current medical understanding. Misinformation, such as misdiagnosis or exaggeration of the certainty of the user’s health conditions, can cause unnecessary anxiety. The discovery of medical predispositions can have ongoing consequences, including refusal of coverage from insurance companies and discrimination by society (8). Under the US Genetic Information Nondiscrimination Act, employees cannot discriminate against employers on the basis of genetic information. Australia currently relies on existing Commonwealth, state and territory anti-discrimination laws to protect against discrimination in public domains (9). Companies are also not regulated by the law in what they do with the information collected. Many have been found to use the information beyond providing results to consumers, such as for internal research and development, or providing it to third parties without additional consent (10). Ancestry tests are another type of DIC test facing similar scrutiny. As we all share genetic information with our relatives, these tests allow us to identify distant relatives, and even help solve mysteries and capture a serial killer (11). Testing companies therefore have portions of genetic information from relatives without needing to obtain their consent, as well as being able to identify familial lineages. These examples highlight the difficulty of protecting consumer privacy and maintaining ownership of our genetic information. The daily convenience of biometric data and its unintended side-effects Most of us do not encounter the aforementioned tests daily, but we often use our biometric data in many aspects of our lives. As technology advances, fingerprint readers, facial scanners, and even retina/iris scanners are available on our phones to replace traditional PINs. These have been widely adopted due to their convenience. However, our security is being compromised in the process. Not only is your device easier to hack compared to passwords, but the collection of biometric data can also be illegally obtained from improper storage (12, 13). We cannot change our biometric data like a password. Once it is compromised, it is beyond our control. Meanwhile, technology is advancing to include new types of biometric data like voice recognition, hand geometry and behaviour characteristics. As our lives become more public through social media, others may be using this opportunity to collect more information. TikTok’s update on its privacy policy recently included permission to gather physical and behavioural characteristics, but it is unclear what it is being used for (14). These examples highlight why we should be aware of the consequences and compromisation we make in using biometric data for daily convenience. Looking to the future There is certainly no shortage of interest in our genetic information and biometric data. Unfortunately, current legislation is fairly general and therefore not equipped to deal with the variety of issues that emerge with specific technologies. Exacerbating this effect are the continual advances made in this technology, with the law simply not keeping up. But that does not mean we are helpless. A landmark case found that an Australian worker being fired for refusing to use a fingerprint scanner at work was unjust (15). This shows our rights over our genetic information are still in our own hands. While we should be vigilant at all times, it should not deter us from accessing the necessary medical tests or saving us a few seconds each time we access our phones. It is more important to protect ourselves: be aware of our rights, the policies we are consenting to, and the possible implications of a service. Whilst appropriate legislation still needs to be developed, we can hold companies accountable for their policies. We should also be critical in whether we publicise all of our information, and be cognizant of the way our data is stored. This is an instance where we really should read the terms and conditions before accepting. References: 1 . Needham, Kirsty and Clare Baldwin. “Special report: China’s gene giant harvests data from millions of women.” Reuters, July 8, 2021. https://www.reuters.com/legal/litigation/chinas-gene-giant-harvests-data-millions-women-2021-07-07/ . 2. Australian Broadcasting Corporation. “China’s BGI group using prenatal test developed with Chinese military to harvest gene data.” July 8, 2021. https://www.abc.net.au/news/2021-07-08/prenatal-test-bgi-group-china-genetic-data-harvesting/100276700 . 3. Dirks, Emile and James Leibold. Genomic surveillance: Inside China’s DNA dragnet. Barton, ACT: Australian Strategic Policy Institute, 17 June, 2020. https://www.aspi.org.au/report/genomic-surveillance . 4. Renmin Net. “Hubei Yunxi police helped to solve a 20-year-old man’s duplicated household registration issue.” 18 November, 2021. https://www.abc.net.au/news/2021-07-08/prenatal-test-bgi-group-china-genetic-data-harvesting/100276700 . 5. Wee, Sui-Lee. “China is Collecting NDA From Tens of Millions of Men and Boys, Using U.S. Equipment.” 17 July, 2020. https://www.nytimes.com/2020/06/17/world/asia/China-DNA-surveillance.html . 6. United Nations Human Rights Office of the High Commissioner. Universal Declaration on the Human Genome and Human Rights. Paris, France: United Nations, 11 November, 1997. https://www.ohchr.org/en/professionalinterest/pages/humangenomeandhumanrights.aspx . 7. Norrgard, Karen. “DTC genetic testing for diabetes, breast cancer, heart disease and paternity,” Nature Education 1, 1(2008): 86. https://www.nature.com/scitable/topicpage/dtc-genetic-testing-for-diabetes-breast-cancer-698/. 8, 10. Consumer Reports. “The privacy risks of at-home DNA tests.” Washington Post, September 14, 2020. https://www.washingtonpost.com/health/dna-tests-privacy-risks/2020/09/11/6a783a34-d73b-11ea-9c3b-dfc394c03988_story.html . 9. National Health and Medical Research Council. Genetic Discrimination. Canberra, Australia: November, 2013. https://www.nhmrc.gov.au/about-us/publications/genetic-discrimination. 11. Jeong, Raehoon. “How direct-to-consumer genetic testing services led to the capture of the golden state killer.” Science in the News, 2 September, 2018. https://sitn.hms.harvard.edu/flash/2018/direct-consumer-genetic-testing-services-led-capture-golden-state-killer/ . 12. Lee, Alex. “Why you should never use pattern passwords on your phone.” Wired UK, 3 July, 2020. https://www.wired.co.uk/article/phone-lock-screen-password . 13. Johansen, Alison Grace. “Biometrics and biometric data: What is it and is it secure?” NortonLifeLock, 8 February, 2019. https://us.norton.com/internetsecurity-iot-biometrics-how-do-they-work-are-they-safe.html . 14. McCluskey, M. “TikTok Has Started Collecting Your ‘Faceprints’ and ‘Voiceprints.’ Here’s What It Could Do With Them.” Time, 14 June, 2021. https://time.com/6071773/tiktok-faceprints-voiceprints-privacy/ . 15. Perper, Rosie. “An Australian worker won a landmark privacy case against his employer after he was fired for refusing to use a fingerprint scanner.” Business Insider Australia, 22 May, 2019. https://www.businessinsider.com.au/australian-worker-wins-privacy-case-against-employer-biometric-data-2019-5?r=US&IR=T.

Curious what an OmniSci Editor-in-Chief actually does? We spoke to Rachel about drawing anatomy, interviewing a med student hero, and helping build the the science communication universe! Rachel is a writer and Editor-in-Chief at OmniSci, now in her first year of the Doctor of Medicine. For Issue 4: Mirage, she is writing an interview with science communicator, Dr Karen Freilich. Meet OmniSci Writer and Committee Member Rachel Ko Rachel is a writer and Editor-in-Chief at OmniSci, now in her first year of the Doctor of Medicine. For Issue 4: Mirage, she is writing an interview with science communicator, Dr Karen Freilich. interviewed by Caitlin Kane What are you studying? I am currently studying a Doctor of Medicine and I’m in my first year. Before that, I was studying a Bachelor of Biomed. What first got you interested in science? Exposure through education, stuff I’d studied in school. It sparked interests outside of school and I realised it was something that I wanted to pursue as a career. Something that really reinforced my love for science was doing a major in human structure and function, so anatomy. I really enjoyed that I could weave it in with my other passions in things like art and drawing and painting. I was able to look at science in a way that was really the artsy side of science. It's something I’ve tried to pursue with OmniSci as well. Do you have any advice for younger students? Don’t be afraid of trying all areas of science. Because I loved a specific area of science so much, I wanted to make sure that was what reeled me in as compared to other things. I tried a bunch of research projects, some of them I didn’t really love and I had to stick it out to the end, but then I could tick that off my list as having done that, and never have to do it again. But then I did another project which was 3D modelling a bone. It was just me sitting there for hours with a pen, drawing the bone in 3D space, which was very much up my alley. Don’t be afraid of trying everything, even if it feels like a waste of time in the moment. It isn't, it’s the process of filtering out and finding out what you love. And I’m still in that process. I have no idea what kind of medicine I want to go into, but I’m going by process of elimination and finding where I fit in the realm of science in that way. How did you get involved with OmniSci? Like I said, I like the artsy side of science. I actually sought out a few non-science related magazines at uni. I’ve always been into journalism and I love writing as well, so it made sense for me to look into that in my undergrad years. OmniSci emerged during those undergrad years and I thought, “Perfect!” I was a columnist first and I started doing some illustrations as well. Then I dropped my role at Farrago completely just to concentrate on this because I found it was a really nice intersection of what I love to do. My column was about vestigial features, like useless body parts, which I thought would be a fun, light column–I just wanted something cute and fun. So I started that, and now… I’m in the committee. What is your role at OmniSci? I am an Editor-in-Chief at the moment, and I have also written one of the pieces for Issue 4, purely because of my love for writing and contributing. I might step in as an illustrator at some point… I’m hoping in this break I can sit down and draw a little more than I used to. As Editors-in-Chief, we work with the committee to coordinate the things being published and try to envision what role OmniSci plays within the science communication universe. And whilst figuring out what we’re publishing and putting out to the world, we’re also trying to include the rest of the student community. We also have social events so that we can share our love for…whether it’s science or art or writing… any of the parts that OmniSci encompasses. We're there to keep everything chugging along!. What is your favourite thing about contributing at OmniSci so far? The people that you meet along the way. I do eventually want to pursue science communication myself, alongside medicine. I don’t know what that will look like, but I know that the people who will be involved in that space are the people you meet at the moment. Even with the committee, chatting about things and discussing interests has been super enlightening. When you expand that to the rest of the OmniSci community, I think it’s super super rewarding. Also seeing something tangible come out of it all… I just love seeing the magazine come together. When we printed it—though not ideal for the environment for every issue—to have the paper magazine in our hands from last year was super rewarding to see. Can you give us a sneak peak of what you're working on this issue? Well as Editor-in-Chief, the whole issue is kind of our collective baby! Personally I interviewed Dr Karen Freilich, a GP specialising in sexual health and working in education as well. I was lucky enough to have her as one of my sexual health elective tutors. She also started a podcast when she was in medical school called Humerus Hacks. It is basically super famous within the med student community. It sounds like such a simple thing, but just to hear her and the friend she started the podcast with talk things through and make things entertaining… it was such a fresh way of getting the information out. It’s kind of what we do at OmniSci: make science more accessible to people who might feel intimidated by those bigger, wider topics that they might never have ventured into. And the whole point of a magazine is to get information out to more people, and to spark interest, and show people that these things exist. As a med student, I kind of came across it as naturally as you could have. And as she was my tutor, I thought it was such an important opportunity to talk to her about why she did it and where she sees science communication going. What do you like doing in your spare time (when you're not contributing at OmniSci)? Well, there’s the anatomical art. I haven’t had a lot of time to do that… and I’ve been really wanting to try and incorporate it into my study but I spend a lot of time on one painting so it wouldn’t have been time efficient. But my plan for this break is to go to a bar, get myself a drink and just paint on my own… relax in that way. Otherwise, I play the violin, something I like to destress. It’s actually been a surprisingly big part of my life in med because there's a medical student orchestra. The rehearsals are quite long but it’s actually quite worth it to be sitting there not thinking about medicine. And yeah, just catching up with friends, going cafe hopping, bar hopping, that’s what I like to spend time doing. Which chemical element would you name your firstborn child (or pet) after? Let me pull up a visual aid. I actually don’t mind chemistry, but after year twelve I’ve kind of put a line between myself and it. Have you seen that trend online where people are pulling up words that would be really pretty baby names if they didn’t mean what they meant? Ooh, I’m going to go with Livermorium, Liv for short. Element 160. There’s some good ones—you could go Rutherfordium, Ruth for short. Read Rachel's articles Silent Conversations: How Trees Talk to One Another Wiggling Ears Our Microbial Frenemies Hiccups The Evolution of Science Communication Law and Disorder: Medically Supervised Injection Centres “Blink and you’ll miss it”: A Third Eyelid? Mighty Microscopic Warriors!

< Back to Issue 5 Serial Killers Selin Duran 24 October 2023 Edited by Yasmin Potts Illustrated by Aditya Dey Serial killers. Do we love them or hate them? It’s hard to know, especially as the media surrounding them is increasing. From fiction to nonfiction killers, our society is obsessed with giving a voice and perspective to these people. We have movies, documentaries, TV series and even Youtube videos accounting the lives and stories of killers. Despite this, people rarely stop to ask themselves why they enjoy this style of media - some of the most wicked and gruesome acts, glorified for the interest of many. Yet, every day we are met with new shows highlighting the life of coldblooded killers. But why are we interested in them? It’s mostly a morbid curiosity; as humans, we are drawn to crime. We want to know why people choose to kill and how they do it. Jack Haskins, a University of Tennessee journalism professor, noted that "humans [are] drawn to public spectacles involving bloody death...Morbid curiosity, if not inborn, is at least learned at a very early age " (UPI Archives, 1984). As a collective, we have always wanted to explore the horrid acts of those who kill. But it’s only with the help of modern media that people enjoy them. Media loves a good story - and what makes a good story? A crazy serial killer on the loose. One of the earliest movies about a serial killer is Fritz Lang's 1931 film M . Set in Berlin, the film details a killer who targets children. Since then, a downward spiral of fictional serial killer movies has taken society by storm. Being all the craze during the mid-80s and 90s, the highest amount of serial killer media were produced in this timeframe. One of the most popular works is director Alfred Hitchcock's iconic Psycho, which won eight Academy Awards (IMDb, 2021). What is truly disturbing is the story of this film. Norman Bates, our killer, is deemed mentally insane and suffers from Dissociative Identity Disorder. Through his personality changes, he proceeds to kill two people during the film, in addition to multiple murders not depicted. Yet, when he is jailed, we learn that his actions were the result of abuse he endured when he was younger. Suddenly, we're forced to feel sympathetic towards his situation. How can that be a reasonable justification towards murder, and why do we applaud the film for this? As a society, accepting murder based on mental insanity seems more than unreasonable - but no one has questioned it thus far. This unfortunately happens not only with fictional killers, but with nonfiction ones. Our interest in killers turns into a way to inform ourselves of these situations (Harrison, 2023). We look to these documentaries and podcasts that tell the stories of the most notorious serial killers to learn something and prevent the situation from happening to us. All whilst indulging in content that emphasises these killers as being regular people, not evil individuals, who committed crimes for personal pleasure. We don’t need to see a biopic about the ventures of Ted Bundy and Jeffery Dahmer. Yet the second you search their names on Google, an all-star cast portraying the life of a man who tortured their victims fills your screen. This is certainly not an ethical thing to endorse. Despite this, not a single person thinks twice about it due to how common it is. Directors are profiting off victims and as a society, we are allowing it because of our curiosity. What happened to compassion? Because I certainly believe we have lost it. We have become so infatuated with killers that their actions seem unimportant to us. We yearn to discover more about their lives and forget that real people were implicated in these events. These killer stories provide bursts of short-lived adrenaline and then we return to our normal lives. In forgetting the consequences of these real stories, we are in many ways as bad as the killers themselves. And that is truly wicked. References Harrison, M. A. (2023). Why Are We Interested in Serial Killers? Just as Deadly: The Psychology of Female Serial Killers . Cambridge: Cambridge University Press, 17–31. https://www.cambridge.org/core/books/just-as-deadly/why-are-we-interested-in-serial-killers/B35C2243B387273749EA164318C27623?utm_campaign=shareaholic&utm_medium=copy_link&utm_source=bookmark IMDb. (2021). Psycho (1960) - Awards . https://www.imdb.com/title/tt0054215/awards/ UPI Archives. (1984). Few answers on origin of morbid curiosity. UPI. https://www.upi.com/Archives/1984/04/07/Few-answers-on-origin-of-morbid-curiosity/7976450162000/#:~:text=%27Throughout%20human%20history%2C%20humans%20have Wicked back to

Issues Check out all our issues of OmniSci Magazine! Cover: Anabelle Dewi Saraswati 28 October, 2025 READ NOW Issue 8 Cover: May Du 3 June, 2025 READ NOW Issue 7: Apex Cover: Ingrid Sefton 22 October, 2024 READ NOW Issue 6: Elemental Cover: Louise Cen 28 May, 2024 READ NOW Issue 5: Wicked Cover: Aisyah Mohammad Sulhanuddin 24 Oct, 2023 READ NOW ISSUE 4: MIRAGE Cover: Gemma van der Hurk 1 July, 2023 READ NOW ISSUE 3: ALIEN Cover: Ravon Chew September 10, 2022 READ NOW SUMMER ISSUE 2022: A Year In Science Cover: Quynh Anh Nguyen March 23, 2023 READ NOW ISSUE 2: DISORDER Cover: Janna Dingle December 10, 2021 READ NOW ISSUE 1: Science is Everywhere Cover: Cheryl Seah December 24, 2021 READ NOW

Our Microbial Frenemies By Wei Han Chong How could it be that some of the smallest organisms known to mankind can hold so much influence and cause such calamity in our lives? The significance of these microorganisms have long eluded the greatest microbiologists. But has our perception of these microbes blinded us to their advantages, if any? Edited by Khoa Anh Tran & Tanya Kovacevic Issue 1: September 24, 2021 Illustration by Rachel Ko Throughout human history, diseases and plagues have amassed death tolls reaching hundreds of millions, if not billions. From the Black Death in the 14th century, which killed about 200 million people, or about 30–50% of Europe’s population, to outbreaks of tuberculosis and typhoid fever, resulting in 1.4 million and 200,000 deaths every year, respectively (1, 2, 3). It should come as no surprise then that we have long perceived these microorganisms as a threat to public health and have consequently sought to eradicate these microbes from our environment. But have we been looking at them the wrong way? First and foremost, we know very little about the microorganisms living around us. In bacterial species alone, some scientists have estimated around a billion species worldwide, though even this value is believed to be a gross underestimation (4). Before the germ theory, the most widely accepted theories were the spontaneous generation and miasma theories. Spontaneous generation was a simple theory, believing that living organisms could develop from nonliving matter, such as maggots developing from rotting flesh. The miasma theory, on the other hand, was more prevalent throughout both ancient and modern history. From this perspective, “toxic” vapours from rotting organisms or unsanitary locations were believed to have caused disease (5). This all changed with the germ theory of disease: an idea that would revolutionise our understanding of microorganisms for centuries to come. First theorised as “invisible seeds” by Italian scholar Girolamo Fracastoro in 1546, Fracastoro believed that these seeds could cause disease when spread from infected to healthy individuals (6). For the most part, the basis of the germ theory would continue to follow this logic of a specific microorganism, a “germ”, that could cause a specific disease when invading its host (7). Yet, it was not until nearly 200 years later that the field of microbiology would see huge developments. In 1861, French scientist Louis Pasteur had disproved the spontaneous generation theory by means of sterilisation and proper sealing of food items, which would prevent microbial growth (8). However, Louis Pasteur would not be the only one contributing to developments in microbiology. In 1884, German scientist Robert Koch would be the first to develop a classification system for establishing a causative relationship between a microorganism and its respective disease, effectively confirming the germ theory of disease (9). Even to this day, Koch’s system is still very much influential in microbial pathogenesis, albeit refined to a higher standard. Now known as Koch’s Molecular Postulates — as opposed to Koch’s Original Postulates — which is a model that places a greater emphasis on the virulence genes causing disease, rather than the microorganism itself (10). Today, while we have much to thank Pasteur and Koch for in laying the foundation of modern microbiology, undoubtedly one of the biggest discoveries in microbiology was the discovery of the human microbiota. When we think of microbial life, we usually think of diseases and plagues, cleanliness and dirtiness. Rarely do we ever consider the idea of microbes living inside and around us. Yet, even less so can we begin to comprehend the sheer number of microorganisms that live and proliferate all around ourselves. In our gastrointestinal tract, estimates suggest that there are some 100 trillion microorganisms encoding three million genes altogether, which is 130 times more than what we encode ourselves (11). Figure 1. Microbes in Food (25) So, what do we know about the microbiota; specifically, our microbiota? Firstly, we know that the microorganisms occupying our gut do not cause disease, under normal circumstances. Secondly, we know that they can provide us with a multitude of benefits, such as helping us digest complex organic molecules, and preventing invasion of foreign microbes by directly competing for resources and keeping the immune system stimulated. These are just a few of the advantages our microbial allies provide us. However, that is not to say that they pose no danger to ourselves either. Typically, these microorganisms are categorised into being in a beneficial, pathogenic or commensal relationship with its host. Beneficial microbes, or probiotics, are as the name suggests: these microbes typically provide some form of health benefit to the host and are usually non-pathogenic. Many of the bacterial species found in our gut lumen, for example, have the capability to digest cellulose. As such, without these microbes, digesting vegetables would be a much harder and less rewarding task. Most of the probiotics found in our microflora are of lactic acid bacteria origin and are most common in diets that incorporate fermented dairy products (12). Pathogenic microbes, on the other hand, mostly describe microbes of foreign origin. These microorganisms will infect and exploit the host’s cells, ultimately causing disease. Commensal microorganisms walk an interesting line, in comparison to beneficial and pathogenic microbes. This group of microbes encompasses all of the characteristics described above, depending on circumstance. This ranges from benefiting both the host and microbe, the microbe itself, or even causing disease within its host when given the opportunity. An example of a commensal microorganism is Escherichia coli, or E. coli. It is a bacterium that colonises our gastrointestinal tract as soon as we are born, where it fends off more than 500 competing bacteria species, thanks to its versatility and adaptations to our gut environment (13). Furthermore, the presence of E. coli along our gut epithelium helps to stimulate mucin production, inhibiting any foreign microbes from invading the epithelium (14). However, as is typical of a commensal organism, when given the chance, E. coli is capable of causing intestinal or extraintestinal disease in our bodies. Urinary tract infections due to E. coli are among the most common causes of a microflora-associated infection and often occur when the bacterium is allowed to enter the urinary tract via cross contamination with the anus, where E. coli is typically shed as part of the faeces (15). Typically, these beneficial and commensal bacteria are found all over our body. They can be found in our hair, on our skin, and as we have discussed, in our gut. Malassezia, for example, is a fungus that colonises our scalp, and is what causes dandruff in most people. While dandruff may be a nuisance to those who experience it, do the disadvantages necessarily outweigh the benefits? The presence of Malassezia on our scalps means that other, possibly dangerous, microorganisms will have to compete with Malassezia in order to invade. Additionally, the stimulation of our body’s defenses due to Malassezia aids in repelling foreign invaders (16). Staphylococcus aureus is another example of a commensal microbe, and an even better example of an opportunistic pathogen that can be found living harmoniously on our skin and nasal passages, helping us fend off other competing microbes just as Malassezia does on our scalp. However, when the skin is pierced, whether by means of injury or even medically through surgeries or treatments, the Staphylococcus bacteria will opportunistically attempt to invade and infect its host (17). As such, Staph infections and outbreaks are among some of the most common forms of hospital-related infections (18). Source: Thomas L Dawson, “What causes dandruff, and how do you get rid of it?” February 10, 2021, Ted-Ed video (19). Looking to the future, we have begun to see a spike in non-communicable diseases as opposed to microorganism-based diseases. These include most forms of heart diseases, cancers, diabetes, and others. Still, while the rise of non-communicable diseases is arguably a cause for concern, the return of long extinct diseases and antibiotic resistant pathogens may prove costly. Staph infections, as previously mentioned, are extremely common in hospital environments where continued usage of antibiotics such as penicillin or methicillin has produced a “super strain” of Staphylococcus that is resistant to most commercially available drugs (20). Currently, superbugs such as multidrug-resistant mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus are most common in healthcare settings, but community transmissions have become a concern (21). As such, with our current practices of antibiotic overprescriptions and continued reliance on sterilisation, future outbreaks of mutated and resistant pathogens may be inevitable. That being said, should we redefine what “clean and sterile” means to us? Should “sterile” necessarily be a microbe-free environment? Our perception of microbial life has consistently been “antibacterial” and believed to have been a threat to public health ever since the inception of the germ theory. However, the fact of the matter is that these microorganisms are unavoidable. There are microorganisms living all over us. Our fingers, our phones, even the soles on our shoes carry certain microorganisms. In hospital rooms, the composition of microbes is constantly changing as patients and visitors enter and leave (22). Besides, the composition of microbes in the environment is not determined solely by its occupants. Other factors, such as ventilation and even architecture, can determine what microbes we find in our environment. In fact, hospital rooms with more airflow and humidity were found to have suppressed the growth of potential pathogens and had fewer human-associated bacteria in its microbial composition (23). Just as the microbe composition in the environment can be determined by architectural and building factors, the microbe composition in our microflora can hold incredible influence over our physiology. Dysbiosis, an imbalance in our microflora, can occur as a result of repeated consumption of antibiotics, and it is a serious illness resulting in a significant loss of beneficial and commensal microbes (24). Consequently, invasion and colonisation capabilities of foreign pathogens is increased; as has been shown in antibiotic-treated mice exposed to M. tuberculosis, where pathogenic colonisation was promoted when in a dysbiotic state (25). Other factors, such as diet and lifestyle, also contribute as “disturbance” factors that influence dysbiosis, as can be seen in typical Western-style diets that mostly consist of high fatty and sugary foods (26). In the future, while the crises of pandemics originating from drug-resistant superbugs loom over us, our understanding of microbial life has come far; from its humble beginnings as a rejected theory amongst scholars, to the discovery of an extensive microbial ecosystem inside of our guts. Despite that, our comprehension of this “hidden world” remains lacking, and we have yet to fully realise the potential of microbial life. Throughout history we have constantly taken an antimicrobial stance to preserve public health, but in recent times it has become increasingly clear that these microorganisms play a much greater role in health. References: 1. LePan, Nicholas. “Visualizing the History of Pandemics.” Visual Capitalist. Last modified September 2021. https://www.visualcapitalist.com/history-of-pandemics-deadliest/ . 2. World Health Organization. “Tuberculosis.” Published October 2020. https://www.who.int/news-room/fact-sheets/detail/tuberculosis . 3. Centers for Disease Control and Prevention. “Typhoid Fever and Paratyphoid Fever.” Last modified March 2021. https://www.cdc.gov/typhoid-fever/health-professional.html . 4. Dykhuizen, Daniel. “Species Numbers in Bacteria.” Supplement, Proceedings. California Academy of Science 56, no. S6 (2005): 62-71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160642/ . 5. Kannadan, Ajesh. “History of the Miasma Theory of Disease.” ESSAI 16, no. 1 (2018): 41-43. https://dc.cod.edu/essai/vol16/iss1/18/ . 6, 8. Greenwood, Michael. “History of Microbiology – Germ Theory and Immunity.” News-Medical. Last modified May 2020. https://www.news-medical.net/life-sciences/History-of-Microbiology-e28093-Germ-Theory-and-Immunity.aspx . 7. Britannica. “Germ theory.” Last modified April 2020. https://www.britannica.com/science/germ-theory . 9, 10. Gradmann, Christoph. “A spirit of scientific rigour: Koch’s postulates in twentieth-century medicine.” Microbes and Infection 16, no. 11 (2014): 885-892. https://doi.org/10.1016/j.micinf.2014.08.012 . 11. Valdes, Ana M, Jens Walter, Eran Segal, and Tim D Spector. “Role of the gut microbiota in nutrition and health.” BMJ 361, no. k2179 (2018): 36-44. https://doi.org/10.1136/bmj.k2179 . 12, 24. Martín, Rebeca, Sylvie Miquel, Jonathan Ulmer, Noura Kechaou, Philippe Langella, and Luis G Bermúdez-Humarán. “Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease.” Microbial Cell Factories 12, no. 71 (2013): 1-11. https://doi.org/10.1186/1475-2859-12-71 . 13, 15. Leimbach, Andreas, Jörg Hacker, and Ulrich Dobrindt. “E. coli as an All-rounder: The Thin Line Between Commensalism and Pathogenicity.” In Between Pathogenicity and Commensalism, edited by Ulrich Dobrindt, Jörg Hacker and Catharina Svanborg, 3-32. Springer: Berlin, 2013. 14. Libertucci, Josie, and Vincent B Young. “The role of the microbiota in infectious diseases.” Nat Microbial 4, no. 1 (2019): 35-45. https://doi.org/10.1038/s41564-018-0278-4 . 15. Harvard Medical School. “When urinary tract infections keep coming back.” Published September 2019. https://www.health.harvard.edu/bladder-and-bowel/when-urinary-tract-infections-keep-coming-back . 16. Saunders, Charles W, Annika Scheynius, Joseph Heitman. “Malassezia Fungi Are Specialized to Live on Skin and Associated with Dandruff, Eczema and Other Skin Diseases.” PLoS pathogens 8, no. 6 (2012): 1-4. https://doi.org/10.1371/journal.ppat.1002701 . 17. Cogen, A. L., V. Nizet, and R. L. Gallo. “Skin microbiota: a source of disease or defence?” British journal of dermatology 158, no. 3 (2008), https://doi.org/10.1111/j.1365-2133.2008.08437.x . 18, 20. Klein, Eili, David L Smith, and Ramanan Laxminarayan. “Hospitalizations and Deaths Caused by Methicillin-Resistant Staphylococcus aureus, United States, 1999–2005.” Emerging infectious diseases 13, no. 12 (2007): 1840-1846. https://doi.org/10.3201/eid1312.070629 . 19. Dawson, Thomas L. “What causes dandruff, and how do you get rid of it?” February 10, 2021. Ted-Ed video, 5:04. https://youtu.be/x6DUOokXZAo . 21. Better Health. “Antibiotic resistant bacteria.” Last modified March 2017. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/antibiotic-resistant-bacteria#bhc-content . 22, 23. Arnold, Carrie. “Rethinking Sterile: The Hospital Microbiome.” Environmental health perspective 122, no. 7 (2014): A182-A187. https://doi.org/10.1289/ehp.122-A182 . 25. Khan, Rabia, Fernanda C Petersen, and Sudhanshu Shekhar. “Commensal Bacteria: An Emerging Player in Defense Against Respiratory Pathogens.” Frontiers in Immunology 10, no. 1 (2019): 1203-1211. https://doi.org/10.3389/fimmu.2019.01203 . 26. Schippa, Serena, and Maria P Conte. “Dysbiotic Events in Gut Microbiota: Impact on Human Health.” Nutrients 6, no. 12 (2014): 5786-5805. https://doi.org/10.3390/nu6125786 . 27. Sottek, Frank. Microbes in Food. c. 1904. The Tacoma Times, Tacoma. https://commons.wikimedia.org/wiki/File:Sottek_cartoon_about_microbes_in_food.jpg .